KR20010108228A - 도파민 ｄ1 수용체 효능제 화합물 - Google Patents

도파민 ｄ1 수용체 효능제 화합물 Download PDF

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Publication number
KR20010108228A
KR20010108228A KR1020017010418A KR20017010418A KR20010108228A KR 20010108228 A KR20010108228 A KR 20010108228A KR 1020017010418 A KR1020017010418 A KR 1020017010418A KR 20017010418 A KR20017010418 A KR 20017010418A KR 20010108228 A KR20010108228 A KR 20010108228A
Authority
KR
South Korea
Prior art keywords
hydrogen
tetrahydro
chloro
mmol
dopamine
Prior art date
Application number
KR1020017010418A
Other languages
English (en)
Korean (ko)
Inventor
틸브룩게리
Original Assignee
스미스 티. 더블유
세너스 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 스미스 티. 더블유, 세너스 리미티드 filed Critical 스미스 티. 더블유
Publication of KR20010108228A publication Critical patent/KR20010108228A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
KR1020017010418A 1999-02-17 2000-02-17 도파민 ｄ1 수용체 효능제 화합물 KR20010108228A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9903671.7A GB9903671D0 (en) 1999-02-17 1999-02-17 Dopamine D-1 receptor agonist compounds
GB9903671.7 1999-02-17
PCT/GB2000/000570 WO2000049000A1 (en) 1999-02-17 2000-02-17 Dopamine d1 receptor agonist compounds

Publications (1)

Publication Number Publication Date
KR20010108228A true KR20010108228A (ko) 2001-12-07

Family

ID=10847990

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017010418A KR20010108228A (ko) 1999-02-17 2000-02-17 도파민 ｄ1 수용체 효능제 화합물

Country Status (17)

Country Link
EP (1) EP1157009A1 (ru)
JP (1) JP2002537288A (ru)
KR (1) KR20010108228A (ru)
CN (1) CN1142916C (ru)
AU (1) AU767332B2 (ru)
BR (1) BR0008329A (ru)
CA (1) CA2363695A1 (ru)
CZ (1) CZ20012973A3 (ru)
EA (1) EA004745B1 (ru)
GB (1) GB9903671D0 (ru)
HU (1) HUP0200057A3 (ru)
IL (1) IL144810A0 (ru)
MX (1) MXPA01008294A (ru)
NO (1) NO20013978L (ru)
PL (1) PL349838A1 (ru)
WO (1) WO2000049000A1 (ru)
ZA (1) ZA200106478B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130576D0 (en) * 2001-12-20 2002-02-06 Cenes Ltd Dopamine D1 receptor agonist pro-drug compounds & derivatives
EP1904069B1 (en) 2005-07-15 2018-06-13 Albany Molecular Research, Inc. Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
CN101296943A (zh) * 2005-08-03 2008-10-29 米亚·利维特 通过多巴胺d1r激动剂杀伤人类淋巴瘤和白血病癌细胞和tcr活化的人类正常细胞
CN101684096A (zh) * 2008-09-23 2010-03-31 中国科学院上海药物研究所 一类新型苯并氮杂卓类化合物及其制备方法和用途
CN102276531A (zh) * 2011-05-30 2011-12-14 扬子江药业集团广州海瑞药业有限公司 一种甲磺酸非诺多泮的制备方法
HUE043705T2 (hu) * 2013-06-27 2019-09-30 Pfizer Heteroaromás vegyületek és dopamin D1 ligandumként történõ alkalmazásuk

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1561305A (en) * 1975-07-02 1980-02-20 Smithkline Corp Benzazepine derivatives and pharmeceutical compositions containing them
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4265889A (en) * 1978-05-05 1981-05-05 Smithkline Corporation 6-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4707483A (en) * 1985-12-20 1987-11-17 Smithkline Beckman Corporation 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders
US4861771A (en) * 1989-01-27 1989-08-29 Smithkline Beckman Corporation Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine as prodrugs

Also Published As

Publication number Publication date
IL144810A0 (en) 2002-06-30
CA2363695A1 (en) 2000-08-24
NO20013978D0 (no) 2001-08-15
AU2563200A (en) 2000-09-04
GB9903671D0 (en) 1999-04-14
JP2002537288A (ja) 2002-11-05
ZA200106478B (en) 2002-02-07
PL349838A1 (en) 2002-09-23
BR0008329A (pt) 2002-01-29
EP1157009A1 (en) 2001-11-28
MXPA01008294A (es) 2002-07-02
EA200100783A1 (ru) 2002-02-28
NO20013978L (no) 2001-08-15
CZ20012973A3 (cs) 2002-01-16
CN1142916C (zh) 2004-03-24
EA004745B1 (ru) 2004-08-26
WO2000049000A1 (en) 2000-08-24
CN1341102A (zh) 2002-03-20
HUP0200057A3 (en) 2004-03-29
HUP0200057A2 (en) 2002-08-28
AU767332B2 (en) 2003-11-06

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Legal Events

Date Code Title Description
N231 Notification of change of applicant
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid