KR20160003899A - 마크롤리드 고체상 형태 - Google Patents
마크롤리드 고체상 형태 Download PDFInfo
- Publication number
- KR20160003899A KR20160003899A KR1020157036690A KR20157036690A KR20160003899A KR 20160003899 A KR20160003899 A KR 20160003899A KR 1020157036690 A KR1020157036690 A KR 1020157036690A KR 20157036690 A KR20157036690 A KR 20157036690A KR 20160003899 A KR20160003899 A KR 20160003899A
- Authority
- KR
- South Korea
- Prior art keywords
- dipiperidinyl
- mycaminosyl
- tylonolide
- polymorph
- crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| AU2007278195B2 (en) | 2006-07-28 | 2012-09-13 | Intervet International B.V. | Macrolide synthesis process |
| EP2019112A1 (en) * | 2007-07-26 | 2009-01-28 | Intervet International BV | Macrolide solid-state forms |
| CN104302653B (zh) | 2011-11-25 | 2017-02-22 | 拜耳知识产权有限责任公司 | 抗菌的泰乐菌素衍生物及其制备方法 |
| CN102816196A (zh) * | 2012-09-10 | 2012-12-12 | 河北远征药业有限公司 | 泰地罗新半抗原、人工抗原及其制备方法 |
| HUE037868T2 (hu) * | 2013-05-23 | 2018-09-28 | Bayer Animal Health Gmbh | Tilozin-származékok és eljárás elõállításukra |
| CN103554203A (zh) * | 2013-08-17 | 2014-02-05 | 齐鲁动物保健品有限公司 | 一种泰地罗新无定形晶及其制备方法 |
| CN104478974B (zh) * | 2014-11-28 | 2016-08-17 | 武汉回盛生物科技有限公司 | 一种20，23-二哌啶基-5-o-碳霉胺糖基-泰乐内酯的合成方法 |
| CN104447919B (zh) * | 2014-11-28 | 2017-03-08 | 武汉回盛生物科技股份有限公司 | 一种20，23‑二哌啶基‑5‑o‑碳霉胺糖基‑泰乐内酯原料药的精制方法 |
| CN104497082B (zh) * | 2015-01-13 | 2017-12-12 | 中国兽医药品监察所 | 一种泰地罗新的合成方法 |
| CN104774223A (zh) * | 2015-03-26 | 2015-07-15 | 宁夏泰瑞制药股份有限公司 | 一种利用泰乐菌素碱生产泰地罗新的方法 |
| CN105254693B (zh) * | 2015-11-13 | 2017-12-22 | 周金华 | 一种泰地罗新的合成方法 |
| CN106046084B (zh) * | 2016-06-02 | 2019-08-09 | 天津大学 | 泰地罗新丙酮溶剂化合物及制备方法 |
| CN106083958B (zh) * | 2016-06-02 | 2019-07-23 | 天津大学 | 泰地罗新环己烷溶剂化合物及制备方法 |
| CN106008629B (zh) * | 2016-06-02 | 2019-11-22 | 天津大学 | 泰地罗新1,4-二氧六环溶剂化合物及制备方法 |
| CN109721633A (zh) * | 2017-10-31 | 2019-05-07 | 齐鲁晟华制药有限公司 | 一种泰地罗新晶型a及其制备方法 |
| CN120795059A (zh) | 2018-08-27 | 2025-10-17 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| CN111349130A (zh) * | 2018-12-21 | 2020-06-30 | 齐鲁动物保健品有限公司 | 一种泰地罗新晶型b及其制备方法 |
| WO2022117701A1 (en) | 2020-12-03 | 2022-06-09 | Intervet International B.V. | A method of treating foot rot |
| CN114213484A (zh) * | 2021-12-21 | 2022-03-22 | 河北远征药业有限公司 | 一种泰地罗新1，2-丙二醇溶剂化合物及其制备方法 |
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| US3761588A (en) * | 1969-02-06 | 1973-09-25 | Meiji Seika Kaisha | Antibiotics and production thereof |
| IL69666A (en) | 1982-09-13 | 1987-10-20 | Lilly Co Eli | 20-amino-20-deoxo-5-o-mycaminosyl-23-o-mycinosyltylonolide derivatives,their preparation and veterinary antibiotic use |
| US4820695A (en) | 1982-09-13 | 1989-04-11 | Eli Lilly And Company | C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics |
| SI8311553A8 (en) * | 1983-07-18 | 1995-06-30 | Pliva Pharm & Chem Works | Process for preparing 7,16-dioxa-2-aza-10-0-cladynosil-12-0-desosaminyl-4,5-dihydroxy-6- ethyl-3,5,9,11,13,15-hexamethylbicyclo (11.2.1.) hexadeca-1(2)-ene-8-ones |
| US4921947A (en) * | 1986-03-31 | 1990-05-01 | Eli Lilly And Company | Process for preparing macrolide derivatives |
| US4920103A (en) | 1986-09-29 | 1990-04-24 | Eli Lilly And Company | Modifications of mycinose and 3-O-demethylmycinose in tylosin-type macrolides |
| PT1216256E (pt) * | 1999-08-30 | 2004-07-30 | Zaidan Hojin Biseibutsu | Antibioticos macrolidos e tratamento de pasteurelose |
| EP1638549A4 (en) * | 2003-03-10 | 2011-06-15 | Optimer Pharmaceuticals Inc | NEW ANTIBACTERIAL AGENTS |
| WO2005019226A1 (en) * | 2003-08-26 | 2005-03-03 | Biocon Limited | A process for the recovery of substantially pure tricyclic macrolide |
| CA2588480A1 (en) * | 2005-01-05 | 2006-08-10 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Amorphous tacrolimus and preparation thereof |
| CN101506220B (zh) * | 2006-07-28 | 2012-10-17 | 英特威国际有限公司 | 大环内酯合成方法 |
| EP2019112A1 (en) * | 2007-07-26 | 2009-01-28 | Intervet International BV | Macrolide solid-state forms |
| AU2007278195B2 (en) * | 2006-07-28 | 2012-09-13 | Intervet International B.V. | Macrolide synthesis process |
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