KR20180038447A - 면역 체크포인트 키메라 수용체 치료법 - Google Patents

면역 체크포인트 키메라 수용체 치료법 Download PDF

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KR20180038447A
KR20180038447A KR1020187002679A KR20187002679A KR20180038447A KR 20180038447 A KR20180038447 A KR 20180038447A KR 1020187002679 A KR1020187002679 A KR 1020187002679A KR 20187002679 A KR20187002679 A KR 20187002679A KR 20180038447 A KR20180038447 A KR 20180038447A
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protein
cell
domain
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intracellular signaling
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이반 엠. 보렐로
수잔 리
킴벌리 에이. 누난
드류 엠. 파돌
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더 존스 홉킨스 유니버시티
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/41—Vertebrate antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70521—CD28, CD152
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
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    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
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  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020187002679A 2015-06-29 2016-06-29 면역 체크포인트 키메라 수용체 치료법 Withdrawn KR20180038447A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562186108P 2015-06-29 2015-06-29
US62/186,108 2015-06-29
PCT/US2016/040010 WO2017004150A1 (en) 2015-06-29 2016-06-29 Immune checkpoint chimeric antigen receptors therapy

Publications (1)

Publication Number Publication Date
KR20180038447A true KR20180038447A (ko) 2018-04-16

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KR1020187002679A Withdrawn KR20180038447A (ko) 2015-06-29 2016-06-29 면역 체크포인트 키메라 수용체 치료법

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Country Link
US (1) US20180185434A1 (enExample)
EP (1) EP3313892A4 (enExample)
JP (1) JP2018520679A (enExample)
KR (1) KR20180038447A (enExample)
CN (1) CN108137707A (enExample)
AU (1) AU2016285859A1 (enExample)
CA (1) CA2991040A1 (enExample)
HK (2) HK1254820A1 (enExample)
IL (1) IL256643A (enExample)
MA (1) MA42272A (enExample)
MX (1) MX2018000278A (enExample)
WO (1) WO2017004150A1 (enExample)

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US9511092B2 (en) 2013-01-28 2016-12-06 St. Jude Children's Research Hospital, Inc. Chimeric receptor with NKG2D specificity for use in cell therapy against cancer and infectious disease
ES2914176T3 (es) 2013-09-17 2022-06-07 Obi Pharma Inc Composiciones de una vacuna glucídica para inducir respuestas inmunitarias y usos de las mismas en el tratamiento de cáncer
US10428305B2 (en) 2014-05-15 2019-10-01 National University Of Singapore Modified natural killer cells that express IL15 and uses thereof
DK3298033T4 (da) 2015-05-18 2023-10-02 Tcr2 Therapeutics Inc Sammensætninger og medicinske anvendelser til tcr-reprogrammering under anvendelse af fusionsproteiner
MA42902A (fr) 2015-07-08 2018-05-16 Univ Johns Hopkins Lymphocytes infiltrant la moelle (mil) en tant que source de lymphocytes t pour une thérapie par des récepteurs chimériques d'un antigène (car)
US10590169B2 (en) * 2015-12-09 2020-03-17 Virogin Biotech Canada Ltd Compositions and methods for inhibiting CD279 interactions
EP4286522A3 (en) * 2016-03-23 2024-02-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Fusion proteins of pd-1 and 4-1bb
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
JP7544465B2 (ja) 2016-04-22 2024-09-03 オービーアイ ファーマ，インコーポレイテッド グロボシリーズの抗原を介した免疫活性化又は免疫調節によるがん免疫療法
KR20190067765A (ko) 2016-07-27 2019-06-17 오비아이 파머 인코퍼레이티드 면역원성/치료 글리칸 조성물 및 그의 용도
TWI786054B (zh) 2016-07-29 2022-12-11 台灣浩鼎生技股份有限公司 人類抗體、醫藥組合物、及其方法
KR20190077103A (ko) 2016-11-21 2019-07-02 오비아이 파머 인코퍼레이티드 접합된 생물학적 분자, 제약 조성물 및 방법
JP7291396B2 (ja) 2016-11-22 2023-06-15 ティーシーアール２ セラピューティクス インク． 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法
CN110267666A (zh) * 2016-12-22 2019-09-20 温德弥尔治疗公司 用于调节免疫系统的组合物和方法
AU2018246235B2 (en) 2017-03-27 2023-12-21 National University Of Singapore Truncated NKG2D chimeric receptors and uses thereof in natural killer cell immunotherapy
WO2018182511A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
US10934336B2 (en) * 2017-04-13 2021-03-02 The Trustees Of The University Of Pennsylvania Use of gene editing to generate universal TCR re-directed T cells for adoptive immunotherapy
US12258381B2 (en) 2018-02-09 2025-03-25 National University Of Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
WO2019193476A1 (en) 2018-04-02 2019-10-10 National University Of Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
US12486514B2 (en) 2018-08-29 2025-12-02 National University Of Singapore Method to specifically stimulate survival and expansion of genetically-modified immune cells
AU2019387242A1 (en) * 2018-11-30 2021-06-03 Windmil Therapeutics, Inc. Marrow infiltrating lymphocytes (MILs) expressing chimeric antigen receptors (CAR), method of manufacturing same, and method of using in therapy
CN118546959A (zh) 2019-03-05 2024-08-27 恩卡尔塔公司 Cd19定向性嵌合抗原受体及其在免疫疗法中的用途
WO2022098985A1 (en) * 2020-11-05 2022-05-12 Windmil Therapeutics, Inc. Glioblastoma specific marrow infiltrating lymphocytes and uses thereof
WO2022109601A1 (en) * 2020-11-19 2022-05-27 Obi Pharma, Inc. Active cancer immunotherapy by immune modulation via globo series antigens

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PE20141520A1 (es) * 2011-07-29 2014-11-17 Univ Pennsylvania Receptores coestimuladores de cambio
JP6074435B2 (ja) * 2011-10-26 2017-02-01 ナショナル キャンサー センター 変異ｃｔｌａ４遺伝子移入ｔ細胞及びこれを含む抗がん免疫治療用組成物
AU2013204922B2 (en) * 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
WO2014184744A1 (en) 2013-05-13 2014-11-20 Cellectis Methods for engineering highly active t cell for immunotherapy
EP4420663A3 (en) 2013-12-20 2024-10-30 Novartis AG Regulatable chimeric antigen receptor
WO2016019300A1 (en) 2014-07-31 2016-02-04 Novartis Ag Subset-optimized chimeric antigen receptor-containing t-cells
CN107109364A (zh) * 2014-09-04 2017-08-29 约翰霍普金斯大学 缺氧与常氧交替条件下的骨髓浸润淋巴细胞的激活
EP3310805B1 (en) * 2015-06-19 2021-02-17 Kobold, Sebastian Pd-1-cd28 fusion proteins and their use in medicine

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JP2018520679A (ja) 2018-08-02
EP3313892A4 (en) 2019-01-02
US20180185434A1 (en) 2018-07-05
MX2018000278A (es) 2018-03-08
MA42272A (fr) 2018-05-02
HK1255637A1 (zh) 2019-08-23
CN108137707A (zh) 2018-06-08
WO2017004150A1 (en) 2017-01-05
HK1254820A1 (zh) 2019-07-26
EP3313892A1 (en) 2018-05-02
IL256643A (en) 2018-02-28
AU2016285859A1 (en) 2018-02-15
CA2991040A1 (en) 2017-01-05

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