EP2134680A4 - Inhibitors of histone deacetylase - Google Patents
Inhibitors of histone deacetylaseInfo
- Publication number
- EP2134680A4 EP2134680A4 EP08733559A EP08733559A EP2134680A4 EP 2134680 A4 EP2134680 A4 EP 2134680A4 EP 08733559 A EP08733559 A EP 08733559A EP 08733559 A EP08733559 A EP 08733559A EP 2134680 A4 EP2134680 A4 EP 2134680A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- inhibitors
- histone deacetylase
- deacetylase
- histone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90673307P | 2007-03-13 | 2007-03-13 | |
US12/043,450 US8030344B2 (en) | 2007-03-13 | 2008-03-06 | Inhibitors of histone deacetylase |
PCT/CA2008/000455 WO2008109994A1 (en) | 2007-03-13 | 2008-03-12 | Inhibitors of histone deacetylase |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2134680A1 EP2134680A1 (en) | 2009-12-23 |
EP2134680A4 true EP2134680A4 (en) | 2012-03-07 |
EP2134680B1 EP2134680B1 (en) | 2016-01-13 |
Family
ID=39758948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08733559.2A Active EP2134680B1 (en) | 2007-03-13 | 2008-03-12 | Inhibitors of histone deacetylase |
Country Status (10)
Country | Link |
---|---|
US (2) | US8030344B2 (en) |
EP (1) | EP2134680B1 (en) |
JP (2) | JP2010520893A (en) |
KR (2) | KR20150080025A (en) |
CN (1) | CN101679239B (en) |
CA (1) | CA2680467C (en) |
ES (1) | ES2565243T3 (en) |
HK (1) | HK1142597A1 (en) |
TW (1) | TWI549676B (en) |
WO (1) | WO2008109994A1 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8030344B2 (en) * | 2007-03-13 | 2011-10-04 | Methylgene Inc. | Inhibitors of histone deacetylase |
JP2011502133A (en) * | 2007-11-02 | 2011-01-20 | メシルジーン インコーポレイテッド | Inhibitors of histone deacetylase |
EP2330894B8 (en) | 2008-09-03 | 2017-04-19 | BioMarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
KR20110117194A (en) * | 2009-02-23 | 2011-10-26 | 에프. 호프만-라 로슈 아게 | Novel ortho-aminoamides for the treatment of cancer |
WO2011053876A1 (en) | 2009-10-30 | 2011-05-05 | Massachusetts Institute Of Technology | The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders |
US20130310379A1 (en) * | 2010-11-19 | 2013-11-21 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
EP2680694B1 (en) | 2011-02-28 | 2019-01-02 | BioMarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
CN102775368B (en) * | 2011-05-10 | 2016-08-17 | 上海驺虞医药科技有限公司 | One class thiazole compound and its production and use |
WO2013075083A1 (en) | 2011-11-18 | 2013-05-23 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
EP2780013A4 (en) | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | Modulators of methyl modifying enzymes, compositions and uses thereof |
WO2013120104A2 (en) | 2012-02-10 | 2013-08-15 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
EP2970305B1 (en) | 2013-03-15 | 2017-02-22 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
ES2680224T3 (en) | 2013-03-15 | 2018-09-05 | Biomarin Pharmaceutical Inc. | HDAC inhibitors |
WO2015023915A1 (en) | 2013-08-15 | 2015-02-19 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
US9274117B2 (en) * | 2013-12-21 | 2016-03-01 | Catholic University Industry Academic | Use of SIRT7 as novel cancer therapy target and method for treating cancer using the same |
US9636298B2 (en) | 2014-01-17 | 2017-05-02 | Methylgene Inc. | Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs |
GB201501870D0 (en) * | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
AU2016288606A1 (en) | 2015-07-02 | 2018-01-18 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibtors |
US10577350B2 (en) | 2015-08-28 | 2020-03-03 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide |
EP3529242A1 (en) | 2016-10-19 | 2019-08-28 | Constellation Pharmaceuticals, Inc. | Synthesis of inhibitors of ezh2 |
Citations (3)
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---|---|---|---|---|
WO2005030705A1 (en) * | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
WO2007055942A2 (en) * | 2005-11-03 | 2007-05-18 | Merck & Co., Inc. | Substituted nicotinamide compounds |
WO2007061880A1 (en) * | 2005-11-23 | 2007-05-31 | Merck & Co., Inc. | Spirocyclic compounds as hdac inhibitors |
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US5332750A (en) | 1991-09-04 | 1994-07-26 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1,2-dihydro-2-oxopyridines |
US5652355A (en) | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
DE19510957A1 (en) | 1995-03-25 | 1996-09-26 | Huels Chemische Werke Ag | Thickened soil stabilizer, as well as packaged ready mix for soil treatments containing it |
JP4105451B2 (en) | 1996-09-30 | 2008-06-25 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | Differentiation inducer |
US6794392B1 (en) | 1996-09-30 | 2004-09-21 | Schering Aktiengesellschaft | Cell differentiation inducer |
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JP4405602B2 (en) | 1998-04-16 | 2010-01-27 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | Histone deacetylase inhibitor |
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US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
AU2002327627B2 (en) | 2001-09-14 | 2006-09-14 | Methylgene Inc. | Inhibitors of histone deacetylase |
US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
AU2003215112A1 (en) * | 2002-02-07 | 2003-09-02 | Axys Pharmaceuticals | Novel bicyclic hydroxamates as inhibitors of histone deacetylase |
EA007270B1 (en) | 2002-03-13 | 2006-08-25 | Янссен Фармацевтика Н.В. | Piperazinyl-, piperadinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
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JP2009501236A (en) | 2005-07-14 | 2009-01-15 | タケダ サン ディエゴ インコーポレイテッド | Histone deacetylase inhibitor |
JP2009525955A (en) | 2006-01-13 | 2009-07-16 | タケダ サン ディエゴ インコーポレイテッド | Histone deacetylase inhibitor |
CA2648804C (en) | 2006-04-07 | 2014-05-27 | Methylgene Inc. | Benzamide derivatives as inhibitors of histone deacetylase |
US8030344B2 (en) * | 2007-03-13 | 2011-10-04 | Methylgene Inc. | Inhibitors of histone deacetylase |
-
2008
- 2008-03-06 US US12/043,450 patent/US8030344B2/en active Active
- 2008-03-12 ES ES08733559.2T patent/ES2565243T3/en active Active
- 2008-03-12 WO PCT/CA2008/000455 patent/WO2008109994A1/en active Application Filing
- 2008-03-12 KR KR1020157016812A patent/KR20150080025A/en not_active Application Discontinuation
- 2008-03-12 KR KR1020097021343A patent/KR101678611B1/en active IP Right Grant
- 2008-03-12 CA CA2680467A patent/CA2680467C/en not_active Expired - Fee Related
- 2008-03-12 EP EP08733559.2A patent/EP2134680B1/en active Active
- 2008-03-12 TW TW097108730A patent/TWI549676B/en active
- 2008-03-12 JP JP2009552982A patent/JP2010520893A/en active Pending
- 2008-03-12 CN CN200880015207.9A patent/CN101679239B/en not_active Expired - Fee Related
-
2010
- 2010-09-22 HK HK10109070.2A patent/HK1142597A1/en not_active IP Right Cessation
-
2011
- 2011-05-11 US US13/105,151 patent/US8354445B2/en not_active Expired - Fee Related
-
2014
- 2014-02-12 JP JP2014024898A patent/JP5885311B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005030705A1 (en) * | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
WO2007055942A2 (en) * | 2005-11-03 | 2007-05-18 | Merck & Co., Inc. | Substituted nicotinamide compounds |
WO2007061880A1 (en) * | 2005-11-23 | 2007-05-31 | Merck & Co., Inc. | Spirocyclic compounds as hdac inhibitors |
Non-Patent Citations (4)
Title |
---|
HAMBLETT ET AL: "The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 17, no. 19, 14 September 2007 (2007-09-14), pages 5300 - 5309, XP022249705, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2007.08.023 * |
MORADEI O ET AL: "HISTONE DEACETYLASE INHIBITORS: LATEST DEVELOPMENTS, TRENDS AND PROSPECTS", CURRENT MEDICINAL CHEMISTRY. ANTI-CANCER AGENTS, BENTHAM SCIENCE PUBLISHERS, HILVERSUM, NL, vol. 5, no. 5, 1 January 2005 (2005-01-01), pages 529 - 560, XP009065870, ISSN: 1568-0118, DOI: 10.2174/1568011054866946 * |
See also references of WO2008109994A1 * |
SUZUKI TAKAYOSHI ET AL: "Rational design of non-hydroxamate histone deacetylase inhibitors", MINI REVIEWS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS, HILVERSUM, NL, vol. 6, no. 5, 1 May 2006 (2006-05-01), pages 515 - 526, XP009155797, ISSN: 1389-5575 * |
Also Published As
Publication number | Publication date |
---|---|
KR20090119004A (en) | 2009-11-18 |
JP5885311B2 (en) | 2016-03-15 |
KR101678611B1 (en) | 2016-11-22 |
KR20150080025A (en) | 2015-07-08 |
US20110212965A1 (en) | 2011-09-01 |
JP2010520893A (en) | 2010-06-17 |
US8030344B2 (en) | 2011-10-04 |
ES2565243T3 (en) | 2016-04-01 |
TW200848015A (en) | 2008-12-16 |
CA2680467A1 (en) | 2008-09-18 |
US8354445B2 (en) | 2013-01-15 |
JP2014159417A (en) | 2014-09-04 |
EP2134680A1 (en) | 2009-12-23 |
CA2680467C (en) | 2016-11-08 |
CN101679239B (en) | 2014-12-10 |
CN101679239A (en) | 2010-03-24 |
TWI549676B (en) | 2016-09-21 |
HK1142597A1 (en) | 2010-12-10 |
EP2134680B1 (en) | 2016-01-13 |
WO2008109994A1 (en) | 2008-09-18 |
US20080227826A1 (en) | 2008-09-18 |
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