KR20100028038A - 인플루엔자의 치료 및 예방 방법 - Google Patents

인플루엔자의 치료 및 예방 방법 Download PDF

Info

Publication number
KR20100028038A
KR20100028038A KR1020097026165A KR20097026165A KR20100028038A KR 20100028038 A KR20100028038 A KR 20100028038A KR 1020097026165 A KR1020097026165 A KR 1020097026165A KR 20097026165 A KR20097026165 A KR 20097026165A KR 20100028038 A KR20100028038 A KR 20100028038A
Authority
KR
South Korea
Prior art keywords
nucleic acid
influenza
virus
seq
construct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020097026165A
Other languages
English (en)
Korean (ko)
Inventor
티모시 제임스 도란
제임스 클라미 맥케이
로버트 존 무어
존 윌리암 로웬탈
스코트 제프리 타이악
Original Assignee
매트 몰타 어드밴스드 테크놀로지스 리미티드
커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2007902616A external-priority patent/AU2007902616A0/en
Application filed by 매트 몰타 어드밴스드 테크놀로지스 리미티드, 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 filed Critical 매트 몰타 어드밴스드 테크놀로지스 리미티드
Publication of KR20100028038A publication Critical patent/KR20100028038A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/054—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function
    • A01K2217/058—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function due to expression of inhibitory nucleic acid, e.g. siRNA, antisense
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/90—Vectors containing a transposable element
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/38—Vector systems having a special element relevant for transcription being a stuffer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/90—Vector systems having a special element relevant for transcription from vertebrates avian

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Husbandry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020097026165A 2007-05-16 2008-05-16 인플루엔자의 치료 및 예방 방법 Ceased KR20100028038A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US93831507P 2007-05-16 2007-05-16
US60/938,315 2007-05-16
AU2007902616A AU2007902616A0 (en) 2007-05-16 Treatment and prevention of influenza
AU2007902616 2007-05-16

Publications (1)

Publication Number Publication Date
KR20100028038A true KR20100028038A (ko) 2010-03-11

Family

ID=40001608

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097026165A Ceased KR20100028038A (ko) 2007-05-16 2008-05-16 인플루엔자의 치료 및 예방 방법

Country Status (16)

Country Link
US (1) US20110209231A1 (enExample)
EP (2) EP2160466A4 (enExample)
JP (1) JP2010526542A (enExample)
KR (1) KR20100028038A (enExample)
CN (1) CN101918558B (enExample)
AU (1) AU2008250973B2 (enExample)
BR (1) BRPI0811870A2 (enExample)
CA (1) CA2687115A1 (enExample)
CO (1) CO6251333A2 (enExample)
EA (1) EA017948B1 (enExample)
IL (1) IL202126A (enExample)
MX (1) MX2009012317A (enExample)
MY (1) MY149171A (enExample)
NZ (2) NZ597601A (enExample)
WO (1) WO2008138072A1 (enExample)
ZA (1) ZA200908100B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013089522A1 (ko) * 2011-12-15 2013-06-20 (주)바이오니아 신규한 올리고뉴클레오티드 접합체 및 그 용도
KR20160076952A (ko) 2014-12-23 2016-07-01 김규리 문자 편집 장치 및 방법
KR102584623B1 (ko) * 2023-03-08 2023-10-06 대한민국 오리 유래 rna 폴리머라제 i 프로모터 및 이를 포함하는 재조합 벡터

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012000565A2 (pt) * 2009-06-19 2016-11-16 Commw Scient Ind Res Org ensaio de vírus.
AU2013204327B2 (en) 2012-04-20 2016-09-01 Aviagen Cell transfection method
CN103966212A (zh) * 2013-02-06 2014-08-06 霍晋 A型流感病毒NP基因有干扰作用的siRNA序列的设计及应用
KR101590997B1 (ko) 2014-01-13 2016-02-02 주식회사 엘지화학 불활성 입자가 코팅되어 있는 전극조립체를 포함하는 전지셀
ES2796930T3 (es) * 2014-01-23 2020-11-30 Univ Colorado State Res Found Silenciamiento de ARNip mediado por E. coli de la gripe aviar en pollos
AU2016305490B2 (en) 2015-08-07 2022-07-14 Commonwealth Scientific And Industrial Research Organisation Method for producing an animal comprising a germline genetic modification
WO2018187381A2 (en) 2017-04-03 2018-10-11 Sivec Biotechnologies, Llc A transkingdom platform for therapeutic nucleic acid delivery
CN109966497B (zh) * 2019-04-08 2021-03-12 中国医学科学院医药生物技术研究所 以ipan或其编码基因为靶点的物质在制备流感病毒抑制剂中的应用
CN111084154A (zh) * 2019-12-30 2020-05-01 集美大学 一种蛙类多层养殖装置

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4504729A (en) * 1980-11-05 1985-03-12 Babcock-Hitachi Kabushiki Kaisha Three o'clock welding method in narrow groove
US4501729A (en) 1982-12-13 1985-02-26 Research Corporation Aerosolized amiloride treatment of retained pulmonary secretions
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4903635A (en) * 1986-07-02 1990-02-27 Embrex, Inc. High speed automated injection system for avian embryos
CA1323293C (en) 1987-12-11 1993-10-19 Keith C. Backman Assay using template-dependent nucleic acid probe reorganization
US5162215A (en) * 1988-09-22 1992-11-10 Amgen Inc. Method of gene transfer into chickens and other avian species
US5056464A (en) 1990-01-18 1991-10-15 Embrex, Inc. Automated injection system for avian embryos with advanced fluid delivery system
US5279833A (en) 1990-04-04 1994-01-18 Yale University Liposomal transfection of nucleic acids into animal cells
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5136979A (en) 1991-09-25 1992-08-11 Embrex, Inc. Modular injection system for avian embryos
US5641656A (en) * 1993-10-22 1997-06-24 University Of Connecticut Nucleic acids encoding avian interferon (IFN) proteins and recombinant methods using them
US5885567A (en) * 1993-10-22 1999-03-23 University Of Connecticut Treatment of infection in fowl by oral administration of avian interferon proteins
US5837533A (en) * 1994-09-28 1998-11-17 American Home Products Corporation Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent
US5932241A (en) 1995-06-07 1999-08-03 Valentis, Incorporated Cationic lipid DNA complexes for gene targeting
US8202979B2 (en) * 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US7067308B1 (en) 2000-03-28 2006-06-27 Bioagri Corporation Vector for genetically modifying non-human animals
CA2433680A1 (en) * 2000-12-28 2002-08-01 Gregory M Arndt Double-stranded rna-mediated gene suppression
US7145057B2 (en) 2002-02-01 2006-12-05 Origen Therapeutics, Inc. Chimeric bird from embryonic stem cells
AU2003266014B2 (en) 2002-05-06 2009-05-14 Alnylam Pharmaceuticals, Inc. Methods for delivery of nucleic acids
US7527966B2 (en) * 2002-06-26 2009-05-05 Transgenrx, Inc. Gene regulation in transgenic animals using a transposon-based vector
US20050196862A1 (en) * 2002-08-30 2005-09-08 Wooddell Christine I. DNA cassette for cellular expression of small RNA
US20040242518A1 (en) * 2002-09-28 2004-12-02 Massachusetts Institute Of Technology Influenza therapeutic
US20060160759A1 (en) * 2002-09-28 2006-07-20 Jianzhu Chen Influenza therapeutic
AU2003279004B2 (en) * 2002-09-28 2009-10-08 Massachusetts Institute Of Technology Influenza therapeutic
WO2006026238A2 (en) * 2004-08-25 2006-03-09 Avigenics, Inc. Rna interference in avians
US20080222743A1 (en) * 2004-08-25 2008-09-11 Avigenics, Inc. RNA interference and disease resistance in avians
US7617795B2 (en) 2004-10-13 2009-11-17 Embrex, Inc. Methods and apparatus for injecting and sampling material through avian egg membranes
WO2006084035A2 (en) 2005-02-01 2006-08-10 Origen Therapeutics, Inc. Transgenic chickens
RU2533804C2 (ru) * 2005-03-31 2014-11-20 Ронен КАХАНА Получение домашней птицы и других животных, устойчивых к вирусному заболеванию
KR20070118703A (ko) * 2005-04-08 2007-12-17 나스텍 파마수티컬 컴퍼니 인코포레이티드 호흡기 바이러스 감염을 치료하는 알엔에이 아이
US7199109B2 (en) * 2005-06-03 2007-04-03 Cal Poly Pomona Foundation Potent inhibition of influenza virus by specifically designed short interfering RNA
US20070099858A1 (en) * 2005-10-03 2007-05-03 Sirna Therapeutics, Inc. RNA interference mediated of inhibition of influenza virus gene expression using short interfering nucleic acid (siNA)
CA2627585A1 (en) * 2005-11-01 2007-05-10 Alnylam Pharmaceuticals, Inc. Rnai inhibition of influenza virus replication

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013089522A1 (ko) * 2011-12-15 2013-06-20 (주)바이오니아 신규한 올리고뉴클레오티드 접합체 및 그 용도
KR20160076952A (ko) 2014-12-23 2016-07-01 김규리 문자 편집 장치 및 방법
KR102584623B1 (ko) * 2023-03-08 2023-10-06 대한민국 오리 유래 rna 폴리머라제 i 프로모터 및 이를 포함하는 재조합 벡터
WO2024186017A1 (ko) * 2023-03-08 2024-09-12 대한민국(농림축산식품부 농림축산검역본부장) 오리 유래 rna 폴리머라제 i 프로모터 및 이를 포함하는 재조합 벡터

Also Published As

Publication number Publication date
US20110209231A1 (en) 2011-08-25
NZ597601A (en) 2013-04-26
CO6251333A2 (es) 2011-02-21
AU2008250973B2 (en) 2012-10-11
CA2687115A1 (en) 2008-11-20
CN101918558A (zh) 2010-12-15
MX2009012317A (es) 2010-04-01
AU2008250973A1 (en) 2008-11-20
EA017948B1 (ru) 2013-04-30
EP2160466A1 (en) 2010-03-10
MY149171A (en) 2013-07-31
BRPI0811870A2 (pt) 2014-10-21
IL202126A0 (en) 2011-08-01
EP2160466A4 (en) 2011-07-13
EP2527445A3 (en) 2013-02-20
IL202126A (en) 2015-10-29
JP2010526542A (ja) 2010-08-05
EP2527445A2 (en) 2012-11-28
CN101918558B (zh) 2016-12-07
ZA200908100B (en) 2012-01-25
WO2008138072A1 (en) 2008-11-20
NZ581542A (en) 2012-02-24
EA200971059A1 (ru) 2010-04-30

Similar Documents

Publication Publication Date Title
CN101918558B (zh) 流感的治疗及预防
KR101761709B1 (ko) 부위 특이적 통합
US7527966B2 (en) Gene regulation in transgenic animals using a transposon-based vector
DK2925866T3 (en) CIRCULAR RNA FOR INHIBITING MICRO-RNA
KR102609858B1 (ko) 점액다당류증의 치료를 위한 아데노-관련 바이러스 벡터
AU2018278516B2 (en) Trait selection in avians
AU2016370487C1 (en) Gene therapy for ocular disorders
KR20220047623A (ko) 세포 유형 운명 특정화의 조절인자를 확인하기 위한 조성물 및 방법
KR20110039258A (ko) 개선된 단백질 발현계
AU2016378480A1 (en) Endothelium-specific nucleic acid regulatory elements and methods and use thereof
AU2017352591B2 (en) A two-part device for T-cell receptor synthesis and stable genomic integration to TCR-presenting cells
CN114026242A (zh) 具有髓鞘蛋白零启动子的aav载体及其用于治疗雪旺细胞相关疾病如charcot-marie-tooth疾病的用途
CN109666647B (zh) 一种过表达igf-1的脐带间充质干细胞及其制备方法和应用
CN111088176B (zh) 产β-胡萝卜素的基因工程菌及其应用
CN112029736B (zh) 一种预防非洲猪瘟重组伪狂犬病病毒活疫苗及其制备方法
CN114231562A (zh) 一种表达荧光素酶基因的淋巴脉络丛脑膜炎病毒及其构建方法和应用
KR101539796B1 (ko) 암 치료법을 위한 다중 발현 카세트를 포함하는 구조물
CZ285116B6 (cs) Imunogenní polypeptid
CN112159822A (zh) 一种PS转座酶与CRISPR/dCpf1融合蛋白表达载体及其介导的定点整合方法
CN109762846B (zh) 利用碱基编辑修复与克拉伯病相关的galcc1586t突变的试剂和方法
CN111801422B (zh) 基于乳酸克鲁维酵母产生保护性单价和多价亚单位疫苗的优化的宿主/载体系统
CN116549630A (zh) 一种由腺相关病毒载体介导表达的抗血管内皮生长因子基因药物及其制备方法和应用
KR102740600B1 (ko) 강력한 적응성 면역반응 유도 및 모체이행항체의 간섭을 극복하는 재조합 구제역 o형 바이러스 및 이를 포함하는 구제역 백신 조성물
KR102740602B1 (ko) 강력한 적응성 면역반응 유도 및 모체이행항체의 간섭을 극복하는 재조합 구제역 a형 바이러스 및 이를 포함하는 구제역 백신 조성물
CN104195153A (zh) 一种双顺反子共表达基因转移体及制备方法

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20091215

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20130404

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20140822

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20141114

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20140822

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I