KR20150080025A - 히스톤 탈아세틸화효소의 억제제 - Google Patents

히스톤 탈아세틸화효소의 억제제 Download PDF

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Publication number
KR20150080025A
KR20150080025A KR1020157016812A KR20157016812A KR20150080025A KR 20150080025 A KR20150080025 A KR 20150080025A KR 1020157016812 A KR1020157016812 A KR 1020157016812A KR 20157016812 A KR20157016812 A KR 20157016812A KR 20150080025 A KR20150080025 A KR 20150080025A
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KR
South Korea
Prior art keywords
hydrocarbyl
phenyl
pyrrolidin
substituted
aminophenylcarbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020157016812A
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English (en)
Korean (ko)
Inventor
실비아 프레체테
루보 이사코빅
이사벨르 파퀸
시몬 로이
오스카 모라데이
아카디 바이스버그
Original Assignee
메틸진 인코포레이티드
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Publication of KR20150080025A publication Critical patent/KR20150080025A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
KR1020157016812A 2007-03-13 2008-03-12 히스톤 탈아세틸화효소의 억제제 Ceased KR20150080025A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US90673307P 2007-03-13 2007-03-13
US60/906,733 2007-03-13
US12/043,450 US8030344B2 (en) 2007-03-13 2008-03-06 Inhibitors of histone deacetylase
US12/043,450 2008-03-06
PCT/CA2008/000455 WO2008109994A1 (en) 2007-03-13 2008-03-12 Inhibitors of histone deacetylase

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020097021343A Division KR101678611B1 (ko) 2007-03-13 2008-03-12 히스톤 탈아세틸화효소의 억제제

Publications (1)

Publication Number Publication Date
KR20150080025A true KR20150080025A (ko) 2015-07-08

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020157016812A Ceased KR20150080025A (ko) 2007-03-13 2008-03-12 히스톤 탈아세틸화효소의 억제제
KR1020097021343A Active KR101678611B1 (ko) 2007-03-13 2008-03-12 히스톤 탈아세틸화효소의 억제제

Family Applications After (1)

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KR1020097021343A Active KR101678611B1 (ko) 2007-03-13 2008-03-12 히스톤 탈아세틸화효소의 억제제

Country Status (9)

Country Link
US (2) US8030344B2 (OSRAM)
EP (1) EP2134680B1 (OSRAM)
JP (2) JP2010520893A (OSRAM)
KR (2) KR20150080025A (OSRAM)
CN (1) CN101679239B (OSRAM)
CA (1) CA2680467C (OSRAM)
ES (1) ES2565243T3 (OSRAM)
TW (1) TWI549676B (OSRAM)
WO (1) WO2008109994A1 (OSRAM)

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NZ599757A (en) 2009-10-30 2014-08-29 Massachusetts Inst Technology The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders
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US9540395B2 (en) 2011-02-28 2017-01-10 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
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Also Published As

Publication number Publication date
ES2565243T3 (es) 2016-04-01
HK1142597A1 (en) 2010-12-10
KR101678611B1 (ko) 2016-11-22
CN101679239A (zh) 2010-03-24
KR20090119004A (ko) 2009-11-18
US20110212965A1 (en) 2011-09-01
CA2680467A1 (en) 2008-09-18
WO2008109994A1 (en) 2008-09-18
CA2680467C (en) 2016-11-08
US20080227826A1 (en) 2008-09-18
JP2014159417A (ja) 2014-09-04
TW200848015A (en) 2008-12-16
EP2134680A1 (en) 2009-12-23
US8354445B2 (en) 2013-01-15
JP2010520893A (ja) 2010-06-17
JP5885311B2 (ja) 2016-03-15
US8030344B2 (en) 2011-10-04
EP2134680B1 (en) 2016-01-13
CN101679239B (zh) 2014-12-10
TWI549676B (zh) 2016-09-21
EP2134680A4 (en) 2012-03-07

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