HRP20100401T1 - DERIVATI PIRAZOLO/3,4-d/AZEPINA KAO HISTAMINSKI H3 ANTAGONISTI - Google Patents

DERIVATI PIRAZOLO/3,4-d/AZEPINA KAO HISTAMINSKI H3 ANTAGONISTI Download PDF

Info

Publication number
HRP20100401T1
HRP20100401T1 HR20100401T HRP20100401T HRP20100401T1 HR P20100401 T1 HRP20100401 T1 HR P20100401T1 HR 20100401 T HR20100401 T HR 20100401T HR P20100401 T HRP20100401 T HR P20100401T HR P20100401 T1 HRP20100401 T1 HR P20100401T1
Authority
HR
Croatia
Prior art keywords
alkyl
tetrahydropyrazolo
azepin
compound
phenyl
Prior art date
Application number
HR20100401T
Other languages
English (en)
Croatian (hr)
Inventor
James Bamford Mark
Matthew Wilson David
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of HRP20100401T1 publication Critical patent/HRP20100401T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20100401T 2005-07-06 2006-07-04 DERIVATI PIRAZOLO/3,4-d/AZEPINA KAO HISTAMINSKI H3 ANTAGONISTI HRP20100401T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0513886.2A GB0513886D0 (en) 2005-07-06 2005-07-06 Novel compounds
PCT/EP2006/006613 WO2007025596A1 (en) 2005-07-06 2006-07-04 Pyrazolo [3 , 4-d] azepine derivatives as histamine h3 antagonists

Publications (1)

Publication Number Publication Date
HRP20100401T1 true HRP20100401T1 (hr) 2010-09-30

Family

ID=34856781

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20100401T HRP20100401T1 (hr) 2005-07-06 2006-07-04 DERIVATI PIRAZOLO/3,4-d/AZEPINA KAO HISTAMINSKI H3 ANTAGONISTI

Country Status (27)

Country Link
US (1) US7888347B2 (enExample)
EP (1) EP1899350B1 (enExample)
JP (1) JP5145218B2 (enExample)
KR (1) KR20080037651A (enExample)
CN (1) CN101258154B (enExample)
AT (1) ATE467636T1 (enExample)
AU (1) AU2006286897A1 (enExample)
BR (1) BRPI0612719A2 (enExample)
CA (1) CA2614232A1 (enExample)
CR (1) CR9622A (enExample)
CY (1) CY1110711T1 (enExample)
DE (1) DE602006014273D1 (enExample)
DK (1) DK1899350T3 (enExample)
EA (1) EA013600B1 (enExample)
ES (1) ES2345841T3 (enExample)
GB (1) GB0513886D0 (enExample)
HR (1) HRP20100401T1 (enExample)
IL (1) IL188184A0 (enExample)
MA (1) MA29623B1 (enExample)
MX (1) MX2008000383A (enExample)
NO (1) NO20080563L (enExample)
PL (1) PL1899350T3 (enExample)
PT (1) PT1899350E (enExample)
SI (1) SI1899350T1 (enExample)
UA (1) UA93047C2 (enExample)
WO (1) WO2007025596A1 (enExample)
ZA (1) ZA200710798B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2655604C (en) 2006-06-23 2016-08-09 Abbott Laboratories Cyclopropyl amine derivatives
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
CA2699787A1 (en) 2007-09-24 2009-04-02 Comentis, Inc. (3-hydroxy-4-amino-butan-2-yl)-3-(2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating
US9186353B2 (en) * 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2012037258A1 (en) 2010-09-16 2012-03-22 Abbott Laboratories Processes for preparing 1,2-substituted cyclopropyl derivatives
CN102952139B (zh) * 2011-08-30 2016-08-10 上海药明康德新药开发有限公司 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
EP2647377A1 (en) 2012-04-06 2013-10-09 Sanofi Use of an h3 receptor antagonist for the treatment of alzheimer's disease
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
US9910887B2 (en) * 2013-04-25 2018-03-06 Facebook, Inc. Variable search query vertical access
BR112018074231A2 (pt) * 2016-05-25 2019-03-06 Akarna Therapeutics, Ltd. compostos bicíclicos fundidos para o tratamento de doença

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010079778A (ko) * 1998-09-09 2001-08-22 이시하라 겐조 제초제로 유용한 융합-벤젠 유도체
WO2000063208A1 (en) * 1999-04-16 2000-10-26 Novo Nordisk A/S Substituted imidazoles, their preparation and use
JP2001220390A (ja) 2000-02-09 2001-08-14 Yamanouchi Pharmaceut Co Ltd 縮合ピラゾール誘導体
WO2003104235A1 (en) * 2002-06-06 2003-12-18 Novo Nordisk A/S Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]pyrazines and decahydropyrazino[1,2-a]azepines
US6770597B2 (en) 2002-07-17 2004-08-03 Ishihara Sangyo Kaisha, Ltd. Benzohydrazide derivatives as herbicides and desiccant compositions containing them
EP1527074A1 (en) 2002-07-25 2005-05-04 Pharmacia Italia S.p.A. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
AU2003256793A1 (en) * 2002-08-20 2004-03-11 Eli Lilly And Company Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
GB0224083D0 (en) 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
ATE441417T1 (de) 2002-12-20 2009-09-15 Glaxo Group Ltd Benzoädüazepinderivate für die behandlung von neurologischen krankheiten
DE602004019118D1 (de) * 2003-09-17 2009-03-05 Janssen Pharmaceutica Nv Kondensierte heterocyclische verbindungen als modulatoren des serotoninrezeptors
GB0329214D0 (en) 2003-12-17 2004-01-21 Glaxo Group Ltd Novel compounds
GB0405628D0 (en) 2004-03-12 2004-04-21 Glaxo Group Ltd Novel compounds
GB0408083D0 (en) 2004-04-08 2004-05-12 Glaxo Group Ltd Novel compounds
EP1756094A1 (en) 2004-06-18 2007-02-28 Glaxo Group Limited 3-cycloalkylbenzazepines as histamine h3 antagonists
GB0418267D0 (en) 2004-08-16 2004-09-15 Glaxo Group Ltd Novel compounds
MX2007006754A (es) 2004-12-07 2007-07-09 Glaxo Group Ltd Derivados de indenilo y uso de los mismos para el tratamiento de trastornos neurologicos.
WO2006097691A1 (en) 2005-03-14 2006-09-21 Glaxo Group Limited Fused thiazole derivatives having affinity for the histamine h3 receptor

Also Published As

Publication number Publication date
BRPI0612719A2 (pt) 2010-11-30
EA013600B1 (ru) 2010-06-30
DE602006014273D1 (de) 2010-06-24
SI1899350T1 (sl) 2010-09-30
DK1899350T3 (da) 2010-09-06
CN101258154B (zh) 2011-01-19
AU2006286897A1 (en) 2007-03-08
CA2614232A1 (en) 2007-03-08
PL1899350T3 (pl) 2010-10-29
NO20080563L (no) 2008-02-01
UA93047C2 (ru) 2011-01-10
US20080176832A1 (en) 2008-07-24
JP2009500366A (ja) 2009-01-08
PT1899350E (pt) 2010-07-21
MA29623B1 (fr) 2008-07-01
GB0513886D0 (en) 2005-08-10
EA200800264A1 (ru) 2008-06-30
US7888347B2 (en) 2011-02-15
CN101258154A (zh) 2008-09-03
EP1899350A1 (en) 2008-03-19
ES2345841T3 (es) 2010-10-04
CR9622A (es) 2008-04-10
IL188184A0 (en) 2008-03-20
KR20080037651A (ko) 2008-04-30
WO2007025596A1 (en) 2007-03-08
EP1899350B1 (en) 2010-05-12
ATE467636T1 (de) 2010-05-15
JP5145218B2 (ja) 2013-02-13
CY1110711T1 (el) 2015-06-10
MX2008000383A (es) 2008-03-07
ZA200710798B (en) 2008-11-26

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