ES2345841T3 - Derivados de pirazolo(3,4-d)azepina como antagonistas de histamina h3. - Google Patents

Derivados de pirazolo(3,4-d)azepina como antagonistas de histamina h3. Download PDF

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Publication number
ES2345841T3
ES2345841T3 ES06818218T ES06818218T ES2345841T3 ES 2345841 T3 ES2345841 T3 ES 2345841T3 ES 06818218 T ES06818218 T ES 06818218T ES 06818218 T ES06818218 T ES 06818218T ES 2345841 T3 ES2345841 T3 ES 2345841T3
Authority
ES
Spain
Prior art keywords
tetrahydropyrazolo
azepin
mmol
phenyl
baselineskip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES06818218T
Other languages
English (en)
Spanish (es)
Inventor
Mark James Bamford
David Matthew Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2345841T3 publication Critical patent/ES2345841T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES06818218T 2005-07-06 2006-07-04 Derivados de pirazolo(3,4-d)azepina como antagonistas de histamina h3. Expired - Lifetime ES2345841T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0513886 2005-07-06
GBGB0513886.2A GB0513886D0 (en) 2005-07-06 2005-07-06 Novel compounds

Publications (1)

Publication Number Publication Date
ES2345841T3 true ES2345841T3 (es) 2010-10-04

Family

ID=34856781

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06818218T Expired - Lifetime ES2345841T3 (es) 2005-07-06 2006-07-04 Derivados de pirazolo(3,4-d)azepina como antagonistas de histamina h3.

Country Status (27)

Country Link
US (1) US7888347B2 (enExample)
EP (1) EP1899350B1 (enExample)
JP (1) JP5145218B2 (enExample)
KR (1) KR20080037651A (enExample)
CN (1) CN101258154B (enExample)
AT (1) ATE467636T1 (enExample)
AU (1) AU2006286897A1 (enExample)
BR (1) BRPI0612719A2 (enExample)
CA (1) CA2614232A1 (enExample)
CR (1) CR9622A (enExample)
CY (1) CY1110711T1 (enExample)
DE (1) DE602006014273D1 (enExample)
DK (1) DK1899350T3 (enExample)
EA (1) EA013600B1 (enExample)
ES (1) ES2345841T3 (enExample)
GB (1) GB0513886D0 (enExample)
HR (1) HRP20100401T1 (enExample)
IL (1) IL188184A0 (enExample)
MA (1) MA29623B1 (enExample)
MX (1) MX2008000383A (enExample)
NO (1) NO20080563L (enExample)
PL (1) PL1899350T3 (enExample)
PT (1) PT1899350E (enExample)
SI (1) SI1899350T1 (enExample)
UA (1) UA93047C2 (enExample)
WO (1) WO2007025596A1 (enExample)
ZA (1) ZA200710798B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2655604C (en) 2006-06-23 2016-08-09 Abbott Laboratories Cyclopropyl amine derivatives
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
CN101868457B (zh) 2007-09-24 2013-02-13 科门蒂斯公司 作为β-分泌酶抑制剂用于治疗的(3-羟基-4-氨基-丁-2-基)-3-(2-噻唑-2-基-吡咯烷-1-羰基)苯甲酰胺衍生物和相关化合物
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
CN102952139B (zh) * 2011-08-30 2016-08-10 上海药明康德新药开发有限公司 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
EP2647377A1 (en) 2012-04-06 2013-10-09 Sanofi Use of an h3 receptor antagonist for the treatment of alzheimer's disease
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
US9910887B2 (en) * 2013-04-25 2018-03-06 Facebook, Inc. Variable search query vertical access
JP2019520335A (ja) * 2016-05-25 2019-07-18 アカーナ・セラピューティクス・リミテッドＡｋａｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｌｔｄ． 疾患治療用の縮合二環式化合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9913503A (pt) * 1998-09-09 2002-01-29 Ishihara Sangyo Kaisha Derivados de benzeno-fundidos úteis como herbicidas
EP1173438A1 (en) * 1999-04-16 2002-01-23 Novo Nordisk A/S Substituted imidazoles, their preparation and use
JP2001220390A (ja) 2000-02-09 2001-08-14 Yamanouchi Pharmaceut Co Ltd 縮合ピラゾール誘導体
AU2003229535A1 (en) * 2002-06-06 2003-12-22 Novo Nordisk A/S Substituted hexahydropyrrolo(1,2-a)pyrazines, octahydropyrido(1,2-a)pyrazines and decahydropyrazino(1,2-a)azepines
US6770597B2 (en) 2002-07-17 2004-08-03 Ishihara Sangyo Kaisha, Ltd. Benzohydrazide derivatives as herbicides and desiccant compositions containing them
MXPA05000945A (es) 2002-07-25 2005-05-16 Pharmacia Italia Spa Biciclo-pirazoles activos como inhibidores de la cinasa, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
AU2003256793A1 (en) * 2002-08-20 2004-03-11 Eli Lilly And Company Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
GB0224083D0 (en) 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
PT1572215E (pt) 2002-12-20 2009-12-09 Glaxo Group Ltd Derivados de benzo[d]azepina para o tratamento de perturbações neurológicas
SG146683A1 (en) * 2003-09-17 2008-10-30 Janssen Pharmaceutica Nv Fused heterocyclic compounds as serotonin receptor modulators
GB0329214D0 (en) 2003-12-17 2004-01-21 Glaxo Group Ltd Novel compounds
GB0405628D0 (en) 2004-03-12 2004-04-21 Glaxo Group Ltd Novel compounds
GB0408083D0 (en) 2004-04-08 2004-05-12 Glaxo Group Ltd Novel compounds
TW200611701A (en) 2004-06-18 2006-04-16 Glaxo Group Ltd Novel compounds
GB0418267D0 (en) 2004-08-16 2004-09-15 Glaxo Group Ltd Novel compounds
BRPI0518841A2 (pt) 2004-12-07 2008-12-09 Glaxo Group Ltd derivados de indenila e uso destes para o tratamento de transtornos neurolàgicos
KR20070113225A (ko) 2005-03-14 2007-11-28 글락소 그룹 리미티드 히스타민 ｈ３ 수용체에 대해 친화성을 갖는 융합된 티아졸유도체

Also Published As

Publication number Publication date
CN101258154A (zh) 2008-09-03
HRP20100401T1 (hr) 2010-09-30
EP1899350B1 (en) 2010-05-12
WO2007025596A1 (en) 2007-03-08
CR9622A (es) 2008-04-10
BRPI0612719A2 (pt) 2010-11-30
EA200800264A1 (ru) 2008-06-30
UA93047C2 (ru) 2011-01-10
JP2009500366A (ja) 2009-01-08
MX2008000383A (es) 2008-03-07
AU2006286897A1 (en) 2007-03-08
PT1899350E (pt) 2010-07-21
NO20080563L (no) 2008-02-01
MA29623B1 (fr) 2008-07-01
CN101258154B (zh) 2011-01-19
ATE467636T1 (de) 2010-05-15
SI1899350T1 (sl) 2010-09-30
PL1899350T3 (pl) 2010-10-29
KR20080037651A (ko) 2008-04-30
EA013600B1 (ru) 2010-06-30
EP1899350A1 (en) 2008-03-19
DE602006014273D1 (de) 2010-06-24
DK1899350T3 (da) 2010-09-06
IL188184A0 (en) 2008-03-20
ZA200710798B (en) 2008-11-26
GB0513886D0 (en) 2005-08-10
JP5145218B2 (ja) 2013-02-13
US20080176832A1 (en) 2008-07-24
US7888347B2 (en) 2011-02-15
CA2614232A1 (en) 2007-03-08
CY1110711T1 (el) 2015-06-10

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