KR20170082494A - 결정 형태의 글루타미나아제 억제제 - Google Patents

결정 형태의 글루타미나아제 억제제 Download PDF

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Publication number
KR20170082494A
KR20170082494A KR1020177006199A KR20177006199A KR20170082494A KR 20170082494 A KR20170082494 A KR 20170082494A KR 1020177006199 A KR1020177006199 A KR 1020177006199A KR 20177006199 A KR20177006199 A KR 20177006199A KR 20170082494 A KR20170082494 A KR 20170082494A
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KR
South Korea
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cancer
salt
compound
crystalline
cell
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Ceased
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KR1020177006199A
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English (en)
Korean (ko)
Inventor
티모시 에프 스탠턴
제임스 제이 스프링거
재클린 엔 윌리암스
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칼리테라 바이오사이언시즈, 인코포레이티드
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Publication of KR20170082494A publication Critical patent/KR20170082494A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020177006199A 2014-08-07 2015-08-07 결정 형태의 글루타미나아제 억제제 Ceased KR20170082494A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462034547P 2014-08-07 2014-08-07
US62/034,547 2014-08-07
PCT/US2015/044301 WO2016022969A1 (en) 2014-08-07 2015-08-07 Crystal forms of glutaminase inhibitors

Publications (1)

Publication Number Publication Date
KR20170082494A true KR20170082494A (ko) 2017-07-14

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KR1020177006199A Ceased KR20170082494A (ko) 2014-08-07 2015-08-07 결정 형태의 글루타미나아제 억제제

Country Status (13)

Country Link
US (2) US10316030B2 (cg-RX-API-DMAC7.html)
EP (1) EP3193876B1 (cg-RX-API-DMAC7.html)
JP (3) JP6889101B2 (cg-RX-API-DMAC7.html)
KR (1) KR20170082494A (cg-RX-API-DMAC7.html)
CN (1) CN106999490A (cg-RX-API-DMAC7.html)
AU (2) AU2015300825B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017002403A2 (cg-RX-API-DMAC7.html)
CA (1) CA2957225A1 (cg-RX-API-DMAC7.html)
EA (1) EA037738B1 (cg-RX-API-DMAC7.html)
IL (1) IL250391B (cg-RX-API-DMAC7.html)
MX (1) MX2017001620A (cg-RX-API-DMAC7.html)
SG (1) SG11201700816YA (cg-RX-API-DMAC7.html)
WO (1) WO2016022969A1 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
US10676472B2 (en) 2020-06-09
WO2016022969A1 (en) 2016-02-11
US20190359607A1 (en) 2019-11-28
US10316030B2 (en) 2019-06-11
US20170226101A1 (en) 2017-08-10
JP6889101B2 (ja) 2021-06-18
EP3193876B1 (en) 2022-01-12
AU2015300825A1 (en) 2017-03-09
AU2019284149A1 (en) 2020-01-30
EP3193876A1 (en) 2017-07-26
JP2021165286A (ja) 2021-10-14
JP2020037588A (ja) 2020-03-12
EA201790337A1 (ru) 2017-09-29
SG11201700816YA (en) 2017-02-27
IL250391A0 (en) 2017-03-30
IL250391B (en) 2021-10-31
BR112017002403A2 (pt) 2017-12-05
MX2017001620A (es) 2017-05-10
CA2957225A1 (en) 2016-02-11
EA037738B1 (ru) 2021-05-17
JP2017523991A (ja) 2017-08-24
AU2015300825B2 (en) 2019-10-10
EP3193876A4 (en) 2017-12-27
CN106999490A (zh) 2017-08-01

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