KR20110042153A - 퓨린 ｐｉ３ｋ 억제 화합물 및 사용 방법 - Google Patents

퓨린 ｐｉ３ｋ 억제 화합물 및 사용 방법 Download PDF

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Publication number
KR20110042153A
KR20110042153A KR1020107026673A KR20107026673A KR20110042153A KR 20110042153 A KR20110042153 A KR 20110042153A KR 1020107026673 A KR1020107026673 A KR 1020107026673A KR 20107026673 A KR20107026673 A KR 20107026673A KR 20110042153 A KR20110042153 A KR 20110042153A
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purin
morpholino
compound
alkylene
methyl
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Korean (ko)
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조젯트 카스타네도
이리나 추코우리
아드리안 폴케스
다니엘 피. 서덜린
난 치 완
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제넨테크, 인크.
에프. 호프만-라 로슈 아게
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Publication of KR20110042153A publication Critical patent/KR20110042153A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020107026673A 2008-05-30 2009-05-29 퓨린 ｐｉ３ｋ 억제 화합물 및 사용 방법 Ceased KR20110042153A (ko)

Applications Claiming Priority (2)

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US5755908P 2008-05-30 2008-05-30
US61/057,559 2008-05-30

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KR20110042153A true KR20110042153A (ko) 2011-04-25

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KR1020107026673A Ceased KR20110042153A (ko) 2008-05-30 2009-05-29 퓨린 ｐｉ３ｋ 억제 화합물 및 사용 방법

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US (2) US8158624B2 (enExample)
EP (1) EP2279188B1 (enExample)
JP (1) JP2011521968A (enExample)
KR (1) KR20110042153A (enExample)
CN (1) CN102105474B (enExample)
AU (1) AU2009251291B2 (enExample)
BR (1) BRPI0909614A2 (enExample)
CA (1) CA2721851A1 (enExample)
ES (1) ES2533788T3 (enExample)
IL (1) IL208838A0 (enExample)
MX (1) MX2010012583A (enExample)
RU (1) RU2509081C2 (enExample)
WO (1) WO2009146406A1 (enExample)
ZA (1) ZA201007524B (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180011068A (ko) * 2015-04-21 2018-01-31 구이저우 바이링 엔터프라이즈 그룹 파마슈티컬 컴퍼니 리미티드 퓨리닐-n-하이드록실 피리미딘 포름아미드 유도체, 이의 제조 방법 및 용도
KR20210069664A (ko) * 2018-09-27 2021-06-11 상하이 잉리 파마슈티컬 컴퍼니 리미티드 모르폴리노 퀴나졸린계 화합물의 결정형태, 이의 제조방법 및 용도

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US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8703778B2 (en) 2008-09-26 2014-04-22 Intellikine Llc Heterocyclic kinase inhibitors
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JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン， エルエルシー 複素環式化合物およびその使用
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CA2761445A1 (en) * 2009-05-27 2010-12-02 Genentech, Inc. Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
MX2012005463A (es) * 2009-11-12 2012-09-12 Hoffmann La Roche Compuestos de purina n/9 sustituida, composiciones y metodos de uso.
BR112012011147A2 (pt) * 2009-11-12 2021-09-08 F.Hoffmann-La Roche Ag Composto, composição farmacêutica e uso de um composto.
EP2571357B1 (en) 2010-05-21 2016-07-06 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
CN103003279B (zh) 2010-07-14 2015-09-23 弗·哈夫曼-拉罗切有限公司 对PI3K P110δ具有选择性的嘌呤化合物及其使用方法
ES2612503T3 (es) * 2010-09-14 2017-05-17 Exelixis, Inc. Compuestos 9H-purina como inhibidores de PI3K-delta y métodos para su preparación
CN103298474B (zh) 2010-11-10 2016-06-29 无限药品股份有限公司 杂环化合物及其用途
EP3053925A1 (en) * 2010-12-16 2016-08-10 F. Hoffmann-La Roche AG Tricyclic pi3k inhibitor compounds and methods of use
TWI546305B (zh) 2011-01-10 2016-08-21 英菲尼提製藥股份有限公司 製備異喹啉酮之方法及異喹啉酮之固體形式
WO2012156379A1 (en) 2011-05-13 2012-11-22 Universität Zürich PIK3/P110α INHIBITORS FOR PREVENTION OF RESTENOSIS BY APPLICATION AS AN IMPLANT COATING
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CN105102000B (zh) 2012-11-01 2021-10-22 无限药品公司 使用pi3激酶亚型调节剂的癌症疗法
CN103936742B (zh) * 2013-01-17 2017-05-03 程鹏 含嘌呤基的新型pi3k抑制剂及其制备方法和应用
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PE20151977A1 (es) * 2013-05-02 2016-01-07 Hoffmann La Roche Nuevos derivados de purina
WO2014185367A1 (ja) * 2013-05-13 2014-11-20 第一三共株式会社 モルホリノプリン誘導体の製造方法
MX389256B (es) 2013-10-04 2025-03-20 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
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CN104557872B (zh) * 2013-10-16 2017-05-24 上海璎黎药业有限公司 稠合杂环化合物、其制备方法、药物组合物和用途
CN103804380B (zh) * 2014-01-24 2016-05-18 温州医科大学 以IKK-β为靶点的2-氨基-8-取代鸟嘌呤衍生物、应用及其制备方法
EA201691872A1 (ru) 2014-03-19 2017-04-28 Инфинити Фармасьютикалз, Инк. Гетероциклические соединения для применения в лечении pi3k-гамма-опосредованных расстройств
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US10172942B2 (en) * 2014-12-17 2019-01-08 Pfizer Inc. Formulations of a PI3K/mTor-inhibitor for intravenous administration
TWI689508B (zh) 2015-03-30 2020-04-01 日商第一三共股份有限公司 可作爲ｐｉ３ｋ抑制劑之吡唑衍生物及其用途
PL236355B1 (pl) * 2015-04-02 2021-01-11 Celon Pharma Spolka Akcyjna Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-α]pirymidyny jako inhibitory kinazy PI3
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CN108349985A (zh) 2015-09-14 2018-07-31 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180011068A (ko) * 2015-04-21 2018-01-31 구이저우 바이링 엔터프라이즈 그룹 파마슈티컬 컴퍼니 리미티드 퓨리닐-n-하이드록실 피리미딘 포름아미드 유도체, 이의 제조 방법 및 용도
KR20210069664A (ko) * 2018-09-27 2021-06-11 상하이 잉리 파마슈티컬 컴퍼니 리미티드 모르폴리노 퀴나졸린계 화합물의 결정형태, 이의 제조방법 및 용도

Also Published As

Publication number Publication date
ZA201007524B (en) 2012-01-25
RU2509081C2 (ru) 2014-03-10
IL208838A0 (en) 2011-01-31
RU2010154428A (ru) 2012-07-10
AU2009251291B2 (en) 2013-05-02
US8158624B2 (en) 2012-04-17
WO2009146406A1 (en) 2009-12-03
BRPI0909614A2 (pt) 2015-09-22
AU2009251291A1 (en) 2009-12-03
EP2279188B1 (en) 2015-01-28
ES2533788T3 (es) 2015-04-14
JP2011521968A (ja) 2011-07-28
US8445487B2 (en) 2013-05-21
CN102105474B (zh) 2014-01-08
EP2279188A1 (en) 2011-02-02
CA2721851A1 (en) 2009-12-03
US20090318411A1 (en) 2009-12-24
CN102105474A (zh) 2011-06-22
US20120135988A1 (en) 2012-05-31
MX2010012583A (es) 2011-02-24

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