KR20090025187A - 의약 조성물 - Google Patents

의약 조성물 Download PDF

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Publication number
KR20090025187A
KR20090025187A KR1020087025510A KR20087025510A KR20090025187A KR 20090025187 A KR20090025187 A KR 20090025187A KR 1020087025510 A KR1020087025510 A KR 1020087025510A KR 20087025510 A KR20087025510 A KR 20087025510A KR 20090025187 A KR20090025187 A KR 20090025187A
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KR
South Korea
Prior art keywords
solvent
solid dispersion
polymer
mixture
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1020087025510A
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English (en)
Korean (ko)
Inventor
케빈 존 비트토프
제프리 피. 캣스트라
필립 가스파
Original Assignee
버텍스 파마슈티칼스 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 버텍스 파마슈티칼스 인코포레이티드 filed Critical 버텍스 파마슈티칼스 인코포레이티드
Publication of KR20090025187A publication Critical patent/KR20090025187A/ko
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020087025510A 2006-03-20 2007-03-19 의약 조성물 Abandoned KR20090025187A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78427506P 2006-03-20 2006-03-20
US60/784,275 2006-03-20
US87169206P 2006-12-22 2006-12-22
US60/871,692 2006-12-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020147022986A Division KR20140107691A (ko) 2006-03-20 2007-03-19 의약 조성물

Publications (1)

Publication Number Publication Date
KR20090025187A true KR20090025187A (ko) 2009-03-10

Family

ID=38523222

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020087025510A Abandoned KR20090025187A (ko) 2006-03-20 2007-03-19 의약 조성물
KR1020147022986A Ceased KR20140107691A (ko) 2006-03-20 2007-03-19 의약 조성물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020147022986A Ceased KR20140107691A (ko) 2006-03-20 2007-03-19 의약 조성물

Country Status (22)

Country Link
US (3) US20070218012A1 (https=)
EP (1) EP2001497A4 (https=)
JP (2) JP2009530416A (https=)
KR (2) KR20090025187A (https=)
CN (1) CN103272234A (https=)
AR (1) AR063468A1 (https=)
AU (2) AU2007226984B2 (https=)
BR (1) BRPI0708957A2 (https=)
CA (1) CA2646335A1 (https=)
EA (1) EA018811B1 (https=)
EC (1) ECSP088759A (https=)
GE (1) GEP20125378B (https=)
IL (1) IL194176A (https=)
MX (1) MX2008011976A (https=)
NO (1) NO20084334L (https=)
NZ (1) NZ571934A (https=)
PE (1) PE20080170A1 (https=)
RS (1) RS20090406A (https=)
SG (1) SG170087A1 (https=)
TW (2) TW201414469A (https=)
UY (1) UY30225A1 (https=)
WO (1) WO2007109605A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013089479A1 (ko) * 2011-12-15 2013-06-20 주식회사 삼양바이오팜 세레콕시브 함유 고체분산체 및 그 제조방법
WO2015147366A1 (ko) * 2014-03-28 2015-10-01 주식회사 일화 세레콕시브 고체분산체 및 그 제조방법

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USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
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US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
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Publication number Priority date Publication date Assignee Title
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WO2015147366A1 (ko) * 2014-03-28 2015-10-01 주식회사 일화 세레콕시브 고체분산체 및 그 제조방법

Also Published As

Publication number Publication date
TW201414469A (zh) 2014-04-16
WO2007109605A3 (en) 2008-01-03
US20090247468A1 (en) 2009-10-01
SG170087A1 (en) 2011-04-29
EP2001497A4 (en) 2012-11-07
JP2014037435A (ja) 2014-02-27
PE20080170A1 (es) 2008-03-10
UY30225A1 (es) 2007-10-31
WO2007109605A2 (en) 2007-09-27
TW200806280A (en) 2008-02-01
US20070218012A1 (en) 2007-09-20
IL194176A (en) 2013-10-31
RS20090406A (sr) 2010-12-31
ECSP088759A (es) 2008-10-31
TWI428125B (zh) 2014-03-01
CN103272234A (zh) 2013-09-04
US8853152B2 (en) 2014-10-07
EA200802008A1 (ru) 2009-04-28
JP2009530416A (ja) 2009-08-27
AU2013205948A1 (en) 2013-06-06
EA018811B1 (ru) 2013-10-30
BRPI0708957A2 (pt) 2011-06-28
KR20140107691A (ko) 2014-09-04
GEP20125378B (en) 2012-01-10
IL194176A0 (en) 2011-08-01
NO20084334L (no) 2008-11-27
AU2007226984B2 (en) 2013-02-21
MX2008011976A (es) 2009-04-07
EP2001497A2 (en) 2008-12-17
CA2646335A1 (en) 2007-09-27
AU2007226984A1 (en) 2007-09-27
US20140183768A1 (en) 2014-07-03
NZ571934A (en) 2012-05-25
AR063468A1 (es) 2009-01-28

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