CN100519559C - 作为抗癌剂的6-[(经取代的)苯基]三唑并嘧啶 - Google Patents

作为抗癌剂的6-[(经取代的)苯基]三唑并嘧啶 Download PDF

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Publication number
CN100519559C
CN100519559C CNB2004800302006A CN200480030200A CN100519559C CN 100519559 C CN100519559 C CN 100519559C CN B2004800302006 A CNB2004800302006 A CN B2004800302006A CN 200480030200 A CN200480030200 A CN 200480030200A CN 100519559 C CN100519559 C CN 100519559C
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CN
China
Prior art keywords
triazolo
pyrimidin
chloro
trifluoro
methylethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB2004800302006A
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English (en)
Chinese (zh)
Other versions
CN1867569A (zh
Inventor
张楠
塞米拉米斯·艾拉尔-卡劳斯蒂昂
阮泰协
吴彦中
佟伟
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Wyeth Holdings LLC
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Wyeth Holdings LLC
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Publication date
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Publication of CN1867569A publication Critical patent/CN1867569A/zh
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Publication of CN100519559C publication Critical patent/CN100519559C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB2004800302006A 2003-09-24 2004-09-17 作为抗癌剂的6-[(经取代的)苯基]三唑并嘧啶 Expired - Fee Related CN100519559C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24
US60/505,544 2003-09-24

Publications (2)

Publication Number Publication Date
CN1867569A CN1867569A (zh) 2006-11-22
CN100519559C true CN100519559C (zh) 2009-07-29

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800302006A Expired - Fee Related CN100519559C (zh) 2003-09-24 2004-09-17 作为抗癌剂的6-[(经取代的)苯基]三唑并嘧啶

Country Status (30)

Country Link
US (1) US7507739B2 (https=)
EP (1) EP1680425B1 (https=)
JP (1) JP2007506744A (https=)
KR (1) KR20060098368A (https=)
CN (1) CN100519559C (https=)
AR (1) AR045810A1 (https=)
AU (1) AU2004276240A1 (https=)
BR (1) BRPI0414700A (https=)
CA (1) CA2539252A1 (https=)
CO (1) CO5690598A2 (https=)
CR (1) CR8288A (https=)
CY (1) CY1106392T1 (https=)
DE (1) DE602004004295T8 (https=)
DK (1) DK1680425T3 (https=)
EC (1) ECSP066458A (https=)
ES (1) ES2279452T3 (https=)
GT (1) GT200400190A (https=)
IL (1) IL174281A0 (https=)
MX (1) MXPA06003206A (https=)
NO (1) NO20061318L (https=)
PA (1) PA8613301A1 (https=)
PE (1) PE20050433A1 (https=)
PL (1) PL1680425T3 (https=)
PT (1) PT1680425E (https=)
RU (1) RU2006107579A (https=)
SA (1) SA04250302A (https=)
SI (1) SI1680425T1 (https=)
TW (1) TW200512211A (https=)
WO (1) WO2005030775A1 (https=)
ZA (1) ZA200602387B (https=)

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US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
GEP20053688B (en) * 2000-06-30 2005-12-12 Wyeth Corp Substituted-Triazolopyrimidines as Anticancer Agents
ES2279452T3 (es) 2003-09-24 2007-08-16 Wyeth Holdings Corporation 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos.
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
MX2007015718A (es) * 2005-06-13 2008-02-21 Wyeth Corp Inhibidor de tubulina y proceso para su preparacion.
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
WO2007000412A1 (de) * 2005-06-27 2007-01-04 Basf Aktiengesellschaft Verfahren zur herstellung von substituierten phenylmalonestern, zwischenverbindungen sowie deren verwendung zur herstellung von 5 , 7-dihydr0xy-6- (2,4, 6-trifluorphenyl) -(1,2 , 4) triazolo (1 , 5-a) pyrimidinen
WO2007075465A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
TW200730530A (en) * 2005-12-16 2007-08-16 Wyeth Corp Lyophilized compositions of a triazolopyrimidine compound
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途
US9649317B2 (en) 2012-09-19 2017-05-16 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
US11623927B2 (en) 2018-03-02 2023-04-11 The Trustees Of The University Of Pennsylvania Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules
JP7646140B2 (ja) * 2020-04-14 2025-03-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 置換された｛１，２，４，｝トリアゾロ｛１，５－ａ｝ピリミジン化合物および微小管の安定化におけるその使用
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2002002563A2 (en) * 2000-06-30 2002-01-10 Wyeth Substituted-triazolopyrimidines as anticancer agents

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US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6521628B1 (en) 1999-01-29 2003-02-18 Basf Aktiengesellschaft Fungicidal mixtures
US6699874B2 (en) 1999-09-24 2004-03-02 Basf Aktiengesellschaft Fungicidal mixtures
AU3154601A (en) 1999-11-18 2001-05-30 Basf Aktiengesellschaft Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
AU1495802A (en) 2000-08-25 2002-03-04 Basf Ag Fungicidal formulation
US6459602B1 (en) * 2000-10-26 2002-10-01 O2 Micro International Limited DC-to-DC converter with improved transient response
JP2004513170A (ja) 2000-11-13 2004-04-30 ビーエーエスエフ　アクチェンゲゼルシャフト ７−（ｒ）−アミノトリアゾロピリミジン類、それらの製造及び植物病原性真菌を防除するためのそれらの使用
DK1341794T3 (da) 2000-12-06 2004-12-06 Wyeth Corp Fungicide 6-(2-trifluormethyl-phenyl)-triazolopyrimidiner
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WO2002002563A2 (en) * 2000-06-30 2002-01-10 Wyeth Substituted-triazolopyrimidines as anticancer agents

Also Published As

Publication number Publication date
PT1680425E (pt) 2007-02-28
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
DK1680425T3 (da) 2007-03-19
US20050090508A1 (en) 2005-04-28
EP1680425B1 (en) 2007-01-10
HK1090374A1 (en) 2006-12-22
IL174281A0 (en) 2006-08-01
PA8613301A1 (es) 2005-11-25
CN1867569A (zh) 2006-11-22
RU2006107579A (ru) 2007-10-27
SI1680425T1 (sl) 2007-04-30
DE602004004295D1 (de) 2007-02-22
DE602004004295T8 (de) 2007-09-20
AR045810A1 (es) 2005-11-16
CA2539252A1 (en) 2005-04-07
PE20050433A1 (es) 2005-07-21
US7507739B2 (en) 2009-03-24
MXPA06003206A (es) 2006-06-23
AU2004276240A1 (en) 2005-04-07
ZA200602387B (en) 2008-11-26
JP2007506744A (ja) 2007-03-22
ECSP066458A (es) 2006-09-18
ES2279452T3 (es) 2007-08-16
CO5690598A2 (es) 2006-10-31
KR20060098368A (ko) 2006-09-18
CY1106392T1 (el) 2011-10-12
BRPI0414700A (pt) 2006-11-14
GT200400190A (es) 2005-05-02
DE602004004295T2 (de) 2007-06-06
NO20061318L (no) 2006-04-21
EP1680425A1 (en) 2006-07-19
TW200512211A (en) 2005-04-01
CR8288A (es) 2006-10-04
WO2005030775A1 (en) 2005-04-07

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Granted publication date: 20090729

Termination date: 20091019