KR20220022051A - 세포내 클로라이드 농도 조절제 - Google Patents

세포내 클로라이드 농도 조절제 Download PDF

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Publication number
KR20220022051A
KR20220022051A KR1020217035857A KR20217035857A KR20220022051A KR 20220022051 A KR20220022051 A KR 20220022051A KR 1020217035857 A KR1020217035857 A KR 1020217035857A KR 20217035857 A KR20217035857 A KR 20217035857A KR 20220022051 A KR20220022051 A KR 20220022051A
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South Korea
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benzoic acid
dimethylsulfamoyl
substituted
unsubstituted
cycloalkyl
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Korean (ko)
Inventor
라우라 칸세다
비보 마르코 드
안드레아 콘테스타빌레
마르코 보르고뇨
안나리사 사바르디
마르티네즈 호세 안토니오 오르테가
Original Assignee
폰다치오네 이스티튜토 이탈리아노 디 테크놀로지아
폰다지오네 텔레톤
알마마 테르 스투디오룸 유니베르시타‘ 디 볼로냐
유니버시타＇ 데글리 스투디 디 제노바
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Application filed by 폰다치오네 이스티튜토 이탈리아노 디 테크놀로지아, 폰다지오네 텔레톤, 알마마 테르 스투디오룸 유니베르시타‘ 디 볼로냐, 유니버시타＇ 데글리 스투디 디 제노바 filed Critical 폰다치오네 이스티튜토 이탈리아노 디 테크놀로지아
Publication of KR20220022051A publication Critical patent/KR20220022051A/ko
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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KR1020217035857A 2019-04-02 2020-04-02 세포내 클로라이드 농도 조절제 Ceased KR20220022051A (ko)

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IT201900004929 2019-04-02
IT102019000004929 2019-04-02
PCT/IB2020/053158 WO2020202072A1 (en) 2019-04-02 2020-04-02 Modulators of intracellular chloride concentration

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US (1) US20220184008A1 (https=)
EP (1) EP3947345A1 (https=)
JP (1) JP7676317B2 (https=)
KR (1) KR20220022051A (https=)
CN (2) CN114174259A (https=)
AU (1) AU2020251023B2 (https=)
CA (1) CA3135339A1 (https=)
IL (1) IL286900B2 (https=)
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IT202300007521A1 (it) * 2023-04-18 2024-10-18 Iama Therapeutics S R L Processo per la preparazione di derivati dell'acido sulfamoilbenzoico
WO2025257786A1 (en) * 2024-06-13 2025-12-18 Iama Therapeutics S.R.L. Benzoimidazole derivatives as nkcc1 inhibitors

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