EA200100783A1 - Соединения - агонисты дофаминовых рецепторов d1 - Google Patents
Соединения - агонисты дофаминовых рецепторов d1Info
- Publication number
- EA200100783A1 EA200100783A1 EA200100783A EA200100783A EA200100783A1 EA 200100783 A1 EA200100783 A1 EA 200100783A1 EA 200100783 A EA200100783 A EA 200100783A EA 200100783 A EA200100783 A EA 200100783A EA 200100783 A1 EA200100783 A1 EA 200100783A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hydrogen
- halogen
- together form
- cyclohexane ring
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Данное изобретение предлагает 2,3,4,5-тетрагидро-1H-3-бензазепины общей формулы (I), где Rпредставляет собой водород, галоген, C-C-алкил или CF; Rпредставляет собой водород, метил или низший алкенил с 3-5 атомами углерода; Rи Rвместе образуют фурановое, дигидрофурановое, тиофеновое, дигидротиофеновое, циклопентановое или циклогексановое кольцо и Rпредставляет собой водород или Rи Rвместе образуют фурановое, дигидрофурановое, тиофеновое, дигидротиофеновое, циклопентановое или циклогексановое кольцо и Rпредставляет собой водород; Rпредставляет собой водород, галоген, CF, CN, NO, или NH; Rпредставляет собой водород, галоген, CF, CN, NOили NH. Исключена определенная комбинация заместителей: R=H, R=H, и Rи R, вместе образуют циклогексановое кольцо, а именно 1-(5,6,7,8-тетрагидронафтален-2-ил)-2,3,4,5-тетрагидро-1H-бензол[d]азепин-7,8-диол. Соединения по изобретению предложены в качестве терапевтических агентов, которые селективно позитивно взаимодействуют с постсинаптическими дофаминовыми рецепторами D1 в полосатом теле, прямо или косвенно, (называемые дофаминовыми D1-агонистами) и являются чрезвычайно полезными в качестве антипаркинсонических агентов.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9903671.7A GB9903671D0 (en) | 1999-02-17 | 1999-02-17 | Dopamine D-1 receptor agonist compounds |
PCT/GB2000/000570 WO2000049000A1 (en) | 1999-02-17 | 2000-02-17 | Dopamine d1 receptor agonist compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200100783A1 true EA200100783A1 (ru) | 2002-02-28 |
EA004745B1 EA004745B1 (ru) | 2004-08-26 |
Family
ID=10847990
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100783A EA004745B1 (ru) | 1999-02-17 | 2000-02-17 | Тетрагидробензазепиновые производные в качестве агонистов дофаминовых рецепторов d1 |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1157009A1 (ru) |
JP (1) | JP2002537288A (ru) |
KR (1) | KR20010108228A (ru) |
CN (1) | CN1142916C (ru) |
AU (1) | AU767332B2 (ru) |
BR (1) | BR0008329A (ru) |
CA (1) | CA2363695A1 (ru) |
CZ (1) | CZ20012973A3 (ru) |
EA (1) | EA004745B1 (ru) |
GB (1) | GB9903671D0 (ru) |
HU (1) | HUP0200057A3 (ru) |
IL (1) | IL144810A0 (ru) |
MX (1) | MXPA01008294A (ru) |
NO (1) | NO20013978L (ru) |
PL (1) | PL349838A1 (ru) |
WO (1) | WO2000049000A1 (ru) |
ZA (1) | ZA200106478B (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0130576D0 (en) * | 2001-12-20 | 2002-02-06 | Cenes Ltd | Dopamine D1 receptor agonist pro-drug compounds & derivatives |
GEP20125566B (en) * | 2005-07-15 | 2012-07-10 | Amr Technology Inc | Aryl-and heteroaryl-substituded tetrahydro-benzazepines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
CN101296943A (zh) * | 2005-08-03 | 2008-10-29 | 米亚·利维特 | 通过多巴胺d1r激动剂杀伤人类淋巴瘤和白血病癌细胞和tcr活化的人类正常细胞 |
CN101684096A (zh) * | 2008-09-23 | 2010-03-31 | 中国科学院上海药物研究所 | 一类新型苯并氮杂卓类化合物及其制备方法和用途 |
CN102276531A (zh) * | 2011-05-30 | 2011-12-14 | 扬子江药业集团广州海瑞药业有限公司 | 一种甲磺酸非诺多泮的制备方法 |
CN105324376B (zh) | 2013-06-27 | 2017-06-23 | 辉瑞大药厂 | 杂芳族化合物及其作为多巴胺d1配体的用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1561305A (en) * | 1975-07-02 | 1980-02-20 | Smithkline Corp | Benzazepine derivatives and pharmeceutical compositions containing them |
US4111957A (en) * | 1977-02-02 | 1978-09-05 | Smithkline Corporation | Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds |
US4265889A (en) * | 1978-05-05 | 1981-05-05 | Smithkline Corporation | 6-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
US4707483A (en) * | 1985-12-20 | 1987-11-17 | Smithkline Beckman Corporation | 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders |
US4861771A (en) * | 1989-01-27 | 1989-08-29 | Smithkline Beckman Corporation | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine as prodrugs |
-
1999
- 1999-02-17 GB GBGB9903671.7A patent/GB9903671D0/en not_active Ceased
-
2000
- 2000-02-17 KR KR1020017010418A patent/KR20010108228A/ko not_active Application Discontinuation
- 2000-02-17 CN CNB00803947XA patent/CN1142916C/zh not_active Expired - Fee Related
- 2000-02-17 HU HU0200057A patent/HUP0200057A3/hu unknown
- 2000-02-17 CA CA002363695A patent/CA2363695A1/en not_active Abandoned
- 2000-02-17 EA EA200100783A patent/EA004745B1/ru not_active IP Right Cessation
- 2000-02-17 EP EP00903881A patent/EP1157009A1/en not_active Withdrawn
- 2000-02-17 WO PCT/GB2000/000570 patent/WO2000049000A1/en not_active Application Discontinuation
- 2000-02-17 BR BR0008329-1A patent/BR0008329A/pt not_active IP Right Cessation
- 2000-02-17 CZ CZ20012973A patent/CZ20012973A3/cs unknown
- 2000-02-17 IL IL14481000A patent/IL144810A0/xx unknown
- 2000-02-17 PL PL00349838A patent/PL349838A1/xx not_active Application Discontinuation
- 2000-02-17 MX MXPA01008294A patent/MXPA01008294A/es unknown
- 2000-02-17 JP JP2000599740A patent/JP2002537288A/ja active Pending
- 2000-02-17 AU AU25632/00A patent/AU767332B2/en not_active Ceased
-
2001
- 2001-08-07 ZA ZA200106478A patent/ZA200106478B/en unknown
- 2001-08-15 NO NO20013978A patent/NO20013978L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA01008294A (es) | 2002-07-02 |
KR20010108228A (ko) | 2001-12-07 |
NO20013978D0 (no) | 2001-08-15 |
PL349838A1 (en) | 2002-09-23 |
AU2563200A (en) | 2000-09-04 |
CN1341102A (zh) | 2002-03-20 |
EA004745B1 (ru) | 2004-08-26 |
BR0008329A (pt) | 2002-01-29 |
GB9903671D0 (en) | 1999-04-14 |
JP2002537288A (ja) | 2002-11-05 |
CZ20012973A3 (cs) | 2002-01-16 |
HUP0200057A2 (en) | 2002-08-28 |
HUP0200057A3 (en) | 2004-03-29 |
IL144810A0 (en) | 2002-06-30 |
WO2000049000A1 (en) | 2000-08-24 |
CN1142916C (zh) | 2004-03-24 |
CA2363695A1 (en) | 2000-08-24 |
AU767332B2 (en) | 2003-11-06 |
ZA200106478B (en) | 2002-02-07 |
EP1157009A1 (en) | 2001-11-28 |
NO20013978L (no) | 2001-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |