DE602004004295T8 - 6-[(Substituiertes)]Triazolopyrimidine als Antikrebsmittel - Google Patents

6-[(Substituiertes)]Triazolopyrimidine als Antikrebsmittel Download PDF

Info

Publication number
DE602004004295T8
DE602004004295T8 DE602004004295T DE602004004295T DE602004004295T8 DE 602004004295 T8 DE602004004295 T8 DE 602004004295T8 DE 602004004295 T DE602004004295 T DE 602004004295T DE 602004004295 T DE602004004295 T DE 602004004295T DE 602004004295 T8 DE602004004295 T8 DE 602004004295T8
Authority
DE
Germany
Prior art keywords
triazolopyrimidines
substituted
anticancer agents
anticancer
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004004295T
Other languages
German (de)
English (en)
Other versions
DE602004004295D1 (de
DE602004004295T2 (de
Inventor
Nan Bayside ZHANG
Semiramis Tarrytown AYRAL-KALOUSTIAN
Hiep Thai Fair Lawn NGUYEN
Yanzhong Bronx WU
Wei Suffern TONG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Wyeth LLC
Original Assignee
Wyeth Holdings LLC
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Holdings LLC, Wyeth LLC filed Critical Wyeth Holdings LLC
Publication of DE602004004295D1 publication Critical patent/DE602004004295D1/de
Application granted granted Critical
Publication of DE602004004295T2 publication Critical patent/DE602004004295T2/de
Publication of DE602004004295T8 publication Critical patent/DE602004004295T8/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602004004295T 2003-09-24 2004-09-17 6-[(Substituiertes)]Triazolopyrimidine als Antikrebsmittel Active DE602004004295T8 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24
US505544P 2003-09-24
PCT/US2004/030515 WO2005030775A1 (en) 2003-09-24 2004-09-17 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents

Publications (3)

Publication Number Publication Date
DE602004004295D1 DE602004004295D1 (de) 2007-02-22
DE602004004295T2 DE602004004295T2 (de) 2007-06-06
DE602004004295T8 true DE602004004295T8 (de) 2007-09-20

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004004295T Active DE602004004295T8 (de) 2003-09-24 2004-09-17 6-[(Substituiertes)]Triazolopyrimidine als Antikrebsmittel

Country Status (30)

Country Link
US (1) US7507739B2 (https=)
EP (1) EP1680425B1 (https=)
JP (1) JP2007506744A (https=)
KR (1) KR20060098368A (https=)
CN (1) CN100519559C (https=)
AR (1) AR045810A1 (https=)
AU (1) AU2004276240A1 (https=)
BR (1) BRPI0414700A (https=)
CA (1) CA2539252A1 (https=)
CO (1) CO5690598A2 (https=)
CR (1) CR8288A (https=)
CY (1) CY1106392T1 (https=)
DE (1) DE602004004295T8 (https=)
DK (1) DK1680425T3 (https=)
EC (1) ECSP066458A (https=)
ES (1) ES2279452T3 (https=)
GT (1) GT200400190A (https=)
IL (1) IL174281A0 (https=)
MX (1) MXPA06003206A (https=)
NO (1) NO20061318L (https=)
PA (1) PA8613301A1 (https=)
PE (1) PE20050433A1 (https=)
PL (1) PL1680425T3 (https=)
PT (1) PT1680425E (https=)
RU (1) RU2006107579A (https=)
SA (1) SA04250302A (https=)
SI (1) SI1680425T1 (https=)
TW (1) TW200512211A (https=)
WO (1) WO2005030775A1 (https=)
ZA (1) ZA200602387B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
GEP20053688B (en) * 2000-06-30 2005-12-12 Wyeth Corp Substituted-Triazolopyrimidines as Anticancer Agents
ES2279452T3 (es) 2003-09-24 2007-08-16 Wyeth Holdings Corporation 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos.
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
MX2007015718A (es) * 2005-06-13 2008-02-21 Wyeth Corp Inhibidor de tubulina y proceso para su preparacion.
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
WO2007000412A1 (de) * 2005-06-27 2007-01-04 Basf Aktiengesellschaft Verfahren zur herstellung von substituierten phenylmalonestern, zwischenverbindungen sowie deren verwendung zur herstellung von 5 , 7-dihydr0xy-6- (2,4, 6-trifluorphenyl) -(1,2 , 4) triazolo (1 , 5-a) pyrimidinen
WO2007075465A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
TW200730530A (en) * 2005-12-16 2007-08-16 Wyeth Corp Lyophilized compositions of a triazolopyrimidine compound
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途
US9649317B2 (en) 2012-09-19 2017-05-16 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
US11623927B2 (en) 2018-03-02 2023-04-11 The Trustees Of The University Of Pennsylvania Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules
JP7646140B2 (ja) * 2020-04-14 2025-03-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 置換された｛１，２，４，｝トリアゾロ｛１，５－ａ｝ピリミジン化合物および微小管の安定化におけるその使用
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW224044B (https=) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108731A (en) 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
EP0984919B1 (en) 1997-03-18 2003-01-22 Basf Aktiengesellschaft Process for the preparation of arylmalonates
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6255309B1 (en) 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
NZ506247A (en) 1998-02-11 2003-03-28 American Cyanamid Co Fungicidal 7-(alkyl, alkenyl, alkadienyl, cycloalkyl, cycloalkenyl or aryl)-[1,2,4]triazolo[1,5-a]pyrimidines
US6124301A (en) 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6284762B1 (en) 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
DE69926119T2 (de) 1998-03-23 2005-12-29 Basf Ag Fungizide 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidine
US6117865A (en) 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6268371B1 (en) 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US6277856B1 (en) 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
ATE240648T1 (de) 1998-09-25 2003-06-15 Basf Ag Fungizide mischungen
SK3662001A3 (en) 1998-09-25 2001-11-06 Basf Ag Non-aqueous suspension concentrate
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6521628B1 (en) 1999-01-29 2003-02-18 Basf Aktiengesellschaft Fungicidal mixtures
US6699874B2 (en) 1999-09-24 2004-03-02 Basf Aktiengesellschaft Fungicidal mixtures
AU3154601A (en) 1999-11-18 2001-05-30 Basf Aktiengesellschaft Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
GEP20053688B (en) * 2000-06-30 2005-12-12 Wyeth Corp Substituted-Triazolopyrimidines as Anticancer Agents
AU1495802A (en) 2000-08-25 2002-03-04 Basf Ag Fungicidal formulation
US6459602B1 (en) * 2000-10-26 2002-10-01 O2 Micro International Limited DC-to-DC converter with improved transient response
JP2004513170A (ja) 2000-11-13 2004-04-30 ビーエーエスエフ　アクチェンゲゼルシャフト ７−（ｒ）−アミノトリアゾロピリミジン類、それらの製造及び植物病原性真菌を防除するためのそれらの使用
DK1341794T3 (da) 2000-12-06 2004-12-06 Wyeth Corp Fungicide 6-(2-trifluormethyl-phenyl)-triazolopyrimidiner
DE10063115A1 (de) 2000-12-18 2002-06-27 Bayer Ag Triazolopyrimidine
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
PL367107A1 (en) 2001-04-11 2005-02-21 Basf Aktiengesellschaft 5-halogen-6-phenyl-7-fluoroalkylamino-triazolopyrimidines as fungicides
DE10124208A1 (de) 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
WO2003008416A1 (en) 2001-07-18 2003-01-30 Basf Aktiengesellschaft Substituted 6-(2-methoxyphenyl) triazolopyrimides as fungicides
ES2279452T3 (es) 2003-09-24 2007-08-16 Wyeth Holdings Corporation 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos.

Also Published As

Publication number Publication date
PT1680425E (pt) 2007-02-28
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
DK1680425T3 (da) 2007-03-19
US20050090508A1 (en) 2005-04-28
EP1680425B1 (en) 2007-01-10
HK1090374A1 (en) 2006-12-22
IL174281A0 (en) 2006-08-01
PA8613301A1 (es) 2005-11-25
CN1867569A (zh) 2006-11-22
RU2006107579A (ru) 2007-10-27
SI1680425T1 (sl) 2007-04-30
DE602004004295D1 (de) 2007-02-22
CN100519559C (zh) 2009-07-29
AR045810A1 (es) 2005-11-16
CA2539252A1 (en) 2005-04-07
PE20050433A1 (es) 2005-07-21
US7507739B2 (en) 2009-03-24
MXPA06003206A (es) 2006-06-23
AU2004276240A1 (en) 2005-04-07
ZA200602387B (en) 2008-11-26
JP2007506744A (ja) 2007-03-22
ECSP066458A (es) 2006-09-18
ES2279452T3 (es) 2007-08-16
CO5690598A2 (es) 2006-10-31
KR20060098368A (ko) 2006-09-18
CY1106392T1 (el) 2011-10-12
BRPI0414700A (pt) 2006-11-14
GT200400190A (es) 2005-05-02
DE602004004295T2 (de) 2007-06-06
NO20061318L (no) 2006-04-21
EP1680425A1 (en) 2006-07-19
TW200512211A (en) 2005-04-01
CR8288A (es) 2006-10-04
WO2005030775A1 (en) 2005-04-07

Similar Documents

Publication Publication Date Title
NO20053955D0 (no) Pyrazolo [1,5-A] pyrimidinderivater
NO20053748D0 (no) Pyrrolopyridazinderivater.
ATE450528T1 (de) Chinazolinderivate als antitumormittel
DE122012000043I1 (de) Pyrrolo[2,3-B]pyridinderivate als proteinkinaseinhibitoren.
NO20033026D0 (no) Trehjuls kjöretöy
DE50212917D1 (de) Pyrrolopyrimidine als phosphodiesterase-vii-hemmer
DE60314427D1 (de) Pyrazolopyrimidine als hemmstoffe cyclin-abhängiger kinasen
IL177259A0 (en) Heteroaryl -fused pyrazolo derivatives
DE50304983D1 (de) Heteroaryloxy-substituierte phenylaminopyrimidine als rho-kinaseinhibitoren
DE60317077D1 (de) Pyrazolopyrimidine als hemmstoffe cyclin-abhängiger kinasen
DE602004004295T8 (de) 6-[(Substituiertes)]Triazolopyrimidine als Antikrebsmittel
DK1608654T3 (da) 8-substituerede-6, 7, 8, 9-tetrahydropyrimido (1,2- a) pyrimidin-4-on-derivater
DK1761533T3 (da) 1-Aza-bicyclo[3.3.1]nonaner
SMP200800029B (it) 2-ammino-7,8-diidro-6h-pirido[4,3-d]pirimidin-5-oni
ATE433977T1 (de) Substituierte 8-perfluoro-6,7,8,9- tetrahydropyrimido 1,2-a pyrimidin-4-on-derivate
DE502004011106D1 (de) 6-arylmethyl-substituierte pyrazolopyrimidine
ATE413809T1 (de) Substituierte arylpyrazole als parasitizide
ATE432077T1 (de) 5-arylpyrimidine als anti-krebs-mittel
IL172098A0 (en) Triazolopyrimidines
ATE372323T1 (de) Als antivirale mittel geeignete 4- carboxypyrazolderivate
ZA200510276B (en) Triazolopyrimidines
NO20054199D0 (no) 6-substituerte imidazopyraziner
DE602005019719D1 (de) 3-piperidinylisochroman-5-ole als dopaminagonisten
DK1899343T3 (da) Halogenerede pyrazolo[1,5-A]pyrimidiner, fremgangsmåder, anvendelser som GABA-A-receptorligand, sammensætninger og mellemprodukter
SE0300382L (sv) Fordonshjul

Legal Events

Date Code Title Description
8364 No opposition during term of opposition