KR20150128997A - 면역치료용 조성물 및 방법 - Google Patents

면역치료용 조성물 및 방법 Download PDF

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KR20150128997A
KR20150128997A KR1020157029137A KR20157029137A KR20150128997A KR 20150128997 A KR20150128997 A KR 20150128997A KR 1020157029137 A KR1020157029137 A KR 1020157029137A KR 20157029137 A KR20157029137 A KR 20157029137A KR 20150128997 A KR20150128997 A KR 20150128997A
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antigen
cells
cell
receptor
ser
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빅터 디. 페도로브
마이클 새들레인
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메모리얼 슬로안-케터링 캔서 센터
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Priority to KR1020227002101A priority Critical patent/KR102466666B1/ko
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Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2948544A4 (en) 2013-01-28 2016-08-03 St Jude Childrens Res Hospital CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES
BR112015023679A2 (pt) * 2013-03-15 2017-10-24 Memorial Sloan Kettering Cancer Center composições e métodos para imunoterapia
ES2831315T3 (es) * 2013-04-03 2021-06-08 Memorial Sloan Kettering Cancer Center Generación efectiva de células T dirigidas al tumor derivadas de células madre pluripotentes
MX377283B (es) 2013-11-21 2025-03-07 Ucl Business Ltd Célula t o nk que coexpresa un receptor antigénico quimérico (car).
AU2015259877B2 (en) 2014-05-15 2021-02-25 National University Of Singapore Modified natural killer cells and uses thereof
JP7023708B2 (ja) 2014-11-12 2022-03-03 アロジーン セラピューティクス，インコーポレイテッド 阻害性キメラ抗原受容体
CN107206025A (zh) 2014-12-03 2017-09-26 朱诺治疗学股份有限公司 用于过继细胞治疗的方法和组合物
IL274903B (en) 2014-12-24 2022-07-01 Ucl Business Ltd A cell that simultaneously expresses a chimeric antigen receptor (car) of 19cd and 22cd
JP6800859B2 (ja) 2015-01-26 2020-12-16 フェイト セラピューティクス，インコーポレイテッド 造血細胞分化を誘導するための方法および組成物
CN114230670B (zh) * 2015-02-27 2025-06-03 美商生物细胞基因治疗有限公司 靶向血液恶性肿瘤之嵌合抗原受体（car）、其组合物及使用方法
WO2016179319A1 (en) * 2015-05-04 2016-11-10 Cellerant Therapeutics, Inc. Chimeric antigen receptors with ctla4 signal transduction domains
IL255697B2 (en) 2015-05-18 2023-11-01 Tcr2 Therapeutics Inc Compositions and methods for TCR programming using fusion proteins
GB201509413D0 (en) * 2015-06-01 2015-07-15 Ucl Business Plc Fusion protein
CA2997551A1 (en) 2015-09-04 2017-03-09 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of use
WO2017058753A1 (en) * 2015-09-28 2017-04-06 Trustees Of Dartmouth College Chimeric antigen receptor, regulatory cells and methods of use
EP3371314B1 (en) 2015-11-04 2023-07-05 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
KR20250033315A (ko) 2015-11-04 2025-03-07 페이트 세러퓨틱스, 인코포레이티드 조혈 세포 분화를 유도하기 위한 방법 및 조성물
WO2017087723A1 (en) * 2015-11-19 2017-05-26 The Regents Of The University Of California Conditionally repressible immune cell receptors and methods of use thereof
AU2016366226B2 (en) 2015-12-09 2023-06-01 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of using same
CN109073635A (zh) 2016-01-25 2018-12-21 豪夫迈·罗氏有限公司 用于测定t细胞依赖性双特异性抗体的方法
CN105567640A (zh) * 2016-01-27 2016-05-11 苏州佰通生物科技有限公司 一种嵌合抗原受体脂肪干细胞及其制备方法
US11768203B2 (en) * 2016-03-31 2023-09-26 University Of Southern California Highly sensitive and specific luciferase based reporter assay for antigen detection
CN121102467A (zh) 2016-04-22 2025-12-12 克莱格医学有限公司 用于细胞免疫疗法的组合物和方法
NZ749136A (en) * 2016-05-25 2023-11-24 Council Queensland Inst Medical Res Methods of immunotherapy
CN105950561A (zh) * 2016-05-26 2016-09-21 江苏杰晟生物科技有限公司 一种靶向乳腺癌干细胞的双特异性嵌合抗原受体基因修饰的t淋巴细胞的制备方法及其产品
WO2017210689A1 (en) * 2016-06-03 2017-12-07 Memorial Sloan-Kettering Cancer Center Adoptive cell therapies as early treatment options
CN109715668A (zh) 2016-08-02 2019-05-03 T细胞受体治疗公司 用于使用融合蛋白进行tcr重编程的组合物和方法
GB201614162D0 (en) * 2016-08-18 2016-10-05 Polytherics Ltd Antibodies, uses thereof and conjugates thereof
CN109863242A (zh) 2016-08-30 2019-06-07 纪念斯隆-凯特林癌症中心 用于治疗病毒感染和其它感染的免疫细胞组合物和使用方法
BR112019006006A2 (pt) 2016-09-28 2019-06-25 Gavish Galilee Bio Appl Ltd molécula de ácido nucleico, vetor, métodos para preparação de um receptor de antígeno quimérico inibidor, para preparar uma célula imune efetora segura, para selecionar um biomarcador personalizado e para tratar o câncer em um paciente com um tumor, célula imune efetora segura, e, combinação de duas ou mais moléculas de ácido nucleico.
IL292551B2 (en) 2016-10-07 2023-10-01 Tcr2 Therapeutics Inc Preparations and methods for reprogramming T-cell receptors using fusion proteins
CN107988164B (zh) * 2016-10-26 2020-07-07 阿思科力(苏州)生物科技有限公司 一种pd-1 car nk-92细胞及其制备方法与应用
EP3315511A1 (en) * 2016-10-29 2018-05-02 Miltenyi Biotec GmbH Adapter chimeric antigen receptor expressing cells for targeting of multiple antigens
AU2017363311A1 (en) 2016-11-22 2019-06-13 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
CN108204958A (zh) * 2016-12-19 2018-06-26 伊缪泰普有限公司 结合测定
JP7078937B2 (ja) * 2016-12-21 2022-06-01 ダンマークス テクニスク ユニバーシテット 免疫細胞を操作するための抗原提示足場
WO2018124766A2 (ko) * 2016-12-28 2018-07-05 주식회사 녹십자랩셀 키메라 항원 수용체 및 이를 발현하는 자연 살해 세포
EP3592368A1 (en) * 2017-03-08 2020-01-15 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of use
CN117384929A (zh) 2017-03-27 2024-01-12 新加坡国立大学 一种编码由细胞表达的嵌合受体的多核苷酸
RU2019128544A (ru) 2017-03-27 2021-04-28 Нэшнл Юниверсити Оф Сингапур Линии стимулирующих клеток для ex vivo размножения и активации клеток-натуральных киллеров
CN107034237B (zh) * 2017-03-31 2018-10-16 北京呈诺医学科技有限公司 一种car-nk细胞及其制备方法与应用
KR20240059648A (ko) * 2017-04-19 2024-05-07 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 조작된 항원 수용체를 발현하는 면역 세포
GB201707779D0 (en) * 2017-05-15 2017-06-28 Autolus Ltd Cell
CA3064597A1 (en) * 2017-06-02 2018-12-06 Juno Therapeutics, Inc. Articles of manufacture and methods related to toxicity associated with cell therapy
EP3688155B1 (en) 2017-09-28 2023-01-04 Immpact-Bio Ltd. A universal platform for preparing an inhibitory chimeric antigen receptor (icar)
CN109593721B (zh) * 2017-09-30 2022-11-01 亘喜生物科技（上海）有限公司 具有自杀基因开关的靶向人间皮素的工程化免疫细胞
GB201717524D0 (en) 2017-10-25 2017-12-06 Autolus Ltd Vectors
WO2019098682A1 (ko) 2017-11-14 2019-05-23 앱클론(주) 항-her2 항체 또는 그의 항원 결합 단편, 및 이를 포함하는 키메라 항원 수용체
US11649294B2 (en) 2017-11-14 2023-05-16 GC Cell Corporation Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
IL316570A (en) 2017-12-05 2024-12-01 Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct T cells containing chimeric receptors for CD138 and CD38 antigens and their use
WO2019111250A1 (en) 2017-12-05 2019-06-13 The Medical Research Infrastructure And Health Services Fund Of The Tel Aviv Medical Center T-cells comprising two different chimeric antigen receptors and uses thereof
GB201721802D0 (en) * 2017-12-22 2018-02-07 Almac Discovery Ltd Ror1-specific antigen binding molecules
BR112020012039A2 (pt) * 2017-12-29 2020-11-24 Memorial Sloan-Kettering Cancer Center receptores antigênicos quiméricos melhorados e usos dos mesmos
CN111867619A (zh) 2018-01-03 2020-10-30 曲生物制品公司 过继性细胞治疗的先天寻靶
AU2019219454A1 (en) 2018-02-09 2020-08-27 National University Of Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
CN109321530B (zh) * 2018-02-12 2021-03-12 华东师范大学 一种安全型嵌合抗原受体t细胞及其用途
CN111918661A (zh) 2018-02-21 2020-11-10 得克萨斯大学体系董事会 用于活化和扩增自然杀伤细胞的方法及其用途
JP7334985B2 (ja) 2018-04-02 2023-08-29 ナショナル ユニヴァーシティー オブ シンガポール 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和
US20210145881A1 (en) * 2018-04-09 2021-05-20 Mayo Foundation For Medical Education And Research Methods and materials for treating graft-versus-host disease
CN110526976A (zh) * 2018-05-25 2019-12-03 深圳宾德生物技术有限公司 一种靶向psma的单链抗体、嵌合抗原受体t细胞及其制备方法和应用
CN110526984A (zh) * 2018-05-25 2019-12-03 深圳宾德生物技术有限公司 一种靶向psma的嵌合抗原受体、嵌合抗原受体t细胞及其制备方法和应用
US20220265709A1 (en) * 2018-06-19 2022-08-25 Nanjing Legend Biotech Co., Ltd. Engineered cells and uses thereof
WO2019244107A1 (en) * 2018-06-21 2019-12-26 Daiichi Sankyo Company, Limited Compositions including cd3 antigen binding fragments and uses thereof
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
EP3856236B1 (en) * 2018-09-28 2023-05-17 ImmPACT-Bio Ltd. Methods for identifying activating antigen receptor (acar)/inhibitory chimeric antigen receptor (icar) pairs for use in cancer therapies
AU2019347873B2 (en) * 2018-09-28 2024-08-22 Memorial Sloan-Kettering Cancer Center Immunoresponsive cells expressing dominant negative Fas and uses thereof
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
EP3873540A4 (en) 2018-10-31 2022-07-27 Mayo Foundation for Medical Education and Research METHODS AND MATERIALS FOR THE TREATMENT OF CANCER
WO2020092839A1 (en) 2018-10-31 2020-05-07 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
CN109517799B (zh) * 2018-11-30 2022-07-26 北京美康基免生物科技有限公司 一种基于cd19和cd22的双重嵌合抗原受体基因修饰的免疫细胞及其应用
US20220133791A1 (en) 2019-01-23 2022-05-05 Miltenyi Biotec B.V. & Co. KG A Combination of compositions for elimination and enhanced engraftment of hematopoietic stem cells in the bone marrow of a subject
AU2020226401A1 (en) * 2019-02-18 2021-10-14 Memorial Sloan-Kettering Cancer Center Combinations of multiple chimeric antigen receptors for immunotherapy
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY
TW202110873A (zh) 2019-04-30 2021-03-16 美商聖堤生物科技股份有限公司 嵌合受體及其使用方法
CN110592014A (zh) * 2019-08-14 2019-12-20 广东美赛尔细胞生物科技有限公司 一种在nk细胞治疗中免辐照体外体内持续去除饲养细胞的方法
EP4017510A4 (en) * 2019-08-20 2023-11-22 Senti Biosciences, Inc. CHIMERIC INHIBITOR RECEPTOR
US20220378822A1 (en) * 2019-08-28 2022-12-01 Senti Bioscience, Inc. Combinatorial cancer immunotherapy
EP4025594A2 (en) * 2019-09-05 2022-07-13 Migal Galilee Research Institute Ltd. Blocking chimeric antigen receptors for prevention of undesired activation of effector and regulatory immune cells
EP4045066A4 (en) * 2019-10-18 2024-03-20 Board of Regents, The University of Texas System HLA-RESTRICTED VCX/Y PEPTIDES AND T-CELL RECEPTORS AND THEIR USE
MX2022006962A (es) 2019-12-11 2022-09-12 A2 Biotherapeutics Inc Receptor quimerico de antigenos basado en el miembro 1 de la subfamilia b de receptores similares a inmunoglobulina de leucocitos (lilrb1).
WO2021156277A1 (en) 2020-02-04 2021-08-12 Miltenyi Biotec B.V. & Co. KG Immune cell expressing adapter chimeric antigen receptor for sensing soluble antigens
JP2023515055A (ja) * 2020-02-20 2023-04-12 センティ バイオサイエンシズ インコーポレイテッド 阻害性キメラ受容体アーキテクチャ
CN111249314B (zh) * 2020-03-03 2022-03-29 深圳未知君生物科技有限公司 人体共生菌群在提高肿瘤免疫治疗应答中的作用
US20230183372A1 (en) * 2020-05-20 2023-06-15 Miltenyi Biotec B.V. & Co. KG Compositions and Methods for Treating Cancer Expressing CD90 and CD326
US12286465B2 (en) 2020-05-28 2025-04-29 Miltenyi Biotec B.V. & Co. KG Chimeric antigen receptor with a spacer comprising C2-set Ig-like domains
WO2022007784A1 (en) * 2020-07-06 2022-01-13 Nanjing Legend Biotech Co., Ltd. Methods of reducing graft rejection of allogeneic cell therapy
WO2022015955A1 (en) 2020-07-16 2022-01-20 Umoja Biopharma, Inc. Gated adapter targeting receptor
US20230257441A1 (en) * 2020-08-13 2023-08-17 A2 Biotherapeutics, Inc. Compositions and methods for treating cancers
EP4190808A4 (en) * 2020-08-19 2024-07-31 Suzhou Immunofoco Biotechnology Co., Ltd. Humanized antibody, chimeric antigen receptor, nucleic acid, vector, cell and use
RS65802B1 (sr) 2020-08-20 2024-08-30 A2 Biotherapeutics Inc Kompozicije i postupci za lečenje egfr pozitivnih kancera
CN116724052A (zh) 2020-08-20 2023-09-08 A2生物治疗股份有限公司 用于治疗ceacam阳性癌症的组合物和方法
MX2023002041A (es) 2020-08-20 2023-04-27 A2 Biotherapeutics Inc Composiciones y métodos para tratar cánceres positivos para mesotelina.
US12215134B2 (en) 2020-09-21 2025-02-04 A2 Biotherapeutics, Inc. Engineered immune cells with dominant signals
WO2022096664A1 (en) 2020-11-09 2022-05-12 Miltenyi Biotec B.V. & Co. KG Methods and compositions for eliminating engineered immune cells
CN114569708B (zh) * 2020-12-02 2023-07-04 四川大学华西医院 Nkg2d car-免疫细胞在抗衰老中应用
EP4255922A1 (en) 2020-12-03 2023-10-11 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
WO2022125578A2 (en) * 2020-12-07 2022-06-16 The Johns Hopkins University Methods of nk cell engineering to enhance tumor targeting
JP2024500847A (ja) 2020-12-18 2024-01-10 センチュリー セラピューティクス，インコーポレイテッド 適合可能な受容体特異性を有するキメラ抗原受容体システム
KR20230137923A (ko) * 2021-02-03 2023-10-05 바이오헝 테라퓨틱스 리미티드 신규한 키메라 항원 수용체 및 이의 용도
IL304857A (en) 2021-02-16 2023-10-01 A2 Biotherapeutics Inc Preparations and methods for treating HER2 POSITIVE cancer
AU2022245215A1 (en) * 2021-03-22 2023-10-12 Memorial Hospital For Cancer And Allied Diseases Cd38 chimeric co-stimulating receptor and uses thereof
WO2023057285A1 (en) 2021-10-06 2023-04-13 Miltenyi Biotec B.V. & Co. KG Method for targeted gene insertion into immune cells
CA3240565A1 (en) 2021-12-17 2023-06-22 Wenfeng Xu Anti-ox40 antibodies and methods of use
CN118488965A (zh) 2021-12-17 2024-08-13 上海复宏汉霖生物技术股份有限公司 抗ox40抗体、多特异性抗体及其使用方法
AU2023240941A1 (en) 2022-03-25 2024-09-19 Shanghai Henlius Biologics Co., Ltd. Anti-msln antibodies and methods of use
WO2024078995A1 (en) 2022-10-15 2024-04-18 Miltenyi Biotec B.V. & Co. KG Transduction of gammadelta t cells with pseudotyped retroviral vectors
CN116785458A (zh) * 2023-02-14 2023-09-22 青岛大学 半滑舌鳎抗病蛋白shp-1基因的应用
CN116376844B (zh) * 2023-05-31 2023-08-11 四川大学华西医院 包含shp2 sh2结构域的靶向her2阳性肿瘤的car-t及制备方法和应用
CN119119191B (zh) * 2024-09-13 2025-04-01 渤海大学 一种海参肠多肽及其在制备胃部疾病药物中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1975A (en) 1841-02-12 Manner of constructing corn-shellers
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
JPS6412935A (en) 1987-07-02 1989-01-17 Mitsubishi Electric Corp Constant-speed travel device for vehicle
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5712149A (en) 1995-02-03 1998-01-27 Cell Genesys, Inc. Chimeric receptor molecules for delivery of co-stimulatory signals
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
JP5531373B2 (ja) 2006-09-25 2014-06-25 国立大学法人名古屋大学 Ｃｄ２０陰転化ｂ細胞性悪性リンパ腫細胞株及びその利用
WO2008095141A2 (en) * 2007-01-31 2008-08-07 Yeda Research And Development Co. Ltd. Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease
US8389282B2 (en) * 2007-03-30 2013-03-05 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
CN114835823A (zh) * 2011-07-29 2022-08-02 宾夕法尼亚大学董事会 转换共刺激受体
WO2014055657A1 (en) * 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
AU2013204922B2 (en) * 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
CN113005091A (zh) 2013-02-06 2021-06-22 细胞基因公司 具有改进特异性的修饰的t淋巴细胞
EP3811954A1 (en) * 2013-02-26 2021-04-28 Memorial Sloan Kettering Cancer Center Compositions and methods for immunotherapy
ES2769574T3 (es) * 2013-03-15 2020-06-26 Michael C Milone Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
BR112015023679A2 (pt) 2013-03-15 2017-10-24 Memorial Sloan Kettering Cancer Center composições e métodos para imunoterapia

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