PL1680425T3 - 6-[(podstawione)fenylo]triazolopirymidyny jako środki przeciwrakowe - Google Patents

6-[(podstawione)fenylo]triazolopirymidyny jako środki przeciwrakowe

Info

Publication number
PL1680425T3
PL1680425T3 PL04788820T PL04788820T PL1680425T3 PL 1680425 T3 PL1680425 T3 PL 1680425T3 PL 04788820 T PL04788820 T PL 04788820T PL 04788820 T PL04788820 T PL 04788820T PL 1680425 T3 PL1680425 T3 PL 1680425T3
Authority
PL
Poland
Prior art keywords
triazolopyrimidines
phenyl
substituted
anticancer agents
anticancer
Prior art date
Application number
PL04788820T
Other languages
English (en)
Polish (pl)
Inventor
Nan Zhang
Semiramis Ayral-Kaloustian
Thai Hiep Nguyen
Yanzhong Wu
Wei Tong
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PL1680425T3 publication Critical patent/PL1680425T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL04788820T 2003-09-24 2004-09-17 6-[(podstawione)fenylo]triazolopirymidyny jako środki przeciwrakowe PL1680425T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24
EP04788820A EP1680425B1 (en) 2003-09-24 2004-09-17 6- [(substituted)phenyl] triazolopyrimidines as anticancer agents
PCT/US2004/030515 WO2005030775A1 (en) 2003-09-24 2004-09-17 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents

Publications (1)

Publication Number Publication Date
PL1680425T3 true PL1680425T3 (pl) 2007-05-31

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04788820T PL1680425T3 (pl) 2003-09-24 2004-09-17 6-[(podstawione)fenylo]triazolopirymidyny jako środki przeciwrakowe

Country Status (30)

Country Link
US (1) US7507739B2 (https=)
EP (1) EP1680425B1 (https=)
JP (1) JP2007506744A (https=)
KR (1) KR20060098368A (https=)
CN (1) CN100519559C (https=)
AR (1) AR045810A1 (https=)
AU (1) AU2004276240A1 (https=)
BR (1) BRPI0414700A (https=)
CA (1) CA2539252A1 (https=)
CO (1) CO5690598A2 (https=)
CR (1) CR8288A (https=)
CY (1) CY1106392T1 (https=)
DE (1) DE602004004295T8 (https=)
DK (1) DK1680425T3 (https=)
EC (1) ECSP066458A (https=)
ES (1) ES2279452T3 (https=)
GT (1) GT200400190A (https=)
IL (1) IL174281A0 (https=)
MX (1) MXPA06003206A (https=)
NO (1) NO20061318L (https=)
PA (1) PA8613301A1 (https=)
PE (1) PE20050433A1 (https=)
PL (1) PL1680425T3 (https=)
PT (1) PT1680425E (https=)
RU (1) RU2006107579A (https=)
SA (1) SA04250302A (https=)
SI (1) SI1680425T1 (https=)
TW (1) TW200512211A (https=)
WO (1) WO2005030775A1 (https=)
ZA (1) ZA200602387B (https=)

Families Citing this family (15)

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US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
AU2001273062B2 (en) * 2000-06-30 2005-11-24 Wyeth Substituted-triazolopyrimidines as anticancer agents
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
SI1680425T1 (sl) 2003-09-24 2007-04-30 Wyeth Corp 6-((substituirani)fenil)triazolopirimidini kot sredstva proti raku
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
AU2006259663A1 (en) * 2005-06-13 2006-12-28 Wyeth Tubulin inhibitor and process for its preparation
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
CN101208289A (zh) * 2005-06-27 2008-06-25 巴斯福股份公司 生产取代的苯基丙二酸酯中间体化合物的方法及其在生产5,7-二羟基-6-(2,4,6-三氟苯基)[1,2,4]三唑并[1,5-a]嘧啶中的用途
WO2007075465A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
JP2009519952A (ja) * 2005-12-16 2009-05-21 ワイス トリアゾロピリミジン化合物の凍結乾燥組成物
BRPI0807458A2 (pt) * 2007-01-08 2014-06-03 Basf Se Uso de compostos, agente, semente, método para combater fungos nocivos fitopatogênicos, e, composto
EP2903436B1 (en) * 2012-09-19 2019-07-17 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
EP3758696B1 (en) * 2018-03-02 2026-02-25 The Trustees of the University of Pennsylvania [1,2,4]triazolo[1,5-a]pyrimidine compounds and use in stabilizing microtubules
WO2021211408A1 (en) * 2020-04-14 2021-10-21 The Trustees Of The University Of Pennsylvania Substituted {1,2,4,} triazolo{1,5-a} pyrimidine compounds and use in stabilizing microtubules
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用

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US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
JP2794510B2 (ja) * 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108731A (en) * 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
IL108747A (en) * 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) * 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
DK0984919T3 (da) 1997-03-18 2003-05-12 Basf Ag Fremgangsmåde til fremstilling af arylmalonater
US5750766A (en) * 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6117876A (en) * 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) * 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US5994360A (en) * 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US6020338A (en) * 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
HUP0100885A3 (en) 1998-02-11 2002-12-28 American Cyanamid Company Madi Fungicidal 7-alkyl-triazolopyrimidines
US6124301A (en) * 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US5981534A (en) * 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6284762B1 (en) * 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
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US6242451B1 (en) * 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
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JP2002525291A (ja) 1998-09-25 2002-08-13 アメリカン サイアナミツド コンパニー 非水性懸濁液濃縮物
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US5985883A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US5986135A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
US6521628B1 (en) * 1999-01-29 2003-02-18 Basf Aktiengesellschaft Fungicidal mixtures
US6699874B2 (en) * 1999-09-24 2004-03-02 Basf Aktiengesellschaft Fungicidal mixtures
WO2001035738A2 (en) 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) * 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
AU2001273062B2 (en) * 2000-06-30 2005-11-24 Wyeth Substituted-triazolopyrimidines as anticancer agents
ES2223932T3 (es) * 2000-08-25 2005-03-01 Basf Aktiengesellschaft Formulacion fungicida.
US6459602B1 (en) * 2000-10-26 2002-10-01 O2 Micro International Limited DC-to-DC converter with improved transient response
JP2004513170A (ja) 2000-11-13 2004-04-30 ビーエーエスエフ　アクチェンゲゼルシャフト ７−（ｒ）−アミノトリアゾロピリミジン類、それらの製造及び植物病原性真菌を防除するためのそれらの使用
DE60013188T2 (de) 2000-12-06 2004-12-30 Basf Ag Fungiizide 6-(trifluormethyl-phenyl)-triazolpyrimidine
DE10063115A1 (de) * 2000-12-18 2002-06-27 Bayer Ag Triazolopyrimidine
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
CZ295558B6 (cs) 2001-04-11 2005-08-17 Basf Aktiengesellschaft 5-Halogen-6-fenyl-7-fluoralkylamino-triazolopyrimidiny, způsob jejich přípravy a prostředek pro potírání fytopatogenních hub
DE10124208A1 (de) * 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
US7038047B2 (en) 2001-07-18 2006-05-02 Basf Aktiengesellschaft Substituted 6-(2-methoxyphenyl) triazolopyrimides as fungicides
SI1680425T1 (sl) 2003-09-24 2007-04-30 Wyeth Corp 6-((substituirani)fenil)triazolopirimidini kot sredstva proti raku

Also Published As

Publication number Publication date
JP2007506744A (ja) 2007-03-22
DK1680425T3 (da) 2007-03-19
AR045810A1 (es) 2005-11-16
MXPA06003206A (es) 2006-06-23
CN1867569A (zh) 2006-11-22
ES2279452T3 (es) 2007-08-16
WO2005030775A1 (en) 2005-04-07
NO20061318L (no) 2006-04-21
EP1680425B1 (en) 2007-01-10
PA8613301A1 (es) 2005-11-25
DE602004004295T8 (de) 2007-09-20
GT200400190A (es) 2005-05-02
AU2004276240A1 (en) 2005-04-07
CN100519559C (zh) 2009-07-29
TW200512211A (en) 2005-04-01
ZA200602387B (en) 2008-11-26
ECSP066458A (es) 2006-09-18
US20050090508A1 (en) 2005-04-28
CR8288A (es) 2006-10-04
SI1680425T1 (sl) 2007-04-30
CO5690598A2 (es) 2006-10-31
US7507739B2 (en) 2009-03-24
SA04250302A (ar) 2005-12-03
DE602004004295T2 (de) 2007-06-06
RU2006107579A (ru) 2007-10-27
CY1106392T1 (el) 2011-10-12
CA2539252A1 (en) 2005-04-07
KR20060098368A (ko) 2006-09-18
DE602004004295D1 (de) 2007-02-22
PE20050433A1 (es) 2005-07-21
BRPI0414700A (pt) 2006-11-14
PT1680425E (pt) 2007-02-28
IL174281A0 (en) 2006-08-01
HK1090374A1 (en) 2006-12-22
EP1680425A1 (en) 2006-07-19

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