UA102069C2 - Конструкція нуклеїнової кислоти для зниження реплікації вірусу грипу а в клітині тварини - Google Patents

Конструкція нуклеїнової кислоти для зниження реплікації вірусу грипу а в клітині тварини

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Publication number
UA102069C2
UA102069C2 UAA200913080A UAA200913080A UA102069C2 UA 102069 C2 UA102069 C2 UA 102069C2 UA A200913080 A UAA200913080 A UA A200913080A UA A200913080 A UAA200913080 A UA A200913080A UA 102069 C2 UA102069 C2 UA 102069C2
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Ukraine
Prior art keywords
nucleic acid
replication
virus
inhibition
animal cell
Prior art date
Application number
UAA200913080A
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English (en)
Russian (ru)
Inventor
Тімоті Джеймс Доран
Джеймс Клімі Маккей
Роберт Джон Мур
Джон Уілльям Лоуентал
Скотт Джеффрі Тайак
Original Assignee
Мат Мальта Едванст Текнолоджиз Лімітед
Коммонвелт Сайєнтіфік Енд Індастріал Рісерч Організейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2007902616A external-priority patent/AU2007902616A0/en
Application filed by Мат Мальта Едванст Текнолоджиз Лімітед, Коммонвелт Сайєнтіфік Енд Індастріал Рісерч Організейшн filed Critical Мат Мальта Едванст Текнолоджиз Лімітед
Priority claimed from PCT/AU2008/000692 external-priority patent/WO2008138072A1/en
Publication of UA102069C2 publication Critical patent/UA102069C2/uk

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/054—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function
    • A01K2217/058—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function due to expression of inhibitory nucleic acid, e.g. siRNA, antisense
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/90—Vector systems having a special element relevant for transcription from vertebrates avian

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  • Genetics & Genomics (AREA)
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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Винахід належить до конструкцій нуклеїнових кислот, що кодують молекули двониткової РНК, які можуть використовуватися для одержання трансгенних свійських птахів, наприклад, курей, так щоб вони були щонайменше менш сприйнятливі до інфекції пташиним грипом. Зазначені молекули нуклеїнової кислоти, що містять двониткову ділянку, можуть використовуватися як терапевтичний засіб для лікування і/або профілактики, наприклад, пташиного грипу в свійських птахів.
UAA200913080A 2007-05-16 2008-05-16 Конструкція нуклеїнової кислоти для зниження реплікації вірусу грипу а в клітині тварини UA102069C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93831507P 2007-05-16 2007-05-16
AU2007902616A AU2007902616A0 (en) 2007-05-16 Treatment and prevention of influenza
PCT/AU2008/000692 WO2008138072A1 (en) 2007-05-16 2008-05-16 Treatment and prevention of influenza

Publications (1)

Publication Number Publication Date
UA102069C2 true UA102069C2 (uk) 2013-06-10

Family

ID=65686633

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200913080A UA102069C2 (uk) 2007-05-16 2008-05-16 Конструкція нуклеїнової кислоти для зниження реплікації вірусу грипу а в клітині тварини

Country Status (1)

Country Link
UA (1) UA102069C2 (uk)

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