JP7676317B2 - 細胞内塩素イオン濃度のモジュレーター - Google Patents

細胞内塩素イオン濃度のモジュレーター Download PDF

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JP7676317B2
JP7676317B2 JP2021560304A JP2021560304A JP7676317B2 JP 7676317 B2 JP7676317 B2 JP 7676317B2 JP 2021560304 A JP2021560304 A JP 2021560304A JP 2021560304 A JP2021560304 A JP 2021560304A JP 7676317 B2 JP7676317 B2 JP 7676317B2
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benzoic acid
dimethylsulfamoyl
trifluorooctylamino
sulfamoyl
amino
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JP2022528271A (ja
JP2022528271A5 (https=
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ローラ キャンセッダ
ヴィーヴォ マルコ デ
アンドレア コンテスタビーレ
マルコ ボルゴーニョ
アンナリーザ サバルディ
マルティネス ホセ アントニオ オルテガ
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Fondazione Istituto Italiano di Tecnologia
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/43—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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PCT/IB2020/053158 WO2020202072A1 (en) 2019-04-02 2020-04-02 Modulators of intracellular chloride concentration

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US (1) US20220184008A1 (https=)
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CN (2) CN114174259A (https=)
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IT202300007521A1 (it) * 2023-04-18 2024-10-18 Iama Therapeutics S R L Processo per la preparazione di derivati dell'acido sulfamoilbenzoico
WO2025257786A1 (en) * 2024-06-13 2025-12-18 Iama Therapeutics S.R.L. Benzoimidazole derivatives as nkcc1 inhibitors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058277A1 (en) 1999-03-31 2000-10-05 American Home Products Corporation Aryl sulfonic acids and derivatives as fsh antagonists
WO2001062718A1 (en) 2000-02-25 2001-08-30 Japan Tobacco, Inc. Benzamide derivative and use thereof
WO2007058960A1 (en) 2005-11-10 2007-05-24 Adolor Corporation Sulfamoyl benzamides as cannabinoid receptor modulators
JP2010508300A (ja) 2006-10-26 2010-03-18 フライン、ギャリー・エー． アクアポリン修飾因子並びに浮腫および体液平衡異常の治療のためのそれらの使用方法
JP2011231094A (ja) 2009-11-02 2011-11-17 Neurotherapeutics Pharma Inc ブメタニド、フロセミド、ピレタニド、アゾセミド、およびトルセミドのアナログ、組成物および使用方法
JP2013136599A (ja) 2006-06-22 2013-07-11 Anadys Pharmaceuticals Inc ピロ［１，２−ｂ］ピリダジノン化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3493584A (en) * 1966-02-21 1970-02-03 Smithkline Corp 4-substituted amino-5-sulfamoylbenzoic acid derivatives and preparation
DE2412884A1 (de) * 1974-03-18 1975-10-16 Hoechst Ag Basisch substituierte benzolsulfonamide und verfahren zu ihrer herstellung
DE2442851A1 (de) * 1974-09-06 1976-03-18 Hoechst Ag Basisch substituierte 3-sulfamoylbenzoesaeurederivate und verfahren zu ihrer herstellung
DE2517183A1 (de) * 1975-04-18 1976-10-28 Hoechst Ag Basisch substituierte 5-sulfamoyl- anthranilsaeurederivate und verfahren zu ihrer herstellung
DE3101960A1 (de) * 1981-01-22 1982-09-02 Hoechst Ag, 6000 Frankfurt "basisch substituierte anthranilsaeuren, verfahren zu ihrer herstellung und ihre verwendung"
BE1012386A3 (fr) * 1999-01-15 2000-10-03 Univ Liege Derives de sulfonamides benzeniques et leurs utilisations.
US6355633B1 (en) * 1999-03-31 2002-03-12 American Home Products Corporation Aryl sulfonic acids and derivatives as FSH antagonists
JP2002201172A (ja) * 2000-02-25 2002-07-16 Japan Tobacco Inc ベンズアミド誘導体及びその用途
EP2389371A4 (en) * 2009-01-22 2012-09-12 Neurotherapeutics Pharma Inc ANALOGUES OF BUMETANIDE, FUROSEMIDE, PIRETANIDE, AZOSEMIDE AND TORSEMID, AND RELATED COMPOSITIONS AND METHODS OF USE

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058277A1 (en) 1999-03-31 2000-10-05 American Home Products Corporation Aryl sulfonic acids and derivatives as fsh antagonists
WO2001062718A1 (en) 2000-02-25 2001-08-30 Japan Tobacco, Inc. Benzamide derivative and use thereof
WO2007058960A1 (en) 2005-11-10 2007-05-24 Adolor Corporation Sulfamoyl benzamides as cannabinoid receptor modulators
JP2013136599A (ja) 2006-06-22 2013-07-11 Anadys Pharmaceuticals Inc ピロ［１，２−ｂ］ピリダジノン化合物
JP2010508300A (ja) 2006-10-26 2010-03-18 フライン、ギャリー・エー． アクアポリン修飾因子並びに浮腫および体液平衡異常の治療のためのそれらの使用方法
JP2011231094A (ja) 2009-11-02 2011-11-17 Neurotherapeutics Pharma Inc ブメタニド、フロセミド、ピレタニド、アゾセミド、およびトルセミドのアナログ、組成物および使用方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Katia D'Ambrosio et al.，Carbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides with Selectivity for Targeting the Tumor Associated Isoforms IX and XII，Journal of Medicinal Chemistry，2008年，51巻，3230-3237頁
REGISTRY(STN)[online]，[検索日 2024.01.22]CAS登録番号2215388-15-9（ED：2018.04.19）, 2215335-41-2（ED：2018.04.19）, 1286648-18-7（ED：2018.04.19）
REGISTRY(STN)[online]，2018年04月20日，1-105頁，［検索日 2024.09.25］CAS登録番号 2216497-28-6, 他多数
Steven J. Culliford et al. ，Specificity of Classical and Putative Cl-Transport Inhibitors on Membrane Transport Pathways in Human Erythrocytes，Cellular Physiology and Biochemistry，2003年，13巻，181-188頁

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