HK1248680A1 - 包含吡嗪并[2，3-b][1，4]恶嗪-3-酮或相关环系的抗菌剂 - Google Patents

包含吡嗪并[2，3-b][1，4]恶嗪-3-酮或相关环系的抗菌剂 Download PDF

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Publication number
HK1248680A1
HK1248680A1 HK18108126.0A HK18108126A HK1248680A1 HK 1248680 A1 HK1248680 A1 HK 1248680A1 HK 18108126 A HK18108126 A HK 18108126A HK 1248680 A1 HK1248680 A1 HK 1248680A1
Authority
HK
Hong Kong
Prior art keywords
pyrazino
oxazin
ring system
antibacterial agents
related ring
Prior art date
Application number
HK18108126.0A
Other languages
English (en)
Chinese (zh)
Inventor
Haifeng Cui
Alan Hennessy
Qi Jin
Timothy James Miles
Stephen Frederick Moss
Neil David Pearson
Original Assignee
Glaxosmithkline Intellectual Property Development Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Intellectual Property Development Limited filed Critical Glaxosmithkline Intellectual Property Development Limited
Publication of HK1248680A1 publication Critical patent/HK1248680A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
HK18108126.0A 2015-08-16 2016-08-15 包含吡嗪并[2，3-b][1，4]恶嗪-3-酮或相关环系的抗菌剂 HK1248680A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562205732P 2015-08-16 2015-08-16
US62/205,732 2015-08-16
US201662308928P 2016-03-16 2016-03-16
US62/308,928 2016-03-16
PCT/IB2016/054890 WO2017029602A2 (en) 2015-08-16 2016-08-15 Compounds for use in antibacterial applications

Publications (1)

Publication Number Publication Date
HK1248680A1 true HK1248680A1 (zh) 2018-10-19

Family

ID=57218948

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18108126.0A HK1248680A1 (zh) 2015-08-16 2016-08-15 包含吡嗪并[2，3-b][1，4]恶嗪-3-酮或相关环系的抗菌剂

Country Status (22)

Country Link
US (2) US10364254B2 (https=)
EP (1) EP3334739A2 (https=)
JP (1) JP6757402B2 (https=)
KR (1) KR20180038046A (https=)
CN (1) CN108137616B (https=)
AU (2) AU2016307969C1 (https=)
CA (1) CA2995715A1 (https=)
CL (1) CL2018000403A1 (https=)
CO (1) CO2018002204A2 (https=)
CR (1) CR20180111A (https=)
DO (1) DOP2018000049A (https=)
EA (1) EA033314B1 (https=)
HK (1) HK1248680A1 (https=)
IL (1) IL257265B (https=)
MA (1) MA42621A (https=)
MX (1) MX2018002033A (https=)
PE (1) PE20181143A1 (https=)
PH (1) PH12018500358A1 (https=)
TW (1) TW201722965A (https=)
UY (1) UY36851A (https=)
WO (1) WO2017029602A2 (https=)
ZA (1) ZA201800722B (https=)

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WO2021009212A1 (en) 2019-07-16 2021-01-21 Idorsia Pharmaceuticals Ltd Antibacterial quinolone derivatives
CN111269247B (zh) * 2020-03-04 2020-11-24 河南科技大学第一附属医院 具有抑制大肠杆菌作用的噻嗪酮药物分子的制备方法
KR20240161147A (ko) 2022-03-14 2024-11-12 슬랩 파마슈티컬스 엘엘씨 다중 사이클릭 화합물
TW202542149A (zh) 2023-12-21 2025-11-01 英商葛蘭素史密斯克藍智慧財產權有限公司 化合物及其用途

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Also Published As

Publication number Publication date
EP3334739A2 (en) 2018-06-20
KR20180038046A (ko) 2018-04-13
US10683307B2 (en) 2020-06-16
US20190031680A1 (en) 2019-01-31
AU2016307969C1 (en) 2019-09-05
EA201890412A1 (ru) 2018-08-31
WO2017029602A2 (en) 2017-02-23
CN108137616A (zh) 2018-06-08
AU2019200226A1 (en) 2019-01-31
AU2019200226B2 (en) 2020-01-23
CN108137616B (zh) 2020-06-26
DOP2018000049A (es) 2018-03-30
US20190270755A1 (en) 2019-09-05
IL257265A (en) 2018-03-29
CR20180111A (es) 2018-04-12
WO2017029602A3 (en) 2017-04-13
UY36851A (es) 2017-03-31
MX2018002033A (es) 2018-06-15
PE20181143A1 (es) 2018-07-17
CO2018002204A2 (es) 2018-06-20
JP6757402B2 (ja) 2020-09-16
CL2018000403A1 (es) 2018-07-06
AU2016307969B2 (en) 2019-02-14
EA033314B1 (ru) 2019-09-30
MA42621A (fr) 2018-06-20
AU2016307969A1 (en) 2018-03-08
JP2018523675A (ja) 2018-08-23
PH12018500358A1 (en) 2018-09-03
TW201722965A (zh) 2017-07-01
CA2995715A1 (en) 2017-02-23
ZA201800722B (en) 2019-07-31
US10364254B2 (en) 2019-07-30
IL257265B (en) 2020-07-30

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