KR20180038046A - 항박테리아 적용에 사용하기 위한 화합물 - Google Patents
항박테리아 적용에 사용하기 위한 화합물 Download PDFInfo
- Publication number
- KR20180038046A KR20180038046A KR1020187007548A KR20187007548A KR20180038046A KR 20180038046 A KR20180038046 A KR 20180038046A KR 1020187007548 A KR1020187007548 A KR 1020187007548A KR 20187007548 A KR20187007548 A KR 20187007548A KR 20180038046 A KR20180038046 A KR 20180038046A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- amino
- pyrazino
- thiazin
- cyclohexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- HGTDGVGWVOGYRN-UHFFFAOYSA-N COc(c(N)n1)ncc1Cl Chemical compound COc(c(N)n1)ncc1Cl HGTDGVGWVOGYRN-UHFFFAOYSA-N 0.000 description 2
- 0 CC(C)(C)OC(N[C@@](CC[C@]1N*)C[C@]1OC(c(cc1)ccc1[N+]([O-])=O)=O)=O Chemical compound CC(C)(C)OC(N[C@@](CC[C@]1N*)C[C@]1OC(c(cc1)ccc1[N+]([O-])=O)=O)=O 0.000 description 1
- IUKYKMHCKDLTJC-RKDXNWHRSA-N CC(C)(C)OC(N[C@H](CCC1)C[C@@H]1O)=O Chemical compound CC(C)(C)OC(N[C@H](CCC1)C[C@@H]1O)=O IUKYKMHCKDLTJC-RKDXNWHRSA-N 0.000 description 1
- BVVCQALGKDETNB-DUFXMDAXSA-N COc1cnc(ccc(F)c2CN[C@@H](CC[C@@H](C3)N)[C@@H]3O)c2n1 Chemical compound COc1cnc(ccc(F)c2CN[C@@H](CC[C@@H](C3)N)[C@@H]3O)c2n1 BVVCQALGKDETNB-DUFXMDAXSA-N 0.000 description 1
- BVVCQALGKDETNB-IUPBHXKESA-N COc1cnc(ccc(F)c2CN[C@H](CC[C@H](C3)N)[C@H]3O)c2n1 Chemical compound COc1cnc(ccc(F)c2CN[C@H](CC[C@H](C3)N)[C@H]3O)c2n1 BVVCQALGKDETNB-IUPBHXKESA-N 0.000 description 1
- ZWJBYHFOIVOXPL-NJAPINKUSA-N COc1cnc(ccc(F)c2CN[C@H](CC[C@H](C3)NCc(cn4)nc(N5)c4OCC5=O)[C@H]3O)c2n1 Chemical compound COc1cnc(ccc(F)c2CN[C@H](CC[C@H](C3)NCc(cn4)nc(N5)c4OCC5=O)[C@H]3O)c2n1 ZWJBYHFOIVOXPL-NJAPINKUSA-N 0.000 description 1
- FHDYLAMSIRNDDL-UHFFFAOYSA-N Nc1nc(Cl)cnc1O Chemical compound Nc1nc(Cl)cnc1O FHDYLAMSIRNDDL-UHFFFAOYSA-N 0.000 description 1
- AXVPMSMOPJYOCS-UHFFFAOYSA-N O=Cc(nc1N2)cnc1OCC2=O Chemical compound O=Cc(nc1N2)cnc1OCC2=O AXVPMSMOPJYOCS-UHFFFAOYSA-N 0.000 description 1
- GKEXMIIYUQZQIF-UHFFFAOYSA-N OCc(nc1N2)cnc1OCC2=O Chemical compound OCc(nc1N2)cnc1OCC2=O GKEXMIIYUQZQIF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562205732P | 2015-08-16 | 2015-08-16 | |
| US62/205,732 | 2015-08-16 | ||
| US201662308928P | 2016-03-16 | 2016-03-16 | |
| US62/308,928 | 2016-03-16 | ||
| PCT/IB2016/054890 WO2017029602A2 (en) | 2015-08-16 | 2016-08-15 | Compounds for use in antibacterial applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20180038046A true KR20180038046A (ko) | 2018-04-13 |
Family
ID=57218948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187007548A Withdrawn KR20180038046A (ko) | 2015-08-16 | 2016-08-15 | 항박테리아 적용에 사용하기 위한 화합물 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10364254B2 (https=) |
| EP (1) | EP3334739A2 (https=) |
| JP (1) | JP6757402B2 (https=) |
| KR (1) | KR20180038046A (https=) |
| CN (1) | CN108137616B (https=) |
| AU (2) | AU2016307969C1 (https=) |
| CA (1) | CA2995715A1 (https=) |
| CL (1) | CL2018000403A1 (https=) |
| CO (1) | CO2018002204A2 (https=) |
| CR (1) | CR20180111A (https=) |
| DO (1) | DOP2018000049A (https=) |
| EA (1) | EA033314B1 (https=) |
| HK (1) | HK1248680A1 (https=) |
| IL (1) | IL257265B (https=) |
| MA (1) | MA42621A (https=) |
| MX (1) | MX2018002033A (https=) |
| PE (1) | PE20181143A1 (https=) |
| PH (1) | PH12018500358A1 (https=) |
| TW (1) | TW201722965A (https=) |
| UY (1) | UY36851A (https=) |
| WO (1) | WO2017029602A2 (https=) |
| ZA (1) | ZA201800722B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201722965A (zh) * | 2015-08-16 | 2017-07-01 | 葛蘭素史密斯克藍智慧財產發展有限公司 | 用於抗菌應用之化合物 |
| WO2019180634A1 (en) | 2018-03-23 | 2019-09-26 | Glaxosmithkline Intellectual Property Development Limited | Synthesis of oxazinone-containing bicyclic aromatic and heteroaromatic aldehydes |
| TW202116782A (zh) | 2019-07-16 | 2021-05-01 | 瑞士商愛杜西亞製藥有限公司 | 喹啉酮衍生物 |
| CN111269247B (zh) * | 2020-03-04 | 2020-11-24 | 河南科技大学第一附属医院 | 具有抑制大肠杆菌作用的噻嗪酮药物分子的制备方法 |
| AU2023235233A1 (en) | 2022-03-14 | 2024-09-12 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| WO2025132870A1 (en) | 2023-12-21 | 2025-06-26 | Glaxosmithkline Intellectual Property (No.4) Limited | Chemical compounds and uses thereof |
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| JP5656996B2 (ja) | 2009-07-13 | 2015-01-21 | ザ ユニバーシティ オブ ノース キャロライナ アット チャペル ヒル | 工学的に作製されたエアロゾル粒子、およびそれに関連した方法 |
| TW201209056A (en) * | 2010-05-25 | 2012-03-01 | Taisho Pharmaceutical Co Ltd | Novel heterocyclic compound or salt thereof |
| CA2840060A1 (en) * | 2011-06-27 | 2013-01-03 | Kyorin Pharmaceutical Co., Ltd. | Bridged bicyclic compounds for the treatment of bacterial infections |
| TW201326180A (zh) * | 2011-11-30 | 2013-07-01 | Actelion Pharmaceuticals Ltd | ３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素 |
| KR20150143720A (ko) | 2013-04-16 | 2015-12-23 | 액테리온 파마슈티칼 리미티드 | 항균성 이방향족 유도체 |
| TW201722965A (zh) * | 2015-08-16 | 2017-07-01 | 葛蘭素史密斯克藍智慧財產發展有限公司 | 用於抗菌應用之化合物 |
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2016
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