CO6251333A2 - Tratamiento y prevencion de influenza - Google Patents
Tratamiento y prevencion de influenzaInfo
- Publication number
- CO6251333A2 CO6251333A2 CO09141981A CO09141981A CO6251333A2 CO 6251333 A2 CO6251333 A2 CO 6251333A2 CO 09141981 A CO09141981 A CO 09141981A CO 09141981 A CO09141981 A CO 09141981A CO 6251333 A2 CO6251333 A2 CO 6251333A2
- Authority
- CO
- Colombia
- Prior art keywords
- influenza
- nucleic acid
- virus
- animal cell
- reduces
- Prior art date
Links
- 206010022000 influenza Diseases 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 2
- 241000712431 Influenza A virus Species 0.000 abstract 5
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 4
- 210000004102 animal cell Anatomy 0.000 abstract 4
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 244000144977 poultry Species 0.000 abstract 2
- 235000013594 poultry meat Nutrition 0.000 abstract 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 abstract 1
- 241000271566 Aves Species 0.000 abstract 1
- 241000287828 Gallus gallus Species 0.000 abstract 1
- 208000002979 Influenza in Birds Diseases 0.000 abstract 1
- 206010064097 avian influenza Diseases 0.000 abstract 1
- 235000013330 chicken meat Nutrition 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/054—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function
- A01K2217/058—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function due to expression of inhibitory nucleic acid, e.g. siRNA, antisense
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/30—Bird
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/38—Vector systems having a special element relevant for transcription being a stuffer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/90—Vector systems having a special element relevant for transcription from vertebrates avian
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se relaciona con moléculas de ácido nucleico que comprenden una región de doble cadena, y la estructura de ácido nucleico que codifican para las mismas, que son útiles para el tratamiento y/o prevención de influenza. En particular, la presente invención se relaciona con la estructura de ácido nucleico que codifican para moléculas de ARN de doble cadena que se pueden utilizar para producir aves de corral transgénicas, por ejemplo pollos, de tal forma que sean menos susceptibles a una infección por influenza aviar. También se proporcionan moléculas de ácido nucleico que comprenden una región de doble cadena que se pueden utilizar como un terapéutico para tratar y/o prevenir, por ejemplo, influenza aviar en aves de corral. 1.- Una estructura de ácido nucleico que codifica para una molécula de ARN caracterizada porque comprende una región de doble cadena, en donde la molécula de ARN reduce la replicación del virus de influenza A en una célula animal y/o reduce la producción de las partículas del virus de influenza A infeccioso en una célula animal y/o reduce la expresión de un polipéptido del virus de influenza A en una célula animal infectada con el virus de influenza A en comparación con una célula animal isogénica infectada con el virus de influenza A que carece de la molécula de ARN.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93831507P | 2007-05-16 | 2007-05-16 | |
AU2007902616A AU2007902616A0 (en) | 2007-05-16 | Treatment and prevention of influenza |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6251333A2 true CO6251333A2 (es) | 2011-02-21 |
Family
ID=40001608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO09141981A CO6251333A2 (es) | 2007-05-16 | 2009-12-11 | Tratamiento y prevencion de influenza |
Country Status (16)
Country | Link |
---|---|
US (1) | US20110209231A1 (es) |
EP (2) | EP2527445A3 (es) |
JP (1) | JP2010526542A (es) |
KR (1) | KR20100028038A (es) |
CN (1) | CN101918558B (es) |
AU (1) | AU2008250973B2 (es) |
BR (1) | BRPI0811870A2 (es) |
CA (1) | CA2687115A1 (es) |
CO (1) | CO6251333A2 (es) |
EA (1) | EA017948B1 (es) |
IL (1) | IL202126A (es) |
MX (1) | MX2009012317A (es) |
MY (1) | MY149171A (es) |
NZ (2) | NZ581542A (es) |
WO (1) | WO2008138072A1 (es) |
ZA (1) | ZA200908100B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102803516A (zh) * | 2009-06-19 | 2012-11-28 | 联邦科学与工业研究机构 | 病毒试验 |
BR112014014730B1 (pt) * | 2011-12-15 | 2021-05-18 | Bioneer Corporation | estrutura de droga polímero terapêutica, métodos para preparar uma estrutura de oligo rna de dupla hélice, nanoparticula e composição farmacêutica |
AU2013204327B2 (en) | 2012-04-20 | 2016-09-01 | Aviagen | Cell transfection method |
CN103966212A (zh) * | 2013-02-06 | 2014-08-06 | 霍晋 | A型流感病毒NP基因有干扰作用的siRNA序列的设计及应用 |
KR101590997B1 (ko) | 2014-01-13 | 2016-02-02 | 주식회사 엘지화학 | 불활성 입자가 코팅되어 있는 전극조립체를 포함하는 전지셀 |
ES2796930T3 (es) * | 2014-01-23 | 2020-11-30 | Univ Colorado State Res Found | Silenciamiento de ARNip mediado por E. coli de la gripe aviar en pollos |
KR20160076952A (ko) | 2014-12-23 | 2016-07-01 | 김규리 | 문자 편집 장치 및 방법 |
EP3332014A4 (en) | 2015-08-07 | 2019-01-23 | Commonwealth Scientific and Industrial Research Organisation | METHOD FOR PRODUCING ANIMAL WITH GENETIC GLAND CARBON MODIFICATION |
AU2018250169B2 (en) | 2017-04-03 | 2024-06-20 | Sivec Biotechnologies, Llc | A transkingdom platform for therapeutic nucleic acid delivery |
CN109966497B (zh) * | 2019-04-08 | 2021-03-12 | 中国医学科学院医药生物技术研究所 | 以ipan或其编码基因为靶点的物质在制备流感病毒抑制剂中的应用 |
CN111084154A (zh) * | 2019-12-30 | 2020-05-01 | 集美大学 | 一种蛙类多层养殖装置 |
KR102584623B1 (ko) * | 2023-03-08 | 2023-10-06 | 대한민국 | 오리 유래 rna 폴리머라제 i 프로모터 및 이를 포함하는 재조합 벡터 |
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AU622426B2 (en) | 1987-12-11 | 1992-04-09 | Abbott Laboratories | Assay using template-dependent nucleic acid probe reorganization |
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US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
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US5641656A (en) * | 1993-10-22 | 1997-06-24 | University Of Connecticut | Nucleic acids encoding avian interferon (IFN) proteins and recombinant methods using them |
US5837533A (en) * | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
US5932241A (en) | 1995-06-07 | 1999-08-03 | Valentis, Incorporated | Cationic lipid DNA complexes for gene targeting |
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US7067308B1 (en) * | 2000-03-28 | 2006-06-27 | Bioagri Corporation | Vector for genetically modifying non-human animals |
JP2004532616A (ja) * | 2000-12-28 | 2004-10-28 | ジョンソン・アンド・ジョンソン・リサーチ・ピー・ティー・ワイ・リミテッド | 二本鎖rna仲介遺伝子抑制 |
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US20040242518A1 (en) * | 2002-09-28 | 2004-12-02 | Massachusetts Institute Of Technology | Influenza therapeutic |
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2008
- 2008-05-16 JP JP2010507765A patent/JP2010526542A/ja not_active Ceased
- 2008-05-16 CA CA002687115A patent/CA2687115A1/en not_active Abandoned
- 2008-05-16 MX MX2009012317A patent/MX2009012317A/es not_active Application Discontinuation
- 2008-05-16 US US12/451,540 patent/US20110209231A1/en not_active Abandoned
- 2008-05-16 EA EA200971059A patent/EA017948B1/ru not_active IP Right Cessation
- 2008-05-16 AU AU2008250973A patent/AU2008250973B2/en not_active Ceased
- 2008-05-16 KR KR1020097026165A patent/KR20100028038A/ko not_active Application Discontinuation
- 2008-05-16 EP EP12181612A patent/EP2527445A3/en not_active Withdrawn
- 2008-05-16 MY MYPI20094835A patent/MY149171A/en unknown
- 2008-05-16 NZ NZ581542A patent/NZ581542A/en not_active IP Right Cessation
- 2008-05-16 EP EP08747962A patent/EP2160466A4/en not_active Withdrawn
- 2008-05-16 CN CN200880024796.7A patent/CN101918558B/zh not_active Expired - Fee Related
- 2008-05-16 NZ NZ597601A patent/NZ597601A/xx not_active IP Right Cessation
- 2008-05-16 WO PCT/AU2008/000692 patent/WO2008138072A1/en active Application Filing
- 2008-05-16 BR BRPI0811870-1A2A patent/BRPI0811870A2/pt not_active IP Right Cessation
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2009
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- 2009-11-17 ZA ZA2009/08100A patent/ZA200908100B/en unknown
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AU2008250973A1 (en) | 2008-11-20 |
EP2527445A2 (en) | 2012-11-28 |
EP2160466A1 (en) | 2010-03-10 |
ZA200908100B (en) | 2012-01-25 |
CN101918558A (zh) | 2010-12-15 |
JP2010526542A (ja) | 2010-08-05 |
US20110209231A1 (en) | 2011-08-25 |
MY149171A (en) | 2013-07-31 |
NZ581542A (en) | 2012-02-24 |
CA2687115A1 (en) | 2008-11-20 |
MX2009012317A (es) | 2010-04-01 |
EP2160466A4 (en) | 2011-07-13 |
CN101918558B (zh) | 2016-12-07 |
WO2008138072A1 (en) | 2008-11-20 |
KR20100028038A (ko) | 2010-03-11 |
BRPI0811870A2 (pt) | 2014-10-21 |
IL202126A0 (en) | 2011-08-01 |
EA017948B1 (ru) | 2013-04-30 |
EA200971059A1 (ru) | 2010-04-30 |
AU2008250973B2 (en) | 2012-10-11 |
IL202126A (en) | 2015-10-29 |
NZ597601A (en) | 2013-04-26 |
EP2527445A3 (en) | 2013-02-20 |
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