KR20040111490A - 새로운 형태의 ｎ－（트랜스－4－이소프로필사이클로헥실카보닐）－ｄ－페닐알라닌 - Google Patents
새로운 형태의 ｎ－（트랜스－4－이소프로필사이클로헥실카보닐）－ｄ－페닐알라닌 Download PDFInfo
- Publication number
- KR20040111490A KR20040111490A KR10-2004-7015883A KR20047015883A KR20040111490A KR 20040111490 A KR20040111490 A KR 20040111490A KR 20047015883 A KR20047015883 A KR 20047015883A KR 20040111490 A KR20040111490 A KR 20040111490A
- Authority
- KR
- South Korea
- Prior art keywords
- trans
- isopropylcyclohexylcarbonyl
- phenylalanine
- methyl ester
- phenylalanine methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- OELFLUMRDSZNSF-OFLPRAFFSA-N (2R)-2-[[oxo-(4-propan-2-ylcyclohexyl)methyl]amino]-3-phenylpropanoic acid Chemical compound C1CC(C(C)C)CCC1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-OFLPRAFFSA-N 0.000 title claims abstract description 19
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical group ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 24
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 21
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- LUSNEIVFFXOKHW-DAWZGUTISA-N methyl (2r)-3-phenyl-2-[(4-propan-2-ylcyclohexanecarbonyl)amino]propanoate Chemical compound C([C@H](C(=O)OC)NC(=O)C1CCC(CC1)C(C)C)C1=CC=CC=C1 LUSNEIVFFXOKHW-DAWZGUTISA-N 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000013078 crystal Substances 0.000 claims description 13
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 12
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 10
- 150000008282 halocarbons Chemical class 0.000 claims description 9
- 239000011541 reaction mixture Substances 0.000 claims description 9
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical group C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 claims description 7
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 claims description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- YRQKWRUZZCBSIG-UHFFFAOYSA-N 4-propan-2-ylcyclohexane-1-carboxylic acid Chemical compound CC(C)C1CCC(C(O)=O)CC1 YRQKWRUZZCBSIG-UHFFFAOYSA-N 0.000 claims description 5
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 5
- YXGDSBSUTMGHOL-UHFFFAOYSA-N 4-propan-2-ylcyclohexane-1-carbonyl chloride Chemical compound CC(C)C1CCC(C(Cl)=O)CC1 YXGDSBSUTMGHOL-UHFFFAOYSA-N 0.000 claims description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- 238000000862 absorption spectrum Methods 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- XNQULTQRGBXLIA-UHFFFAOYSA-O phosphonic anhydride Chemical compound O[P+](O)=O XNQULTQRGBXLIA-UHFFFAOYSA-O 0.000 claims description 4
- 239000002244 precipitate Substances 0.000 claims description 4
- 239000001294 propane Substances 0.000 claims description 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 4
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims description 3
- 239000003208 petroleum Substances 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000002024 ethyl acetate extract Substances 0.000 claims description 2
- 150000007522 mineralic acids Chemical class 0.000 claims description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 abstract description 6
- 238000002441 X-ray diffraction Methods 0.000 abstract description 2
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 238000002329 infrared spectrum Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 239000012044 organic layer Substances 0.000 description 6
- SWVMLNPDTIFDDY-SBSPUUFOSA-N methyl (2r)-2-amino-3-phenylpropanoate;hydrochloride Chemical compound Cl.COC(=O)[C@H](N)CC1=CC=CC=C1 SWVMLNPDTIFDDY-SBSPUUFOSA-N 0.000 description 5
- 239000012267 brine Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910018072 Al 2 O 3 Inorganic materials 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- TYZXWNYMZXLYSH-CQSZACIVSA-N (2r)-2-(cyclohexanecarbonylamino)-3-phenylpropanoic acid Chemical compound C([C@H](C(=O)O)NC(=O)C1CCCCC1)C1=CC=CC=C1 TYZXWNYMZXLYSH-CQSZACIVSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2002/000114 WO2003093222A1 (en) | 2002-04-29 | 2002-04-29 | Novel form of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20040111490A true KR20040111490A (ko) | 2004-12-31 |
Family
ID=29287383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-2004-7015883A Ceased KR20040111490A (ko) | 2002-04-29 | 2002-04-29 | 새로운 형태의 ｎ－（트랜스－4－이소프로필사이클로헥실카보닐）－ｄ－페닐알라닌 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7314955B2 (enExample) |
| EP (1) | EP1499586A4 (enExample) |
| JP (1) | JP4137053B2 (enExample) |
| KR (1) | KR20040111490A (enExample) |
| AU (1) | AU2002304281A1 (enExample) |
| CA (1) | CA2481322A1 (enExample) |
| CZ (1) | CZ2004997A3 (enExample) |
| HR (1) | HRP20040920A2 (enExample) |
| HU (1) | HUP0500259A2 (enExample) |
| IL (1) | IL164327A0 (enExample) |
| MX (1) | MXNL04000084A (enExample) |
| SK (1) | SK287644B6 (enExample) |
| WO (1) | WO2003093222A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ2004997A3 (cs) | 2002-04-29 | 2005-01-12 | Biocon Limited | Nová forma N-(trans-4-isopropylcyklohexylkarbonyl)-D-fenylalaninu |
| US6861553B2 (en) | 2002-07-03 | 2005-03-01 | Teva Pharmaceuticals Industries Ltd. | Process for preparing nateglinide and intermediates thereof |
| US7148376B2 (en) | 2002-07-18 | 2006-12-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
| US7358390B2 (en) | 2002-07-18 | 2008-04-15 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
| US7420084B2 (en) | 2002-07-18 | 2008-09-02 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
| US7534913B2 (en) | 2002-07-18 | 2009-05-19 | Teva Pharmaceutica Industries Ltd. | Crystalline form of nateglinide |
| WO2004020396A1 (en) * | 2002-08-28 | 2004-03-11 | Dr. Reddy's Laboratories Limited | Crystalline form of nateglinide and process for preparation thereof |
| WO2004074330A1 (ja) * | 2003-02-18 | 2004-09-02 | Konishi Co., Ltd. | 硬化性樹脂、その製造方法及び硬化性樹脂組成物 |
| HU227073B1 (hu) * | 2003-07-10 | 2010-06-28 | Richter Gedeon Nyrt | Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata |
| US20070231393A1 (en) * | 2004-05-19 | 2007-10-04 | University Of South Carolina | System and Device for Magnetic Drug Targeting with Magnetic Drug Carrier Particles |
| GB0413084D0 (en) * | 2004-06-11 | 2004-07-14 | Cipla Ltd | Process |
| US20100004334A1 (en) * | 2008-07-01 | 2010-01-07 | Mead Johnson Nutrition Company | Nutritional Compositions Containing Punicalagins |
| US11390830B2 (en) | 2018-10-05 | 2022-07-19 | The Chemours Company Fc, Llc | Compositions comprising 1,2-dichloro-1,2-difluoroethylene for use in cleaning and solvent applications |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6354321A (ja) * | 1985-03-27 | 1988-03-08 | Ajinomoto Co Inc | 血糖降下剤 |
| US4814684A (en) * | 1987-09-30 | 1989-03-21 | Trw Inc. | Apparatus for extending the Vout/Vin ratio of a DC-to-DC converter |
| EP0526171B1 (en) * | 1991-07-30 | 1997-03-05 | Ajinomoto Co., Inc. | Crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing them |
| US5463116A (en) * | 1991-07-30 | 1995-10-31 | Ajinomoto Co., Inc. | Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them |
| CZ2004997A3 (cs) | 2002-04-29 | 2005-01-12 | Biocon Limited | Nová forma N-(trans-4-isopropylcyklohexylkarbonyl)-D-fenylalaninu |
-
2002
- 2002-04-29 CZ CZ2004997A patent/CZ2004997A3/cs unknown
- 2002-04-29 CA CA002481322A patent/CA2481322A1/en not_active Abandoned
- 2002-04-29 JP JP2004501362A patent/JP4137053B2/ja not_active Expired - Fee Related
- 2002-04-29 WO PCT/IN2002/000114 patent/WO2003093222A1/en not_active Ceased
- 2002-04-29 MX MXNL04000084A patent/MXNL04000084A/es not_active Application Discontinuation
- 2002-04-29 SK SK5005-2004A patent/SK287644B6/sk not_active IP Right Cessation
- 2002-04-29 HU HU0500259A patent/HUP0500259A2/hu unknown
- 2002-04-29 AU AU2002304281A patent/AU2002304281A1/en not_active Abandoned
- 2002-04-29 KR KR10-2004-7015883A patent/KR20040111490A/ko not_active Ceased
- 2002-04-29 EP EP02733208A patent/EP1499586A4/en not_active Withdrawn
- 2002-04-29 HR HR20040920A patent/HRP20040920A2/xx not_active Application Discontinuation
- 2002-04-29 US US10/508,364 patent/US7314955B2/en not_active Expired - Fee Related
-
2004
- 2004-09-28 IL IL16432704A patent/IL164327A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK50052004A3 (sk) | 2005-03-04 |
| WO2003093222A1 (en) | 2003-11-13 |
| EP1499586A1 (en) | 2005-01-26 |
| US20050165108A1 (en) | 2005-07-28 |
| HUP0500259A2 (hu) | 2005-06-28 |
| IL164327A0 (en) | 2005-12-18 |
| MXNL04000084A (es) | 2006-02-28 |
| EP1499586A4 (en) | 2006-01-18 |
| JP2005523933A (ja) | 2005-08-11 |
| JP4137053B2 (ja) | 2008-08-20 |
| HRP20040920A2 (en) | 2005-02-28 |
| SK287644B6 (sk) | 2011-05-06 |
| CZ2004997A3 (cs) | 2005-01-12 |
| AU2002304281A1 (en) | 2003-11-17 |
| CA2481322A1 (en) | 2003-11-13 |
| US7314955B2 (en) | 2008-01-01 |
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Legal Events
| Date | Code | Title | Description |
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| PA0105 | International application |
Patent event date: 20041005 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20070123 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20071207 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20080703 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20071207 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |