KR20050057673A - Ｊｎｋ 억제제를 이용한 통증의 치료 - Google Patents
Ｊｎｋ 억제제를 이용한 통증의 치료 Download PDFInfo
- Publication number
- KR20050057673A KR20050057673A KR1020057007019A KR20057007019A KR20050057673A KR 20050057673 A KR20050057673 A KR 20050057673A KR 1020057007019 A KR1020057007019 A KR 1020057007019A KR 20057007019 A KR20057007019 A KR 20057007019A KR 20050057673 A KR20050057673 A KR 20050057673A
- Authority
- KR
- South Korea
- Prior art keywords
- pain
- alkyl
- aryl
- independently
- heterocycle
- Prior art date
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- 239000013543 active substance Substances 0.000 claims abstract description 50
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- 125000000217 alkyl group Chemical group 0.000 claims description 151
- -1 hydroxy, carboxy Chemical group 0.000 claims description 142
- 125000001424 substituent group Chemical group 0.000 claims description 99
- 125000003118 aryl group Chemical group 0.000 claims description 89
- 150000001875 compounds Chemical class 0.000 claims description 86
- 125000000623 heterocyclic group Chemical group 0.000 claims description 73
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- 150000002431 hydrogen Chemical class 0.000 claims description 40
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 33
- 150000003839 salts Chemical class 0.000 claims description 30
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42110402P | 2002-10-24 | 2002-10-24 | |
| US60/421,104 | 2002-10-24 | ||
| US10/693,793 | 2003-10-23 | ||
| US10/693,793 US20040087642A1 (en) | 2002-10-24 | 2003-10-23 | Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20050057673A true KR20050057673A (ko) | 2005-06-16 |
Family
ID=32179841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057007019A Ceased KR20050057673A (ko) | 2002-10-24 | 2003-10-24 | Ｊｎｋ 억제제를 이용한 통증의 치료 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20040087642A1 (https=) |
| EP (1) | EP1553951A4 (https=) |
| JP (1) | JP2006511495A (https=) |
| KR (1) | KR20050057673A (https=) |
| AU (1) | AU2003284980B2 (https=) |
| BR (1) | BR0315573A (https=) |
| CA (1) | CA2503616A1 (https=) |
| MX (1) | MXPA05004180A (https=) |
| NZ (1) | NZ540027A (https=) |
| TW (1) | TW200418460A (https=) |
| WO (1) | WO2004039325A2 (https=) |
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| US6984652B2 (en) * | 2003-09-05 | 2006-01-10 | Warner-Lambert Company Llc | Gyrase inhibitors |
| KR20060123183A (ko) * | 2003-10-24 | 2006-12-01 | 셀진 코포레이션 | 탈리도미드를 포함하는 섬유근육통 치료용 조성물 및 그방법 |
| US20050100529A1 (en) * | 2003-11-06 | 2005-05-12 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders |
| ZA200704889B (en) * | 2004-11-23 | 2008-09-25 | Celgene Corp | JNK inhibitors for treatment of CNS injury |
| US7767710B2 (en) * | 2005-05-25 | 2010-08-03 | Calosyn Pharma, Inc. | Method for treating osteoarthritis |
| US20060269579A1 (en) * | 2005-05-25 | 2006-11-30 | Musculoskeletal Research Llc | Compositions for treating osteoarthritis |
| WO2008024776A1 (en) * | 2006-08-22 | 2008-02-28 | Children's Medical Center Corporation | Inhibiting jnk signaling promotes cns axon regeneration |
| US20100179176A1 (en) * | 2006-12-13 | 2010-07-15 | N.V. Organon | V3 antagonists for the treatment or prevention of chronic pain |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| JP5451602B2 (ja) * | 2007-06-08 | 2014-03-26 | アッヴィ・インコーポレイテッド | キナーゼ阻害薬としての５−ヘテロアリール置換インダゾール類 |
| CA2695384A1 (en) * | 2007-07-31 | 2009-02-05 | Burnham Institute For Medical Research | Bi-dentate compounds as kinase inhibitors |
| US8372431B2 (en) * | 2007-10-26 | 2013-02-12 | Bial-Portela & C.A., S.A. | Pharmaceutical composition comprising licarbazepine acetate |
| WO2010009166A1 (en) | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Oxindolyl inhibitor compounds |
| NZ602832A (en) | 2008-07-14 | 2014-04-30 | Gilead Sciences Inc | Fused heterocyclic hdac inhibitor compounds |
| JP5640005B2 (ja) | 2008-07-14 | 2014-12-10 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｄａｃおよび／またはｃｄｋ阻害剤としてのイミダゾシルピリジン化合物 |
| JP2011529504A (ja) | 2008-07-28 | 2011-12-08 | ギリアード サイエンシーズ， インコーポレイテッド | シクロアルキリデンヒストン脱アセチル化酵素阻害剤化合物およびヘテロシクロアルキリデンヒストン脱アセチル化酵素阻害剤化合物 |
| US20100056609A1 (en) * | 2008-08-26 | 2010-03-04 | Washington University | Methods and compositions for inhibition of axonal degeneration by modulation of the dlk/jnk pathway |
| WO2010144378A2 (en) | 2009-06-08 | 2010-12-16 | Gilead Colorado, Inc. | Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds |
| KR20120031170A (ko) | 2009-06-08 | 2012-03-30 | 길리애드 사이언시즈, 인코포레이티드 | 알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물 |
| WO2011160653A1 (en) * | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
| BR112013015460B1 (pt) * | 2010-12-20 | 2022-01-25 | Merck Serono S.A. | Derivados de indazolil triazol, kit, e composição farmacêutica |
| US20120328629A1 (en) * | 2011-06-24 | 2012-12-27 | University Of Miami | Therapeutic Applications Targeting SARM1 |
| WO2021067749A2 (en) * | 2019-10-02 | 2021-04-08 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for the treatment of osteoarthritis |
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| US3095415A (en) * | 1958-05-30 | 1963-06-25 | Ciba Ltd | Anthraquinone dyestuffs containing a 2-chloro, 4-hydroxy (lower) alkylamino, triazinylamino group |
| CH428043A (fr) * | 1965-08-16 | 1967-01-15 | Sandoz Ag | Procédé de fabrication de colorants de dispersion isothiazolantroniques |
| US3541110A (en) * | 1967-01-20 | 1970-11-17 | American Home Prod | Indazole-5-sulfonamides |
| JPS63184364A (ja) * | 1987-01-27 | 1988-07-29 | Toshiba Corp | 半導体装置の製造方法 |
| NZ227841A (en) * | 1988-02-12 | 1991-08-27 | Merck Sharp & Dohme | Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions |
| US5434136A (en) * | 1990-12-14 | 1995-07-18 | Mathias; John R. | Treatment of motility disorders with a GNRH analog |
| MY113463A (en) * | 1994-01-04 | 2002-03-30 | Novo Nordisk As | Novel heterocyclic compounds |
| US5766605A (en) * | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
| DK0851753T3 (da) * | 1995-09-19 | 2004-03-15 | Fujisawa Pharmaceutical Co | Aerosolpræparater |
| GB9622363D0 (en) * | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
| EP0973767A1 (en) * | 1997-03-31 | 2000-01-26 | Dupont Pharmaceuticals Company | Indazoles of cyclic ureas useful as hiv protease inhibitors |
| US6258819B1 (en) * | 1999-08-05 | 2001-07-10 | Syntex (U.S.A.) Llc | Substituted 2(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)-4(3H)-azaquinazolinones |
| MXPA02001565A (es) * | 1999-08-13 | 2005-07-14 | Vertex Pharma | Inhibidores de cinasas c-jun n-terminal (jnk) y de otras cinasas proteicas. |
| HK1053107A1 (zh) * | 1999-08-19 | 2003-10-10 | Signal Pharmaceuticals, Inc. | 作为jnk抗化剂的pyrazoloanthrone及其衍生物和它们的成份 |
| YU54202A (sh) * | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| ATE267629T1 (de) * | 2000-07-21 | 2004-06-15 | Ortho Mcneil Pharm Inc | Verwendung von carbamat verbindungen zur vorbeugung oder behandlung von neuropathischen- , cluster- und migräneartigen kopfschmerzen |
| US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| DE60131032T2 (de) * | 2000-08-25 | 2008-08-14 | Research Corp. Technologies, Inc., Tucson | Verwendung von antikonvulsiven Aminosäure zur Behandlung von Migräne |
| US7129242B2 (en) * | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| US6987184B2 (en) * | 2001-02-15 | 2006-01-17 | Signal Pharmaceuticals, Llc | Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related |
| ES2365905T3 (es) * | 2001-03-30 | 2011-10-13 | King Pharmaceuticals, Inc. | Compuestos de tiofeno condensados y uso de los mismos en el tratamiento del dolor crónico. |
| GB0108770D0 (en) * | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
| US6562033B2 (en) * | 2001-04-09 | 2003-05-13 | Baylis Medical Co. | Intradiscal lesioning apparatus |
| CN1300116C (zh) * | 2001-04-16 | 2007-02-14 | 卫材株式会社 | 1h－吲唑化合物 |
| GB0112494D0 (en) * | 2001-05-22 | 2001-07-11 | Arachnova Therapeutics Ltd | New therapeutic use |
| GB0115182D0 (en) * | 2001-06-20 | 2001-08-15 | Glaxo Group Ltd | Medicaments |
| IL160915A0 (en) * | 2001-09-19 | 2004-08-31 | Aventis Pharma Sa | Indolizines inhibiting kinase proteins |
| TW200302722A (en) * | 2002-02-13 | 2003-08-16 | Astrazeneca Ab | Therapeutic agents |
| AU2003217961B2 (en) * | 2002-03-08 | 2008-02-28 | Signal Pharmaceuticals, Llc | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
-
2003
- 2003-10-23 US US10/693,793 patent/US20040087642A1/en not_active Abandoned
- 2003-10-24 KR KR1020057007019A patent/KR20050057673A/ko not_active Ceased
- 2003-10-24 NZ NZ540027A patent/NZ540027A/en unknown
- 2003-10-24 MX MXPA05004180A patent/MXPA05004180A/es not_active Application Discontinuation
- 2003-10-24 WO PCT/US2003/034006 patent/WO2004039325A2/en not_active Ceased
- 2003-10-24 EP EP03779300A patent/EP1553951A4/en not_active Withdrawn
- 2003-10-24 TW TW092129557A patent/TW200418460A/zh unknown
- 2003-10-24 CA CA002503616A patent/CA2503616A1/en not_active Abandoned
- 2003-10-24 AU AU2003284980A patent/AU2003284980B2/en not_active Ceased
- 2003-10-24 JP JP2004548497A patent/JP2006511495A/ja active Pending
- 2003-10-24 BR BR0315573-0A patent/BR0315573A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1553951A2 (en) | 2005-07-20 |
| US20040087642A1 (en) | 2004-05-06 |
| NZ540027A (en) | 2008-04-30 |
| JP2006511495A (ja) | 2006-04-06 |
| AU2003284980B2 (en) | 2008-08-07 |
| MXPA05004180A (es) | 2005-09-20 |
| EP1553951A4 (en) | 2008-06-11 |
| BR0315573A (pt) | 2005-08-30 |
| WO2004039325A2 (en) | 2004-05-13 |
| WO2004039325A3 (en) | 2004-11-11 |
| CA2503616A1 (en) | 2004-05-13 |
| AU2003284980A1 (en) | 2004-05-25 |
| TW200418460A (en) | 2004-10-01 |
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