CN114174259A - 细胞内氯化物浓度的调节剂 - Google Patents
细胞内氯化物浓度的调节剂 Download PDFInfo
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- CN114174259A CN114174259A CN202080041313.5A CN202080041313A CN114174259A CN 114174259 A CN114174259 A CN 114174259A CN 202080041313 A CN202080041313 A CN 202080041313A CN 114174259 A CN114174259 A CN 114174259A
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- Prior art keywords
- benzoic acid
- group
- dimethylsulfamoyl
- substituted
- unsubstituted
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/18—Sulfonamides
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/43—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202510862455.2A CN120661491A (zh) | 2019-04-02 | 2020-04-02 | 细胞内氯化物浓度的调节剂 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT201900004929 | 2019-04-02 | ||
| IT102019000004929 | 2019-04-02 | ||
| PCT/IB2020/053158 WO2020202072A1 (en) | 2019-04-02 | 2020-04-02 | Modulators of intracellular chloride concentration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202510862455.2A Division CN120661491A (zh) | 2019-04-02 | 2020-04-02 | 细胞内氯化物浓度的调节剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114174259A true CN114174259A (zh) | 2022-03-11 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080041313.5A Pending CN114174259A (zh) | 2019-04-02 | 2020-04-02 | 细胞内氯化物浓度的调节剂 |
| CN202510862455.2A Pending CN120661491A (zh) | 2019-04-02 | 2020-04-02 | 细胞内氯化物浓度的调节剂 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202510862455.2A Pending CN120661491A (zh) | 2019-04-02 | 2020-04-02 | 细胞内氯化物浓度的调节剂 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220184008A1 (https=) |
| EP (1) | EP3947345A1 (https=) |
| JP (1) | JP7676317B2 (https=) |
| KR (1) | KR20220022051A (https=) |
| CN (2) | CN114174259A (https=) |
| AU (1) | AU2020251023B2 (https=) |
| CA (1) | CA3135339A1 (https=) |
| IL (1) | IL286900B2 (https=) |
| SG (1) | SG11202110950XA (https=) |
| WO (1) | WO2020202072A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202300007521A1 (it) * | 2023-04-18 | 2024-10-18 | Iama Therapeutics S R L | Processo per la preparazione di derivati dell'acido sulfamoilbenzoico |
| WO2025257786A1 (en) * | 2024-06-13 | 2025-12-18 | Iama Therapeutics S.R.L. | Benzoimidazole derivatives as nkcc1 inhibitors |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4406895A (en) * | 1981-01-22 | 1983-09-27 | Hoechst Aktiengesellschaft | Base-substituted anthranilic acids, a process for their preparation and their use |
| WO2000042004A1 (fr) * | 1999-01-15 | 2000-07-20 | Universite De Liege | Derives de sulfonamides benzeniques et leurs utilisations |
| JP2002201172A (ja) * | 2000-02-25 | 2002-07-16 | Japan Tobacco Inc | ベンズアミド誘導体及びその用途 |
| US20080058302A1 (en) * | 2005-11-10 | 2008-03-06 | Dolle Roland E | Sulfamoyl Benzamides and Methods of Their Use |
| WO2008052190A2 (en) * | 2006-10-26 | 2008-05-02 | Flynn Gary A | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance |
| CN102341380A (zh) * | 2009-01-22 | 2012-02-01 | 神经病治疗药物股份有限公司 | 布美他尼、呋塞米、吡咯他尼、佐塞米和托拉塞米类似物、组合物和使用方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3493584A (en) * | 1966-02-21 | 1970-02-03 | Smithkline Corp | 4-substituted amino-5-sulfamoylbenzoic acid derivatives and preparation |
| DE2412884A1 (de) * | 1974-03-18 | 1975-10-16 | Hoechst Ag | Basisch substituierte benzolsulfonamide und verfahren zu ihrer herstellung |
| DE2442851A1 (de) * | 1974-09-06 | 1976-03-18 | Hoechst Ag | Basisch substituierte 3-sulfamoylbenzoesaeurederivate und verfahren zu ihrer herstellung |
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- 2020-04-02 WO PCT/IB2020/053158 patent/WO2020202072A1/en not_active Ceased
- 2020-04-02 JP JP2021560304A patent/JP7676317B2/ja active Active
- 2020-04-02 KR KR1020217035857A patent/KR20220022051A/ko not_active Ceased
- 2020-04-02 CN CN202080041313.5A patent/CN114174259A/zh active Pending
- 2020-04-02 IL IL286900A patent/IL286900B2/en unknown
- 2020-04-02 SG SG11202110950XA patent/SG11202110950XA/en unknown
- 2020-04-02 AU AU2020251023A patent/AU2020251023B2/en active Active
- 2020-04-02 US US17/594,070 patent/US20220184008A1/en active Pending
- 2020-04-02 CA CA3135339A patent/CA3135339A1/en active Pending
- 2020-04-02 CN CN202510862455.2A patent/CN120661491A/zh active Pending
- 2020-04-02 EP EP20716121.7A patent/EP3947345A1/en active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| CA3135339A1 (en) | 2020-10-08 |
| JP7676317B2 (ja) | 2025-05-14 |
| US20220184008A1 (en) | 2022-06-16 |
| CN120661491A (zh) | 2025-09-19 |
| BR112021019935A2 (pt) | 2022-03-03 |
| JP2022528271A (ja) | 2022-06-09 |
| SG11202110950XA (en) | 2021-10-28 |
| WO2020202072A1 (en) | 2020-10-08 |
| AU2020251023B2 (en) | 2025-11-27 |
| EP3947345A1 (en) | 2022-02-09 |
| KR20220022051A (ko) | 2022-02-23 |
| IL286900A (en) | 2021-10-31 |
| AU2020251023A1 (en) | 2021-11-04 |
| IL286900B2 (en) | 2025-03-01 |
| IL286900B1 (en) | 2024-11-01 |
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