KR20100038295A - 피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘 - Google Patents

피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘 Download PDF

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KR20100038295A
KR20100038295A KR1020097025393A KR20097025393A KR20100038295A KR 20100038295 A KR20100038295 A KR 20100038295A KR 1020097025393 A KR1020097025393 A KR 1020097025393A KR 20097025393 A KR20097025393 A KR 20097025393A KR 20100038295 A KR20100038295 A KR 20100038295A
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South Korea
Prior art keywords
difluorophenyl
pyrrolidin
mmol
chloro
fluorophenyl
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Korean (ko)
Inventor
클라스 소네손
라르스 스반손
프레드릭 페터손
니콜라스 바터스
수산나 바터스
Original Assignee
엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게
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Publication of KR20100038295A publication Critical patent/KR20100038295A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020097025393A 2007-06-05 2008-06-04 피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘 Withdrawn KR20100038295A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0701387 2007-06-05
SE0701387-3 2007-06-05

Publications (1)

Publication Number Publication Date
KR20100038295A true KR20100038295A (ko) 2010-04-14

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KR1020097025393A Withdrawn KR20100038295A (ko) 2007-06-05 2008-06-04 피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘

Country Status (16)

Country Link
US (1) US8188301B2 (https=)
EP (1) EP2155671B8 (https=)
JP (1) JP5444535B2 (https=)
KR (1) KR20100038295A (https=)
CN (1) CN101808987A (https=)
AU (1) AU2008258599B2 (https=)
BR (1) BRPI0812740A2 (https=)
CA (1) CA2690091A1 (https=)
CO (1) CO6251288A2 (https=)
IL (1) IL202045A0 (https=)
MX (1) MX2009012787A (https=)
NZ (1) NZ581364A (https=)
RU (1) RU2471781C2 (https=)
UA (1) UA98783C2 (https=)
WO (1) WO2008148801A2 (https=)
ZA (1) ZA200908592B (https=)

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CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
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RU2612521C2 (ru) 2009-07-06 2017-03-09 Онтории, Инк. Новые пролекарства нуклеиновых кислот и способы их применения
JP5868324B2 (ja) * 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
CN103796657B (zh) 2011-07-19 2017-07-11 波涛生命科学有限公司 合成官能化核酸的方法
CA2879066C (en) 2012-07-13 2019-08-13 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
PL2872485T3 (pl) 2012-07-13 2021-05-31 Wave Life Sciences Ltd. Asymetryczna grupa pomocnicza
KR102213609B1 (ko) 2012-07-13 2021-02-08 웨이브 라이프 사이언시스 리미티드 키랄 제어
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
BR112016016400A2 (pt) 2014-01-16 2017-10-03 Wave Life Sciences Ltd Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos
PT3297987T (pt) 2015-05-20 2019-06-19 Integrative Res Laboratories Sweden Ab Novos derivados de azetidina úteis como moduladores da neurotransmissão catecolaminérgica cortical
WO2017138588A1 (ja) 2016-02-10 2017-08-17 住友化学株式会社 １－メチルピロリジン－３－オールの製造方法
EP3625213B1 (en) 2017-05-19 2023-03-08 Integrative Research Laboratories Sweden AB (+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine fumarate, a process for its preparation and uses thereof

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Also Published As

Publication number Publication date
NZ581364A (en) 2011-10-28
US8188301B2 (en) 2012-05-29
US20100179211A1 (en) 2010-07-15
WO2008148801A3 (en) 2009-01-29
AU2008258599B2 (en) 2013-06-13
RU2009143104A (ru) 2011-07-20
EP2155671B1 (en) 2017-12-20
CN101808987A (zh) 2010-08-18
IL202045A0 (en) 2010-06-16
WO2008148801A2 (en) 2008-12-11
BRPI0812740A2 (pt) 2016-07-19
CA2690091A1 (en) 2008-12-11
JP2010529081A (ja) 2010-08-26
JP5444535B2 (ja) 2014-03-19
EP2155671B8 (en) 2018-02-21
CO6251288A2 (es) 2011-02-21
EP2155671A2 (en) 2010-02-24
ZA200908592B (en) 2011-02-23
AU2008258599A1 (en) 2008-12-11
WO2008148801A8 (en) 2009-12-10
MX2009012787A (es) 2009-12-15
UA98783C2 (en) 2012-06-25
RU2471781C2 (ru) 2013-01-10

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Date Code Title Description
PA0105 International application

Patent event date: 20091204

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid