JP2018520679A - 免疫チェックポイントキメラ抗原受容体療法 - Google Patents

免疫チェックポイントキメラ抗原受容体療法 Download PDF

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JP2018520679A
JP2018520679A JP2017568207A JP2017568207A JP2018520679A JP 2018520679 A JP2018520679 A JP 2018520679A JP 2017568207 A JP2017568207 A JP 2017568207A JP 2017568207 A JP2017568207 A JP 2017568207A JP 2018520679 A JP2018520679 A JP 2018520679A
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protein
cell
domain
intracellular signaling
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JP2018520679A5 (enExample
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イヴァン エム． ボレロ，
イヴァン エム． ボレロ，
スーザン リー，
スーザン リー，
キンバリー エー． ヌーナン，
キンバリー エー． ヌーナン，
ドリュー エム． パードール，
ドリュー エム． パードール，
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ザ・ジョンズ・ホプキンス・ユニバーシティー
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JP2017568207A 2015-06-29 2016-06-29 免疫チェックポイントキメラ抗原受容体療法 Pending JP2018520679A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562186108P 2015-06-29 2015-06-29
US62/186,108 2015-06-29
PCT/US2016/040010 WO2017004150A1 (en) 2015-06-29 2016-06-29 Immune checkpoint chimeric antigen receptors therapy

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JP2018520679A true JP2018520679A (ja) 2018-08-02
JP2018520679A5 JP2018520679A5 (enExample) 2019-08-08

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US (1) US20180185434A1 (enExample)
EP (1) EP3313892A4 (enExample)
JP (1) JP2018520679A (enExample)
KR (1) KR20180038447A (enExample)
CN (1) CN108137707A (enExample)
AU (1) AU2016285859A1 (enExample)
CA (1) CA2991040A1 (enExample)
HK (2) HK1254820A1 (enExample)
IL (1) IL256643A (enExample)
MA (1) MA42272A (enExample)
MX (1) MX2018000278A (enExample)
WO (1) WO2017004150A1 (enExample)

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EP3046588B1 (en) 2013-09-17 2022-03-02 OBI Pharma, Inc. Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment
EP3805371A1 (en) 2014-05-15 2021-04-14 National University of Singapore Modified natural killer cells and uses thereof
EP3770168A1 (en) 2015-05-18 2021-01-27 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
PT3310805T (pt) 2015-06-19 2021-05-19 Kobold Sebastian Proteínas de fusão pd-1-cd28 e a sua utilização em medicina
WO2017008019A1 (en) * 2015-07-08 2017-01-12 The Johns Hopkins University Marrow infiltrating lymphocytes (mils) as a source of t-cells for chimeric antigen receptor (car) therapy
US10590169B2 (en) * 2015-12-09 2020-03-17 Virogin Biotech Canada Ltd Compositions and methods for inhibiting CD279 interactions
US11365237B2 (en) * 2016-03-23 2022-06-21 Helmholtz Zentrum Muenchen—Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) Fusion proteins of PD-1 and 4-1BB
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
IL262296B2 (en) 2016-04-22 2024-09-01 Obi Pharma Inc Cancer immunotherapy by immune activation or immune modulation via globo series antigens
KR20190067765A (ko) 2016-07-27 2019-06-17 오비아이 파머 인코퍼레이티드 면역원성/치료 글리칸 조성물 및 그의 용도
KR102528998B1 (ko) 2016-07-29 2023-05-03 오비아이 파머 인코퍼레이티드 인간 항체, 제약 조성물 및 방법
WO2018094414A1 (en) 2016-11-21 2018-05-24 Obi Pharma, Inc. Conjugated biological molecules, pharmaceutical compositions and methods
CN110177803A (zh) 2016-11-22 2019-08-27 T细胞受体治疗公司 用于使用融合蛋白进行tcr重新编程的组合物和方法
CN117363636A (zh) 2017-03-27 2024-01-09 新加坡国立大学 一种编码嵌合受体的多核苷酸
MX2019011570A (es) 2017-03-27 2019-11-18 Nat Univ Singapore Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales.
US10934336B2 (en) * 2017-04-13 2021-03-02 The Trustees Of The University Of Pennsylvania Use of gene editing to generate universal TCR re-directed T cells for adoptive immunotherapy
JP7360174B2 (ja) 2018-02-09 2023-10-12 ナショナル ユニヴァーシティー オブ シンガポール ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用
US12441787B2 (en) 2018-04-02 2025-10-14 National University Of Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
WO2020044239A1 (en) 2018-08-29 2020-03-05 National University Of Singapore A method to specifically stimulate survival and expansion of genetically-modified immune cells
CN113226340A (zh) 2018-11-26 2021-08-06 恩卡尔塔公司 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途
SG11202104637VA (en) * 2018-11-30 2021-06-29 Windmil Therapeutics Inc MARROW INFILTRATING LYMPHOCYTES (MILs) EXPRESSING CHIMERIC ANTIGEN RECEPTORS (CAR), METHOD OF MANUFACTURING SAME, AND METHOD OF USING IN THERAPY
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
WO2022098985A1 (en) * 2020-11-05 2022-05-12 Windmil Therapeutics, Inc. Glioblastoma specific marrow infiltrating lymphocytes and uses thereof
CN116847875A (zh) * 2020-11-19 2023-10-03 台湾浩鼎生技股份有限公司 通过经由globo系列抗原的免疫调节的主动式癌症免疫疗法

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JP2020512284A (ja) * 2016-12-22 2020-04-23 ウィンドミル セラピューティクス インコーポレイテッド 免疫系調節組成物および方法

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WO2017004150A1 (en) 2017-01-05
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KR20180038447A (ko) 2018-04-16
HK1254820A1 (zh) 2019-07-26
US20180185434A1 (en) 2018-07-05
EP3313892A1 (en) 2018-05-02
MX2018000278A (es) 2018-03-08
AU2016285859A1 (en) 2018-02-15
IL256643A (en) 2018-02-28
CA2991040A1 (en) 2017-01-05

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