KR20060085682A - 피브레이트 및 스타틴을 함유하는 고형 제제 - Google Patents
피브레이트 및 스타틴을 함유하는 고형 제제 Download PDFInfo
- Publication number
- KR20060085682A KR20060085682A KR1020067006884A KR20067006884A KR20060085682A KR 20060085682 A KR20060085682 A KR 20060085682A KR 1020067006884 A KR1020067006884 A KR 1020067006884A KR 20067006884 A KR20067006884 A KR 20067006884A KR 20060085682 A KR20060085682 A KR 20060085682A
- Authority
- KR
- South Korea
- Prior art keywords
- fenofibrate
- pharmaceutically acceptable
- granule
- solid
- acceptable salt
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200301503 | 2003-10-10 | ||
DKPA200301503 | 2003-10-10 | ||
DKPA200400464 | 2004-03-23 | ||
DKPA200400464 | 2004-03-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20060085682A true KR20060085682A (ko) | 2006-07-27 |
Family
ID=34436500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020067006884A KR20060085682A (ko) | 2003-10-10 | 2004-10-01 | 피브레이트 및 스타틴을 함유하는 고형 제제 |
Country Status (10)
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009142421A2 (ko) * | 2008-05-17 | 2009-11-26 | 한올제약주식회사 | 약제학적 제제 |
WO2012015168A2 (ko) * | 2010-07-28 | 2012-02-02 | 씨제이제일제당 (주) | 로수바스타틴 또는 이의 약학적 허용염을 포함하는 약학 조성물 |
KR102501636B1 (ko) * | 2021-12-07 | 2023-02-21 | 에이스바이오팜 주식회사 | 페노피브린산을 포함하는 경구용 정제 및 이의 제조방법 |
WO2023146320A1 (ko) * | 2022-01-28 | 2023-08-03 | 동광제약 주식회사 | 로수바스타틴 또는 이의 약학적으로 허용되는 염 및 페노피브레이트를 함유하는 캡슐 제제 |
Families Citing this family (47)
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PT1487416E (pt) | 2002-03-26 | 2010-01-25 | Teva Pharma | Micropartículas de fármacos |
WO2006037347A1 (en) * | 2004-10-01 | 2006-04-13 | Lifecycle Pharma A/S | Pharmaceutical compositions comprising fenofibrate and atorvastatin |
JPWO2006011495A1 (ja) * | 2004-07-30 | 2008-05-01 | 興和株式会社 | 高コレステロール血症及び/又は高トリグリセリド血症治療剤 |
KR20070038553A (ko) | 2004-08-06 | 2007-04-10 | 트렌스폼 파마수티컬스 인코퍼레이티드 | 신규한 스타틴 약제학적 조성물 및 관련된 치료방법 |
WO2006037348A1 (en) * | 2004-10-01 | 2006-04-13 | Lifecycle Pharma A/S | Pharmaceutical compositions comprising fenofibrate and a statin |
WO2006037346A1 (en) * | 2004-10-01 | 2006-04-13 | Lifecycle Pharma A/S | Pharmaceutical compositions comprising fenofibrate and simvastatin |
JP2008521878A (ja) * | 2004-12-02 | 2008-06-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 非晶質アトルバスタチンの医薬組成物及びその製造のための方法 |
AU2005330266A1 (en) * | 2005-03-30 | 2006-10-12 | Teva Pharmaceutical Industries Ltd. | Improved formulations of fenofibrate containing menthol or PEG/poloxamer |
BRPI0609497A2 (pt) * | 2005-03-30 | 2010-04-13 | Teva Pharma | formulações aprimoradas de fenofibrato |
EP1707197A1 (en) * | 2005-03-30 | 2006-10-04 | Teva Pharmaceutical Industries Ltd. | Formulations containing fenofibrate and a surfactant mixture |
WO2006119779A2 (en) * | 2005-05-10 | 2006-11-16 | Lifecycle Pharma A/S | A pharmaceutical composition comprising an aldosterone antagonist in form of solid solution |
JP2007008923A (ja) * | 2005-05-31 | 2007-01-18 | Aska Pharmaceutical Co Ltd | フィブラート系薬剤を含有する製剤及びその製造方法 |
JP2009522258A (ja) * | 2005-12-28 | 2009-06-11 | テバ ファーマシューティカル インダストリーズ リミティド | 増大したバイオアベイラビリティを有するフェノフィブラートの医薬製剤 |
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CZ300047B6 (cs) * | 2007-03-02 | 2009-01-21 | Zentiva, A. S. | Farmaceutická kompozice s obsahem úcinné látky atorvastatinu |
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BRPI0816513A2 (pt) * | 2007-10-19 | 2015-03-24 | Purdue Research Foundation | Composição farmacêutica e método para preparar a suspensão sólida |
GR1006173B (el) * | 2007-12-21 | 2008-11-26 | Ανωνυμος Φαρμακευτικη-Χημικη Βιομηχανια Medichromα.Ε. | Χημικη συνθεση του (3r, 5r) - διυδροξυ - 7 - [2-(4-φθοροφαινυλ) - 5 - σοπροπυλ - 3 - φαινυλ - 4 - φαινυλκαρβαμοϋλο - πυρρολυλο - τριενυδρο - επτανοϊκου ασβεστιου, εφαρμογη φαρμακευτικου σκευασματος και παραγωγικη διαδικασια |
WO2009113522A1 (ja) * | 2008-03-11 | 2009-09-17 | あすか製薬株式会社 | 固体分散体とその医薬組成物、並びにそれらの製造方法 |
KR101784647B1 (ko) * | 2008-05-02 | 2017-10-11 | 길리애드 사이언시즈, 인코포레이티드 | 제약 제제의 가공성 향상을 위한 고체 담체 입자의 용도 |
AU2009255333B2 (en) * | 2008-05-30 | 2015-07-09 | Psychogenics, Inc. | Treatment for neurological and mental disorders |
JP5723287B2 (ja) | 2008-12-15 | 2015-05-27 | バナー ライフ サイエンシズ エルエルシー | 非水溶性活性薬剤の放出および吸収を増強するための方法 |
JPWO2010092925A1 (ja) * | 2009-02-12 | 2012-08-16 | あすか製薬株式会社 | 固体分散体とその医薬組成物、並びにそれらの製造方法 |
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RU2547574C2 (ru) * | 2013-07-09 | 2015-04-10 | Общество с ограниченной ответственностью "Трейдсервис" | Лекарственная форма гиполипидемического действия и способ ее изготовления |
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FR2803203B1 (fr) * | 1999-12-31 | 2002-05-10 | Fournier Ind & Sante | Nouvelles formulations galeniques du fenofibrate |
ATE367802T1 (de) * | 2000-09-20 | 2007-08-15 | Jagotec Ag | Verfahren zur sprühtrocknung von zusammensetzungen enthaltend fenofibrat |
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US20030224058A1 (en) * | 2002-05-24 | 2003-12-04 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
JP2002212075A (ja) * | 2001-01-17 | 2002-07-31 | Otsuka Pharmaceut Factory Inc | 脂肪乳剤及び医薬製剤 |
CA2440355C (en) * | 2001-02-22 | 2011-03-08 | Skyepharma Canada Inc. | Fibrate-statin combinations with reduced fed-fasted effects |
US20030212102A1 (en) * | 2001-06-12 | 2003-11-13 | Koretke Todd W | Novel solid dispersion compositions |
BR0210867A (pt) * | 2001-07-06 | 2004-06-29 | Lifecycle Pharma As | Processo para a preparação de um material particulado, métodos para aglomeração controlada de um material sólido finamente disperso, para melhorar a biodisponibilidade de uma substância terapêutica e/ou profilaticamente ativa, e para melhorar a vida em prateleira de uma composição farmacêutica, material articulado, composição farmacêutica, uso de um veìculo, material particulado farmacêutico, e, uso de aluminossilicato de magnésio e/ou de aluminometassilicato de magnésio |
WO2003013608A1 (en) * | 2001-08-07 | 2003-02-20 | Galephar M/F | ORAL PHARMACEUTICAL COMPOSITION CONTAINING A COMBINAITION OF PPARα AND A HMG-COA REDUCTASE INHIBITOR |
US20030091630A1 (en) * | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
US20030162827A1 (en) * | 2002-01-30 | 2003-08-28 | Suresh Venkataram | HMG CoA reductase inhibiting composition, method of preparation thereof and method for competitively inhibiting HMG CoA reductase using such composition |
US20040005339A1 (en) * | 2002-06-28 | 2004-01-08 | Shojaei Amir H. | Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability |
WO2004073689A1 (en) * | 2003-02-19 | 2004-09-02 | Lifecycle Pharma A/S | Use of a silica or silica derivative as a sorption material |
JP2006524190A (ja) * | 2003-02-20 | 2006-10-26 | テバ ファーマシューティカル インダストリーズ リミティド | 薬剤のメントール溶液 |
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BRPI0609497A2 (pt) * | 2005-03-30 | 2010-04-13 | Teva Pharma | formulações aprimoradas de fenofibrato |
US20070148233A1 (en) * | 2005-12-28 | 2007-06-28 | Lerner E I | Pharmaceutical formulations of fenofibrate having improved bioavailability |
US20070015834A1 (en) * | 2005-07-18 | 2007-01-18 | Moshe Flashner-Barak | Formulations of fenofibrate containing PEG/Poloxamer |
-
2004
- 2004-10-01 MX MXPA06003813A patent/MXPA06003813A/es not_active Application Discontinuation
- 2004-10-01 CA CA002541382A patent/CA2541382A1/en not_active Abandoned
- 2004-10-01 EP EP04762888A patent/EP1680086A2/en not_active Withdrawn
- 2004-10-01 BR BRPI0415121-6A patent/BRPI0415121A/pt not_active IP Right Cessation
- 2004-10-01 JP JP2006529649A patent/JP2007508249A/ja active Pending
- 2004-10-01 RU RU2006115596/15A patent/RU2343905C2/ru not_active IP Right Cessation
- 2004-10-01 KR KR1020067006884A patent/KR20060085682A/ko not_active Application Discontinuation
- 2004-10-01 US US10/513,778 patent/US20060068015A1/en not_active Abandoned
- 2004-10-01 WO PCT/DK2004/000668 patent/WO2005034908A2/en active Application Filing
- 2004-11-15 US US10/988,828 patent/US20060105050A1/en not_active Abandoned
- 2004-11-15 US US10/988,917 patent/US20070009603A1/en not_active Abandoned
-
2009
- 2009-05-12 AU AU2009201881A patent/AU2009201881A1/en not_active Abandoned
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009142421A2 (ko) * | 2008-05-17 | 2009-11-26 | 한올제약주식회사 | 약제학적 제제 |
WO2009142421A3 (ko) * | 2008-05-17 | 2010-03-11 | 한올제약주식회사 | 약제학적 제제 |
WO2012015168A2 (ko) * | 2010-07-28 | 2012-02-02 | 씨제이제일제당 (주) | 로수바스타틴 또는 이의 약학적 허용염을 포함하는 약학 조성물 |
WO2012015168A3 (ko) * | 2010-07-28 | 2012-04-19 | 씨제이제일제당 (주) | 로수바스타틴 또는 이의 약학적 허용염을 포함하는 약학 조성물 |
KR102501636B1 (ko) * | 2021-12-07 | 2023-02-21 | 에이스바이오팜 주식회사 | 페노피브린산을 포함하는 경구용 정제 및 이의 제조방법 |
WO2023146320A1 (ko) * | 2022-01-28 | 2023-08-03 | 동광제약 주식회사 | 로수바스타틴 또는 이의 약학적으로 허용되는 염 및 페노피브레이트를 함유하는 캡슐 제제 |
Also Published As
Publication number | Publication date |
---|---|
JP2007508249A (ja) | 2007-04-05 |
BRPI0415121A (pt) | 2006-11-28 |
US20060105050A1 (en) | 2006-05-18 |
EP1680086A2 (en) | 2006-07-19 |
US20060068015A1 (en) | 2006-03-30 |
CA2541382A1 (en) | 2005-04-21 |
AU2004279661A1 (en) | 2005-04-21 |
WO2005034908A3 (en) | 2005-08-11 |
WO2005034908A2 (en) | 2005-04-21 |
RU2343905C2 (ru) | 2009-01-20 |
MXPA06003813A (es) | 2006-06-14 |
US20070009603A1 (en) | 2007-01-11 |
AU2009201881A1 (en) | 2009-06-04 |
RU2006115596A (ru) | 2007-11-27 |
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