RU2013136906A - Новые производные сульфамидпиперазина в качестве ингибиторов протеинтирозинкиназы и их фармацевтическое применение - Google Patents

Новые производные сульфамидпиперазина в качестве ингибиторов протеинтирозинкиназы и их фармацевтическое применение Download PDF

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Publication number
RU2013136906A
RU2013136906A RU2013136906/04A RU2013136906A RU2013136906A RU 2013136906 A RU2013136906 A RU 2013136906A RU 2013136906/04 A RU2013136906/04 A RU 2013136906/04A RU 2013136906 A RU2013136906 A RU 2013136906A RU 2013136906 A RU2013136906 A RU 2013136906A
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Russia
Prior art keywords
diazaspiro
pyrrolo
pyrimidin
methyl
octane
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RU2013136906/04A
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English (en)
Russian (ru)
Inventor
Серен Христиан Схоу
Даниель Родригез Греве
Симон Фельдбек НИЛЬСЕН
Йенс Бьерн ЙЕНСЕН
Кевин Нил Дэк
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Лео Фарма А/С
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Application filed by Лео Фарма А/С filed Critical Лео Фарма А/С
Publication of RU2013136906A publication Critical patent/RU2013136906A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2013136906/04A 2011-01-07 2012-01-06 Новые производные сульфамидпиперазина в качестве ингибиторов протеинтирозинкиназы и их фармацевтическое применение RU2013136906A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161430670P 2011-01-07 2011-01-07
US61/430,670 2011-01-07
PCT/EP2012/050187 WO2012093169A1 (en) 2011-01-07 2012-01-06 Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof

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RU2013136906A true RU2013136906A (ru) 2015-02-20

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US (1) US9233964B2 (enExample)
EP (1) EP2661436B1 (enExample)
JP (1) JP2014501772A (enExample)
KR (1) KR20140058402A (enExample)
CN (1) CN103298817A (enExample)
AU (1) AU2012204843A1 (enExample)
BR (1) BR112013017184A2 (enExample)
CA (1) CA2823935A1 (enExample)
MX (1) MX2013007792A (enExample)
RU (1) RU2013136906A (enExample)
TW (1) TW201309703A (enExample)
WO (1) WO2012093169A1 (enExample)

Cited By (1)

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US9963456B2 (en) 2014-06-24 2018-05-08 Taiho Pharmaceutical Co., Ltd Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof

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EP3145512B1 (en) * 2014-05-19 2019-07-17 Jiangsu Hengrui Medicine Co., Ltd. Substituted ethynyl heterobicyclic compounds as tyrosine kinase inhibitors
CN110291090A (zh) * 2017-01-20 2019-09-27 利奥制药有限公司 作为新型jak激酶抑制剂的双环胺
US10799507B2 (en) 2017-02-03 2020-10-13 Leo Pharma A/S 5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors
CN108822048A (zh) * 2018-07-23 2018-11-16 上海昌肽生物科技有限公司 4-(4-乙基-4,7二氮杂螺环[3,3]辛基)-2-硝基苯胺的合成工艺
CN116730927A (zh) * 2023-03-21 2023-09-12 广州佳途科技股份有限公司 一种新型高效合成4,7-二氮杂螺[2.5]辛烷盐酸盐的方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9963456B2 (en) 2014-06-24 2018-05-08 Taiho Pharmaceutical Co., Ltd Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof
US10174040B2 (en) 2014-06-24 2019-01-08 Taiho Pharmaceutical Co., Ltd. Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof

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AU2012204843A1 (en) 2013-05-02
JP2014501772A (ja) 2014-01-23
US20130345194A1 (en) 2013-12-26
CA2823935A1 (en) 2012-07-12
BR112013017184A2 (pt) 2016-09-20
EP2661436A1 (en) 2013-11-13
WO2012093169A1 (en) 2012-07-12
TW201309703A (zh) 2013-03-01
MX2013007792A (es) 2013-07-30
CN103298817A (zh) 2013-09-11
EP2661436B1 (en) 2016-04-13
US9233964B2 (en) 2016-01-12
KR20140058402A (ko) 2014-05-14

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