KR20140091707A - 크실리톨로 안정화된 에타너셉트 제형 - Google Patents

크실리톨로 안정화된 에타너셉트 제형 Download PDF

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Publication number
KR20140091707A
KR20140091707A KR1020147013305A KR20147013305A KR20140091707A KR 20140091707 A KR20140091707 A KR 20140091707A KR 1020147013305 A KR1020147013305 A KR 1020147013305A KR 20147013305 A KR20147013305 A KR 20147013305A KR 20140091707 A KR20140091707 A KR 20140091707A
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South Korea
Prior art keywords
composition
etanercept
peak
less
hic
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KR1020147013305A
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English (en)
Korean (ko)
Inventor
마크 매닝
브라이언 머피
Original Assignee
코히러스 바이오사이언시즈, 인코포레이티드
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Publication of KR20140091707A publication Critical patent/KR20140091707A/ko
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Inorganic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Pregnancy & Childbirth (AREA)
KR1020147013305A 2011-10-18 2012-10-18 크실리톨로 안정화된 에타너셉트 제형 Withdrawn KR20140091707A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161548518P 2011-10-18 2011-10-18
US61/548,518 2011-10-18
US201261669480P 2012-07-09 2012-07-09
US61/669,480 2012-07-09
PCT/US2012/060745 WO2013059410A1 (en) 2011-10-18 2012-10-18 Etanercept formulations stabilized with xylitol

Publications (1)

Publication Number Publication Date
KR20140091707A true KR20140091707A (ko) 2014-07-22

Family

ID=48136153

Family Applications (7)

Application Number Title Priority Date Filing Date
KR1020147013306A Withdrawn KR20140079491A (ko) 2011-10-18 2012-10-18 당과 폴리올과의 배합물로 안정화된 에타너셉트 제형
KR1020207000845A Expired - Fee Related KR102163150B1 (ko) 2011-10-18 2012-10-18 금속 이온들로 안정화된 에타너셉트 제형
KR1020147013303A Expired - Fee Related KR102068462B1 (ko) 2011-10-18 2012-10-18 금속 이온들로 안정화된 에타너셉트 제형
KR1020147013301A Withdrawn KR20140091705A (ko) 2011-10-18 2012-10-18 메글루민으로 안정화된 에타너셉트 제형
KR1020147013302A Withdrawn KR20140083037A (ko) 2011-10-18 2012-10-18 아미노산으로 안정화된 에타너셉트 제형
KR1020147013304A Withdrawn KR20140091706A (ko) 2011-10-18 2012-10-18 염화나트륨으로 안정화된 에타너셉트 제형
KR1020147013305A Withdrawn KR20140091707A (ko) 2011-10-18 2012-10-18 크실리톨로 안정화된 에타너셉트 제형

Family Applications Before (6)

Application Number Title Priority Date Filing Date
KR1020147013306A Withdrawn KR20140079491A (ko) 2011-10-18 2012-10-18 당과 폴리올과의 배합물로 안정화된 에타너셉트 제형
KR1020207000845A Expired - Fee Related KR102163150B1 (ko) 2011-10-18 2012-10-18 금속 이온들로 안정화된 에타너셉트 제형
KR1020147013303A Expired - Fee Related KR102068462B1 (ko) 2011-10-18 2012-10-18 금속 이온들로 안정화된 에타너셉트 제형
KR1020147013301A Withdrawn KR20140091705A (ko) 2011-10-18 2012-10-18 메글루민으로 안정화된 에타너셉트 제형
KR1020147013302A Withdrawn KR20140083037A (ko) 2011-10-18 2012-10-18 아미노산으로 안정화된 에타너셉트 제형
KR1020147013304A Withdrawn KR20140091706A (ko) 2011-10-18 2012-10-18 염화나트륨으로 안정화된 에타너셉트 제형

Country Status (28)

Country Link
US (21) US10293049B2 (enExample)
EP (6) EP2768533A4 (enExample)
JP (6) JP6104922B2 (enExample)
KR (7) KR20140079491A (enExample)
CN (6) CN104010654B (enExample)
AR (6) AR088460A1 (enExample)
AU (6) AU2012326171B2 (enExample)
BR (6) BR112014009073A2 (enExample)
CA (6) CA2851646A1 (enExample)
CY (1) CY1121843T1 (enExample)
DK (1) DK2768525T3 (enExample)
EA (6) EA025267B1 (enExample)
ES (1) ES2734070T3 (enExample)
HK (3) HK1200718A1 (enExample)
HR (1) HRP20191215T1 (enExample)
HU (1) HUE045624T2 (enExample)
IL (6) IL231826A0 (enExample)
IN (3) IN2014CN02527A (enExample)
LT (1) LT2768525T (enExample)
MX (7) MX2014004733A (enExample)
PL (1) PL2768525T3 (enExample)
PT (1) PT2768525T (enExample)
RS (1) RS59179B1 (enExample)
SG (6) SG11201401519RA (enExample)
SI (1) SI2768525T1 (enExample)
SM (1) SMT201900422T1 (enExample)
TW (6) TW201325608A (enExample)
WO (6) WO2013059405A1 (enExample)

Families Citing this family (34)

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