NZ540027A - Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain - Google Patents

Info

Publication number

NZ540027A

NZ540027A NZ540027A NZ54002703A NZ540027A NZ 540027 A NZ540027 A NZ 540027A NZ 540027 A NZ540027 A NZ 540027A NZ 54002703 A NZ54002703 A NZ 54002703A NZ 540027 A NZ540027 A NZ 540027A

Authority

NZ

New Zealand

Prior art keywords

heterocycle

pain

alkyl

aryl

arylalkyl

Prior art date

2002-10-24

Links

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• 230000036407 pain Effects 0.000 title claims abstract description 202
• 239000012825 JNK inhibitor Substances 0.000 title claims abstract description 125
• 229940118135 JNK inhibitor Drugs 0.000 title claims abstract description 111
• 239000000203 mixture Substances 0.000 title claims abstract description 45
• 238000011282 treatment Methods 0.000 title claims description 33
• 230000004048 modification Effects 0.000 title claims description 18
• 238000012986 modification Methods 0.000 title claims description 18
• 230000002265 prevention Effects 0.000 title claims description 15
• 238000000034 method Methods 0.000 title description 56
• 150000003839 salts Chemical class 0.000 claims abstract description 32
• 239000012453 solvate Substances 0.000 claims abstract description 18
• 238000004519 manufacturing process Methods 0.000 claims abstract description 10
• 125000000217 alkyl group Chemical group 0.000 claims description 140
• 125000001424 substituent group Chemical group 0.000 claims description 95
• 125000003118 aryl group Chemical group 0.000 claims description 87
• -1 hydroxy, carboxy Chemical group 0.000 claims description 82
• 125000000623 heterocyclic group Chemical group 0.000 claims description 81
• 150000001875 compounds Chemical class 0.000 claims description 77
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 65
• 239000013543 active substance Substances 0.000 claims description 50
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 48
• 229910052739 hydrogen Inorganic materials 0.000 claims description 44
• 239000001257 hydrogen Substances 0.000 claims description 44
• 125000003545 alkoxy group Chemical group 0.000 claims description 43
• 208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims description 37
• 229910052736 halogen Inorganic materials 0.000 claims description 36
• 150000002367 halogens Chemical class 0.000 claims description 36
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 36
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 35
• 239000003112 inhibitor Substances 0.000 claims description 33
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• 125000004103 aminoalkyl group Chemical group 0.000 claims description 20
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