KR20160060100A - 치환된 아미노피리미딘 화합물 및 이용 방법 - Google Patents

치환된 아미노피리미딘 화합물 및 이용 방법 Download PDF

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Publication number
KR20160060100A
KR20160060100A KR1020167010190A KR20167010190A KR20160060100A KR 20160060100 A KR20160060100 A KR 20160060100A KR 1020167010190 A KR1020167010190 A KR 1020167010190A KR 20167010190 A KR20167010190 A KR 20167010190A KR 20160060100 A KR20160060100 A KR 20160060100A
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South Korea
Prior art keywords
alkylene
heterocyclyl
cycloalkyl
alkyl
compound
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KR1020167010190A
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English (en)
Korean (ko)
Inventor
닝 시
량 왕
팅진 왕
Original Assignee
칼리토르 사이언시즈, 엘엘씨
선샤인 레이크 파르마 컴퍼니 리미티드
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Publication of KR20160060100A publication Critical patent/KR20160060100A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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KR1020167010190A 2013-09-22 2014-09-17 치환된 아미노피리미딘 화합물 및 이용 방법 Ceased KR20160060100A (ko)

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US201361880974P 2013-09-22 2013-09-22
US61/880,974 2013-09-22
US201461983444P 2014-04-23 2014-04-23
US61/983,444 2014-04-23
PCT/US2014/055967 WO2015042078A2 (en) 2013-09-22 2014-09-17 Substituted aminopyrimidine compounds and methods of use

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KR1020167010188A Ceased KR20160058889A (ko) 2013-09-22 2014-09-17 치환된 아미노피리미딘 화합물 및 이용 방법

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US (4) US9670194B2 (cg-RX-API-DMAC7.html)
EP (2) EP3046921A4 (cg-RX-API-DMAC7.html)
JP (2) JP6494634B2 (cg-RX-API-DMAC7.html)
KR (2) KR20160060100A (cg-RX-API-DMAC7.html)
AU (2) AU2014321419B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016003229A8 (cg-RX-API-DMAC7.html)
CA (2) CA2920059A1 (cg-RX-API-DMAC7.html)
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RU (2) RU2683793C2 (cg-RX-API-DMAC7.html)
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