JP2014501772A - タンパク質チロシンキナーゼ阻害薬としての新規スルファミドピペラジン誘導体およびその医薬用途 - Google Patents

タンパク質チロシンキナーゼ阻害薬としての新規スルファミドピペラジン誘導体およびその医薬用途 Download PDF

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JP2014501772A
JP2014501772A JP2013547865A JP2013547865A JP2014501772A JP 2014501772 A JP2014501772 A JP 2014501772A JP 2013547865 A JP2013547865 A JP 2013547865A JP 2013547865 A JP2013547865 A JP 2013547865A JP 2014501772 A JP2014501772 A JP 2014501772A
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methyl
pyrrolo
diazaspiro
octane
pyrimidin
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JP2014501772A5 (enExample
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セレン・クリスティアン・ショウ
ダニエル・ロドリゲス・グレーヴェ
シモン・フェルベク・ニールセン
イェンス・ビョーン・イェンセン
ケビン・ニール・ダック
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レオ ファーマ アクティーゼルスカブ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013547865A 2011-01-07 2012-01-06 タンパク質チロシンキナーゼ阻害薬としての新規スルファミドピペラジン誘導体およびその医薬用途 Pending JP2014501772A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161430670P 2011-01-07 2011-01-07
US61/430,670 2011-01-07
PCT/EP2012/050187 WO2012093169A1 (en) 2011-01-07 2012-01-06 Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof

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Publication Number Publication Date
JP2014501772A true JP2014501772A (ja) 2014-01-23
JP2014501772A5 JP2014501772A5 (enExample) 2015-02-26

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JP2013547865A Pending JP2014501772A (ja) 2011-01-07 2012-01-06 タンパク質チロシンキナーゼ阻害薬としての新規スルファミドピペラジン誘導体およびその医薬用途

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US (1) US9233964B2 (enExample)
EP (1) EP2661436B1 (enExample)
JP (1) JP2014501772A (enExample)
KR (1) KR20140058402A (enExample)
CN (1) CN103298817A (enExample)
AU (1) AU2012204843A1 (enExample)
BR (1) BR112013017184A2 (enExample)
CA (1) CA2823935A1 (enExample)
MX (1) MX2013007792A (enExample)
RU (1) RU2013136906A (enExample)
TW (1) TW201309703A (enExample)
WO (1) WO2012093169A1 (enExample)

Cited By (1)

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JP2017519733A (ja) * 2014-05-19 2017-07-20 エタニティ バイオサイエンス インコーポレーテッド チロシンキナーゼ阻害剤としての置換エチニルヘテロ二環式化合物

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PT3103802T (pt) 2014-06-24 2017-12-11 Taiho Pharmaceutical Co Ltd Novo composto de pirrolopirimidina ou seu sal, composição farmacêutica que o contém, especialmente agente para prevenção e/ou tratamento de tumores etc. com base no efeito inibidor de nae
JP7101685B2 (ja) * 2017-01-20 2022-07-15 レオ ファーマ アクティーゼルスカブ 新規ｊａｋキナーゼ阻害剤としての二環式アミン
EP3576743B1 (en) 2017-02-03 2023-01-18 LEO Pharma A/S 5-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2 5]octane-8-carboxylic acid derivatives as jak kinase inhibitors
CN108822048A (zh) * 2018-07-23 2018-11-16 上海昌肽生物科技有限公司 4-(4-乙基-4,7二氮杂螺环[3,3]辛基)-2-硝基苯胺的合成工艺
CN116730927A (zh) * 2023-03-21 2023-09-12 广州佳途科技股份有限公司 一种新型高效合成4,7-二氮杂螺[2.5]辛烷盐酸盐的方法

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JP2008525463A (ja) * 2004-12-22 2008-07-17 インサイト・コーポレイション ＪＡＮＵＳキナーゼ阻害剤としてのピロロ［２，３−ｂ］ピリジン−４−イル−アミンおよびピロロ［２，３−ｂ］ピリミジン−４−イル−アミン
JP2010535813A (ja) * 2007-08-08 2010-11-25 レクシコン ファーマシューティカルズ インコーポレイテッド 癌及び炎症の治療のためのキナーゼ阻害剤としての（７ｈ−ピロロ［２，３−ｄ］ピリミジン−４−イル）−ピペラジン
JP5690823B2 (ja) * 2009-07-08 2015-03-25 レオ ファーマ アクティーゼルスカブ Ｊａｋ受容体およびタンパク質チロシンキナーゼ阻害薬としての複素環化合物

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JP2017519733A (ja) * 2014-05-19 2017-07-20 エタニティ バイオサイエンス インコーポレーテッド チロシンキナーゼ阻害剤としての置換エチニルヘテロ二環式化合物

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TW201309703A (zh) 2013-03-01
EP2661436A1 (en) 2013-11-13
WO2012093169A1 (en) 2012-07-12
AU2012204843A1 (en) 2013-05-02
RU2013136906A (ru) 2015-02-20
CA2823935A1 (en) 2012-07-12
US9233964B2 (en) 2016-01-12
MX2013007792A (es) 2013-07-30
EP2661436B1 (en) 2016-04-13
BR112013017184A2 (pt) 2016-09-20
US20130345194A1 (en) 2013-12-26
CN103298817A (zh) 2013-09-11

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