KR20060091050A - 항균 활성을 갖는 신규 린코마이신 유도체 - Google Patents
항균 활성을 갖는 신규 린코마이신 유도체 Download PDFInfo
- Publication number
- KR20060091050A KR20060091050A KR1020057024291A KR20057024291A KR20060091050A KR 20060091050 A KR20060091050 A KR 20060091050A KR 1020057024291 A KR1020057024291 A KR 1020057024291A KR 20057024291 A KR20057024291 A KR 20057024291A KR 20060091050 A KR20060091050 A KR 20060091050A
- Authority
- KR
- South Korea
- Prior art keywords
- propyl
- tetrahydro
- pyran
- trihydroxy
- carboxylic acid
- Prior art date
Links
- 0 C*(*)C(C1)N(*)CCC1(*)F Chemical compound C*(*)C(C1)N(*)CCC1(*)F 0.000 description 22
- URESCWBVZXFNIH-YBXAARCKSA-N CS[C@H]([C@@H]([C@H]1O)O)O[C@H](CC2CCCC2)[C@@H]1O Chemical compound CS[C@H]([C@@H]([C@H]1O)O)O[C@H](CC2CCCC2)[C@@H]1O URESCWBVZXFNIH-YBXAARCKSA-N 0.000 description 2
- HGKCSODIVQXSDF-UHFFFAOYSA-N CC(C)(C)C(OCC(O1)=C(C)OC1=O)=O Chemical compound CC(C)(C)C(OCC(O1)=C(C)OC1=O)=O HGKCSODIVQXSDF-UHFFFAOYSA-N 0.000 description 1
- HLTIJRLFQJVIAZ-UHFFFAOYSA-N CC(C)(C)CC(O1)=C(C)OC1=O Chemical compound CC(C)(C)CC(O1)=C(C)OC1=O HLTIJRLFQJVIAZ-UHFFFAOYSA-N 0.000 description 1
- BZNVAHMBUXQQQK-DWYQZRHDSA-N CC(C[C@H]([C@@H]1O)OCCC1O)O Chemical compound CC(C[C@H]([C@@H]1O)OCCC1O)O BZNVAHMBUXQQQK-DWYQZRHDSA-N 0.000 description 1
- FDFZZLROGUOSRN-OLZOCXBDSA-N CCC([C@H]1NCC[C@@H](CCCSc2ccc[s]2)C1)=O Chemical compound CCC([C@H]1NCC[C@@H](CCCSc2ccc[s]2)C1)=O FDFZZLROGUOSRN-OLZOCXBDSA-N 0.000 description 1
- FWKVABSODRWXDO-OADOJKOFSA-N CCCCC(C1)CN(C)[C@@H]1C(N[C@H](C(C)C)[C@H]([C@@H]([C@@H]1O)O)O[C@H](CCC)[C@@H]1O)=O Chemical compound CCCCC(C1)CN(C)[C@@H]1C(N[C@H](C(C)C)[C@H]([C@@H]([C@@H]1O)O)O[C@H](CCC)[C@@H]1O)=O FWKVABSODRWXDO-OADOJKOFSA-N 0.000 description 1
- GALHOGYTPCAZHF-VHSXEESVSA-N CCC[C@@]1(C)C[C@@H](C=O)NCC1 Chemical compound CCC[C@@]1(C)C[C@@H](C=O)NCC1 GALHOGYTPCAZHF-VHSXEESVSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
- C07H15/16—Lincomycin; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47950203P | 2003-06-17 | 2003-06-17 | |
| US47929603P | 2003-06-17 | 2003-06-17 | |
| US60/479,296 | 2003-06-17 | ||
| US60/479,502 | 2003-06-17 | ||
| US10/642,807 US7164011B2 (en) | 2002-08-15 | 2003-08-15 | Lincomycin derivatives possessing antibacterial activity |
| US10/642,807 | 2003-08-15 | ||
| US10/777,455 | 2004-02-11 | ||
| US10/777,455 US7199105B2 (en) | 2002-08-15 | 2004-02-11 | Lincomycin derivatives possessing antibacterial activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020097018355A Division KR20090099594A (ko) | 2001-06-20 | 2004-06-17 | 항균 활성을 갖는 신규 린코마이신 유도체 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20060091050A true KR20060091050A (ko) | 2006-08-17 |
Family
ID=40203032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057024291A KR20060091050A (ko) | 2003-06-17 | 2004-06-17 | 항균 활성을 갖는 신규 린코마이신 유도체 |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1644393A2 (ja) |
| JP (1) | JP2007516172A (ja) |
| KR (1) | KR20060091050A (ja) |
| AU (1) | AU2004261550A1 (ja) |
| BR (1) | BRPI0411534A (ja) |
| CA (1) | CA2528592A1 (ja) |
| EC (1) | ECSP056233A (ja) |
| GE (1) | GEP20084437B (ja) |
| HK (1) | HK1090061A1 (ja) |
| IL (1) | IL172183A0 (ja) |
| IS (1) | IS8147A (ja) |
| MA (1) | MA27860A1 (ja) |
| MX (1) | MXPA05013915A (ja) |
| NO (1) | NO20055893L (ja) |
| OA (1) | OA13179A (ja) |
| RS (1) | RS20050931A (ja) |
| WO (1) | WO2005012320A2 (ja) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7199105B2 (en) | 2002-08-15 | 2007-04-03 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antibacterial activity |
| JP2006504673A (ja) | 2002-08-15 | 2006-02-09 | バイクロン ファーマシューティカルズ， インコーポレイテッド | 抗菌活性を有するリンコマイシン誘導体 |
| WO2005007665A2 (en) * | 2003-06-17 | 2005-01-27 | Vicuron Pharmaceuticals Inc. | Lincomycin derivatives possessing antibacterial activity |
| US7256177B2 (en) | 2003-06-17 | 2007-08-14 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antibacterial activity |
| US7199106B2 (en) | 2003-06-17 | 2007-04-03 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antimicrobial activity |
| US7361743B2 (en) * | 2004-02-11 | 2008-04-22 | Pfizer Inc | Lincomycin derivatives possessing antibacterial activity |
| WO2007027599A1 (en) * | 2005-08-31 | 2007-03-08 | Wyeth | 9-aminocarbonylsubstituted derivatives of glycylcyclines |
| EP1970377A4 (en) | 2005-12-09 | 2013-02-27 | Meiji Seika Kaisha | LINCOMYCIN DERIVATIVE AND ANTIBACTERIAL AGENT CONTAINING THIS AS AN ACTIVE SUBSTANCE |
| WO2008146917A1 (ja) * | 2007-05-31 | 2008-12-04 | Meiji Seika Kaisha, Ltd. | リンコマイシン誘導体及びこれを有効成分とする抗菌剤 |
| EP2166015A4 (en) | 2007-05-31 | 2012-09-05 | Meiji Seika Kaisha | LINCOSAMIDE DERIVATIVE AND ANTIBACTERIAL AGENT CONTAINING ACTIVE SUBSTANCE |
| US8822679B2 (en) * | 2011-06-24 | 2014-09-02 | California Institute Of Technology | Quaternary heteroatom containing compounds |
| US20130267699A1 (en) | 2011-06-24 | 2013-10-10 | California Institute Of Technology | Quaternary heteroatom containing compounds |
| US10421696B2 (en) | 2014-12-18 | 2019-09-24 | California Institute Of Technology | Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation |
| CA2981041C (en) | 2015-03-27 | 2023-09-05 | California Institute Of Technology | Asymmetric catalytic decarboxylative alkyl alkylation using low catalyst concentrations and a robust precatalyst |
| EP3426391A4 (en) | 2016-03-11 | 2019-08-28 | California Institute of Technology | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMEN |
| EP3480190B1 (en) | 2017-11-01 | 2023-01-04 | California Institute of Technology | Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols |
| US11214568B2 (en) | 2018-10-18 | 2022-01-04 | California Institute Of Technology | Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same |
| CN110357839A (zh) * | 2019-08-29 | 2019-10-22 | 重庆经致制药技术开发有限公司 | 布瓦西坦手性中间体的制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL128232C (ja) * | 1964-04-13 | |||
| US3268556A (en) * | 1964-04-13 | 1966-08-23 | Upjohn Co | Novel lincomycin derivatives |
| NL146501C (ja) * | 1964-07-01 | |||
| US3282917A (en) * | 1964-08-17 | 1966-11-01 | Upjohn Co | Methyl n-(1-alkyl-4-alkoxy-prolyl)-alpha-thiolincosaminide compounds and process therefor |
| NL140527B (nl) * | 1965-02-08 | 1973-12-17 | Upjohn Co | Werkwijze ter bereiding van aan lincomycine verwante verbindingen. |
| US3496163A (en) * | 1965-02-08 | 1970-02-17 | Upjohn Co | 7-halo-7-deoxylincomycins and process for preparing the same |
| US3555007A (en) * | 1968-07-22 | 1971-01-12 | Upjohn Co | 7-deoxy-7-halo lincomycin d derivatives |
| US3549615A (en) * | 1968-10-17 | 1970-12-22 | Upjohn Co | Lincomycin derivatives and process for producing the same |
| DE2118636A1 (de) * | 1970-04-20 | 1971-11-04 | The Upjohn Co., Kalamazoo, Mich. (V.StA.) | 3-Nucleotide von Lincomycin und deren Analogen, Verfahren zu ihrer Herstellung und ihre Verwendung in therapeutischen Präparaten |
| US3787390A (en) * | 1971-06-23 | 1974-01-22 | Upjohn Co | Analogs of lincomycin and process |
| US3849396A (en) * | 1973-01-08 | 1974-11-19 | Upjohn Co | Lincomycin and clindamycin 1-o-ethers |
| US3923602A (en) * | 1973-10-25 | 1975-12-02 | Upjohn Co | Composition of matter and process |
| JPS5641239A (en) * | 1979-09-13 | 1981-04-17 | Hitachi Cable Ltd | Flame-retardant composition |
| US4278789A (en) * | 1979-11-23 | 1981-07-14 | The Upjohn Company | Lincomycin compounds |
| JP2006504673A (ja) * | 2002-08-15 | 2006-02-09 | バイクロン ファーマシューティカルズ， インコーポレイテッド | 抗菌活性を有するリンコマイシン誘導体 |
| BRPI0411537A (pt) * | 2003-06-17 | 2006-08-01 | Vicuron Pharm Inc | derivados de lincomicina que possuem atividade antibacteriana |
-
2004
- 2004-06-17 BR BRPI0411534-1A patent/BRPI0411534A/pt not_active IP Right Cessation
- 2004-06-17 OA OA1200500364A patent/OA13179A/en unknown
- 2004-06-17 KR KR1020057024291A patent/KR20060091050A/ko active Search and Examination
- 2004-06-17 GE GEAP20049117A patent/GEP20084437B/en unknown
- 2004-06-17 MX MXPA05013915A patent/MXPA05013915A/es unknown
- 2004-06-17 WO PCT/US2004/019689 patent/WO2005012320A2/en active Application Filing
- 2004-06-17 RS YUP-2005/0931A patent/RS20050931A/sr unknown
- 2004-06-17 JP JP2006517464A patent/JP2007516172A/ja active Pending
- 2004-06-17 AU AU2004261550A patent/AU2004261550A1/en not_active Abandoned
- 2004-06-17 EP EP04776816A patent/EP1644393A2/en not_active Withdrawn
- 2004-06-17 CA CA002528592A patent/CA2528592A1/en not_active Abandoned
-
2005
- 2005-11-24 IS IS8147A patent/IS8147A/is unknown
- 2005-11-24 IL IL172183A patent/IL172183A0/en unknown
- 2005-12-12 NO NO20055893A patent/NO20055893L/no not_active Application Discontinuation
- 2005-12-16 EC EC2005006233A patent/ECSP056233A/es unknown
- 2005-12-16 MA MA28672A patent/MA27860A1/fr unknown
-
2006
- 2006-09-21 HK HK06110528.4A patent/HK1090061A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005012320A2 (en) | 2005-02-10 |
| BRPI0411534A (pt) | 2006-08-22 |
| HK1090061A1 (en) | 2006-12-15 |
| JP2007516172A (ja) | 2007-06-21 |
| WO2005012320A3 (en) | 2005-10-20 |
| GEP20084437B (en) | 2008-07-25 |
| ECSP056233A (es) | 2006-04-19 |
| IS8147A (is) | 2005-11-24 |
| OA13179A (en) | 2006-12-13 |
| AU2004261550A1 (en) | 2005-02-10 |
| NO20055893L (no) | 2006-03-14 |
| EP1644393A2 (en) | 2006-04-12 |
| MA27860A1 (fr) | 2006-04-03 |
| CA2528592A1 (en) | 2005-02-10 |
| MXPA05013915A (es) | 2006-07-03 |
| RS20050931A (en) | 2008-04-04 |
| IL172183A0 (en) | 2011-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7361743B2 (en) | Lincomycin derivatives possessing antibacterial activity | |
| KR20060091050A (ko) | 항균 활성을 갖는 신규 린코마이신 유도체 | |
| US6797820B2 (en) | Succinate compounds, compositions and methods of use and preparation | |
| IL166476A (en) | Lincomycin derivatives possessing antibacterial activity | |
| JP2009504631A (ja) | 新規な抗菌剤化合物 | |
| EP1237862A1 (en) | Succinate compounds, compositions and methods of use and preparation | |
| TW201247693A (en) | C-4" position substituted macrolide derivative | |
| WO2007142150A1 (ja) | 新規アミノグリコシド系抗生物質 | |
| US7199106B2 (en) | Lincomycin derivatives possessing antimicrobial activity | |
| US7256177B2 (en) | Lincomycin derivatives possessing antibacterial activity | |
| US20040230046A1 (en) | Lincomycin derivatives possessing antibacterial activity | |
| WO2005007665A2 (en) | Lincomycin derivatives possessing antibacterial activity | |
| KR20090099594A (ko) | 항균 활성을 갖는 신규 린코마이신 유도체 | |
| CN1823083B (zh) | 具备抗微生物活性的林可霉素衍生物 | |
| EP3693374B1 (en) | Novel 2-carboxypenam compound or salt thereof, pharmaceutical composition containing said compound or salt, and application thereof | |
| JP2007528360A (ja) | 抗菌活性を有するリンコマイシン誘導体 | |
| MXPA05014064A (en) | Lincomycin derivatives possessing antibacterial activity | |
| JP2003512472A (ja) | ハイグロマイシンａプロドラッグ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| AMND | Amendment | ||
| E902 | Notification of reason for refusal | ||
| AMND | Amendment | ||
| E902 | Notification of reason for refusal | ||
| AMND | Amendment | ||
| E902 | Notification of reason for refusal | ||
| AMND | Amendment | ||
| E902 | Notification of reason for refusal | ||
| AMND | Amendment | ||
| E601 | Decision to refuse application | ||
| J201 | Request for trial against refusal decision | ||
| A107 | Divisional application of patent | ||
| AMND | Amendment | ||
| B601 | Maintenance of original decision after re-examination before a trial | ||
| J301 | Trial decision |
Free format text: TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20090803 Effective date: 20101030 |