KR20200093439A - 구강용 스테인 제거제, 구강용 스테인 형성 억제제 및 구강용 조성물 - Google Patents
구강용 스테인 제거제, 구강용 스테인 형성 억제제 및 구강용 조성물 Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/51—Chelating agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
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JPJP-P-2017-230366 | 2017-11-30 | ||
JP2017230381 | 2017-11-30 | ||
JPJP-P-2017-230381 | 2017-11-30 | ||
JP2017230366 | 2017-11-30 | ||
PCT/JP2018/043498 WO2019107332A1 (fr) | 2017-11-30 | 2018-11-27 | Agent d'élimination de taches buccales, agent inhibiteur de formation de taches buccales, et composition buccale |
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KR20200093439A true KR20200093439A (ko) | 2020-08-05 |
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KR1020197038562A KR20200093439A (ko) | 2017-11-30 | 2018-11-27 | 구강용 스테인 제거제, 구강용 스테인 형성 억제제 및 구강용 조성물 |
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JP (1) | JP7173043B2 (fr) |
KR (1) | KR20200093439A (fr) |
CN (1) | CN111417381B (fr) |
WO (1) | WO2019107332A1 (fr) |
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---|---|---|---|---|
JP2020100596A (ja) * | 2018-12-25 | 2020-07-02 | ライオン株式会社 | 口腔バイオフィルム除去剤及び口腔用組成物 |
JPWO2022131147A1 (fr) * | 2020-12-14 | 2022-06-23 | ||
CN114617791B (zh) * | 2022-03-07 | 2024-01-16 | 桂林市啄木鸟医疗器械有限公司 | 一种牙科喷砂粉组合物以及应用 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0729907A (ja) | 1993-07-15 | 1995-01-31 | Nec Corp | Lsi配線構造およびその形成方法 |
JPH09175966A (ja) | 1995-12-26 | 1997-07-08 | Lion Corp | 口腔用組成物 |
JP2000247851A (ja) | 1999-02-26 | 2000-09-12 | Lion Corp | 着色抑制コーティング剤 |
JP2003081797A (ja) | 2001-07-05 | 2003-03-19 | Sunstar Inc | 口腔用組成物 |
JP2013142061A (ja) | 2012-01-10 | 2013-07-22 | Lion Corp | 歯磨組成物 |
JP2015174830A (ja) | 2014-03-13 | 2015-10-05 | アース製薬株式会社 | 口腔用ステイン形成阻害剤および口腔用組成物 |
WO2016194645A1 (fr) | 2015-05-29 | 2016-12-08 | ライオン株式会社 | Composition destinée à être utilisée dans la cavité buccale |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4661341A (en) * | 1984-10-30 | 1987-04-28 | The Procter & Gamble Company | Oral compositions |
JPH09175968A (ja) * | 1995-12-26 | 1997-07-08 | Lion Corp | 口腔用組成物 |
US6685916B1 (en) * | 2002-10-31 | 2004-02-03 | Cadbury Adams Usa Llc | Compositions for removing stains from dental surfaces, and methods of making and using the same |
JP2006347986A (ja) * | 2005-06-17 | 2006-12-28 | Sunstar Inc | 口腔用組成物 |
JP2008201704A (ja) * | 2007-02-20 | 2008-09-04 | Lion Corp | 歯牙美白用組成物 |
US8361942B2 (en) * | 2008-12-09 | 2013-01-29 | The Clorox Company | Hypochlorite denture compositions and methods of use |
JP5705513B2 (ja) * | 2010-11-29 | 2015-04-22 | 花王株式会社 | 液体口腔用組成物 |
JP5682264B2 (ja) * | 2010-11-30 | 2015-03-11 | ライオン株式会社 | 口腔用組成物及び歯周病原因菌の歯面付着抑制剤 |
JP5834881B2 (ja) * | 2011-12-20 | 2015-12-24 | ライオン株式会社 | 歯磨剤組成物 |
KR102146681B1 (ko) * | 2013-07-18 | 2020-08-21 | 라이온 가부시키가이샤 | 구강 바이오필름 제거제 및 구강용 조성물 |
CN110494123A (zh) * | 2017-04-21 | 2019-11-22 | 狮王株式会社 | 口腔生物膜去除剂和口腔用组合物 |
-
2018
- 2018-11-27 CN CN201880076794.6A patent/CN111417381B/zh active Active
- 2018-11-27 JP JP2019557223A patent/JP7173043B2/ja active Active
- 2018-11-27 KR KR1020197038562A patent/KR20200093439A/ko not_active Application Discontinuation
- 2018-11-27 WO PCT/JP2018/043498 patent/WO2019107332A1/fr active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0729907A (ja) | 1993-07-15 | 1995-01-31 | Nec Corp | Lsi配線構造およびその形成方法 |
JPH09175966A (ja) | 1995-12-26 | 1997-07-08 | Lion Corp | 口腔用組成物 |
JP2000247851A (ja) | 1999-02-26 | 2000-09-12 | Lion Corp | 着色抑制コーティング剤 |
JP2003081797A (ja) | 2001-07-05 | 2003-03-19 | Sunstar Inc | 口腔用組成物 |
JP2013142061A (ja) | 2012-01-10 | 2013-07-22 | Lion Corp | 歯磨組成物 |
JP2015174830A (ja) | 2014-03-13 | 2015-10-05 | アース製薬株式会社 | 口腔用ステイン形成阻害剤および口腔用組成物 |
WO2016194645A1 (fr) | 2015-05-29 | 2016-12-08 | ライオン株式会社 | Composition destinée à être utilisée dans la cavité buccale |
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JP7173043B2 (ja) | 2022-11-16 |
CN111417381A (zh) | 2020-07-14 |
CN111417381B (zh) | 2023-06-30 |
JPWO2019107332A1 (ja) | 2020-11-26 |
WO2019107332A1 (fr) | 2019-06-06 |
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