CN103467548A - 大环内酯固态晶型 - Google Patents

大环内酯固态晶型 Download PDF

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Publication number
CN103467548A
CN103467548A CN2013102805250A CN201310280525A CN103467548A CN 103467548 A CN103467548 A CN 103467548A CN 2013102805250 A CN2013102805250 A CN 2013102805250A CN 201310280525 A CN201310280525 A CN 201310280525A CN 103467548 A CN103467548 A CN 103467548A
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CN
China
Prior art keywords
tylonolide
dipiperidinyl
mycaminosyl
polymorph
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2013102805250A
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English (en)
Chinese (zh)
Inventor
F·布拉特尔
M·布伦纳
G·胡
T·拉赫尔
R·瓦拉斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Intervet International BV
Original Assignee
Microbial Chemistry Research Foundation
Intervet International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation, Intervet International BV filed Critical Microbial Chemistry Research Foundation
Publication of CN103467548A publication Critical patent/CN103467548A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
CN2013102805250A 2007-07-26 2008-07-25 大环内酯固态晶型 Pending CN103467548A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07113244.3 2007-07-26
EP07113244A EP2019112A1 (en) 2007-07-26 2007-07-26 Macrolide solid-state forms

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2008801005518A Division CN101778858B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型

Publications (1)

Publication Number Publication Date
CN103467548A true CN103467548A (zh) 2013-12-25

Family

ID=39467287

Family Applications (5)

Application Number Title Priority Date Filing Date
CN2013102805250A Pending CN103467548A (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN201310279877.4A Active CN103360445B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN201310280229.0A Active CN103360447B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN201310280228.6A Active CN103360446B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN2008801005518A Active CN101778858B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN201310279877.4A Active CN103360445B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN201310280229.0A Active CN103360447B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN201310280228.6A Active CN103360446B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型
CN2008801005518A Active CN101778858B (zh) 2007-07-26 2008-07-25 大环内酯固态晶型

Country Status (13)

Country Link
EP (3) EP2019112A1 (enExample)
JP (7) JP5925989B2 (enExample)
KR (2) KR102508115B1 (enExample)
CN (5) CN103467548A (enExample)
AU (1) AU2008278969B8 (enExample)
BR (1) BRPI0814318B1 (enExample)
CA (1) CA2693801C (enExample)
ES (2) ES2608978T3 (enExample)
HU (1) HUE031449T2 (enExample)
RU (1) RU2476438C2 (enExample)
TW (1) TWI427083B (enExample)
WO (1) WO2009013351A2 (enExample)
ZA (1) ZA201000188B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2019112A1 (en) * 2007-07-26 2009-01-28 Intervet International BV Macrolide solid-state forms
KR101538599B1 (ko) 2006-07-28 2015-07-21 인터벳 인터내셔널 비.브이. 마크롤라이드 합성 방법
AU2012342548B2 (en) 2011-11-25 2017-08-24 Elanco Animal Health Gmbh Antibacterial tylosin derivatives and methods for their preparation
CN102816196A (zh) * 2012-09-10 2012-12-12 河北远征药业有限公司 泰地罗新半抗原、人工抗原及其制备方法
SI2999707T1 (en) * 2013-05-23 2018-07-31 Bayer Animal Health Gmbh Tylosin derivatives and their preparation process
CN103554203A (zh) * 2013-08-17 2014-02-05 齐鲁动物保健品有限公司 一种泰地罗新无定形晶及其制备方法
CN104478974B (zh) * 2014-11-28 2016-08-17 武汉回盛生物科技有限公司 一种20，23-二哌啶基-5-o-碳霉胺糖基-泰乐内酯的合成方法
CN104447919B (zh) * 2014-11-28 2017-03-08 武汉回盛生物科技股份有限公司 一种20，23‑二哌啶基‑5‑o‑碳霉胺糖基‑泰乐内酯原料药的精制方法
CN104497082B (zh) * 2015-01-13 2017-12-12 中国兽医药品监察所 一种泰地罗新的合成方法
CN104774223A (zh) * 2015-03-26 2015-07-15 宁夏泰瑞制药股份有限公司 一种利用泰乐菌素碱生产泰地罗新的方法
CN105254693B (zh) * 2015-11-13 2017-12-22 周金华 一种泰地罗新的合成方法
CN106008629B (zh) * 2016-06-02 2019-11-22 天津大学 泰地罗新1,4-二氧六环溶剂化合物及制备方法
CN106083958B (zh) * 2016-06-02 2019-07-23 天津大学 泰地罗新环己烷溶剂化合物及制备方法
CN106046084B (zh) * 2016-06-02 2019-08-09 天津大学 泰地罗新丙酮溶剂化合物及制备方法
CN109721633A (zh) * 2017-10-31 2019-05-07 齐鲁晟华制药有限公司 一种泰地罗新晶型a及其制备方法
IL280880B2 (en) 2018-08-27 2025-04-01 Regeneron Pharma Using Raman Spectroscopy in Downstream Purification
CN111349130A (zh) * 2018-12-21 2020-06-30 齐鲁动物保健品有限公司 一种泰地罗新晶型b及其制备方法
CA3202396A1 (en) 2020-12-03 2022-06-09 Intervet International B.V. A method of treating foot rot
CN114213484A (zh) * 2021-12-21 2022-03-22 河北远征药业有限公司 一种泰地罗新1，2-丙二醇溶剂化合物及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL33732A (en) * 1969-02-06 1973-05-31 Meiji Seika Kaisha The new antibiotics sf-837,sf-837-a2,sf-837-a3 and sf-837-a4 and their production
US4820695A (en) 1982-09-13 1989-04-11 Eli Lilly And Company C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics
AU561147B2 (en) 1982-09-13 1987-04-30 Eli Lilly And Company 20-amino macrolide antibiotics
YU43658B (en) * 1983-07-18 1989-10-31 Pliva Pharm & Chem Works Process for preparing 7,16-dioxa-2-aza-10-0-cladinosyl-12,0-desosaminyl-4,5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethyl-bicyclo(11.2.1)hexadeca-1(2)-ene-8
US4921947A (en) * 1986-03-31 1990-05-01 Eli Lilly And Company Process for preparing macrolide derivatives
US4920103A (en) 1986-09-29 1990-04-24 Eli Lilly And Company Modifications of mycinose and 3-O-demethylmycinose in tylosin-type macrolides
DK1216256T3 (da) * 1999-08-30 2004-06-21 Zaidan Hojin Biseibutsu Makrolid-antibiotika og behandling af pasteurellosis
CA2529817C (en) * 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
AU2003269473A1 (en) * 2003-08-26 2005-03-10 Biocon Limited A process for the recovery of substantially pure tricyclic macrolide
MX2007006119A (es) * 2005-01-05 2007-07-19 Teva Gyogyszergyar Zartkoruen Tacrolimus amorfo y preparacion de el.
UA98303C2 (ru) * 2006-07-28 2012-05-10 Интервет Интернешонал Б.В. Способ синтеза макролидов
KR101538599B1 (ko) * 2006-07-28 2015-07-21 인터벳 인터내셔널 비.브이. 마크롤라이드 합성 방법
EP2019112A1 (en) * 2007-07-26 2009-01-28 Intervet International BV Macrolide solid-state forms

Also Published As

Publication number Publication date
KR102508115B1 (ko) 2023-03-08
AU2008278969B2 (en) 2011-11-17
EP3170833A1 (en) 2017-05-24
ES2805534T3 (es) 2021-02-12
WO2009013351A3 (en) 2009-04-02
JP2020172516A (ja) 2020-10-22
JP2014088394A (ja) 2014-05-15
EP2181117A2 (en) 2010-05-05
CN103360447A (zh) 2013-10-23
AU2008278969A1 (en) 2009-01-29
JP5925989B2 (ja) 2016-05-25
TWI427083B (zh) 2014-02-21
CN101778858B (zh) 2013-12-04
CN103360447B (zh) 2016-04-06
AU2008278969B8 (en) 2012-03-15
EP3170833B1 (en) 2020-05-20
JP6343624B2 (ja) 2018-06-13
KR20100044864A (ko) 2010-04-30
ES2608978T3 (es) 2017-04-17
CN103360446B (zh) 2016-04-06
JP2010534635A (ja) 2010-11-11
JP2018104449A (ja) 2018-07-05
JP2020172517A (ja) 2020-10-22
BRPI0814318B1 (pt) 2021-04-06
HUE031449T2 (en) 2017-07-28
JP2016147858A (ja) 2016-08-18
CN103360445A (zh) 2013-10-23
WO2009013351A2 (en) 2009-01-29
CN101778858A (zh) 2010-07-14
EP2019112A1 (en) 2009-01-28
BRPI0814318A2 (pt) 2015-01-06
RU2476438C2 (ru) 2013-02-27
TW200918547A (en) 2009-05-01
EP2181117B1 (en) 2016-11-09
JP2018109020A (ja) 2018-07-12
ZA201000188B (en) 2010-09-29
CN103360445B (zh) 2016-05-18
CA2693801A1 (en) 2009-01-29
CA2693801C (en) 2018-08-14
CN103360446A (zh) 2013-10-23
KR20160003899A (ko) 2016-01-11
RU2010107057A (ru) 2011-09-10

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Application publication date: 20131225

RJ01 Rejection of invention patent application after publication