KR20070091607A - 폐쇄성 동맥 질환용의 설폰아미드 주변 치환된바이사이클릭 화합물 - Google Patents
폐쇄성 동맥 질환용의 설폰아미드 주변 치환된바이사이클릭 화합물 Download PDFInfo
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- KR20070091607A KR20070091607A KR1020077010837A KR20077010837A KR20070091607A KR 20070091607 A KR20070091607 A KR 20070091607A KR 1020077010837 A KR1020077010837 A KR 1020077010837A KR 20077010837 A KR20077010837 A KR 20077010837A KR 20070091607 A KR20070091607 A KR 20070091607A
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- 0 C*c1c[n](C)c2c(C)cccc12 Chemical compound C*c1c[n](C)c2c(C)cccc12 0.000 description 3
- CRGREZDPYNLXTC-UHFFFAOYSA-N CC(c(cc(cc1C)F)c1N1C)C1=O Chemical compound CC(c(cc(cc1C)F)c1N1C)C1=O CRGREZDPYNLXTC-UHFFFAOYSA-N 0.000 description 1
- QXSGPVUSUQURNO-UHFFFAOYSA-N CC(c(cccc1C)c1N1C)C1=O Chemical compound CC(c(cccc1C)c1N1C)C1=O QXSGPVUSUQURNO-UHFFFAOYSA-N 0.000 description 1
- GEWHFKGRFGCFEE-AATRIKPKSA-N COC(/C=C/c(cccc1C23OCCO2)c1NC3=O)=O Chemical compound COC(/C=C/c(cccc1C23OCCO2)c1NC3=O)=O GEWHFKGRFGCFEE-AATRIKPKSA-N 0.000 description 1
- CHMMLTKWCZEWHS-VAWYXSNFSA-N COC(/C=C/c1cccc(C23OCCO2)c1N(Cc1cc(cccc2)c2cc1)C3=O)=O Chemical compound COC(/C=C/c1cccc(C23OCCO2)c1N(Cc1cc(cccc2)c2cc1)C3=O)=O CHMMLTKWCZEWHS-VAWYXSNFSA-N 0.000 description 1
- RZTIAKZTSHAJEI-UHFFFAOYSA-N Cc(cccc1C23OCCO2)c1N(C)C3=O Chemical compound Cc(cccc1C23OCCO2)c1N(C)C3=O RZTIAKZTSHAJEI-UHFFFAOYSA-N 0.000 description 1
- FWIFXCARKJCTGL-UHFFFAOYSA-N Cc1c2[n](C)cc(C=O)c2ccc1 Chemical compound Cc1c2[n](C)cc(C=O)c2ccc1 FWIFXCARKJCTGL-UHFFFAOYSA-N 0.000 description 1
- SEIWGTKMFAPUGC-UHFFFAOYSA-N Cc1c2[n](C)ccc2cc(F)c1 Chemical compound Cc1c2[n](C)ccc2cc(F)c1 SEIWGTKMFAPUGC-UHFFFAOYSA-N 0.000 description 1
- KATIOHPPAYHCKE-UHFFFAOYSA-N Cc1c[n](C)c(c(C)c2)c1cc2F Chemical compound Cc1c[n](C)c(c(C)c2)c1cc2F KATIOHPPAYHCKE-UHFFFAOYSA-N 0.000 description 1
- ODAKCTALIIAAAU-UHFFFAOYSA-N Cc1cccc2c1[n](C)cc2CO Chemical compound Cc1cccc2c1[n](C)cc2CO ODAKCTALIIAAAU-UHFFFAOYSA-N 0.000 description 1
- MLLAKYWBHVJPMX-UHFFFAOYSA-N Cc1cccc2c1[n](C)cc2COC Chemical compound Cc1cccc2c1[n](C)cc2COC MLLAKYWBHVJPMX-UHFFFAOYSA-N 0.000 description 1
- ZOYGCECVAYPVEX-UHFFFAOYSA-N NSc1ccc[s]1 Chemical compound NSc1ccc[s]1 ZOYGCECVAYPVEX-UHFFFAOYSA-N 0.000 description 1
- ZOYGCECVAYPVEX-UHFFFAOYSA-O N[SH+]c1ccc[s]1 Chemical compound N[SH+]c1ccc[s]1 ZOYGCECVAYPVEX-UHFFFAOYSA-O 0.000 description 1
- YMMIUSPIFYMVTO-OUKQBFOZSA-O O=C(/C=C/c1cccc(C23OCCO2)c1N(Cc1ccc(cccc2)c2c1)C3=O)N[SH+]c1ccc[s]1 Chemical compound O=C(/C=C/c1cccc(C23OCCO2)c1N(Cc1ccc(cccc2)c2c1)C3=O)N[SH+]c1ccc[s]1 YMMIUSPIFYMVTO-OUKQBFOZSA-O 0.000 description 1
- MQRSAKACOQMKIC-UHFFFAOYSA-N O=CNCc1cc(cccc2)c2cc1 Chemical compound O=CNCc1cc(cccc2)c2cc1 MQRSAKACOQMKIC-UHFFFAOYSA-N 0.000 description 1
- HUQNLNOGYLYTST-ZHACJKMWSA-N OC(/C=C/c1cccc(C23OCCO2)c1N(Cc1ccc(cccc2)c2c1)C3=O)=O Chemical compound OC(/C=C/c1cccc(C23OCCO2)c1N(Cc1ccc(cccc2)c2c1)C3=O)=O HUQNLNOGYLYTST-ZHACJKMWSA-N 0.000 description 1
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- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| EP1715921B1 (en) * | 2003-09-25 | 2013-04-24 | Abraxis BioScience, Inc. | Tetrahydroindolone derivatives for treatment of neurological conditions |
| DE602005026553D1 (de) * | 2004-10-12 | 2011-04-07 | Decode Genetics Ehf | Peri-substituierte bicyclische sulfonamide gegen arterielle verschlusskrankheit |
| CN101076531A (zh) * | 2004-10-12 | 2007-11-21 | 解码遗传学公司 | 用于阻塞性血管疾病的羧酸迫位取代的双环化合物 |
| TW200740435A (en) * | 2005-08-10 | 2007-11-01 | Takeda Pharmaceuticals Co | Therapeutic agent for diabetes |
| US20080125477A1 (en) * | 2006-05-16 | 2008-05-29 | Decode Genetics, Ehf. | 7-(acryloyl) indole compositions and methods of making and using same |
| CA2652152A1 (en) * | 2006-05-16 | 2007-11-29 | Decode Genetics Ehf | Process for preparing 7-(acryloyl)indoles |
| WO2007143825A1 (en) * | 2006-06-12 | 2007-12-21 | Merck Frosst Canada Ltd. | Indoline amide derivatives as ep4 receptor ligands |
| WO2008127274A2 (en) * | 2006-09-22 | 2008-10-23 | Ptc Therapeutics, Inc. | Heterocyclic inhibitors of bacterial peptidyl trna hydrolase and uses thereof |
| TW200843739A (en) * | 2007-03-30 | 2008-11-16 | Shionogi & Co | Novel pyrrolinone derivative and composition containing the same |
| EP2219648A4 (en) * | 2007-11-09 | 2010-11-03 | Cenomed Biosciences Llc | TREATMENT OF POSTRAUMATIC STRESS WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS |
| US20090264443A1 (en) * | 2008-04-18 | 2009-10-22 | David Helton | Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds |
| PE20110946A1 (es) * | 2008-11-21 | 2012-01-05 | Iroko Cardio Llc | Metodo para reducir la trombocitopenia y mortalidad asociada a la trombocitopenia |
| AR086411A1 (es) | 2011-05-20 | 2013-12-11 | Nippon Soda Co | Compuesto heterociclico conteniendo nitrogeno y fungicida para el uso en agricultura y jardineria |
| JP5841361B2 (ja) * | 2011-06-29 | 2016-01-13 | 壽製薬株式会社 | 三環性化合物及びそれを含有する医薬組成物 |
| WO2014005274A1 (zh) * | 2012-07-03 | 2014-01-09 | 海南卫康制药(潜山)有限公司 | 多取代的8-氮杂环【3.2.1】辛烷化合物 |
| BR112018007664B1 (pt) | 2015-10-16 | 2023-12-19 | Eisai R&D Management Co., Ltd | Compostos antagonistas de ep4, composição compreendendo o composto e uso dos mesmos para tratar câncer |
| WO2020008317A1 (en) * | 2018-07-03 | 2020-01-09 | Janssen Pharmaceutica Nv | Acylsufonamide compounds useful as ep3 receptor antagonists |
| CN112552450A (zh) * | 2019-09-10 | 2021-03-26 | 天津大学 | 一种单离子交替共聚物锂盐及其制备方法 |
| WO2024206284A2 (en) * | 2023-03-27 | 2024-10-03 | Rutgers, The State University Of New Jersey | Therapeutic compounds |
| CN119100992B (zh) * | 2023-06-02 | 2025-09-16 | 帕潘纳(北京)科技有限公司 | 一种特戈拉赞中间体及其衍生物的制备方法 |
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| JPS5030632B2 (enExample) * | 1971-11-29 | 1975-10-02 | ||
| DK151884C (da) * | 1979-03-07 | 1988-06-13 | Pfizer | Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf |
| GB8927981D0 (en) * | 1989-12-11 | 1990-02-14 | Ici Plc | Carbamoyl derivative |
| US5545644A (en) * | 1990-10-15 | 1996-08-13 | Pfizer Inc. | Indole derivatives |
| EP0511477B1 (en) * | 1991-03-11 | 1996-07-10 | Kyowa Hakko Kogyo Co., Ltd. | Indole derivatives |
| GB9122590D0 (en) * | 1991-10-24 | 1991-12-04 | Lilly Industries Ltd | Pharmaceutical compounds |
| JPH06297860A (ja) * | 1993-04-14 | 1994-10-25 | New Oji Paper Co Ltd | 感熱記録体 |
| GB9412719D0 (en) * | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
| WO1996010569A1 (en) * | 1994-09-30 | 1996-04-11 | Nippon Chemiphar Co., Ltd. | Quinoline derivative |
| EP0845451A4 (en) * | 1995-07-26 | 1999-10-13 | Ono Pharmaceutical Co | NAPHTHYLOXYACETIC ACID DERIVATIVES AND MEDICINAL PRODUCTS INTEGRATING THESE DERIVATIVES AS ACTIVE INGREDIENTS |
| WO1997024334A1 (en) | 1995-12-28 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| CN1209809A (zh) * | 1996-01-22 | 1999-03-03 | 藤泽药品工业株式会社 | 新化合物 |
| JP4373497B2 (ja) * | 1996-06-19 | 2009-11-25 | ローン−プーラン・ロレ・リミテツド | 置換されたアザビシクロ化合物、ならびにtnfおよびサイクリックampホスホジエステラーゼ産生の阻害剤としてのそれらの使用 |
| ZA984040B (en) * | 1997-05-15 | 1998-11-20 | Ono Pharmaceutical Co | Benzenesulfonamide compounds |
| AU745081B2 (en) * | 1997-06-27 | 2002-03-14 | Fujisawa Pharmaceutical Co., Ltd. | Sulfonamide compounds and medicinal use thereof |
| JP3256513B2 (ja) * | 1998-02-11 | 2002-02-12 | ファイザー製薬株式会社 | ベンゾイミダゾールシクロオキシゲナーゼ−2阻害剤 |
| US6242493B1 (en) * | 1998-03-13 | 2001-06-05 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
| EP1123091A1 (en) * | 1998-10-23 | 2001-08-16 | Merck Frosst Canada & Co. | Combination product comprising an e-type prostaglandin ligand and a cox-2 selective inhibitor and methods of use |
| US6348032B1 (en) * | 1998-11-23 | 2002-02-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with benzimidazole derivatives |
| EP1312601A4 (en) * | 2000-08-22 | 2005-09-21 | Ono Pharmaceutical Co | CARBOXYLENE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICAMENTS CONTAINING THEM AS AN ACTIVE SUBSTANCE |
| TWI314457B (enExample) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| CN101284773A (zh) * | 2001-08-09 | 2008-10-15 | 小野药品工业株式会社 | 羧酸衍生物及以它为活性成分的药剂 |
| DE602005026553D1 (de) * | 2004-10-12 | 2011-04-07 | Decode Genetics Ehf | Peri-substituierte bicyclische sulfonamide gegen arterielle verschlusskrankheit |
| US20080125477A1 (en) * | 2006-05-16 | 2008-05-29 | Decode Genetics, Ehf. | 7-(acryloyl) indole compositions and methods of making and using same |
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2005
- 2005-06-27 DE DE602005026553T patent/DE602005026553D1/de not_active Expired - Lifetime
- 2005-06-27 CN CNA2005800426037A patent/CN101142184A/zh active Pending
- 2005-06-27 RU RU2007115410/04A patent/RU2403240C2/ru not_active IP Right Cessation
- 2005-06-27 NZ NZ554491A patent/NZ554491A/en not_active IP Right Cessation
- 2005-06-27 CA CA002583667A patent/CA2583667A1/en not_active Abandoned
- 2005-06-27 KR KR1020077010837A patent/KR20070091607A/ko not_active Ceased
- 2005-06-27 MX MX2007004525A patent/MX2007004525A/es active IP Right Grant
- 2005-06-27 BR BRPI0516003-0A patent/BRPI0516003A/pt not_active IP Right Cessation
- 2005-06-27 EP EP05769472A patent/EP1812388B1/en not_active Expired - Lifetime
- 2005-06-27 WO PCT/US2005/023009 patent/WO2006044000A1/en not_active Ceased
- 2005-06-27 JP JP2007536680A patent/JP2008515971A/ja active Pending
- 2005-06-27 US US11/169,161 patent/US7598397B2/en not_active Expired - Fee Related
- 2005-06-27 AT AT05769472T patent/ATE499344T1/de not_active IP Right Cessation
- 2005-06-27 AU AU2005296305A patent/AU2005296305A1/en not_active Abandoned
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2007
- 2007-04-11 IL IL182488A patent/IL182488A0/en unknown
- 2007-05-02 NO NO20072288A patent/NO20072288L/no not_active Application Discontinuation
-
2009
- 2009-08-03 US US12/534,390 patent/US20090291948A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2403240C2 (ru) | 2010-11-10 |
| NZ554491A (en) | 2009-07-31 |
| DE602005026553D1 (de) | 2011-04-07 |
| EP1812388A1 (en) | 2007-08-01 |
| CN101142184A (zh) | 2008-03-12 |
| JP2008515971A (ja) | 2008-05-15 |
| IL182488A0 (en) | 2007-09-20 |
| WO2006044000A1 (en) | 2006-04-27 |
| ATE499344T1 (de) | 2011-03-15 |
| US20090291948A1 (en) | 2009-11-26 |
| CA2583667A1 (en) | 2006-04-27 |
| EP1812388B1 (en) | 2011-02-23 |
| NO20072288L (no) | 2007-06-25 |
| RU2007115410A (ru) | 2008-11-10 |
| US20060079520A1 (en) | 2006-04-13 |
| BRPI0516003A (pt) | 2008-04-29 |
| MX2007004525A (es) | 2007-09-19 |
| US7598397B2 (en) | 2009-10-06 |
| AU2005296305A1 (en) | 2006-04-27 |
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