KR20170055771A - Composition for preventing hair loss and improving hair growth comprising plant extract - Google Patents
Composition for preventing hair loss and improving hair growth comprising plant extract Download PDFInfo
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- KR20170055771A KR20170055771A KR1020150158971A KR20150158971A KR20170055771A KR 20170055771 A KR20170055771 A KR 20170055771A KR 1020150158971 A KR1020150158971 A KR 1020150158971A KR 20150158971 A KR20150158971 A KR 20150158971A KR 20170055771 A KR20170055771 A KR 20170055771A
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- Prior art keywords
- hair
- composition
- plant extract
- plant
- growth
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
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Abstract
Description
The present invention relates to a composition for preventing hair loss and improving hair growth comprising a plant extract.
Unlike the hair of other mammals, human hair is recognized for its biological purposes, namely, the protection of head and scalp, and its importance in aesthetic and sexual aspects.
It is known that about 50 to 100 hair of a normal person naturally falls out in a day. On the other hand, hair loss due to various causes is called hair loss. Representative examples of hair loss include circular hair loss caused by immune system abnormality and male pattern hair loss caused by age.
The precise mechanisms of hair growth and hair loss have not been completely elucidated until now. However, the cause of hair loss is a decrease of hair follicle function due to the involvement of male hormone, a decrease in the metabolism function of hair follicle and parental part, a local blood flow disorder due to scalp tension, Stress, drug side effects, genetic factors, autoimmunity, local infections, chemicals, diseases such as leukemia or tuberculosis, and abuse of hair products.
The most typical form of hair loss, androgen alopecia, is known to occur genetically as a result of androgen hormones. Testosterone and dihydrotestosterone (DHT) are the major androgen hormones in mammals, and DHT is reported to occur in patients with hair loss.
In addition, hair loss frequently occurs in a person having a hair loss related gene, but hair loss does not necessarily occur in a person having a hair loss related gene, and hair loss is progressed only when a hair loss related gene is expressed. Expression of genes related to hair loss is known to be related to age, stress, environment and the like.
On the other hand, in the early stage of hair loss, it is known that heat is generated in the scalp, inflammation process occurs, and hair tends to be thin and elasticity is lost.
Currently available hair growth promoters or hair growth agents include vasodilators such as, for example, capronium chloride and minoxidil (loggene), hormone agents to inhibit male hormone action such as estrogen and estradiol , Pentatencanic acid, and finasteride. In addition, a number of different types of hair loss inhibitors are available, including propecia, trichomin, Spironolactone, Cyproteron Acetate, Nizoral, Cimetidine and oral contraceptives. However, these effects have not been clearly proven.
In recent years, finasteride (proscar), which inhibits the action of 5-alpha-reductase and 5-alpha-reductase to inhibit the production of dihydrotestosterone, has been approved by the US FDA as a drug for treating and preventing alopecia They are expensive, however, they are inexpensive when applied directly to the scalp, and have side effects such as side effects when administered orally.
Therefore, it is necessary to develop an anti-hair restorer or hair growth promoter derived from substances that have no side effects on the human body.
One embodiment of the present invention is to provide a composition for preventing hair loss and improving hair growth comprising a plant extract.
Another embodiment of the present invention is to provide a pharmaceutical, food and skin external composition composition comprising a composition for preventing hair loss and improving hair growth.
An embodiment of the present invention includes a plant extract, wherein the plant extract is selected from the group consisting of ginseng, black bean, ginseng, gugija, licorice, dermis, jujube, japanese leaf, green tea leaf, And a hair growth improving composition.
Wherein the ginseng is 6 to 12 wt%, the black bean is 10 to 15 wt%, the whorl is 6 to 12 wt%, the goji is 6 to 12 wt%, the licorice is 10 The green leaf is 10 to 15 weight% and the white leaf is 6 to 12 weight%, the jujube is 6 to 12 weight%, the jujube is 6 to 12 weight%, the self leaf is 6 to 12 weight% By weight.
Wherein the plant extract is selected from the group consisting of water, C1 to C4 alcohols, acetic acid, DMF, DMSO, acetone, acetonitrile, ethyl acetate, methyl acetate, pentane, hexane, chloroform, diethyl ether, And THF. ≪ / RTI >
The plant extract is extracted with water.
The plant extract inhibits 5α-reductase expression of human dermal papilla cells (HFDPC).
The plant extract promotes the beta -catenin expression of human dermal papilla cells (HFDPC).
Another embodiment of the present invention provides a hair loss prevention and hair growth improving medicament comprising the hair loss prevention and hair growth improving composition.
Another embodiment of the present invention provides a hair-loss preventing and hair growth improving food comprising the hair loss preventing and hair growth improving composition.
Another embodiment of the present invention provides a composition for preventing hair loss and improving hair growth, comprising the composition for preventing hair loss and improving hair growth.
The hair growth improving external application composition may further comprise at least one component selected from water, oil, surfactant, humectant, thickener, alcohol, pigment, preservative and fragrance.
The composition for external application for skin may be at least one selected from the group consisting of hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair conditioner, hair treatment, hair cream, hair nutrition cream, hair moisturizing cream, Hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair dyes, hair fresheners, , A hair mousse, and a hair spray.
In another embodiment of the present invention, there is provided a method for manufacturing a plant, comprising: milling a dried plant to produce a plant dry powder; Adding plant dry powder and solvent to a still and heating the still; And a step of collecting and cooling the steam generated from the distiller by the heating to produce a distillate stock solution, wherein the dried plant is selected from the group consisting of ginseng, black bean, ginseng, gugija, licorice, , A green tea leaf and a white sachet.
Wherein said ginseng is 6 to 12 wt%, said black beans are 10 to 15 wt%, said algal germ is 6 to 12 wt%, said goji is 6 to 12 wt%, said licorice is 10 to 15 wt% The green leaf is 10 to 15 weight%, and the white leaf is 6 to 10 weight%, the dermis is 6 to 12 weight%, the jujube is 6 to 12 weight%, the self leaf is 6 to 12 weight% Lt; / RTI >
The composition for preventing hair loss and hair growth according to one embodiment of the present invention includes a plant extract and has no side effects and is excellent in hair loss prevention and hair growth improving effect.
Figures 1a and 1b show the results of 5α-reductase expression in human dermal papilla cells (HFDPC).
Figures 2a and 2b show the results of 5α-reductase expression in human dermal papilla cells (HFDPC).
Figures 3a and 3b show the expression of beta -catenin in human dermal papilla cells (HFDPC).
Hereinafter, the present invention will be described in detail with reference to examples, preparation examples and test examples.
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. However, the scope of the present invention is not limited to these specific embodiments. It is to be understood that all changes, equivalents, or alternatives falling within the spirit and scope of the present invention are included in the scope of the present invention.
The first embodiment of the present invention provides a composition for preventing hair loss and improving hair growth comprising a plant extract.
In the first embodiment of the present invention, "extract" means an active ingredient isolated from any material. In addition, the extract may contain the active ingredient and the extraction solvent used for the extraction of the active ingredient. For example, when an active ingredient extracted from a substance is dissolved or dispersed in an extraction solvent, the extract can be interpreted to include both an active ingredient and an extraction solvent.
In addition, plant extract means an active ingredient isolated from a plant. When an active ingredient of a plant is extracted using a solvent, the plant extract may be interpreted to include both the extractant and the active ingredient isolated from the plant.
The plant extract may also be referred to as an extract, a dried powder thereof, and a work product in a formulated state using the same.
In addition, the "plant extract" may include not only crude extracts commonly used in the art, but also fractions obtained by further fractionating crude extracts as described above. That is, the plant extract includes not only an extract obtained by using an extraction solvent but also a purified product obtained by further applying a purification process thereto. Fractions obtained through various purification methods, for example, separation by various chromatographies, etc., may also be applicable to the plant extract of the present invention.
The plant extract according to the first embodiment of the present invention is extracted from a plant group including ginseng, black beans, horseradish, gugija, licorice, dermis, jujube, japonica, green tea leaves and white algae. That is, the plant extract according to the first embodiment of the present invention includes ginseng extract, black bean extract, horseradish extract, Gugija extract, licorice extract, dermatophyte extract, jujube extract, green leaf extract, green tea leaf extract and white algae extract .
According to a first embodiment of the present invention, the plant group comprises 6 to 12 wt% of ginseng, 10 to 15 wt% of black beans, 6 to 12 wt% 10 to 15% by weight of licorice, 6 to 12% by weight of dermis, 6 to 12% by weight of jujube, 6 to 12% by weight of selfleaf, 10 to 15% To 10% by weight of bagasse.
Hereinafter, each plant component will be described.
(1) Ginseng is a perennial plant belonging to the Araliaceae, and is cultivated mostly for medicinal purposes. The height is 60 centimeters and the stem grows straight one each year, and three or four leaves turn at its end. Ginseng is used to strengthen the body, weakness in the body, boredom, fatigue, loss of appetite, vomiting and diarrhea. Ginseng has pharmacological effects such as cerebral cortex excitement and inhibition, equilibrium, anti-fatigue, anti-aging, immune enhancement, heart contraction, gonadal stimulation, hyperglycemia inhibition, protein synthesis promotion, homeostasis, anticancer, It is known to help function. According to the first embodiment of the present invention, roots of ginseng are used.
(2) Black beans are generally called black beans, such as black tea, seomyeotae, and seolite. Black teas are large in size among black beans, and are mainly used to make beans. Seoritae is black, but the inside is blue. It is often used to make lucerne and black currant, and recently it is also used as raw material of chungkukjang. Seomok-tae is also called bean because it looks like a mouse's eye. Black beans contain anthocyanins and isoflavones, which are effective in improving blood circulation and preventing aging. Lecithin, also contained in black beans, is known to help brain nutrition.
(3) Hwasungcho is a perennial herb belonging to Saururus chinensis. The official name is aniline. When flowering, roots are picked and dried in the shade is called jujube, and it is used in the treatment of gonorrhea or urethritis in one room. Dried leaves of Hwasungcho are known to be effective on wounds caused by boils or pustules. It is also known that Hwasungcho is a preventive and diuretic effect of arteriosclerosis. According to the first embodiment of the present invention, the stem and leaves of Rhododendron are used.
(4) Gugija is the fruit of Gugija. Gugija, a deciduous shrub belonging to the branches, is the fruit of autumn, which is picked up and dried in the sun. Gugija is known to boost energy, and it is said to lower blood pressure, especially when it is effective in restoring fatigue.
(5) Licorice is a perennial plant belonging to the leguminosae family. It grows in Siberia, Mongolia, eastern China and northern China. The licorice stem is straight and covered with hair, and the leaf is a compound leaf structure composed of 7 ~ 17 leaves. In July and August, light purple flowers bloom on the axilla. The fruit of licorice is opened by meadows, bent like a bow, covered with brown hairs. Dried roots in the sun is used as a medicinal herb. It has a flavor and a unique flavor, which is used to eliminate the toxic smell and taste of Chinese medicine. According to the first embodiment of the present invention, licorice stem and roots are used.
(6) The dermis is the skin of a mandarin orange. Generally, the dermis is made by drying the skin of the mandarin. Components of the dermis include volatile essential oils, hesperidin (flavone glycosides), citric acid, and vitamin B1. Dermis is mainly used for non-glaucoma, menopausal treatment, and also for liver and cervical treatment. The dermis is also used for symptoms such as fulminant insomnia (incompatible with the stomach), anorexia, nausea, and vomiting caused by indigestion. The dermis also removes sputum when symptoms of bronchitis or upper respiratory infections occur, and expands the airway to make breathing easier.
(7) Jujube is the fruit of the jujube, and it is also called red vinegar. Flesh of jujube contains sugar, mucilage, malic acid, tartaric acid and the like. The jujube seeds include betulin, betulic acid, and fat. Jujube is used as a medicinal agent for diuretic, calmness, and nausea in oriental medicine.
(8) Japanese leaf is an annual plant attached to Lamiaceae. It is also called Chachoji, Chajisugi, and Lobulus. All lobular leaves are purple, fragrant, about 30 cm tall, and wide oval. According to the first embodiment of the present invention, a leaf of a self lobed leaf is used.
(9) Green tea leaves are tea leaves. The tea tree is an evergreen broad-leaved tree (綠 綠 葉 tree). The leaves of this tea are called green tea or green tea leaves. The green tea leaves are long and round and vaginal, the surface is flat, slippery and glossy. In addition, green tea leaves are well-burned or steamed, dried and then green tea leaves. Green tea leaves are rich in vitamins, catechins, and minerals.
(10) It is also called by other names such as mockery, mackerel, sunflower, new mockery, multiply roots. The efficacy of nourishing lotion, blood, blood, It is used for weakness, anemia, early white hair, nervous breakdown, and chronic airflow. There are two kinds of red and white sutra, which is called white suture. BACKGROUND OF THE INVENTION [0003] BACKGROUND OF THE INVENTION [0004] BACKGROUND OF THE INVENTION [0005] BACKGROUND OF THE INVENTION [0004] BACKGROUND OF THE INVENTION [0005] BACKGROUND OF THE INVENTION [ According to a first embodiment of the present invention, a bag of sewerage roots is used.
The plant extract according to the first embodiment of the present invention can be produced by solvent extraction using dry powder of plants.
Extraction methods applied when extracting natural products or herbals for the production of plant extracts can be applied without limitation. Those skilled in the art will be able to select an appropriate extraction method from the known extraction methods to suit the application.
For the production of plant extracts, dry powders of plants obtained by drying and pulverizing plants may be used.
According to the first embodiment of the present invention, the dried powder of the plant is prepared by mixing 6 to 12 parts by weight of ginseng powder, 10 to 15 parts by weight of black soybean powder, 6 to 12 parts by weight of an almond powder, From 6 to 12 parts by weight of ginger powder, from 10 to 15 parts by weight of licorice powder, from 6 to 12 parts by weight of dermis powder, from 6 to 12 parts by weight of jujube powder, from 6 to 12 parts by weight of self leaf lobe, from 10 to 15 parts by weight of green tea leaf powder, 6 to 10 parts by weight of bagasse powder.
Examples of solvents which can be used for solvent extraction include water, C1-C4 alcohol, acetic acid, dimethylformamide (DMFO), dimethyl sulfoxide (DMSO), acetone, acetonitrile, ethyl acetate, methyl acetate, pentane, Hexane, chloroform, diethyl ether, carbon tetrachloride, and tetrahydrofuran (THF). Examples of the C1 to C4 alcohols include methanol, ethanol, propanol, n-butanol and iso-butanol.
As a solvent for preparing a plant extract, water may be used in particular, and ethanol may be used. Further, the plant extract according to the first embodiment of the present invention can be obtained by, for example, hot water extraction using water.
The plant extracts may be prepared by mixing all of the plants used for the production of plant extracts at once or extracting each plant under optimal conditions.
The method for producing a plant extract includes, for example, a step of pulverizing a dried plant to prepare a plant dry powder, a step of putting the plant dry powder and the solvent into a still, then heating the still, And collecting and cooling the resulting vapor to produce a distillate stock solution
Specifically, according to the first embodiment of the present invention, the plant dry powder mixture is put in a cotton bag and put in a still, and then about 10 to 20 times volume of water is added and heated to collect steam And cooling the solution to prepare a distillate stock solution. Here, the distillation stock solution is a plant extract. The vapor collection can be performed for 100 to 150 minutes with the solvent heated to 95 to 105 < 0 > C. Further, the step of cooling the steam and then removing the impurities by filtration may be further included.
When water is used as a solvent for the production of plant extracts, for example, water is added to the plant dry powder to prepare a mixture, and then the mixture is heated at a temperature of 70 ° C or more or 80 ° C or more for 2 hours or more, Hour, and the heated mixture may be filtered to produce a plant extract in an extractive state.
When the mixture is heated at an excessively high temperature, the extraction time is reduced, but the active ingredient may be destroyed, and if heated at a low temperature, the effective ingredient of the plant may not be extracted sufficiently. Therefore, it is necessary to appropriately adjust the extraction temperature and the extraction time.
Liquid extracts can be used as dried or as extracted.
Further, in order to remove solid particles suspended in the liquid extract, the particles may be filtered using nylon or the like, or filtration may be performed using a freeze filtration method or the like.
Examples of the drying method include freeze drying, vacuum drying, hot air drying, spray drying and the like.
The thus-obtained plant extract itself may be used as a composition for preventing hair loss and improving hair growth, and other active ingredients may be added to such plant extracts. The composition for preventing hair loss and hair growth according to the first embodiment of the present invention may further contain other ingredients that prevent hair loss and inhibit hair growth activity, in addition to plant extracts.
In the hair loss prevention and hair growth improving composition according to the first embodiment of the present invention, the content of the plant extract may be variously adjusted.
The hair loss prevention and hair growth improving composition according to the first embodiment of the present invention may contain 0.001 to 50.0% by weight of the plant extract based on the total weight of the composition.
The plant extract according to the first embodiment of the present invention grows the length of the hair-fiber constituting the hair, promotes the growth of the papilla cells, inhibits the activity of the 5? -Reductase, ≪ / RTI > Therefore, the plant extract according to the first embodiment of the present invention can be used for promoting hair growth or preventing hair loss.
That is, the hair loss prevention and hair growth improving composition according to the first embodiment of the present invention can be used in pharmaceuticals for preventing hair loss, promoting hair growth, food and skin external composition compositions and the like.
The second embodiment of the present invention provides a pharmaceutical product comprising the composition for preventing hair loss and hair growth according to the first embodiment of the present invention.
The pharmaceutical product according to the second embodiment of the present invention is not particularly limited in its formulation, and may be formulated into oral preparations, parenteral preparations, topical administration preparations and the like.
Oral preparations may have formulations such as powders, granules, tablets, capsules and the like and may contain binders, lubricants, disintegrants, excipients, solubilizers, dispersants, stabilizers, suspending agents, coloring matters, . Examples of liquid preparations in oral formulations include suspensions, solutions, emulsions and syrups. Such oral liquid preparations may contain diluents such as water or liquid paraffin, and may contain wetting agents, sweetening agents, perfumes, preservatives and the like.
Parenteral preparations include ointments, spray agents, lotions, patches, pads, and creams.
There are injections for topical administration. Injectables may include buffering agents, preservatives, anaglytic agents, solubilizers, isotonic agents, stabilizers, and the like.
A third embodiment of the present invention provides a food comprising the composition for preventing hair loss and improving hair growth according to the first embodiment of the present invention.
The food according to the third embodiment of the present invention is, for example, a health food. Such health foods may be prepared in formulations such as tablets, capsules, powders, granules, liquid preparations, and circles.
The fourth embodiment of the present invention provides a composition for external application for skin comprising a composition for preventing hair loss and improving hair growth according to the first embodiment of the present invention.
The composition for external application for skin according to the fourth embodiment of the present invention may contain, in addition to the composition for preventing hair loss and hair growth, the composition for improving hair loss and hair growth according to the first embodiment, such as a moisturizing agent, humectant, emollient, surfactant, alcohol, Powder, an antioxidant, a pH adjuster, a coloring matter, a perfume, and the like. The composition of the external preparation for skin may vary depending on the formulation or purpose of use.
When the skin external composition for hair loss prevention and hair growth improvement is a cosmetic composition, in addition to the hair loss prevention and hair growth improving composition according to the first embodiment, for example, water, oil, surfactant, humectant, thickeners, alcohol, Antioxidants, preservatives, and flavoring agents.
As the fat-retaining component, ester-based fat, hydrocarbon based fat, silicon based fat, fluorine based fat, animal fat, and plant fat can be used.
A water-soluble low molecular weight moisturizer, a lipid-soluble low molecular weight moisturizer, a water-soluble polymer moisturizer, and a lipid-soluble polymer moisturizer.
Emollient zero long chain acyl glutamic acid cholesteryl ester, hydroxystearic acid cholesteryl, 12-hydroxystearic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl ester and the like.
As the surfactant, a nonionic surfactant, an anionic surfactant, a cationic surfactant, and a positive surfactant may be used.
The composition for external application for skin according to the fourth embodiment of the present invention is not particularly limited in its formulation and may be, for example, hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, Hair cosmetic cream, hair cream, hair cream, hair cream, hair cream, hair cream, hair cream, hair cosmetic cream, hair wax, hair aerosol, hair pack, hair nutrition pack, hair soap, hair cleansing foam, Hair dyes, hair lacquers, hair moisturizers, hair mousses, hair sprays, and the like, for example.
Production examples and test examples are described below. However, the scope of the present invention is not limited by the production examples or the test examples.
≪ Preparation Example 1 > Preparation of plant extract
First, the plant materials, namely, ginseng, black beans, rhubarb, gugija, licorice, dermis, jujube, japanese leaf, green tea leaf and white bagasse are prepared.
Each prepared plant material is first dried in a shade maintained at 15 ° C to 20 ° C for 6 days to make a semi-dried material. The primary dried semi-dried material is re-dried for 3 days in the sun at a temperature of 25 ° C or higher to make the dried material.
Each of the dried plant materials was pulverized to prepare dry powder of each plant and the dry powder of each plant was mixed according to the content ratio shown in Table 1 below to prepare a mixed plant dry powder (hereinafter referred to as "plant dry powder" 1 kg.
On the other hand, the dried plant powder may be prepared by mixing and pulverizing each dried plant into a crusher by a necessary amount.
1 kg of the dried plant powder thus prepared is placed in a cotton bag and put in a still, and then 20 liters of water is added and heated. The vapor resulting from boiling of the water by heating is cooled to prepare a distillate stock solution. Specifically, the steam generated by heating at 100 DEG C for 120 minutes is cooled, and impurities are removed by filtration to obtain a distillate stock solution. The distillation stock solution thus obtained is referred to as a plant extract or "plant extract 10 ".
≪ Test Example 1 > Evaluation of activity of human dermal papilla cells
The hair is grown by the process of dividing the epithelial cell surrounding the dermal papilla and creating a hair shaft. At this time, the dermal papilla cell regulates the division of the epithelial cell . In addition, male hormones that play an important role in male hair loss, hair follicles also play a role in hair follicles, the hair duck pods play an important role.
Dihydrotestosterone (DHT) is known as an active male hormone that causes hair loss. That is, dihydrotestosterone (hereinafter referred to as "DHT") is known to be the most important contributor to male hair loss caused by shrinking hair follicles. Specifically, about 5% of testosterone, the male hormone, undergoes 5α-reduction (5α-reduction) and becomes a powerful androgen DHT. At this time, the enzyme that promotes the production of DHT is 5? -Reductase (5? -Reductase).
Thus, DHT induces progressive scaling of dermal papilla cells and hair follicles and inhibits hair growth. It has also been found that the conversion of testosterone to DHT is mediated by 5? -Reductase activity. Based on these results, it can be seen that reducing DHT through inhibition of 5α-reductase activity helps hair growth. On the other hand, it is known that beta -catenin is known as a signal protein for determining hair follicle cells, and hair growth is promoted by the activity of beta -catenin.
Hereinafter, the effect of the "plant extract 10 " produced in Preparation Example 1 on dermal papilla cells is confirmed through in vitro experiments.
Specifically, in order to confirm the effect of preventing the hair loss of "Plant Extract 10" prepared in Production Example 1, human hair dermal papilla cells were treated with DHT to create a hair loss environment, and then hair loss was induced using Western blot Protein inhibition and increase of hair growth related proteins are confirmed.
(1) Orientation of Human Hair Follicle Dermal Papilla Cell (HFDPC)
A culture medium supplemented with 10% fetal bovine serum (FBS) and 1% antibiotics in a Dulbecco Modified Eagle Medium (DMEM) low glucose basal medium was used as a culture medium do. Human dermal papilla cells (HFDPC) are grown by cell adhesion and cultured in the state that Poly-L-Lysin is coated on a culture plate. At this time, 1x10 < 6 > cells are seeded in a 175T flask.
2) Creating a hair loss environment
Cultured human dermis dermal papilla cells (HFDPC) were seeded at 3 × 10 6 cells per well of a 6-well plate (3 × 10 6 / well) to produce cell samples. Prepared cell samples are cultured for one day and then cultured for another day on a medium containing no FBS. The culture is carried out in an incubator at 37 ° C, 5% CO 2 environment.
After that, each cell sample is treated with DHT, the test group is treated with "Plant Extract 10", and the cells are cultured for 3 hours, 5 hours and 24 hours.
A cell sample to which DHT was not added, that is, a DHT-free cell sample was referred to as a control group, and a cell sample to which DHT was added but to which no plant extract 10 was added was referred to as comparative group 1. DHT and plant extract 10 The added cell sample is called the test group. The test group includes test group 1 in which plant extract 10 was treated at a concentration of 5%, test group 2 at a concentration of 10%, and test group 3 at a concentration of 20%.
In addition, a sample of cells treated with finasteride known as hair growth inhibitor with DHT is referred to as comparative group 2.
(3) 5α-Reductase Inhibitory Effect
The amount of 5α-reductase (5α-reductase) expressed in the cell samples of the test group, the comparative group and the control group is determined by Western blotting.
Specifically, according to the Western blot method, 20 ug of the protein extracted from the test group, the comparative group and the control cell sample was loaded on a SDS gel, transferred to a PVDF membrane, and 5α-reductase (5α-reductase) . At this time, actin protein is used for comparison of the amount of protein. Actin protein is a protein existing in cells regardless of 5a-reductase, which is a hair loss related factor, and the concentration of actin protein is proportional to the amount of cells.
Figures 1a, 1b, 2a and 2b show the results of 5α-reductase expression in human dermal papilla cells (HFDPC).
Specifically, FIG. 1A is a photograph showing the 5α-reductase concentration of a cell sample cultured for 3 hours after DHT treatment, FIG. 1B is a graph showing the relative concentration of 5α-reductase in the test group and the comparative group, to be.
FIG. 2A is a photograph showing the 5α-reductase concentration of a cell sample cultured for 5 hours after DHT treatment, and FIG. 2B is a graph showing a relative concentration of 5α-reductase in a test group and a comparative group as compared to a control group.
In particular, the graphs of FIG. 1B and FIG. 2B show the relative absorbance of the control group, the test group and the control group when the absorbance of the control group is 100% %).
1a, 1b, 2a and 2b, DHT was treated with human dermal papilla cells (HFDPC), and then the plant extract 10 prepared in Preparation Example 1 of the present invention was further treated (Test Groups 1, 2, 3), it can be confirmed that the expression of 5a-reductase, which is an anti-depilation antibody, is suppressed.
Thus, it can be seen that the plant extract according to the first embodiment of the present invention inhibits the expression of 5? -Reductase in human dermal papilla cells (HFDPC), thereby preventing or suppressing hair loss.
(4) Effect of β-catenin expression
The amount of β-catenin expressed in the test group, the comparative group, and the control cell sample is determined using the WESTERN BLOT method.
Specifically, according to the Western blot method, 20 ug of the protein extracted from the test group, the comparative group and the control cell sample is loaded on the SDS gel, transferred to a PVDF membrane, and then the β-catenin is detected. At this time, actin protein is used for comparison of the amount of protein. Actin protein is a protein existing in cells regardless of β-catenin, which is a hair growth related factor, and the concentration of actin protein is proportional to the amount of cells.
Figures 3a and 3b show the expression of beta -catenin in human dermal papilla cells (HFDPC).
Specifically, FIG. 3A is a photograph showing the β-catenin concentration of the sample cultured for 24 hours after the DHT treatment, and FIG. 3B is a graph comparing the relative concentrations of β-catenin in the test group and the comparison group with respect to the control group.
The graph of FIG. 3B shows the relative absorbance of the control group and the test group as a percentage (%) when the absorbance of the control group, the control group and the test group is measured and the absorbance of the control group is 100%.
3A and 3B, DHT treatment of human dermis dermal papilla cells (HFDPC) followed by treatment with the plant extract 10 prepared in Preparation Example 1 of the present invention (test groups 1, 2 and 3) It is confirmed that the expression of? -Catenin as a related factor is increased.
Thus, it can be seen that the plant extract according to the first embodiment of the present invention promotes the expression of beta -catenin in human dermal papilla cells (HFDPC), thereby promoting or promoting hair growth.
INDUSTRIAL APPLICABILITY As described above, it can be seen that the plant extract 10 produced in Production Example 1 of the present invention has an effect of preventing hair loss and promoting hair growth. In addition, it can be seen that the hair loss prevention and hair growth improving composition comprising the plant extract prepared in Production Example 1 of the present invention prevents hair loss and promotes hair growth without side effects.
Hereinafter, the plant extracts 10 prepared in Preparation Example 1 are used to prepare products and compositions of various formulations at the following mixing ratios.
≪ Preparation Example 2 > Production of hair tonic
The components of Table 2 are mixed and a hair tonic is prepared according to a conventional manufacturing method.
≪ Preparation Example 3 > Preparation of hair conditioner
The ingredients of Table 3 are mixed to prepare a hair conditioner according to a conventional manufacturing method.
≪ Preparation Example 4 > Production of hair lotion
The components of Table 4 are mixed to prepare a hair lotion according to a conventional manufacturing method.
≪ Preparation Example 5 > Production of hair soap
The ingredients of Table 5 are mixed and hair soap is prepared according to the usual production method.
≪ Preparation Example 6 > Preparation of tablet
The ingredients of Table 6 are mixed and tableted according to the conventional preparation method of tablets.
≪ Preparation Example 7 > Preparation of capsules
Ingredients in Table 7 are mixed and the capsules are prepared by charging the ingredients into a gelatin capsule according to the conventional preparation method of capsules.
≪ Preparation Example 8 > Production of liquid agent
The components of Table 8 are mixed according to the usual method for producing a liquid agent, and then filled in a brown bottle and sterilized to prepare a liquid agent.
It is of course possible to use other fragrance instead of cinnamon. Fruit flavor such as lemon flavor may be used, or herbal medicine flavor may be used.
≪ Preparation Example 9 > Production of beverage
The ingredients in Table 9 were mixed according to the usual beverage preparation method, and the mixture was stirred and heated at 85 DEG C for about 1 hour. The resulting solution was filtered to obtain a sterilized 2 liter container which was sealed and sterilized, Used for manufacturing.
The composition ratio of the vitamin and mineral mixture in Table 9 may be arbitrarily changed. In addition, the ingredients of Table 9 may be mixed according to a conventional food manufacturing method, and then granules may be prepared and used for the production of other foods.
The composition ratios in Table 9 may vary depending on the regional and national preferences, such as the demand level, the demanding country, and the intended use.
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is clearly understood that the same is by way of illustration and example only and is not to be taken by way of limitation, You will know. It is, therefore, to be understood that the embodiments described above are illustrative and not restrictive.
Claims (11)
Wherein said plant extract is derived from a plant group consisting of ginseng, black bean, rhizome, ginger, licorice, dermis, jujube, japanese lobule, green tea leaf and white algae.
Wherein the ginseng is 6 to 12 wt%, the black beans are 10 to 15 wt%, the whorl is 6 to 12 wt%, the goji is 6 to 12 wt%, the licorice is 10 to 15 wt% The hair growth preventing and hair growth promoting hair growth of the present invention has a content of 12 to 12% by weight, the jujube of 6 to 12% by weight, the baby leaf of 6 to 12% by weight, the green tea leaf of 10 to 15% / RTI >
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| JP2016216093A JP6978192B2 (en) | 2015-11-12 | 2016-11-04 | Hat-type virtual reality display video system |
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| EP2944999A1 (en) * | 2014-05-15 | 2015-11-18 | Intral Strategy Execution S. L. | Display cap |
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| KR102009610B1 (en) * | 2018-12-20 | 2019-08-09 | 함미경 | Composition for hair loss prevention and hair growth promotion, production method thereof |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP6978192B2 (en) | 2021-12-08 |
| KR101758998B1 (en) | 2017-07-17 |
| JP2017089087A (en) | 2017-05-25 |
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