KR20070043036A - ｃＰＬＡ2 저해제로서 유용한 합성 Ｃ―２, Ｃ―３ 치환Ｎ-알킬화 인돌의 제조 방법 - Google Patents

ｃＰＬＡ2 저해제로서 유용한 합성 Ｃ―２, Ｃ―３ 치환Ｎ-알킬화 인돌의 제조 방법 Download PDF

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Publication number
KR20070043036A
KR20070043036A KR1020077005610A KR20077005610A KR20070043036A KR 20070043036 A KR20070043036 A KR 20070043036A KR 1020077005610 A KR1020077005610 A KR 1020077005610A KR 20077005610 A KR20077005610 A KR 20077005610A KR 20070043036 A KR20070043036 A KR 20070043036A
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KR
South Korea
Prior art keywords
formula
compound
alkyl
group
mol
Prior art date
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KR1020077005610A
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English (en)
Korean (ko)
Inventor
에스. 마이칼락 로날드
마흐무트 레벤트
제이. 비버버그 프레데릭
알. 보야지안 아라
파놀릴 라빈드라나쓰
미첼 캔틴
알랜 스톡톤
더블류. 윈클리 마이클
모우스미 고쉬
크리스토프 덴하르트
챨스 귀노소
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와이어쓰
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Publication of KR20070043036A publication Critical patent/KR20070043036A/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020077005610A 2004-08-19 2005-08-18 ｃＰＬＡ2 저해제로서 유용한 합성 Ｃ―２, Ｃ―３ 치환Ｎ-알킬화 인돌의 제조 방법 Ceased KR20070043036A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60312404P 2004-08-19 2004-08-19
US60/603,124 2004-08-19

Publications (1)

Publication Number Publication Date
KR20070043036A true KR20070043036A (ko) 2007-04-24

Family

ID=35219553

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077005610A Ceased KR20070043036A (ko) 2004-08-19 2005-08-18 ｃＰＬＡ2 저해제로서 유용한 합성 Ｃ―２, Ｃ―３ 치환Ｎ-알킬화 인돌의 제조 방법

Country Status (24)

Country Link
US (3) US7582772B2 (https=)
EP (1) EP1778629B1 (https=)
JP (1) JP2008510707A (https=)
KR (1) KR20070043036A (https=)
CN (2) CN101006048B (https=)
AR (1) AR053410A1 (https=)
AT (1) ATE517084T1 (https=)
AU (1) AU2005277392A1 (https=)
BR (1) BRPI0514431A (https=)
CA (1) CA2576008A1 (https=)
CR (1) CR8936A (https=)
EC (1) ECSP077244A (https=)
GT (1) GT200500224A (https=)
HN (1) HN2005000474A (https=)
IL (1) IL181364A0 (https=)
MX (1) MX2007002042A (https=)
NO (1) NO20071253L (https=)
PE (1) PE20060628A1 (https=)
RU (1) RU2401829C2 (https=)
SG (1) SG155214A1 (https=)
SV (1) SV2006002200A (https=)
TW (1) TW200609214A (https=)
UA (1) UA85428C2 (https=)
WO (1) WO2006023611A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US7713964B2 (en) * 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US7342119B2 (en) * 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es) 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
GT200600228A (es) * 2005-05-27 2006-12-26 Inhibidores de la fosfolipasa a2 citosolica
BRPI0718042A2 (pt) * 2006-10-31 2013-11-12 Wyeth Corp Formulações semissólidas de inibidores de enzima fosfolipase
EP2104498A2 (en) * 2006-10-31 2009-09-30 Wyeth Liquid formulations of phospholipase enzyme inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02115157A (ja) * 1988-10-24 1990-04-27 Hokko Chem Ind Co Ltd スルホニルグリシン誘導体および除草剤
ATE440824T1 (de) * 1999-12-09 2009-09-15 Bayer Cropscience Ag Nitro-sulfobenzamide
US7101875B2 (en) * 2001-12-03 2006-09-05 Wyeth Methods for treating arthritic disorders
US7713964B2 (en) * 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US6797708B2 (en) * 2001-12-03 2004-09-28 Wyeth Inhibitors of cytosolic phospholipase A2
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US6984735B2 (en) * 2001-12-03 2006-01-10 Wyeth Process for making an aldehyde
JP4657605B2 (ja) * 2001-12-03 2011-03-23 ワイス・エルエルシー 細胞質内ホスホリパーゼａ２の阻害剤
US6635771B2 (en) * 2001-12-03 2003-10-21 Wyeth N-benzhydryl indole compounds
TW200510305A (en) * 2003-07-25 2005-03-16 Wyeth Corp Process for the preparation of CPLA2 inhibitors
WO2005012235A1 (en) 2003-07-29 2005-02-10 Ciba Specialty Chemicals Holding Inc. 3-aryl-2-cyano-3-hydroxy-acrylic acid derivatives
US7582771B2 (en) * 2003-09-03 2009-09-01 Wyeth Process for the synthesis of cPLA2 inhibitors
US7342119B2 (en) * 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es) * 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles

Also Published As

Publication number Publication date
IL181364A0 (en) 2007-07-04
HN2005000474A (es) 2009-04-07
RU2007105231A (ru) 2008-09-27
US20090306428A1 (en) 2009-12-10
CN101006048A (zh) 2007-07-25
SV2006002200A (es) 2006-05-09
PE20060628A1 (es) 2006-08-14
NO20071253L (no) 2007-05-15
WO2006023611A1 (en) 2006-03-02
US8034960B2 (en) 2011-10-11
TW200609214A (en) 2006-03-16
CN101006048B (zh) 2011-07-06
MX2007002042A (es) 2007-03-29
ECSP077244A (es) 2007-03-29
CA2576008A1 (en) 2006-03-02
RU2401829C2 (ru) 2010-10-20
EP1778629B1 (en) 2011-07-20
CN101830837A (zh) 2010-09-15
JP2008510707A (ja) 2008-04-10
AU2005277392A1 (en) 2006-03-02
US20060041005A1 (en) 2006-02-23
SG155214A1 (en) 2009-09-30
GT200500224A (es) 2006-03-21
BRPI0514431A (pt) 2008-06-10
US7582772B2 (en) 2009-09-01
CR8936A (es) 2007-04-26
AR053410A1 (es) 2007-05-09
ATE517084T1 (de) 2011-08-15
EP1778629A1 (en) 2007-05-02
UA85428C2 (ru) 2009-01-26
US7842837B2 (en) 2010-11-30
US20110054189A1 (en) 2011-03-03

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