AU2015300825B2 - Crystal forms of glutaminase inhibitors - Google Patents

Crystal forms of glutaminase inhibitors Download PDF

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Publication number
AU2015300825B2
AU2015300825B2 AU2015300825A AU2015300825A AU2015300825B2 AU 2015300825 B2 AU2015300825 B2 AU 2015300825B2 AU 2015300825 A AU2015300825 A AU 2015300825A AU 2015300825 A AU2015300825 A AU 2015300825A AU 2015300825 B2 AU2015300825 B2 AU 2015300825B2
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AU
Australia
Prior art keywords
cancer
salt
compound
crystalline
cell
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2015300825A
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English (en)
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AU2015300825A1 (en
Inventor
James J. Springer
Timothy F. Stanton
Jacqueline N. Williams
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Calithera Biosciences Inc
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Calithera Biosciences Inc
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Publication of AU2015300825A1 publication Critical patent/AU2015300825A1/en
Application granted granted Critical
Publication of AU2015300825B2 publication Critical patent/AU2015300825B2/en
Priority to AU2019284149A priority Critical patent/AU2019284149A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2015300825A 2014-08-07 2015-08-07 Crystal forms of glutaminase inhibitors Ceased AU2015300825B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019284149A AU2019284149A1 (en) 2014-08-07 2019-12-31 Crystal forms of glutaminase inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462034547P 2014-08-07 2014-08-07
US62/034,547 2014-08-07
PCT/US2015/044301 WO2016022969A1 (en) 2014-08-07 2015-08-07 Crystal forms of glutaminase inhibitors

Related Child Applications (1)

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AU2019284149A Division AU2019284149A1 (en) 2014-08-07 2019-12-31 Crystal forms of glutaminase inhibitors

Publications (2)

Publication Number Publication Date
AU2015300825A1 AU2015300825A1 (en) 2017-03-09
AU2015300825B2 true AU2015300825B2 (en) 2019-10-10

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AU2015300825A Ceased AU2015300825B2 (en) 2014-08-07 2015-08-07 Crystal forms of glutaminase inhibitors
AU2019284149A Abandoned AU2019284149A1 (en) 2014-08-07 2019-12-31 Crystal forms of glutaminase inhibitors

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AU2019284149A Abandoned AU2019284149A1 (en) 2014-08-07 2019-12-31 Crystal forms of glutaminase inhibitors

Country Status (13)

Country Link
US (2) US10316030B2 (cg-RX-API-DMAC7.html)
EP (1) EP3193876B1 (cg-RX-API-DMAC7.html)
JP (3) JP6889101B2 (cg-RX-API-DMAC7.html)
KR (1) KR20170082494A (cg-RX-API-DMAC7.html)
CN (1) CN106999490A (cg-RX-API-DMAC7.html)
AU (2) AU2015300825B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017002403A2 (cg-RX-API-DMAC7.html)
CA (1) CA2957225A1 (cg-RX-API-DMAC7.html)
EA (1) EA037738B1 (cg-RX-API-DMAC7.html)
IL (1) IL250391B (cg-RX-API-DMAC7.html)
MX (1) MX2017001620A (cg-RX-API-DMAC7.html)
SG (1) SG11201700816YA (cg-RX-API-DMAC7.html)
WO (1) WO2016022969A1 (cg-RX-API-DMAC7.html)

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JP5388854B2 (ja) 2006-09-26 2014-01-15 セルジーン コーポレイション ５−置換キナゾリノン誘導体、それを含む組成物、及びその使用方法
SMT201800032T1 (it) 2011-03-11 2018-03-08 Celgene Corp Forme solide di 3-(5-ammino-2-metil-4-osso-4h-chinazolin-3-il)-piperidina-2,6-dione, e loro composizioni farmaceutiche e usi
US8604016B2 (en) 2011-11-21 2013-12-10 Calithera Biosciences Inc. Heterocyclic inhibitors of glutaminase
US9682952B2 (en) 2012-09-04 2017-06-20 Celgene Corporation Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl) piperidine-2-6-dione and methods of preparation thereof
HRP20211610T1 (hr) 2012-11-16 2022-02-04 Calithera Biosciences, Inc. Inhibitori heterocikličke glutaminaze
JP6798890B2 (ja) 2014-06-13 2020-12-09 キャリセラ バイオサイエンシーズ， インコーポレイテッド グルタミナーゼ阻害剤との併用療法
AU2015300825B2 (en) 2014-08-07 2019-10-10 Calithera Biosciences, Inc. Crystal forms of glutaminase inhibitors
SG11201708034SA (en) * 2015-03-30 2017-10-30 Calithera Biosciences Inc Methods of administering glutaminase inhibitors
US10441587B2 (en) 2015-04-06 2019-10-15 Calithera Biosciences, Inc. Treatment of lung cancer with inhibitors of glutaminase
US10258619B2 (en) 2015-10-05 2019-04-16 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors and immuno-oncology agents
SG11201901389XA (en) 2016-08-25 2019-03-28 Calithera Biosciences Inc Combination therapy with glutaminase inhibitors
EP3503893A4 (en) 2016-08-25 2020-04-29 Calithera Biosciences, Inc. COMBINATION THERAPY WITH GLUTAMINE INHIBITORS
US20210177880A1 (en) * 2017-10-31 2021-06-17 President And Fellows Of Harvard College Methods and compositions for treating acute myeloid leukemia
AU2020249868A1 (en) * 2019-03-26 2021-10-21 Tonix Pharma Holdings Limited Salt forms of S-(N, N-diethylcarbamoyl)glutathione
CN114295836B (zh) * 2021-12-22 2024-12-31 融智生物科技（青岛）有限公司 一种计算设备、存储介质和胶质瘤idh分型检测装置及系统

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Also Published As

Publication number Publication date
US10676472B2 (en) 2020-06-09
WO2016022969A1 (en) 2016-02-11
US20190359607A1 (en) 2019-11-28
US10316030B2 (en) 2019-06-11
US20170226101A1 (en) 2017-08-10
JP6889101B2 (ja) 2021-06-18
EP3193876B1 (en) 2022-01-12
AU2015300825A1 (en) 2017-03-09
AU2019284149A1 (en) 2020-01-30
EP3193876A1 (en) 2017-07-26
JP2021165286A (ja) 2021-10-14
JP2020037588A (ja) 2020-03-12
EA201790337A1 (ru) 2017-09-29
SG11201700816YA (en) 2017-02-27
IL250391A0 (en) 2017-03-30
IL250391B (en) 2021-10-31
BR112017002403A2 (pt) 2017-12-05
MX2017001620A (es) 2017-05-10
CA2957225A1 (en) 2016-02-11
EA037738B1 (ru) 2021-05-17
JP2017523991A (ja) 2017-08-24
KR20170082494A (ko) 2017-07-14
EP3193876A4 (en) 2017-12-27
CN106999490A (zh) 2017-08-01

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