RU2013136906A - Новые производные сульфамидпиперазина в качестве ингибиторов протеинтирозинкиназы и их фармацевтическое применение - Google Patents

Новые производные сульфамидпиперазина в качестве ингибиторов протеинтирозинкиназы и их фармацевтическое применение Download PDF

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Publication number
RU2013136906A
RU2013136906A RU2013136906/04A RU2013136906A RU2013136906A RU 2013136906 A RU2013136906 A RU 2013136906A RU 2013136906/04 A RU2013136906/04 A RU 2013136906/04A RU 2013136906 A RU2013136906 A RU 2013136906A RU 2013136906 A RU2013136906 A RU 2013136906A
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Russia
Prior art keywords
diazaspiro
pyrrolo
pyrimidin
methyl
octane
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RU2013136906/04A
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English (en)
Russian (ru)
Inventor
Серен Христиан Схоу
Даниель Родригез Греве
Симон Фельдбек НИЛЬСЕН
Йенс Бьерн ЙЕНСЕН
Кевин Нил Дэк
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Лео Фарма А/С
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Application filed by Лео Фарма А/С filed Critical Лео Фарма А/С
Publication of RU2013136906A publication Critical patent/RU2013136906A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Epidemiology (AREA)
  • Diabetes (AREA)
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  • Oncology (AREA)
  • Transplantation (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2013136906/04A 2011-01-07 2012-01-06 Новые производные сульфамидпиперазина в качестве ингибиторов протеинтирозинкиназы и их фармацевтическое применение RU2013136906A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161430670P 2011-01-07 2011-01-07
US61/430,670 2011-01-07
PCT/EP2012/050187 WO2012093169A1 (en) 2011-01-07 2012-01-06 Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof

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RU2013136906A true RU2013136906A (ru) 2015-02-20

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US (1) US9233964B2 (enExample)
EP (1) EP2661436B1 (enExample)
JP (1) JP2014501772A (enExample)
KR (1) KR20140058402A (enExample)
CN (1) CN103298817A (enExample)
AU (1) AU2012204843A1 (enExample)
BR (1) BR112013017184A2 (enExample)
CA (1) CA2823935A1 (enExample)
MX (1) MX2013007792A (enExample)
RU (1) RU2013136906A (enExample)
TW (1) TW201309703A (enExample)
WO (1) WO2012093169A1 (enExample)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
US9963456B2 (en) 2014-06-24 2018-05-08 Taiho Pharmaceutical Co., Ltd Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof

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JP6427599B2 (ja) * 2014-05-19 2018-11-21 チャンスー ヘンルイ メディシン カンパニー，リミテッド チロシンキナーゼ阻害剤としての置換エチニルヘテロ二環式化合物
JP7101685B2 (ja) * 2017-01-20 2022-07-15 レオ ファーマ アクティーゼルスカブ 新規ｊａｋキナーゼ阻害剤としての二環式アミン
EP3576743B1 (en) 2017-02-03 2023-01-18 LEO Pharma A/S 5-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2 5]octane-8-carboxylic acid derivatives as jak kinase inhibitors
CN108822048A (zh) * 2018-07-23 2018-11-16 上海昌肽生物科技有限公司 4-(4-乙基-4,7二氮杂螺环[3,3]辛基)-2-硝基苯胺的合成工艺
CN116730927A (zh) * 2023-03-21 2023-09-12 广州佳途科技股份有限公司 一种新型高效合成4,7-二氮杂螺[2.5]辛烷盐酸盐的方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9963456B2 (en) 2014-06-24 2018-05-08 Taiho Pharmaceutical Co., Ltd Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof
US10174040B2 (en) 2014-06-24 2019-01-08 Taiho Pharmaceutical Co., Ltd. Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof

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CA2823935A1 (en) 2012-07-12
CN103298817A (zh) 2013-09-11
EP2661436B1 (en) 2016-04-13
KR20140058402A (ko) 2014-05-14
MX2013007792A (es) 2013-07-30
WO2012093169A1 (en) 2012-07-12
JP2014501772A (ja) 2014-01-23
US9233964B2 (en) 2016-01-12
AU2012204843A1 (en) 2013-05-02
EP2661436A1 (en) 2013-11-13
TW201309703A (zh) 2013-03-01
BR112013017184A2 (pt) 2016-09-20
US20130345194A1 (en) 2013-12-26

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