JP6104922B2 - アミノ酸によって安定化されたエタネルセプト製剤 - Google Patents

アミノ酸によって安定化されたエタネルセプト製剤 Download PDF

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JP6104922B2
JP6104922B2 JP2014537218A JP2014537218A JP6104922B2 JP 6104922 B2 JP6104922 B2 JP 6104922B2 JP 2014537218 A JP2014537218 A JP 2014537218A JP 2014537218 A JP2014537218 A JP 2014537218A JP 6104922 B2 JP6104922 B2 JP 6104922B2
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etanercept
peak
formulation
composition
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JP2014530254A (ja
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マニング，マーク
マーフィ，ブライアン
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コヒラス・バイオサイエンシズ・インコーポレイテッド
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K39/39591—Stabilisation, fragmentation
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    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Cell Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
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  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
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  • Toxicology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Inorganic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
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JP2014537218A 2011-10-18 2012-10-18 アミノ酸によって安定化されたエタネルセプト製剤 Expired - Fee Related JP6104922B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161548518P 2011-10-18 2011-10-18
US61/548,518 2011-10-18
US201261669480P 2012-07-09 2012-07-09
US61/669,480 2012-07-09
PCT/US2012/060738 WO2013059405A1 (en) 2011-10-18 2012-10-18 Etanercept formulations stabilized with amino acids

Publications (2)

Publication Number Publication Date
JP2014530254A JP2014530254A (ja) 2014-11-17
JP6104922B2 true JP6104922B2 (ja) 2017-03-29

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JP2014537218A Expired - Fee Related JP6104922B2 (ja) 2011-10-18 2012-10-18 アミノ酸によって安定化されたエタネルセプト製剤
JP2014537220A Expired - Fee Related JP6220788B2 (ja) 2011-10-18 2012-10-18 塩化ナトリウムによって安定化されたエタネルセプト製剤
JP2014537222A Expired - Fee Related JP6113176B2 (ja) 2011-10-18 2012-10-18 キシリトールによって安定化されたエタネルセプト製剤
JP2014537219A Expired - Fee Related JP6110393B2 (ja) 2011-10-18 2012-10-18 金属イオンによって安定化されたエタネルセプト製剤
JP2014537221A Expired - Fee Related JP6199298B2 (ja) 2011-10-18 2012-10-18 メグルミンによって安定化されたエタネルセプト製剤
JP2014537223A Expired - Fee Related JP6220789B2 (ja) 2011-10-18 2012-10-18 糖およびポリオールの組合せによって安定化されたエタネルセプト製剤

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JP2014537220A Expired - Fee Related JP6220788B2 (ja) 2011-10-18 2012-10-18 塩化ナトリウムによって安定化されたエタネルセプト製剤
JP2014537222A Expired - Fee Related JP6113176B2 (ja) 2011-10-18 2012-10-18 キシリトールによって安定化されたエタネルセプト製剤
JP2014537219A Expired - Fee Related JP6110393B2 (ja) 2011-10-18 2012-10-18 金属イオンによって安定化されたエタネルセプト製剤
JP2014537221A Expired - Fee Related JP6199298B2 (ja) 2011-10-18 2012-10-18 メグルミンによって安定化されたエタネルセプト製剤
JP2014537223A Expired - Fee Related JP6220789B2 (ja) 2011-10-18 2012-10-18 糖およびポリオールの組合せによって安定化されたエタネルセプト製剤

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Country Link
US (21) US10293049B2 (enExample)
EP (6) EP2768533A4 (enExample)
JP (6) JP6104922B2 (enExample)
KR (7) KR20140091706A (enExample)
CN (6) CN104010654B (enExample)
AR (6) AR088460A1 (enExample)
AU (6) AU2012326080B2 (enExample)
BR (6) BR112014009087A2 (enExample)
CA (6) CA2851646A1 (enExample)
CY (1) CY1121843T1 (enExample)
DK (1) DK2768525T3 (enExample)
EA (6) EA201490804A1 (enExample)
ES (1) ES2734070T3 (enExample)
HK (3) HK1200722A1 (enExample)
HR (1) HRP20191215T1 (enExample)
HU (1) HUE045624T2 (enExample)
IL (6) IL231824A0 (enExample)
IN (3) IN2014CN02591A (enExample)
LT (1) LT2768525T (enExample)
MX (7) MX367054B (enExample)
PL (1) PL2768525T3 (enExample)
PT (1) PT2768525T (enExample)
RS (1) RS59179B1 (enExample)
SG (6) SG11201401562RA (enExample)
SI (1) SI2768525T1 (enExample)
SM (1) SMT201900422T1 (enExample)
TW (6) TW201325606A (enExample)
WO (6) WO2013059408A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138181A2 (en) 2005-06-14 2006-12-28 Amgen Inc. Self-buffering protein formulations
SG11201401562RA (en) * 2011-10-18 2014-09-26 Coherus Biosciences Inc Etanercept formulations stabilized with sodium chloride
US10493151B2 (en) 2011-10-18 2019-12-03 Coherus Biosciences, Inc. Etanercept formulations stabilized with sodium chloride
JP6271536B2 (ja) * 2012-07-09 2018-01-31 コヒラス・バイオサイエンシズ・インコーポレイテッド 肉眼不可視粒子の著しい低減を示すエタネルセプト製剤
AU2013315750B9 (en) * 2012-09-11 2018-11-15 Coherus Biosciences, Inc. Correctly folded etanercept in high purity and excellent yield
JP2016518386A (ja) * 2013-05-02 2016-06-23 マブキシェンス エス．アー． ＴＮＦＲ：Ｆｃ融合ポリペプチドの代替配合物
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