KR20200010220A - 피라졸로퀴놀린 유도체를 함유하는 루이소체 질병 치료제 - Google Patents
피라졸로퀴놀린 유도체를 함유하는 루이소체 질병 치료제 Download PDFInfo
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- KR20200010220A KR20200010220A KR1020197033124A KR20197033124A KR20200010220A KR 20200010220 A KR20200010220 A KR 20200010220A KR 1020197033124 A KR1020197033124 A KR 1020197033124A KR 20197033124 A KR20197033124 A KR 20197033124A KR 20200010220 A KR20200010220 A KR 20200010220A
- Authority
- KR
- South Korea
- Prior art keywords
- dementia
- disease
- parkinson
- formula
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 201000002832 Lewy body dementia Diseases 0.000 title claims abstract description 33
- 238000011282 treatment Methods 0.000 title claims description 7
- 208000009829 Lewy Body Disease Diseases 0.000 title abstract description 19
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- 150000003839 salts Chemical class 0.000 claims abstract description 32
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762513727P | 2017-06-01 | 2017-06-01 | |
| US62/513,727 | 2017-06-01 | ||
| PCT/JP2018/020650 WO2018221551A1 (ja) | 2017-06-01 | 2018-05-30 | ピラゾロキノリン誘導体を含有するレビー小体病治療剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20200010220A true KR20200010220A (ko) | 2020-01-30 |
Family
ID=64456542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197033124A Ceased KR20200010220A (ko) | 2017-06-01 | 2018-05-30 | 피라졸로퀴놀린 유도체를 함유하는 루이소체 질병 치료제 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11311530B2 (https=) |
| EP (1) | EP3632438B1 (https=) |
| JP (1) | JP7269875B2 (https=) |
| KR (1) | KR20200010220A (https=) |
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| WO2018221550A1 (ja) | 2017-06-01 | 2018-12-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピラゾロキノリン誘導体とメマンチンの併用による認知症治療剤 |
| RU2019135834A (ru) | 2017-06-01 | 2021-07-13 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Терапевтическое средство для лечения деменции, представляющее собой комбинацию производного пиразолохинолина и донепезила |
| KR20200010211A (ko) | 2017-06-01 | 2020-01-30 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Pde9 저해제를 포함하는 약제학적 조성물 |
| WO2023064857A1 (en) | 2021-10-14 | 2023-04-20 | Incyte Corporation | Quinoline compounds as inhibitors of kras |
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| US8563565B2 (en) | 2011-10-07 | 2013-10-22 | Eisai R&D Management Co., Ltd. | Pyrazoloquinoline derivatives |
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| DE19642591A1 (de) | 1996-10-15 | 1998-04-16 | Basf Ag | Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung |
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| WO2018221550A1 (ja) | 2017-06-01 | 2018-12-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピラゾロキノリン誘導体とメマンチンの併用による認知症治療剤 |
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| IL270357A (https=) | 2020-02-27 |
| BR112019023552A2 (pt) | 2020-06-02 |
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| TW201902479A (zh) | 2019-01-16 |
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| AU2018278422B2 (en) | 2022-03-17 |
| MX394435B (es) | 2025-03-12 |
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| MX2019013397A (es) | 2020-02-07 |
| AU2018278422A1 (en) | 2019-11-21 |
| WO2018221551A1 (ja) | 2018-12-06 |
| IL270357B1 (en) | 2023-10-01 |
| TWI784006B (zh) | 2022-11-21 |
| JPWO2018221551A1 (ja) | 2020-04-02 |
| CN110612102A (zh) | 2019-12-24 |
| CA3061884A1 (en) | 2019-10-29 |
| RU2019135690A3 (https=) | 2021-08-25 |
| US20200155541A1 (en) | 2020-05-21 |
| EP3632438A1 (en) | 2020-04-08 |
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