KR20080037651A - 히스타민 ｈ３ 길항제로서의 피라졸로 [３,４-ｄ] 아제핀유도체 - Google Patents
히스타민 ｈ３ 길항제로서의 피라졸로 [３,４-ｄ] 아제핀유도체 Download PDFInfo
- Publication number
- KR20080037651A KR20080037651A KR1020087000265A KR20087000265A KR20080037651A KR 20080037651 A KR20080037651 A KR 20080037651A KR 1020087000265 A KR1020087000265 A KR 1020087000265A KR 20087000265 A KR20087000265 A KR 20087000265A KR 20080037651 A KR20080037651 A KR 20080037651A
- Authority
- KR
- South Korea
- Prior art keywords
- mmol
- alkyl
- methanol
- mixture
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 O=*(CCC1)CCN1c1ccccc1 Chemical compound O=*(CCC1)CCN1c1ccccc1 0.000 description 6
- NHLUUDFTIYLGCR-UHFFFAOYSA-N CC(C)N(CCc1c2)CCc1n[n]2-c(cc1)ccc1N(CCC1)C1=O Chemical compound CC(C)N(CCc1c2)CCc1n[n]2-c(cc1)ccc1N(CCC1)C1=O NHLUUDFTIYLGCR-UHFFFAOYSA-N 0.000 description 1
- GMHPWGYTSXHHPI-UHFFFAOYSA-N O=C1CCNCCC1 Chemical compound O=C1CCNCCC1 GMHPWGYTSXHHPI-UHFFFAOYSA-N 0.000 description 1
- PJVRZZUYFFUPHR-UHFFFAOYSA-N O=CC(CCN(CC1)P)=C1Cl Chemical compound O=CC(CCN(CC1)P)=C1Cl PJVRZZUYFFUPHR-UHFFFAOYSA-N 0.000 description 1
- TZYAOUOEZBDAKN-UHFFFAOYSA-N PN1CCc2n[nH]cc2CC1 Chemical compound PN1CCc2n[nH]cc2CC1 TZYAOUOEZBDAKN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0513886.2 | 2005-07-06 | ||
| GBGB0513886.2A GB0513886D0 (en) | 2005-07-06 | 2005-07-06 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20080037651A true KR20080037651A (ko) | 2008-04-30 |
Family
ID=34856781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087000265A Ceased KR20080037651A (ko) | 2005-07-06 | 2006-07-04 | 히스타민 ｈ３ 길항제로서의 피라졸로 [３,４-ｄ] 아제핀유도체 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7888347B2 (enExample) |
| EP (1) | EP1899350B1 (enExample) |
| JP (1) | JP5145218B2 (enExample) |
| KR (1) | KR20080037651A (enExample) |
| CN (1) | CN101258154B (enExample) |
| AT (1) | ATE467636T1 (enExample) |
| AU (1) | AU2006286897A1 (enExample) |
| BR (1) | BRPI0612719A2 (enExample) |
| CA (1) | CA2614232A1 (enExample) |
| CR (1) | CR9622A (enExample) |
| CY (1) | CY1110711T1 (enExample) |
| DE (1) | DE602006014273D1 (enExample) |
| DK (1) | DK1899350T3 (enExample) |
| EA (1) | EA013600B1 (enExample) |
| ES (1) | ES2345841T3 (enExample) |
| GB (1) | GB0513886D0 (enExample) |
| HR (1) | HRP20100401T1 (enExample) |
| IL (1) | IL188184A0 (enExample) |
| MA (1) | MA29623B1 (enExample) |
| MX (1) | MX2008000383A (enExample) |
| NO (1) | NO20080563L (enExample) |
| PL (1) | PL1899350T3 (enExample) |
| PT (1) | PT1899350E (enExample) |
| SI (1) | SI1899350T1 (enExample) |
| UA (1) | UA93047C2 (enExample) |
| WO (1) | WO2007025596A1 (enExample) |
| ZA (1) | ZA200710798B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008016343A (es) | 2006-06-23 | 2009-01-19 | Abbott Lab | Derivados ciclopropil amina como moduladores del receptro de histamina h3. |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| EP2205596A1 (en) | 2007-09-24 | 2010-07-14 | Comentis, Inc. | (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating |
| US9186353B2 (en) * | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| CN102952139B (zh) * | 2011-08-30 | 2016-08-10 | 上海药明康德新药开发有限公司 | 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法 |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| EP2647377A1 (en) | 2012-04-06 | 2013-10-09 | Sanofi | Use of an h3 receptor antagonist for the treatment of alzheimer's disease |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| US9910887B2 (en) * | 2013-04-25 | 2018-03-06 | Facebook, Inc. | Variable search query vertical access |
| SG11201810292YA (en) * | 2016-05-25 | 2018-12-28 | Akarna Therapeutics Ltd | Fused bicyclic compounds for the treatment of disease |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010079778A (ko) * | 1998-09-09 | 2001-08-22 | 이시하라 겐조 | 제초제로 유용한 융합-벤젠 유도체 |
| AU3956900A (en) * | 1999-04-16 | 2000-11-02 | Boehringer Ingelheim International Gmbh | Substituted imidazoles, their preparation and use |
| JP2001220390A (ja) | 2000-02-09 | 2001-08-14 | Yamanouchi Pharmaceut Co Ltd | 縮合ピラゾール誘導体 |
| AU2003229535A1 (en) * | 2002-06-06 | 2003-12-22 | Novo Nordisk A/S | Substituted hexahydropyrrolo(1,2-a)pyrazines, octahydropyrido(1,2-a)pyrazines and decahydropyrazino(1,2-a)azepines |
| US6770597B2 (en) | 2002-07-17 | 2004-08-03 | Ishihara Sangyo Kaisha, Ltd. | Benzohydrazide derivatives as herbicides and desiccant compositions containing them |
| EP1527074A1 (en) | 2002-07-25 | 2005-05-04 | Pharmacia Italia S.p.A. | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| EP1539704A1 (en) * | 2002-08-20 | 2005-06-15 | Eli Lilly And Company | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses |
| GB0224083D0 (en) | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| CA2509413C (en) | 2002-12-20 | 2012-05-01 | Glaxo Group Limited | Benzazepine derivatives for the treatment of neurological disorders |
| CN103788089A (zh) * | 2003-09-17 | 2014-05-14 | 詹森药业有限公司 | 作为血清素受体调节剂的稠合杂环化合物 |
| GB0329214D0 (en) | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
| GB0405628D0 (en) | 2004-03-12 | 2004-04-21 | Glaxo Group Ltd | Novel compounds |
| GB0408083D0 (en) | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
| PE20060302A1 (es) | 2004-06-18 | 2006-04-08 | Glaxo Group Ltd | Derivados de benzazepina como antagonistas del receptor h3 |
| GB0418267D0 (en) | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Novel compounds |
| EP1833796A1 (en) | 2004-12-07 | 2007-09-19 | Glaxo Group Limited | Indenyl derivatives and use thereof for the treatment of neurological disorders |
| ES2321028T3 (es) | 2005-03-14 | 2009-06-01 | Glaxo Group Limited | Derivados de tiazol condensados que tienen afinidad por el receptor h3 de histamina. |
-
2005
- 2005-07-06 GB GBGB0513886.2A patent/GB0513886D0/en not_active Ceased
-
2006
- 2006-07-04 PL PL06818218T patent/PL1899350T3/pl unknown
- 2006-07-04 DE DE602006014273T patent/DE602006014273D1/de active Active
- 2006-07-04 CA CA002614232A patent/CA2614232A1/en not_active Abandoned
- 2006-07-04 ES ES06818218T patent/ES2345841T3/es active Active
- 2006-07-04 BR BRPI0612719-3A patent/BRPI0612719A2/pt not_active IP Right Cessation
- 2006-07-04 AT AT06818218T patent/ATE467636T1/de active
- 2006-07-04 PT PT06818218T patent/PT1899350E/pt unknown
- 2006-07-04 HR HR20100401T patent/HRP20100401T1/hr unknown
- 2006-07-04 WO PCT/EP2006/006613 patent/WO2007025596A1/en not_active Ceased
- 2006-07-04 DK DK06818218.7T patent/DK1899350T3/da active
- 2006-07-04 EP EP06818218A patent/EP1899350B1/en active Active
- 2006-07-04 AU AU2006286897A patent/AU2006286897A1/en not_active Abandoned
- 2006-07-04 MX MX2008000383A patent/MX2008000383A/es active IP Right Grant
- 2006-07-04 EA EA200800264A patent/EA013600B1/ru not_active IP Right Cessation
- 2006-07-04 US US11/994,689 patent/US7888347B2/en not_active Expired - Fee Related
- 2006-07-04 UA UAA200800190A patent/UA93047C2/ru unknown
- 2006-07-04 KR KR1020087000265A patent/KR20080037651A/ko not_active Ceased
- 2006-07-04 SI SI200630733T patent/SI1899350T1/sl unknown
- 2006-07-04 JP JP2008519862A patent/JP5145218B2/ja not_active Expired - Fee Related
- 2006-07-04 CN CN2006800322776A patent/CN101258154B/zh not_active Expired - Fee Related
-
2007
- 2007-12-12 ZA ZA200710798A patent/ZA200710798B/xx unknown
- 2007-12-17 IL IL188184A patent/IL188184A0/en unknown
- 2007-12-20 CR CR9622A patent/CR9622A/es not_active Application Discontinuation
-
2008
- 2008-01-09 MA MA30562A patent/MA29623B1/fr unknown
- 2008-01-30 NO NO20080563A patent/NO20080563L/no not_active Application Discontinuation
-
2010
- 2010-07-29 CY CY20101100713T patent/CY1110711T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0612719A2 (pt) | 2010-11-30 |
| EP1899350B1 (en) | 2010-05-12 |
| PT1899350E (pt) | 2010-07-21 |
| WO2007025596A1 (en) | 2007-03-08 |
| MA29623B1 (fr) | 2008-07-01 |
| EP1899350A1 (en) | 2008-03-19 |
| AU2006286897A1 (en) | 2007-03-08 |
| JP5145218B2 (ja) | 2013-02-13 |
| PL1899350T3 (pl) | 2010-10-29 |
| DE602006014273D1 (de) | 2010-06-24 |
| ATE467636T1 (de) | 2010-05-15 |
| NO20080563L (no) | 2008-02-01 |
| CN101258154B (zh) | 2011-01-19 |
| JP2009500366A (ja) | 2009-01-08 |
| IL188184A0 (en) | 2008-03-20 |
| CY1110711T1 (el) | 2015-06-10 |
| CA2614232A1 (en) | 2007-03-08 |
| US20080176832A1 (en) | 2008-07-24 |
| DK1899350T3 (da) | 2010-09-06 |
| ES2345841T3 (es) | 2010-10-04 |
| GB0513886D0 (en) | 2005-08-10 |
| SI1899350T1 (sl) | 2010-09-30 |
| EA013600B1 (ru) | 2010-06-30 |
| MX2008000383A (es) | 2008-03-07 |
| US7888347B2 (en) | 2011-02-15 |
| HRP20100401T1 (hr) | 2010-09-30 |
| CN101258154A (zh) | 2008-09-03 |
| EA200800264A1 (ru) | 2008-06-30 |
| UA93047C2 (ru) | 2011-01-10 |
| ZA200710798B (en) | 2008-11-26 |
| CR9622A (es) | 2008-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20080104 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20110704 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20121120 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20130520 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20121120 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |