KR101183139B1 - Composition for hair cosmetic - Google Patents

Abstract

PURPOSE: A hair cosmetic composition containing a mixture extract of Sibjeondaebotang and biotin is provided to promote hair growth and to promote hair growth. CONSTITUTION: A hair cosmetic composition contains 0.1-10 wt% of Sibjeondaebotang(ginseng, Astragali Radix, Stractylodis Rhizoma alba, Angelicae gigantis Radix, Wolfiporia cocos, Rehmanniae Radix, Cnidii Rhizoma, Paeoniae Radix, Cinnamomi Ramulus, AND Glycyrrhizae radix) and biotin mixture extract. Sibjeondaebotang is extracted using water or hydrous or anhydrous alcohol of 1-4 carbon atoms.

Description

Composition for hair cosmetics {Composition for hair cosmetic}

The present invention relates to a cosmetic composition for hair showing the hair growth, wool and hair regrowth effect, including a mixed extract of Sipjeondaebotang (Ginseng, Astragalus, Baekchul, Dongguk, Bokyeong, Chihwang, Cheongung, Peony, Caji, Licorice) and biotin .

[Prior Art Literature]

[Patent Literature]

Korean Registered Patent KR 10-0674363, pp. 2-3 (Banggye Ryong) 2007. 01. 19 Registration

[Non-Patent Documents]

Biotin, Naver Knowledge Dictionary (Search date: October 13, 2011)

Lee, Kyung-Mi, Hair Growth Promoting Effect of Sewage Hot Water Extract in C57BL / 6 Mice, pp. 1-2

Hair protects the brain from everyday irritation or shock, protects it from UV rays, and has a decorative function of expressing beauty while changing human appearance. Hair as a body part has personal characteristics such as skin, and hair condition varies according to external factors such as age and environment and internal factors such as physical and mental health.

As the society is becoming more and more advanced and industrialized, the cosmetic aspect is becoming more important nowadays. Exposure to harmful environment rather than male hair loss caused by hair loss or hereditary phenomena, Alopecia is caused by various living conditions such as various stresses, irregular eating habits, and changes in eating habits, and the age group is gradually decreasing. In particular, women account for 20-30% of all hair loss patients due to work stress, diet, and pregnancy among women in their 20s and 30s. Today, hair loss is considered the most serious phenomenon for modern people. It has become so high that it is a direct cause of launching various products in the cosmetics market.

Drugs known to promote hair growth include Minoxidil, Finasteride and Propecia, which have been approved by the US Food and Dug Administration (FDA). Minoxidil was initially developed as a vasodilator for the treatment of hypertension, but as a side effect, hirsutism was reported. The mechanism of action on the hair growth effect of minoxidil has not been clarified until now, but it is thought that the increase of nutrient supply through vasodilation and potassium channel opening effect induce hair growth. However, until now, no hair and hair loss treatment agent is completely treated.

In the sense of consent, the heart is extremely tired and depleted, and in most cases the food is diminished and the mind is dizzy, and the heart is everything in the body, such as hair, hair, Muscle and bone, bone marrow (기), Gi (氣) and blood (血), etc. are all lacking state, Huh is described as giving birth to the disease (百病).

In oriental medicine, there are herbal medicines formulated with prescription medicines and medicinal herbs that treat these symptoms for a long time. Herbal medicines have various effects different from a single prescription because various ingredients in one prescription are checked and complied with each other. This is the difference between folk medicine and herbal medicine that uses a combination of one or two drugs, and it is characteristic of only one medicine.

In Chinese medicine, Yinheo, Yangheo, Yinyangheo, and other medicines that control huoheung, Huangbaek, Jimo, Jizhihuang, and Deer Antler ,, Doo First, Baekjak, Baekchul, White Ginseng, Ginseng, Ban-Ha, Omiza, Hwang Gi, Hwang Gi, Hwang-Gi, Baek Bok-Ryung ( White, Sanctuary, Texan, Sansuyu, Wind-proof, Umbrella, Wonji Gugija, Keel, Rhubarb (생강) Ginger (生薑), Cheongung (川芎), Hasuo (何首烏), etc. These herbal medicines are not only used as a herbal medicine, but also as a folk medicine is passed down.

Among the herbal medicines, in particular, ginseng, Hwanggi (黄 출), Baekchul (白 朮), Dongguk (복), Bokryeong (茯 笭), Jihwang (地 黄), Cheongung (川芎), Peony (계), Gyeji (桂枝), Sipjeondaebotang containing the extract of licorice (초 草) is known to be effective for those who have a stamina and strength, such as chronic illness, after a serious illness, weak, elderly, infants, etc. in one shot.

Biotin, on the other hand, is also called vitamin H and is mostly produced by good bacteria in the colon. Biotin is indispensable for the synthesis of Phospholipids, which make up the cells of the barrier. Phospholipids must be present in the barrier enough to survive invasion of all kinds of dirty foods, molds, viruses, enzymes, etc., and to allow the intestines to function normally. If the barrier is not protected by fatty acids, the function of the intestine is significantly reduced, and the intestinal function is reduced, causing skin rash or hair loss.

The present inventors have completed the present invention by finding out that the composition containing Sipjeondaebo-tang and biotin, which are known to govern the above-mentioned hues, has an excellent effect on hair growth and hair growth.

An object of the present invention is a hair cosmetic composition having excellent hair growth, hair growth, and wool effect, including a mixed extract of Sipjeondaebotang (Ginseng, Astragalus, Baekchul, Dongguk, Bokryeong, Chihwang, Cheongung, Peony, Caji, licorice extract) and biotin It is to provide.

In order to solve the above problems, the present invention provides a hair cosmetic composition comprising a mixed extract of Sipjeondaebotang (Ginseng, Astragalus, Baekchul, Angelica, Fueryeong, Chihwang, Cheongung, Peony, Cinnamon, Licorice extract) and biotin .

Mixed extract of the cosmetic composition of the present invention, ginseng, Astragalus, Baekchul, Dongguk, Bokryeong, Jihwang, Cheongung, Peony, Cinnamon, licorice is prepared by adding biotin to the Junjeondaebotang extracted by mixing.

Sipjeondaebotang contained in the composition of the present invention, preferably ginseng, Astragalus, Baekchul, Angelica, Fukryeong, Chihwang, Cheongung, Peony, Gyeji, Licorice on the basis of dry weight 5: 4: 5: 5: 5: 5 It is extracted by mixing in a ratio of 5: 5: 4: 3.

Sipjeondaebotang contained in the composition of the present invention is preferably extracted with one or more solvents selected from water, anhydrous or hydrous alcohol of 1 to 4 carbon atoms.

Mixture extracts of Siopjeondaebotang and biotin included in the composition of the present invention, ginseng, Astragalus, Baekchul, Angelica, Fuling, Chihwang, Cheongung, Peony, Caji, licorice, preferably 5: 4: 5: 5: 5: 5: 5: 5: 4: 3 mixed and chopped, and extracted with one or more solvents selected from water, anhydrous or hydrous alcohols having 1 to 4 carbon atoms, and biotin is preferably used 10% by weight of the solution was added, and the mixture was left at room temperature, filtered, and concentrated and dried to granulate.

The amount of biotin used in the mixed extract of the present invention may be 5 to 20% by weight of ginseng, Astragalus, Baekgi, Angelica, Fuling, Chihwang, Cheongung, Peony, Gyeji, and licorice gross weight used in the jeonjeondaebotang.

The composition of the present invention contains the mixed extract of Siegejeonbotang and biotin in an amount of 0.1% to 10% by weight based on the total liquid weight of the cosmetic composition, and 0.001 to 5% by weight, based on the total dry weight of the cosmetic composition. Preferably it may be contained in an amount of 0.01 to 3% by weight.

The composition of the present invention is preferably a cosmetic hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nutrition cream, hair moisturizer cream, hair massage cream , Hair wax, hair aerosol, hair pack, hair nutrition pack, hair soap, hair cleansing foam, hair oil, hair drier, hair preservative, hair dye, hair wave agent, hair bleach, hair gel, hair glaze, hair dresser, hair A cosmetic composition for hair, which is one selected from the formulations of lacquer, hair moisturizer, hair mousse or hair spray.

The compositions of the present invention exhibit excellent effects on hair growth, hair growth and wool action.

1 is a diagram confirming the hair growth effect by treating a mouse of the composition of the present invention. In Figure 1, d means the number of days that have elapsed after the treatment of the composition of the present invention.
2 is a diagram of a mouse treated with a negative control group. In Figure 2, d means the number of days after treatment with saline as a sample.
3 is a diagram confirming the hair growth effect by treating a mouse with a commercial hair regrowth. In Figure 3, d means the number of days after the minoxidil treated with a sample.
Figure 4 is a diagram confirming the hair growth effect by treating the mixture of ginseng and biotin to the mouse. In Figure 4, day means the number of days after treatment with a mixed extract of ginseng and biotin.
5 is a diagram confirming the hair growth effect by treating the mouse with a mixed extract of Astragalus and biotin. In Figure 5, day means the number of days after treatment with a mixed extract of sulfur and biotin.
6 is a diagram showing the hair growth effect by treating the mice with biotin. In Figure 6, day refers to the number of days after treatment with biotin.

The cosmetic composition of the present invention is prepared as follows.

First, the ginseng, Astragalus, Baekchul, Dongguk, Bokryeong, Jihwang, Cheongung, Peony, Gyeji, Licorice used in Sipjeondaebotang is dried and can be used in the herbal medicine market.

The mixed extract contained in the composition of the present invention is preferably mixed with ginseng, Astragalus, baekchul, Dongguk, Bokryeong, Chihwang, Cheongung, Peony, Gyeji, Licorice in a dried state, 1 to 15 times the dry weight thereof. It is prepared by adding water, a lower alcohol having 1 to 4 carbon atoms or a mixed solvent of water and such a lower alcohol, or one or more solvents selected from ethyl acetate, glycerin, ethylene glycol, propylene glycol and butylene glycol, and then adding biotin.

The extraction temperature is preferably 50 to 100 ℃.

Specifically, the mixed extract included in the cosmetic composition of the present invention, dried ginseng, Astragalus, Baekchul, Angelica, Fukryeong, Chihwang, Cheongung, Peony, Keji, Licorice 5: 4: 5: 5: 5: 5: 5: Prepare and mix at a ratio of 5: 4: 3, and chop the dry matter, and then, in water of 1 to 15 times the volume of the dry weight, lower alcohol having 1 to 4 carbon atoms or a mixed solvent of these lower alcohols and water After extracting the active ingredient by adding the selected extraction solvent and immersing at 4 ~ 30 ℃ for 3 to 20 days, the biotin is added by 10% by weight of medicinal herb of Jeopjeondaebotang and concentrated by a concentrated concentration under reduced pressure concentrator. In addition, in order to prevent the solvent from evaporating, an extractor equipped with a cooling condenser is extracted by heating for 3 to 48 hours at 30 to 100 ° C or by depositing at 5 to 30 ° C for 1 to 5 days to extract the active ingredient, and reducing the extraction solvent. Obtained by concentration with a thickener.

Moreover, it can manufacture using well-known ultrasonic extraction method.

Mixed extracts of Sipjeondaebotang and biotin are contained in an amount of 0.1% to 10% by weight based on the total liquid weight of the cosmetic composition, or 0.001 to 5% by weight, preferably 0.01 to 3, based on the total dry weight of the cosmetic composition. A cosmetic composition is prepared to be contained in an amount of% by weight.

The cosmetic composition of the present invention is not particularly limited in the formulation, for example, hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair Nourishing Cream, Hair Moisture Cream, Hair Massage Cream, Hair Wax, Hair Aerosol, Hair Pack, Hair Nutrition Pack, Hair Soap, Hair Cleansing Foam, Hair Oil, Hair Dryer, Hair Preservative, Hair Dye, Hair Wave, Hair Decolorant, Hair Cosmetic composition, characterized in that the formulation of the gel, hair glaze, hair dresser, hair lacquer, hair moisturizer, hair mousse or hair spray. In addition, in the cosmetic composition of each formulation, other components in addition to the mixed extracts of the above Junjeondaebotang and biotin can be arbitrarily selected and blended according to the formulation or purpose of use of other cosmetics.

The cosmetic composition of the present invention is preferable as a cosmetic composition exhibiting a hair growth effect.

Hereinafter, the configuration and effects of the present invention will be described in detail with reference to Examples and Comparative Examples, but the present invention is not limited thereto.

< Example  1> Mixed extract of the present invention Hair growth  Confirm

1. Preparation of Mixed Extract of Siopjeondaebotang and Biotin

The ingredients of Sibjeondaebotang are purchased at the Chinese herbal medicine market (http://www.hanyakjae.net/) and dried and then seasoned with ginseng (50g), Astragalus (40g), Baekchul (50g), Angelica (50g), and Bokryeong (50g) , 5kg distilled water was added to the sample of Gehwang (50g), Cheongung (50g), Peony (50g), Cinnamon (40g), Licorice (30g), boiled at 80 ℃ for 4 hours in an extractor equipped with a cooling condenser and extracted with 300mesh filter paper. After filtration, biotin (50 g, DSM; Importer: Philchem) was added thereto, and the mixture was left at room temperature for 1 week, and the precipitate was filtered twice using Edventech No. 5 filter paper and Whatman GFC 150 mm filter paper. And concentrated using a vacuum concentrator at a temperature of 40 ~ 50 ℃ and then powdered by using a spray dryer (BUCHI).

2. In vivo hair growth test using mouse C57BL / 6

C57BL / 6CrN mice (Orient Bio Inc., Korea) have black hair, which makes it easy to observe the hair growth, and natural hair loss due to aging occurs. In this experiment, four-week-old mice were purchased and then adapted to a laboratory environment for one month, and the mice were freely ingested with water and feed during the experiment, and were bred at 23 ° C and 55% humidity.

Hair removal cream (Veet, Reckitt Benckiser, UK) consisting of thioglycolic acid was used to remove hair from mice.

In order to determine the hair growth effect, the sample of the mixed extract powder of the present invention prepared in 1. of Example 1 dissolved in a saline solution at a concentration of 5%, once every morning 100μL in the back of the mouse after the start of the experiment The negative control group was treated in the same manner using the same amount of saline as a sample.

As a result of the experiment, in all four mice coated with the sample containing the mixed extract of the present invention, the hair growth progressed more than 95% after 5 days in the photograph (see Fig. 1).

Experimental results of the negative control group showed little progression as shown in FIG. 2.

<Comparative Example 1> Comparison of Hair Regrowth with Commercial Hair Regrowth

In order to compare with the hair growth effect with a commercial hair regrowth agent, 3% MXD (minoxidil, modern drug) in the same manner as in 2. of Example 1, the mouse was treated to check the hair growth effect.

As a result, hair growth progressed after 5 days in all 4 animals, and the hair growth rate progressed more than 95%, but hair growth progressed more slowly than the mouse coated with the sample containing the mixed extract of the present invention (see FIG. 3). In other words, it was confirmed that the compound of the present invention is more excellent in terms of the progress of hair growth.

< Comparative example  2> with known herbal medicines containing hair growth effect Hair growth  compare

Mixed extracts of ginseng, Astragalus, and biotin, which are known to have a hair regrowth effect, were prepared in the same manner as in Example 1. In addition, treatment with only biotin (50 g) confirmed the hair growth effect. The above herbal medicines were purchased from the Chinese herbal medicine market (http://www.hanyakjae.net/) and dried and used.The samples of fine ginseng (500g) and Astragalus (500g) were extracted as in Example 1 and then biotin ( 50 g) and concentrated to dry powder.

As a result, the ginseng extract and the biotin-containing extract showed a hair growth rate of about 75% only in three rats after 5 days, and after 15 days, two mice had a hair growth rate of 95% and 2 mice (90%). 4).

Astragalus extract and biotin-containing extract showed hair growth rate of about 80% in one rat after 5 days, and after 15 days, one hair showed 90% hair growth, two hair 80% hair and one hair hair 75% hair growth rate. (See FIG. 5).

After 5 days of treatment with the mice, the hair growth rate was about 50% in only two mice, and after 15 days, the hair growth rate was 90%, 1 was 80%, and 1 was 60%. 6).

In view of the above results, it can be seen that the composition containing the mixed extract of the present invention has excellent hair growth and hair growth effects.

Preparation Example 1 Preparation of Hair Tonic

1.0 g of powder of Example 1

55.0 g of ethanol

Castor Oil 5.0g

Glycerin 3.0g

0.1 g of pyrotonamine

Spices, pigments

Purified water balance

100 g in total

Preparation Example 2 Preparation of Hair Lotion

1.0 g of powder of Example 1

Cetostearyl alcohol 2.0g

2.0 g of stearyl triethylammonium chloride

0.5 g of hydroxyethyl cellulose

0.1 g of pyrotonolamine

Fragrance, pigment 0.5g

Purified water balance

100 g in total

Claims (6)

Sipjeondaebotang (Ginseng, Astragalus, Baekchul, Angelica, Fukryeong, Chihwang, Cheongung, Peony, Gyeji, Licorice extract) and biotin mixed extracts; , Hair ratio, licorice and biotin ratio of 5: 4: 5: 5: 5: 5: 5: 5: 4: 3: 5 based on dry weight. delete delete The hair cosmetic composition according to claim 1, wherein the Siopjeondaebotang is extracted with at least one solvent selected from water, anhydrous or hydrous alcohol having 1 to 4 carbon atoms. According to claim 1, The mixed extract is 0.1 to 10% by weight relative to the total weight of the cosmetic cosmetic composition for hair. The method of claim 1, wherein the cosmetics are hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nutrition cream, hair moisturizer cream, hair massage cream, hair Wax, Hair Aerosol, Hair Pack, Hair Nutrition Pack, Hair Soap, Hair Cleansing Foam, Hair Oil, Hair Dryer, Hair Preservative, Hair Dye, Hair Wave Agent, Hair Decolorant, Hair Gel, Hair Glaze, Hair Dresser, Hair Lacquer, A cosmetic composition for hair, which is one selected from a formulation of a hair moisturizer, hair mousse or hair spray.

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