MX2019011908A - Macrociclos de peptidos anti-bacterianos y uso de los mismos. - Google Patents

Macrociclos de peptidos anti-bacterianos y uso de los mismos.

Info

Publication number
MX2019011908A
MX2019011908A MX2019011908A MX2019011908A MX2019011908A MX 2019011908 A MX2019011908 A MX 2019011908A MX 2019011908 A MX2019011908 A MX 2019011908A MX 2019011908 A MX2019011908 A MX 2019011908A MX 2019011908 A MX2019011908 A MX 2019011908A
Authority
MX
Mexico
Prior art keywords
bacterial peptide
peptide macrocycles
macrocycles
bacterial
infections
Prior art date
Application number
MX2019011908A
Other languages
English (en)
Inventor
Hilpert Hans
Amrein Kurt
Kolczewski Sabine
Bleicher Konrad
Fasching Bernhard
KROLL Carsten
Schaeublin Adrian
ZAMPALONI Claudia
Alanine Alexander
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2019011908A publication Critical patent/MX2019011908A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula (I), en donde X1 a X8 y R1 a R8 son como se describen en la presente, así como sus sales farmacéuticamente aceptables para su uso en el tratamiento o prevención de infecciones y enfermedades resultantes causadas por Pseudomonas aeruginosa.
MX2019011908A 2017-04-10 2018-04-09 Macrociclos de peptidos anti-bacterianos y uso de los mismos. MX2019011908A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17165651.5A EP3388444A1 (en) 2017-04-10 2017-04-10 Anti-bacterial peptide macrocycles and use thereof
PCT/EP2018/058957 WO2018189065A1 (en) 2017-04-10 2018-04-09 Anti-bacterial peptide macrocycles and use thereof

Publications (1)

Publication Number Publication Date
MX2019011908A true MX2019011908A (es) 2020-01-09

Family

ID=58530421

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019011908A MX2019011908A (es) 2017-04-10 2018-04-09 Macrociclos de peptidos anti-bacterianos y uso de los mismos.

Country Status (11)

Country Link
US (1) US11066443B2 (es)
EP (2) EP3388444A1 (es)
JP (1) JP7330887B2 (es)
KR (1) KR20190137775A (es)
CN (1) CN110366556B (es)
AU (1) AU2018250843B2 (es)
BR (1) BR112019021049A2 (es)
CA (1) CA3054596A1 (es)
IL (1) IL269798A (es)
MX (1) MX2019011908A (es)
WO (1) WO2018189065A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20180796A1 (es) 2015-10-27 2018-05-09 Hoffmann La Roche Macrociclos peptidicos contra acinetobacter baumannii
EP3388444A1 (en) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
IL289445B2 (en) 2019-06-25 2025-03-01 Amtixbio Co Ltd Derivative of an aminoalkanoic acid containing a biphenyl group and an antifungal pharmaceutical preparation containing it
CN118932710A (zh) * 2024-07-01 2024-11-12 宿迁逸达新材料有限公司 一种抗菌涤纶面料的制备方法

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JP3821562B2 (ja) * 1997-12-18 2006-09-13 三井化学株式会社 有機電界発光素子
US6660832B1 (en) 1999-08-20 2003-12-09 Isis Pharmaceuticals, Inc. Macrocyclic compounds and preparation methods thereof
DE10226921A1 (de) 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
EP2210612B1 (en) 2003-06-18 2016-10-05 Ocera Therapeutics, Inc. Macrocyclic antagonists of the motilin receptor
US7491695B2 (en) 2003-06-18 2009-02-17 Tranzyme Pharma Inc. Methods of using macrocyclic modulators of the ghrelin receptor
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
EP1498422A1 (de) 2003-07-17 2005-01-19 Jerini AG C5a-Rezeptor-Antagonisten
ATE490264T1 (de) 2003-07-31 2010-12-15 Tranzyme Pharma Inc Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen
US7550431B2 (en) 2003-07-31 2009-06-23 Tranzyme Pharma Inc. Spatially-defined macrocycles incorporating peptide bond surrogates
CA2540646A1 (en) 2003-10-01 2005-04-14 Bayer Healthcare Ag Antibacterial amide macrocycles
US8193310B2 (en) 2004-03-19 2012-06-05 The University Of Queensland Alpha helical mimics, their uses and methods for their production
DE102004025731A1 (de) * 2004-05-26 2005-12-15 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen III
US20080161232A1 (en) 2005-01-17 2008-07-03 Jerini Ag C5a Receptor Antagonist
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
US20070215889A1 (en) * 2006-03-20 2007-09-20 Semiconductor Energy Laboratory Co., Ltd. Aromatic amine compound, and light-emitting element, light-emitting device, and electronic appliance using the aromatic amine compound
GB0609492D0 (en) 2006-05-15 2006-06-21 Angeletti P Ist Richerche Bio Therapeutic agents
MX2009008540A (es) 2007-02-08 2009-08-18 Tibotec Pharm Ltd Inhibidores de virus de hepatitis c macrociclicos sustituidos con pirimidina.
CN104474529A (zh) 2008-02-08 2015-04-01 爱勒让治疗公司 治疗性的拟肽大环化合物
WO2010022249A2 (en) 2008-08-20 2010-02-25 Ensemble Discovery Corporation Macrocyclic compounds for inhibition of tumor necrosis factor alpha
EP2491020A4 (en) 2009-10-23 2013-04-24 Tranzyme Pharma Inc PROCESS FOR USE OF MACROCYCLIC INHIBITORS OF SERIN PROTEASE CYMS
CA2778990A1 (en) 2009-10-30 2011-05-05 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor antagonists and inverse agonists and methods of using the same
CA2807685C (en) 2010-08-13 2020-10-06 Aileron Therapeutics, Inc. P53 derived peptidomimetic macrocycle
US20130123196A1 (en) 2011-08-31 2013-05-16 New York University Thioether-, ether-, and alkylamine-linked hydrogen bond surrogate peptidomimetics
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
CN103387601B (zh) 2012-05-11 2017-01-11 南开大学 抗登革热病毒(denv)杂环肽类化合物及其制备方法和用途
CN104903302B (zh) 2012-11-21 2019-03-29 阿奇克斯制药公司 大环广谱抗生素
US9493510B2 (en) 2013-01-10 2016-11-15 Noliva Therapeutics Llc Peptidomimetic compounds
PE20180796A1 (es) * 2015-10-27 2018-05-09 Hoffmann La Roche Macrociclos peptidicos contra acinetobacter baumannii
EP3388444A1 (en) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof

Also Published As

Publication number Publication date
AU2018250843B2 (en) 2021-12-16
JP7330887B2 (ja) 2023-08-22
JP2020516580A (ja) 2020-06-11
KR20190137775A (ko) 2019-12-11
EP3388444A1 (en) 2018-10-17
WO2018189065A1 (en) 2018-10-18
CN110366556A (zh) 2019-10-22
IL269798A (en) 2019-11-28
US20200040031A1 (en) 2020-02-06
BR112019021049A2 (pt) 2020-05-12
US11066443B2 (en) 2021-07-20
AU2018250843A1 (en) 2019-07-11
EP3609904A1 (en) 2020-02-19
CN110366556B (zh) 2024-01-05
CA3054596A1 (en) 2018-10-18
EP3609904B1 (en) 2022-11-30

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