KR20170113710A - Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산 - Google Patents

Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산 Download PDF

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KR20170113710A
KR20170113710A KR1020177026945A KR20177026945A KR20170113710A KR 20170113710 A KR20170113710 A KR 20170113710A KR 1020177026945 A KR1020177026945 A KR 1020177026945A KR 20177026945 A KR20177026945 A KR 20177026945A KR 20170113710 A KR20170113710 A KR 20170113710A
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ala
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val
gly
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데렉 엘. 그린필드
엘리자베스 제이. 클라크
엘리 에스. 그로반
비크란트 알라가다
성원 이
쉐지 리
지하오 흐
바오롱 주
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알이지 라이프 사이언시스, 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0105—Long-chain-fatty-acyl-CoA reductase (1.2.1.50)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/99—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with other acceptors (1.2.99)
    • C12Y102/99006—Carboxylate reductase (1.2.99.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01041—Beta-ketoacyl-acyl-carrier-protein synthase I (2.3.1.41)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P2203/00—Fermentation products obtained from optionally pretreated or hydrolyzed cellulosic or lignocellulosic material as the carbon source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020177026945A 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산 Ceased KR20170113710A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261619309P 2012-04-02 2012-04-02
US61/619,309 2012-04-02
PCT/US2013/035040 WO2013152052A2 (en) 2012-04-02 2013-04-02 Novel car enzymes and improved production of fatty alcohols

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KR1020147030704A Division KR101831331B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산

Related Child Applications (2)

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KR1020197005741A Division KR102114841B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020197017717A Division KR102185762B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산

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KR1020177026945A Ceased KR20170113710A (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020197005741A Expired - Fee Related KR102114841B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020197017717A Expired - Fee Related KR102185762B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020207009760A Expired - Fee Related KR102282677B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020217023277A Ceased KR20210095226A (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020147030704A Active KR101831331B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산

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KR1020197005741A Expired - Fee Related KR102114841B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020197017717A Expired - Fee Related KR102185762B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020207009760A Expired - Fee Related KR102282677B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020217023277A Ceased KR20210095226A (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020147030704A Active KR101831331B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산

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US (4) US9340801B2 (enExample)
EP (6) EP3385374B1 (enExample)
JP (1) JP6230594B2 (enExample)
KR (6) KR20170113710A (enExample)
CN (1) CN104704113B (enExample)
AU (2) AU2013243602B2 (enExample)
BR (2) BR112014024674B1 (enExample)
CA (1) CA2883064A1 (enExample)
CO (1) CO7170148A2 (enExample)
ES (3) ES2786633T3 (enExample)
MX (2) MX358177B (enExample)
MY (1) MY170889A (enExample)
SI (1) SI3385374T1 (enExample)
WO (1) WO2013152052A2 (enExample)

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US12649937B2 (en) 2021-03-29 2026-06-09 Genomatica, Inc. Production of non-native monounsaturated fatty acids in bacteria
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CN104704113A (zh) 2015-06-10
WO2013152052A2 (en) 2013-10-10
KR102282677B1 (ko) 2021-07-28
KR20200038559A (ko) 2020-04-13
KR102114841B1 (ko) 2020-05-26
CO7170148A2 (es) 2015-01-28
AU2013243602A1 (en) 2014-11-13
EP3385374A1 (en) 2018-10-10
EP3985108A1 (en) 2022-04-20
CA2883064A1 (en) 2013-10-10
EP2834350B1 (en) 2016-11-16
MX358177B (es) 2018-08-08
US9340801B2 (en) 2016-05-17
KR20190076059A (ko) 2019-07-01
US11034937B2 (en) 2021-06-15
CN104704113B (zh) 2018-01-23
ES2786633T3 (es) 2020-10-13
EP3153579B1 (en) 2018-03-14
EP3153579A1 (en) 2017-04-12
AU2016231497A1 (en) 2016-10-06
MX2014011903A (es) 2015-05-12
JP6230594B2 (ja) 2017-11-15
SI3385374T1 (sl) 2020-09-30
KR102185762B1 (ko) 2020-12-02
KR20150032660A (ko) 2015-03-27
EP3674399B1 (en) 2021-09-22
ES2666157T3 (es) 2018-05-03
AU2013243602B2 (en) 2016-11-24
JP2015512645A (ja) 2015-04-30
BR122019026987B1 (pt) 2022-01-18
WO2013152052A3 (en) 2014-03-13
KR20210095226A (ko) 2021-07-30
US9758769B2 (en) 2017-09-12
US20160326499A1 (en) 2016-11-10
US20180135028A1 (en) 2018-05-17
US10301603B2 (en) 2019-05-28
EP3674399A1 (en) 2020-07-01
BR112014024674A2 (pt) 2018-11-21
ES2613553T3 (es) 2017-05-24
MX343296B (es) 2016-11-01
BR112014024674B1 (pt) 2022-06-07
KR20190022935A (ko) 2019-03-06
MY170889A (en) 2019-09-12
EP2834350A2 (en) 2015-02-11
AU2016231497B2 (en) 2017-08-31
US20150064757A1 (en) 2015-03-05
EP4186974A1 (en) 2023-05-31
KR101831331B1 (ko) 2018-02-23
EP3385374B1 (en) 2020-01-08
US20200109374A1 (en) 2020-04-09

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