KR20060098368A - 항암제로서의 6-[(치환된)페닐]트리아졸로피리미딘 - Google Patents

항암제로서의 6-[(치환된)페닐]트리아졸로피리미딘 Download PDF

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Publication number
KR20060098368A
KR20060098368A KR1020067005785A KR20067005785A KR20060098368A KR 20060098368 A KR20060098368 A KR 20060098368A KR 1020067005785 A KR1020067005785 A KR 1020067005785A KR 20067005785 A KR20067005785 A KR 20067005785A KR 20060098368 A KR20060098368 A KR 20060098368A
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KR
South Korea
Prior art keywords
pyrimidin
compound
chloro
triazolo
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020067005785A
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English (en)
Korean (ko)
Inventor
난 장
세미라미스 에이럴-칼로우스티안
타이 히엡 구엔
옌중 우
웨이 퉁
Original Assignee
와이어쓰 홀딩스 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 와이어쓰 홀딩스 코포레이션 filed Critical 와이어쓰 홀딩스 코포레이션
Publication of KR20060098368A publication Critical patent/KR20060098368A/ko
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020067005785A 2003-09-24 2004-09-17 항암제로서의 6-[(치환된)페닐]트리아졸로피리미딘 Withdrawn KR20060098368A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24
US60/505,544 2003-09-24

Publications (1)

Publication Number Publication Date
KR20060098368A true KR20060098368A (ko) 2006-09-18

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020067005785A Withdrawn KR20060098368A (ko) 2003-09-24 2004-09-17 항암제로서의 6-[(치환된)페닐]트리아졸로피리미딘

Country Status (30)

Country Link
US (1) US7507739B2 (https=)
EP (1) EP1680425B1 (https=)
JP (1) JP2007506744A (https=)
KR (1) KR20060098368A (https=)
CN (1) CN100519559C (https=)
AR (1) AR045810A1 (https=)
AU (1) AU2004276240A1 (https=)
BR (1) BRPI0414700A (https=)
CA (1) CA2539252A1 (https=)
CO (1) CO5690598A2 (https=)
CR (1) CR8288A (https=)
CY (1) CY1106392T1 (https=)
DE (1) DE602004004295T8 (https=)
DK (1) DK1680425T3 (https=)
EC (1) ECSP066458A (https=)
ES (1) ES2279452T3 (https=)
GT (1) GT200400190A (https=)
IL (1) IL174281A0 (https=)
MX (1) MXPA06003206A (https=)
NO (1) NO20061318L (https=)
PA (1) PA8613301A1 (https=)
PE (1) PE20050433A1 (https=)
PL (1) PL1680425T3 (https=)
PT (1) PT1680425E (https=)
RU (1) RU2006107579A (https=)
SA (1) SA04250302A (https=)
SI (1) SI1680425T1 (https=)
TW (1) TW200512211A (https=)
WO (1) WO2005030775A1 (https=)
ZA (1) ZA200602387B (https=)

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US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
GEP20053688B (en) * 2000-06-30 2005-12-12 Wyeth Corp Substituted-Triazolopyrimidines as Anticancer Agents
ES2279452T3 (es) 2003-09-24 2007-08-16 Wyeth Holdings Corporation 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos.
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
MX2007015718A (es) * 2005-06-13 2008-02-21 Wyeth Corp Inhibidor de tubulina y proceso para su preparacion.
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
WO2007000412A1 (de) * 2005-06-27 2007-01-04 Basf Aktiengesellschaft Verfahren zur herstellung von substituierten phenylmalonestern, zwischenverbindungen sowie deren verwendung zur herstellung von 5 , 7-dihydr0xy-6- (2,4, 6-trifluorphenyl) -(1,2 , 4) triazolo (1 , 5-a) pyrimidinen
WO2007075465A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
TW200730530A (en) * 2005-12-16 2007-08-16 Wyeth Corp Lyophilized compositions of a triazolopyrimidine compound
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途
US9649317B2 (en) 2012-09-19 2017-05-16 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
US11623927B2 (en) 2018-03-02 2023-04-11 The Trustees Of The University Of Pennsylvania Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules
JP7646140B2 (ja) * 2020-04-14 2025-03-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 置換された｛１，２，４，｝トリアゾロ｛１，５－ａ｝ピリミジン化合物および微小管の安定化におけるその使用
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用

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IL108731A (en) 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
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US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
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TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
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US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
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US6124301A (en) 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
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US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
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US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US6277856B1 (en) 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
ATE240648T1 (de) 1998-09-25 2003-06-15 Basf Ag Fungizide mischungen
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US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6521628B1 (en) 1999-01-29 2003-02-18 Basf Aktiengesellschaft Fungicidal mixtures
US6699874B2 (en) 1999-09-24 2004-03-02 Basf Aktiengesellschaft Fungicidal mixtures
AU3154601A (en) 1999-11-18 2001-05-30 Basf Aktiengesellschaft Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
GEP20053688B (en) * 2000-06-30 2005-12-12 Wyeth Corp Substituted-Triazolopyrimidines as Anticancer Agents
AU1495802A (en) 2000-08-25 2002-03-04 Basf Ag Fungicidal formulation
US6459602B1 (en) * 2000-10-26 2002-10-01 O2 Micro International Limited DC-to-DC converter with improved transient response
JP2004513170A (ja) 2000-11-13 2004-04-30 ビーエーエスエフ　アクチェンゲゼルシャフト ７−（ｒ）−アミノトリアゾロピリミジン類、それらの製造及び植物病原性真菌を防除するためのそれらの使用
DK1341794T3 (da) 2000-12-06 2004-12-06 Wyeth Corp Fungicide 6-(2-trifluormethyl-phenyl)-triazolopyrimidiner
DE10063115A1 (de) 2000-12-18 2002-06-27 Bayer Ag Triazolopyrimidine
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
PL367107A1 (en) 2001-04-11 2005-02-21 Basf Aktiengesellschaft 5-halogen-6-phenyl-7-fluoroalkylamino-triazolopyrimidines as fungicides
DE10124208A1 (de) 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
WO2003008416A1 (en) 2001-07-18 2003-01-30 Basf Aktiengesellschaft Substituted 6-(2-methoxyphenyl) triazolopyrimides as fungicides
ES2279452T3 (es) 2003-09-24 2007-08-16 Wyeth Holdings Corporation 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos.

Also Published As

Publication number Publication date
PT1680425E (pt) 2007-02-28
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
DK1680425T3 (da) 2007-03-19
US20050090508A1 (en) 2005-04-28
EP1680425B1 (en) 2007-01-10
HK1090374A1 (en) 2006-12-22
IL174281A0 (en) 2006-08-01
PA8613301A1 (es) 2005-11-25
CN1867569A (zh) 2006-11-22
RU2006107579A (ru) 2007-10-27
SI1680425T1 (sl) 2007-04-30
DE602004004295D1 (de) 2007-02-22
DE602004004295T8 (de) 2007-09-20
CN100519559C (zh) 2009-07-29
AR045810A1 (es) 2005-11-16
CA2539252A1 (en) 2005-04-07
PE20050433A1 (es) 2005-07-21
US7507739B2 (en) 2009-03-24
MXPA06003206A (es) 2006-06-23
AU2004276240A1 (en) 2005-04-07
ZA200602387B (en) 2008-11-26
JP2007506744A (ja) 2007-03-22
ECSP066458A (es) 2006-09-18
ES2279452T3 (es) 2007-08-16
CO5690598A2 (es) 2006-10-31
CY1106392T1 (el) 2011-10-12
BRPI0414700A (pt) 2006-11-14
GT200400190A (es) 2005-05-02
DE602004004295T2 (de) 2007-06-06
NO20061318L (no) 2006-04-21
EP1680425A1 (en) 2006-07-19
TW200512211A (en) 2005-04-01
CR8288A (es) 2006-10-04
WO2005030775A1 (en) 2005-04-07

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20060323

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid