KR20140058402A - 단백질 티로신 키나제 억제제로서의 신규한 설파미드 피페라진 유도체 및 이의 약제학적 용도 - Google Patents
단백질 티로신 키나제 억제제로서의 신규한 설파미드 피페라진 유도체 및 이의 약제학적 용도 Download PDFInfo
- Publication number
- KR20140058402A KR20140058402A KR1020137020834A KR20137020834A KR20140058402A KR 20140058402 A KR20140058402 A KR 20140058402A KR 1020137020834 A KR1020137020834 A KR 1020137020834A KR 20137020834 A KR20137020834 A KR 20137020834A KR 20140058402 A KR20140058402 A KR 20140058402A
- Authority
- KR
- South Korea
- Prior art keywords
- pyrrolo
- pyrimidin
- octane
- diazaspiro
- sulfonamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Diabetes (AREA)
- Dermatology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
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- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161430670P | 2011-01-07 | 2011-01-07 | |
| US61/430,670 | 2011-01-07 | ||
| PCT/EP2012/050187 WO2012093169A1 (en) | 2011-01-07 | 2012-01-06 | Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20140058402A true KR20140058402A (ko) | 2014-05-14 |
Family
ID=45478318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137020834A Withdrawn KR20140058402A (ko) | 2011-01-07 | 2012-01-06 | 단백질 티로신 키나제 억제제로서의 신규한 설파미드 피페라진 유도체 및 이의 약제학적 용도 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9233964B2 (enExample) |
| EP (1) | EP2661436B1 (enExample) |
| JP (1) | JP2014501772A (enExample) |
| KR (1) | KR20140058402A (enExample) |
| CN (1) | CN103298817A (enExample) |
| AU (1) | AU2012204843A1 (enExample) |
| BR (1) | BR112013017184A2 (enExample) |
| CA (1) | CA2823935A1 (enExample) |
| MX (1) | MX2013007792A (enExample) |
| RU (1) | RU2013136906A (enExample) |
| TW (1) | TW201309703A (enExample) |
| WO (1) | WO2012093169A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015178955A1 (en) * | 2014-05-19 | 2015-11-26 | Eternity Bioscience Inc. | Substituted ethynyl heterobicyclic compounds as tyrosine kinase inhibitors |
| RU2658008C2 (ru) | 2014-06-24 | 2018-06-19 | Тайхо Фармасьютикал Ко., Лтд. | Новое пирролопиримидиновое соединение или его соль, фармацевтическая композиция, содержащая ее, в частности, агент для предотвращения и/или лечения опухолей, и тому подобное, на основе ингибиторного воздействия на nae |
| CN110291090A (zh) * | 2017-01-20 | 2019-09-27 | 利奥制药有限公司 | 作为新型jak激酶抑制剂的双环胺 |
| JP7101176B2 (ja) * | 2017-02-03 | 2022-07-14 | レオ ファーマ アクティーゼルスカブ | 新規ＪＡＫキナーゼ阻害剤としての５－（７Ｈ－ピロロ［２，３－ｄ］ピリミジン－４－イル）－５－アザスピロ［２．５］オクタン－８－カルボン酸誘導体 |
| CN108822048A (zh) * | 2018-07-23 | 2018-11-16 | 上海昌肽生物科技有限公司 | 4-(4-乙基-4,7二氮杂螺环[3,3]辛基)-2-硝基苯胺的合成工艺 |
| CN116730927A (zh) * | 2023-03-21 | 2023-09-12 | 广州佳途科技股份有限公司 | 一种新型高效合成4,7-二氮杂螺[2.5]辛烷盐酸盐的方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| PL198640B1 (pl) | 1998-06-19 | 2008-07-31 | Pfizer Prod Inc | Związki pirolo[2,3-d]pirymidynowe, środek farmaceutyczny i zastosowanie tych związków |
| EA006227B1 (ru) * | 1999-12-10 | 2005-10-27 | Пфайзер Продактс Инк. | СОЕДИНЕНИЯ ПИРРОЛО[2,3-d]ПИРИМИДИНА |
| US7115741B2 (en) | 2001-09-06 | 2006-10-03 | Levy Daniel E | 4-thieno[2,3-D]pyrimidin-4-YL piperazine compounds |
| CA2502356A1 (en) * | 2002-10-15 | 2004-04-29 | Synta Pharmaceuticals Corp. | Aromatic bicyclic heterocyles to modulate 1l - 12 production |
| SE0301372D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
| US20050130954A1 (en) | 2003-11-21 | 2005-06-16 | Mitchell Ian S. | AKT protein kinase inhibitors |
| CA2545192A1 (en) | 2003-11-25 | 2005-06-09 | Pfizer Products Inc. | Method of treatment of atherosclerosis |
| CA2549485A1 (en) | 2003-12-17 | 2005-07-07 | Pfizer Products Inc. | Pyrrolo [2,3-d] pyrimidine compounds for treating transplant rejection |
| US7745436B2 (en) * | 2004-04-13 | 2010-06-29 | Synta Pharmaceuticals Corporation | Disalt inhibitors of IL-12 production |
| AR054416A1 (es) * | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
| EP1844050B1 (en) | 2005-02-03 | 2009-01-14 | Vertex Pharmaceuticals, Inc. | Pyrrolopyrimidines useful as inhibitors of protein kinase |
| WO2006091450A1 (en) * | 2005-02-18 | 2006-08-31 | Lexicon Genetics Incorporated | 4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds |
| KR20080016659A (ko) | 2005-05-20 | 2008-02-21 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제의 억제제로서 유용한 피롤로피리딘 |
| CN102127078A (zh) * | 2005-07-14 | 2011-07-20 | 安斯泰来制药株式会社 | Janus激酶3的杂环类抑制剂 |
| SG169369A1 (en) | 2006-02-02 | 2011-03-30 | Millennium Pharm Inc | Inhibitors of e1 activating enzymes |
| JP2009533323A (ja) | 2006-03-11 | 2009-09-17 | ヴァーナリス アールアンドディー リミテッド | Ｈｓｐ９０阻害剤として用いられるピロロピリミジン誘導体 |
| GB0604944D0 (en) * | 2006-03-11 | 2006-04-19 | Vernalis R&D Ltd | Pyrrolopyrimidine compounds |
| CA2648250A1 (en) * | 2006-04-05 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Deazapurines useful as inhibitors of janus kinases |
| CA2682733A1 (en) | 2007-04-13 | 2008-10-23 | Supergen, Inc. | Axl kinase inhibitors |
| PT2188289E (pt) | 2007-08-08 | 2015-12-21 | Lexicon Pharmaceuticals Inc | (7h-pirrolo[2,3-d]pirimidin-4-il)piperazinas como inibidores de quinases para o tratamento de cancro e de inflamação |
| BR112012000422A2 (pt) * | 2009-07-08 | 2017-05-09 | Leo Pharma As | composto, composição farmacêutica, uso de um composto, e, método para a prevenir tratar ou melhorar doenças do sistema imune |
-
2012
- 2012-01-06 KR KR1020137020834A patent/KR20140058402A/ko not_active Withdrawn
- 2012-01-06 BR BR112013017184A patent/BR112013017184A2/pt not_active IP Right Cessation
- 2012-01-06 WO PCT/EP2012/050187 patent/WO2012093169A1/en not_active Ceased
- 2012-01-06 CN CN2012800048283A patent/CN103298817A/zh active Pending
- 2012-01-06 US US13/977,408 patent/US9233964B2/en not_active Expired - Fee Related
- 2012-01-06 JP JP2013547865A patent/JP2014501772A/ja active Pending
- 2012-01-06 MX MX2013007792A patent/MX2013007792A/es not_active Application Discontinuation
- 2012-01-06 RU RU2013136906/04A patent/RU2013136906A/ru not_active Application Discontinuation
- 2012-01-06 EP EP12700266.5A patent/EP2661436B1/en not_active Not-in-force
- 2012-01-06 CA CA2823935A patent/CA2823935A1/en not_active Abandoned
- 2012-01-06 AU AU2012204843A patent/AU2012204843A1/en not_active Abandoned
- 2012-01-09 TW TW101100842A patent/TW201309703A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2013007792A (es) | 2013-07-30 |
| WO2012093169A1 (en) | 2012-07-12 |
| EP2661436B1 (en) | 2016-04-13 |
| US20130345194A1 (en) | 2013-12-26 |
| EP2661436A1 (en) | 2013-11-13 |
| JP2014501772A (ja) | 2014-01-23 |
| TW201309703A (zh) | 2013-03-01 |
| US9233964B2 (en) | 2016-01-12 |
| BR112013017184A2 (pt) | 2016-09-20 |
| RU2013136906A (ru) | 2015-02-20 |
| CN103298817A (zh) | 2013-09-11 |
| AU2012204843A1 (en) | 2013-05-02 |
| CA2823935A1 (en) | 2012-07-12 |
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Patent event date: 20130806 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |