KR20050037583A - 베타-락타마제 억제제 전구약물 - Google Patents
베타-락타마제 억제제 전구약물 Download PDFInfo
- Publication number
- KR20050037583A KR20050037583A KR1020057002983A KR20057002983A KR20050037583A KR 20050037583 A KR20050037583 A KR 20050037583A KR 1020057002983 A KR1020057002983 A KR 1020057002983A KR 20057002983 A KR20057002983 A KR 20057002983A KR 20050037583 A KR20050037583 A KR 20050037583A
- Authority
- KR
- South Korea
- Prior art keywords
- prodrug
- beta
- hydroxymethyl
- oxo
- heptane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000000651 prodrug Substances 0.000 title claims abstract description 167
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- 238000000034 method Methods 0.000 claims abstract description 41
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- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 57
- NNYHKYDYHWSHKQ-UHFFFAOYSA-N 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound OC(=O)C1CSC2CCN12 NNYHKYDYHWSHKQ-UHFFFAOYSA-N 0.000 claims description 56
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- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40564002P | 2002-08-23 | 2002-08-23 | |
| US60/405,640 | 2002-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20050037583A true KR20050037583A (ko) | 2005-04-22 |
Family
ID=31946909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057002983A Abandoned KR20050037583A (ko) | 2002-08-23 | 2003-08-11 | 베타-락타마제 억제제 전구약물 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7091197B2 (https=) |
| EP (1) | EP1534717B1 (https=) |
| JP (1) | JP2005539037A (https=) |
| KR (1) | KR20050037583A (https=) |
| CN (1) | CN1688589A (https=) |
| AP (1) | AP2005003231A0 (https=) |
| AR (1) | AR041028A1 (https=) |
| AT (1) | ATE349452T1 (https=) |
| AU (1) | AU2003250489A1 (https=) |
| BR (1) | BR0313683A (https=) |
| CA (1) | CA2494953A1 (https=) |
| DE (1) | DE60310733D1 (https=) |
| EA (1) | EA007540B1 (https=) |
| EC (1) | ECSP055625A (https=) |
| GT (1) | GT200300179A (https=) |
| HR (1) | HRP20050162A2 (https=) |
| IL (1) | IL166719A0 (https=) |
| IS (1) | IS7693A (https=) |
| MA (1) | MA27387A1 (https=) |
| MX (1) | MXPA05001446A (https=) |
| NO (1) | NO20051497D0 (https=) |
| NZ (1) | NZ538340A (https=) |
| OA (1) | OA12909A (https=) |
| PA (1) | PA8579701A1 (https=) |
| PE (1) | PE20040899A1 (https=) |
| PL (1) | PL375988A1 (https=) |
| TN (1) | TNSN05054A1 (https=) |
| TW (1) | TWI250162B (https=) |
| UY (1) | UY27947A1 (https=) |
| WO (1) | WO2004018484A1 (https=) |
| ZA (1) | ZA200501513B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004108733A1 (en) * | 2003-06-05 | 2004-12-16 | Pfizer Products Inc. | Beta-lactamase inhibitor prodrug |
| US20060105941A1 (en) * | 2004-11-12 | 2006-05-18 | Allergan, Inc. | Mixed antibiotic codrugs |
| EP1913378A1 (de) * | 2005-07-29 | 2008-04-23 | Sigma-Aldrich Production GmbH | Ionisierungsadditive enthaltende lc/ms-blends |
| WO2010118968A1 (en) | 2009-04-16 | 2010-10-21 | Nicox S.A. | No-donor aspirin derivatives |
| WO2013056163A1 (en) * | 2011-10-14 | 2013-04-18 | The Regents Of The University Of California | Beta-lactamase inhibitors |
| CN104159587A (zh) * | 2012-01-06 | 2014-11-19 | 南佛罗里达大学 | 组合物、使用方法、以及治疗方法 |
| CN109422765B (zh) * | 2017-09-05 | 2020-08-28 | 香港理工大学深圳研究院 | C类β-内酰胺酶抑制剂及其制备方法和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE34011B1 (en) | 1969-03-13 | 1975-01-08 | Leo Pharm Prod Ltd | New penicillin esters |
| IE34019B1 (en) | 1969-03-18 | 1975-01-08 | Leo Pharm Prod Ltd | New semi-synthetic penicillin esters |
| GB1267936A (en) | 1969-05-28 | 1972-03-22 | Beecham Group Ltd | DERIVATIVES OF alpha-AMINOPENICILLINS |
| US3957764A (en) | 1969-11-11 | 1976-05-18 | Lovens Kemiske Fabrik Produktionsaktieselskab | 6-aminopenicillanic acid derivatives |
| US3862181A (en) | 1970-10-28 | 1975-01-21 | Squibb & Sons Inc | Process for preparing cephalosporins |
| GB1315566A (en) | 1970-11-06 | 1973-05-02 | Leo Pharm Prod Ltd | Penicillanic acid derivatives |
| CA996929A (en) | 1971-04-05 | 1976-09-14 | Kohzi Nakano | Acyloxyalkyl ester derivatives of penicillin |
| GB1433131A (en) | 1972-03-13 | 1976-04-22 | Astra Laekemedel Ab | Penicillins |
| GB1426717A (en) | 1972-03-13 | 1976-03-03 | Astra Laekemedel Ab | Penicillins |
| US4397783A (en) | 1979-03-05 | 1983-08-09 | Pfizer Inc. | Process for converting 6,6-disubstituted penicillanic acid derivatives to the 6-β-congeners |
| DE2927004A1 (de) * | 1979-07-04 | 1981-05-27 | Bayer Ag, 5090 Leverkusen | Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel |
| US4287181A (en) * | 1979-10-22 | 1981-09-01 | Pfizer Inc. | Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors |
| US4432970A (en) | 1979-11-23 | 1984-02-21 | Pfizer Inc. | 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors |
| GB2076812A (en) * | 1980-05-22 | 1981-12-09 | Ciba Geigy Ag | Penam-dioxide compounds, processes for their manufacture, and their use |
| JPS5849387A (ja) | 1981-09-17 | 1983-03-23 | Sankyo Co Ltd | ７−メトキシセフアロスポリン化合物およびその製法 |
| DE3274453D1 (en) * | 1981-09-22 | 1987-01-15 | Kureha Chemical Ind Co Ltd | Penicillin derivatives |
| US4406887A (en) | 1981-10-13 | 1983-09-27 | Bristol-Myers Company | Method for treating resistant bacteria including anaerobes |
| US4428935A (en) * | 1982-05-24 | 1984-01-31 | Pfizer Inc. | Penicillanic acid dioxide prodrug |
| US4521533A (en) | 1984-07-12 | 1985-06-04 | Pfizer Inc. | Salts of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide esters and beta-lactam antibiotics |
| DE3901405A1 (de) | 1989-01-19 | 1990-07-26 | Hoechst Ag | Cephalosporinderivate und verfahren zu ihrer herstellung |
| JPH03206038A (ja) | 1990-01-08 | 1991-09-09 | Yoshitomi Pharmaceut Ind Ltd | 抗菌剤 |
| GB9001405D0 (en) | 1990-01-22 | 1990-03-21 | Leo Pharm Prod Ltd | New intermediates,their production and use |
| GB9208492D0 (en) | 1992-04-16 | 1992-06-03 | Glaxo Spa | Heterocyclic compounds |
| WO2004108733A1 (en) | 2003-06-05 | 2004-12-16 | Pfizer Products Inc. | Beta-lactamase inhibitor prodrug |
-
2003
- 2003-08-06 PA PA20038579701A patent/PA8579701A1/es unknown
- 2003-08-11 MX MXPA05001446A patent/MXPA05001446A/es unknown
- 2003-08-11 KR KR1020057002983A patent/KR20050037583A/ko not_active Abandoned
- 2003-08-11 DE DE60310733T patent/DE60310733D1/de not_active Expired - Lifetime
- 2003-08-11 PL PL03375988A patent/PL375988A1/xx unknown
- 2003-08-11 EP EP03792574A patent/EP1534717B1/en not_active Expired - Lifetime
- 2003-08-11 NZ NZ538340A patent/NZ538340A/en unknown
- 2003-08-11 WO PCT/IB2003/003582 patent/WO2004018484A1/en not_active Ceased
- 2003-08-11 HR HR20050162A patent/HRP20050162A2/xx not_active Application Discontinuation
- 2003-08-11 AU AU2003250489A patent/AU2003250489A1/en not_active Abandoned
- 2003-08-11 CA CA002494953A patent/CA2494953A1/en not_active Abandoned
- 2003-08-11 JP JP2004530453A patent/JP2005539037A/ja not_active Abandoned
- 2003-08-11 CN CNA038243164A patent/CN1688589A/zh active Pending
- 2003-08-11 AT AT03792574T patent/ATE349452T1/de not_active IP Right Cessation
- 2003-08-11 AP AP2005003231A patent/AP2005003231A0/xx unknown
- 2003-08-11 BR BR0313683-3A patent/BR0313683A/pt not_active IP Right Cessation
- 2003-08-11 EA EA200500398A patent/EA007540B1/ru unknown
- 2003-08-11 OA OA1200500051A patent/OA12909A/en unknown
- 2003-08-19 PE PE2003000840A patent/PE20040899A1/es not_active Application Discontinuation
- 2003-08-21 UY UY27947A patent/UY27947A1/es not_active Application Discontinuation
- 2003-08-21 AR ARP030103023A patent/AR041028A1/es unknown
- 2003-08-22 TW TW092123156A patent/TWI250162B/zh not_active IP Right Cessation
- 2003-08-22 GT GT200300179A patent/GT200300179A/es unknown
- 2003-08-25 US US10/648,408 patent/US7091197B2/en not_active Expired - Fee Related
-
2005
- 2005-02-07 IL IL16671905A patent/IL166719A0/xx unknown
- 2005-02-10 IS IS7693A patent/IS7693A/is unknown
- 2005-02-21 ZA ZA200501513A patent/ZA200501513B/en unknown
- 2005-02-23 EC EC2005005625A patent/ECSP055625A/es unknown
- 2005-02-23 MA MA28119A patent/MA27387A1/fr unknown
- 2005-02-23 TN TNP2005000054A patent/TNSN05054A1/fr unknown
- 2005-03-21 NO NO20051497A patent/NO20051497D0/no not_active Application Discontinuation
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