WO2015199418A3 - 신규한 헤테로고리 화합물 - Google Patents
신규한 헤테로고리 화합물 Download PDFInfo
- Publication number
- WO2015199418A3 WO2015199418A3 PCT/KR2015/006377 KR2015006377W WO2015199418A3 WO 2015199418 A3 WO2015199418 A3 WO 2015199418A3 KR 2015006377 W KR2015006377 W KR 2015006377W WO 2015199418 A3 WO2015199418 A3 WO 2015199418A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- heterocyclic compound
- novel heterocyclic
- same
- prs
- prolyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ727715A NZ727715A (en) | 2014-06-23 | 2015-06-23 | Novel heterocyclic compounds having prs enzyme inhibitory effect |
ES15812382T ES2795368T3 (es) | 2014-06-23 | 2015-06-23 | Compuesto heterocíclico novedoso |
AU2015280874A AU2015280874B2 (en) | 2014-06-23 | 2015-06-23 | Novel heterocyclic compound |
CA2951798A CA2951798C (en) | 2014-06-23 | 2015-06-23 | Febrifugine derivatives and their use as prolyl-trna synthetase (prs) inhibitors |
RS20200562A RS60264B1 (sr) | 2014-06-23 | 2015-06-23 | Novo heterociklično jedinjenje |
SI201531212T SI3159335T1 (sl) | 2014-06-23 | 2015-06-23 | Nova heterociklična spojina |
JP2016571347A JP6272510B2 (ja) | 2014-06-23 | 2015-06-23 | 新規なヘテロ環化合物 |
CN201580029527.XA CN106458923B (zh) | 2014-06-23 | 2015-06-23 | 杂环化合物 |
EP15812382.8A EP3159335B1 (en) | 2014-06-23 | 2015-06-23 | Novel heterocyclic compound |
US15/312,192 US10081634B2 (en) | 2014-06-23 | 2015-06-23 | Heterocyclic compound |
PL15812382T PL3159335T3 (pl) | 2014-06-23 | 2015-06-23 | Nowy związek heterocykliczny |
PH12016502568A PH12016502568B1 (en) | 2014-06-23 | 2016-12-21 | Novel heterocyclic compound |
HRP20200785TT HRP20200785T1 (hr) | 2014-06-23 | 2020-05-13 | Novi heterociklični spoj |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20140076674 | 2014-06-23 | ||
KR10-2014-0076674 | 2014-06-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2015199418A2 WO2015199418A2 (ko) | 2015-12-30 |
WO2015199418A3 true WO2015199418A3 (ko) | 2016-04-14 |
Family
ID=54938901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2015/006377 WO2015199418A2 (ko) | 2014-06-23 | 2015-06-23 | 신규한 헤테로고리 화합물 |
Country Status (18)
Country | Link |
---|---|
US (1) | US10081634B2 (ko) |
EP (1) | EP3159335B1 (ko) |
JP (1) | JP6272510B2 (ko) |
KR (1) | KR102276340B1 (ko) |
CN (1) | CN106458923B (ko) |
AU (1) | AU2015280874B2 (ko) |
CA (1) | CA2951798C (ko) |
ES (1) | ES2795368T3 (ko) |
HR (1) | HRP20200785T1 (ko) |
HU (1) | HUE049482T2 (ko) |
MY (1) | MY174343A (ko) |
NZ (1) | NZ727715A (ko) |
PH (1) | PH12016502568B1 (ko) |
PL (1) | PL3159335T3 (ko) |
PT (1) | PT3159335T (ko) |
RS (1) | RS60264B1 (ko) |
SI (1) | SI3159335T1 (ko) |
WO (1) | WO2015199418A2 (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102277538B1 (ko) * | 2015-06-08 | 2021-07-14 | 주식회사 대웅제약 | 신규한 헤테로 고리 화합물, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
JP2019196308A (ja) | 2016-09-15 | 2019-11-14 | 武田薬品工業株式会社 | 複素環アミド化合物 |
AR110963A1 (es) * | 2017-02-07 | 2019-05-22 | Dae Woong Pharma | Compuestos heterocíclicos, su método de preparación y composición farmacéutica que los comprende |
WO2024080777A1 (ko) * | 2022-10-12 | 2024-04-18 | 주식회사 대웅제약 | 신장염의 예방 또는 치료용 약학적 조성물 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010019210A2 (en) * | 2008-08-11 | 2010-02-18 | President And Fellows Of Harvard College | Halofuginone analogs for inhibition of trna synthetases and uses thereof |
WO2010096170A2 (en) * | 2009-02-19 | 2010-08-26 | President And Fellows Of Harvard College | Inhibition of trna synthetases and therapeutic applications thereof |
WO2013106702A1 (en) * | 2012-01-13 | 2013-07-18 | President And Fellows Of Harvard College | Halofuginol derivatives and their use in cosmetic and pharmaceutical compositions |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102277538B1 (ko) | 2015-06-08 | 2021-07-14 | 주식회사 대웅제약 | 신규한 헤테로 고리 화합물, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
-
2015
- 2015-06-23 EP EP15812382.8A patent/EP3159335B1/en active Active
- 2015-06-23 PT PT158123828T patent/PT3159335T/pt unknown
- 2015-06-23 NZ NZ727715A patent/NZ727715A/en unknown
- 2015-06-23 CN CN201580029527.XA patent/CN106458923B/zh active Active
- 2015-06-23 SI SI201531212T patent/SI3159335T1/sl unknown
- 2015-06-23 WO PCT/KR2015/006377 patent/WO2015199418A2/ko active Application Filing
- 2015-06-23 KR KR1020150088872A patent/KR102276340B1/ko active IP Right Grant
- 2015-06-23 ES ES15812382T patent/ES2795368T3/es active Active
- 2015-06-23 RS RS20200562A patent/RS60264B1/sr unknown
- 2015-06-23 MY MYPI2016704579A patent/MY174343A/en unknown
- 2015-06-23 HU HUE15812382A patent/HUE049482T2/hu unknown
- 2015-06-23 AU AU2015280874A patent/AU2015280874B2/en active Active
- 2015-06-23 US US15/312,192 patent/US10081634B2/en active Active
- 2015-06-23 JP JP2016571347A patent/JP6272510B2/ja active Active
- 2015-06-23 CA CA2951798A patent/CA2951798C/en active Active
- 2015-06-23 PL PL15812382T patent/PL3159335T3/pl unknown
-
2016
- 2016-12-21 PH PH12016502568A patent/PH12016502568B1/en unknown
-
2020
- 2020-05-13 HR HRP20200785TT patent/HRP20200785T1/hr unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010019210A2 (en) * | 2008-08-11 | 2010-02-18 | President And Fellows Of Harvard College | Halofuginone analogs for inhibition of trna synthetases and uses thereof |
WO2010096170A2 (en) * | 2009-02-19 | 2010-08-26 | President And Fellows Of Harvard College | Inhibition of trna synthetases and therapeutic applications thereof |
WO2013106702A1 (en) * | 2012-01-13 | 2013-07-18 | President And Fellows Of Harvard College | Halofuginol derivatives and their use in cosmetic and pharmaceutical compositions |
Non-Patent Citations (5)
Title |
---|
CUI, W ET AL.: "Efficient one-pot synthesis of 2-substituted benzimidazoles from triacyloxyborane intermediates", SYNLETT, vol. 23, 2012, pages 247 - 250, XP055335138 * |
JAIN, V. ET AL.: "Structure of prolyl-tRNA synthetase-halofuginone complex provides basis for development of drugs against malaria and toxoplasmosis", STRUCTURE, vol. 23, no. 5, 5 May 2015 (2015-05-05), pages 819 - 829, XP029229262, DOI: doi:10.1016/j.str.2015.02.011 * |
KELLER, T. L. ET AL.: "Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase", NATURE CHEMICAL BIOLOGY, vol. 8, no. 3, 2012, pages 311 - 317, XP055065300, DOI: doi:10.1038/nchembio.790 * |
ROY, P. ET AL.: "One-pot sequential synthesis of 1, 2-disubstituted benzimidazoles under metal-free conditions", TETRAHEDRON LETTERS, vol. 54, no. 38, 2013, pages 5243 - 5245, XP055335135 * |
ZHOU, H. ET AL.: "ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase", NATURE, vol. 494, no. 7435, 2013, pages 121 - 125, XP055375882 * |
Also Published As
Publication number | Publication date |
---|---|
JP6272510B2 (ja) | 2018-01-31 |
PH12016502568A1 (en) | 2017-04-17 |
EP3159335B1 (en) | 2020-04-29 |
EP3159335A4 (en) | 2017-11-15 |
WO2015199418A2 (ko) | 2015-12-30 |
CN106458923B (zh) | 2019-09-10 |
EP3159335A2 (en) | 2017-04-26 |
US20170088551A1 (en) | 2017-03-30 |
CA2951798C (en) | 2018-07-24 |
HUE049482T2 (hu) | 2020-09-28 |
PL3159335T3 (pl) | 2020-10-05 |
NZ727715A (en) | 2017-09-29 |
CN106458923A (zh) | 2017-02-22 |
AU2015280874B2 (en) | 2017-12-14 |
PH12016502568B1 (en) | 2017-04-17 |
KR20150146462A (ko) | 2015-12-31 |
AU2015280874A1 (en) | 2017-01-12 |
MY174343A (en) | 2020-04-09 |
SI3159335T1 (sl) | 2020-07-31 |
JP2017520539A (ja) | 2017-07-27 |
HRP20200785T1 (hr) | 2020-08-07 |
ES2795368T3 (es) | 2020-11-23 |
KR102276340B1 (ko) | 2021-07-12 |
RS60264B1 (sr) | 2020-06-30 |
PT3159335T (pt) | 2020-06-05 |
CA2951798A1 (en) | 2015-12-30 |
US10081634B2 (en) | 2018-09-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12019501811A1 (en) | Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same | |
WO2016011390A8 (en) | Irak4 inhibiting agents | |
EP4071149A3 (en) | Heterocyclic compounds and uses thereof | |
PH12016501813A1 (en) | 1,3-benzodioxole derivative | |
WO2016130920A3 (en) | Lrrk2 inhibitors and methods of making and using the same | |
MY192521A (en) | Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors | |
MY197698A (en) | Oxysterols and methods of use thereof | |
MX2017014035A (es) | Formas solidas novedosas. | |
NZ729037A (en) | Carboxylic acid compound, method for preparation thereof, and use thereof | |
WO2017106429A3 (en) | Bipyrazolyl derivatives useful for the treatment of autoimmune diseases | |
MY194468A (en) | Oxy-fluoropiperidine derivatives as kinase inhhiitor | |
MY194116A (en) | Pharmaceutical compounds | |
WO2016046260A8 (en) | 1-alkyl-6-oxo-1,6-dihydropyridin-3-yl compounds and use as sgrm modulators | |
PH12016502568A1 (en) | Novel heterocyclic compound | |
PH12017501735A1 (en) | Novel heterocyclic compound, method for preparing the same, and pharmaceutical composition comprising the same | |
MX2017013099A (es) | Metodos para el tratamiento de trastornos inflamatorios. | |
WO2016006974A3 (en) | Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof | |
WO2016006975A3 (en) | Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof | |
WO2015001541A3 (en) | Pharmaceutical film composition | |
PH12017501955A1 (en) | Tetrahydrofurane-fused aminohydrothiazine derivatives which are useful in the treatment of alzheimer`s disease | |
WO2017034242A3 (ko) | 신규한 카테콜 유도체 및 이를 포함하는 약학적 조성물 | |
MX2017008076A (es) | DERIVADOS DE IMIDAZOPIRIDAZINA ENLAZADOS A HETEROCICLILO COMO INHIBIDORES DE PI3Kß. | |
WO2016020408A3 (en) | Compounds for preventing ototoxicity | |
MX2017002544A (es) | Derivados de isoquinolinona utiles en el tratamiento contra el cancer. | |
WO2017214423A3 (en) | Derivatives of thailanstatin a, methods of treatment and methods of synthesis thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 15812382 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 15312192 Country of ref document: US |
|
ENP | Entry into the national phase |
Ref document number: 2016571347 Country of ref document: JP Kind code of ref document: A |
|
REEP | Request for entry into the european phase |
Ref document number: 2015812382 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2015812382 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2951798 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12016502568 Country of ref document: PH |
|
WWE | Wipo information: entry into national phase |
Ref document number: IDP00201608904 Country of ref document: ID |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2015280874 Country of ref document: AU Date of ref document: 20150623 Kind code of ref document: A |